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Nowadays, sustainable materials are receiving significant attention due to the fact that they will be crucial for the development of the next generation of products and devices. In the present work, hydrogels have been successfully synthesized using lignin which is non-valorized biopolymer from the paper industry. Hydrogels were prepared via crosslinking with Poly(ethylene) glycol diglycidyl ether (PEGDGE). Different crosslinker ratios were used to determine their influence on the structural and chemical properties of the resulting hydrogels. It has been found that pore size was reduced by increasing crosslinker amount. The greater crosslinking density increased the swelling capacity of the hydrogels due to the presence of more hydrophilic groups in the hydrogel network. Paracetamol release test showed higher drug diffusion for hydrogels produced with a ratio lignin:PEGDGE 1:1. The obtained results demonstrate that the proposed approach is a promising route to utilize lignocellulose waste for producing porous materials for advanced biomedical applications in the pharmacy industry.
Mario Culebras; Mahboubeh Pishnamazi; Gavin Walker; Maurice Collins. Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms. Molecules 2021, 26, 1593 .
AMA StyleMario Culebras, Mahboubeh Pishnamazi, Gavin Walker, Maurice Collins. Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms. Molecules. 2021; 26 (6):1593.
Chicago/Turabian StyleMario Culebras; Mahboubeh Pishnamazi; Gavin Walker; Maurice Collins. 2021. "Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms." Molecules 26, no. 6: 1593.
Carbon capture and storage (CCS) has attracted renewed interest in the re-evaluation of the equations of state (EoS) for the prediction of thermodynamic properties. This study also evaluates EoS for Peng–Robinson (PR) and Soave–Redlich–Kwong (SRK) and their capability to predict the thermodynamic properties of CO2-rich mixtures. The investigation was carried out using machine learning such as an artificial neural network (ANN) and a classified learner. A lower average absolute relative deviation (AARD) of 7.46% was obtained for the PR in comparison with SRK (AARD = 15.0%) for three components system of CO2 with N2 and CH4. Moreover, it was found to be 13.5% for PR and 19.50% for SRK in the five components’ (CO2 with N2, CH4, Ar, and O2) case. In addition, applying machine learning provided promise and valuable insight to deal with engineering problems. The implementation of machine learning in conjunction with EoS led to getting lower predictive AARD in contrast to EoS. An of AARD 2.81% was achieved for the three components and 12.2% for the respective five components mixture.
George Truc; Nejat Rahmanian; Mahboubeh Pishnamazi. Assessment of Cubic Equations of State: Machine Learning for Rich Carbon-Dioxide Systems. Sustainability 2021, 13, 2527 .
AMA StyleGeorge Truc, Nejat Rahmanian, Mahboubeh Pishnamazi. Assessment of Cubic Equations of State: Machine Learning for Rich Carbon-Dioxide Systems. Sustainability. 2021; 13 (5):2527.
Chicago/Turabian StyleGeorge Truc; Nejat Rahmanian; Mahboubeh Pishnamazi. 2021. "Assessment of Cubic Equations of State: Machine Learning for Rich Carbon-Dioxide Systems." Sustainability 13, no. 5: 2527.
Paracetamol crystals often exhibit poor compressibility properties, which results in capping issues. The Particle Size Distribution (PSD) of paracetamol was engineered to improve the compressibility of paracetamol crystals. This was accomplished by growing paracetamol crystals in the presence of additives. The active pharmaceutical ingredient Phenacetin and impurity 4-chloroacetanalide were used to modify the crystal properties of paracetamol. In solution, the phenacetin or 4-chloroacetanalide molecules adsorb onto the paracetamol crystal faces selectively (110 or 011) and inhibit the further growth of the paracetamol crystal and consequently, the paracetamol crystal growth is reduced substantially. For controlling the PSD of crystal to improve the compressibility of paracetamol crystals, a set of cooling crystallization experiments in the presence of additive was designed. According to a statistical experimental design, the cooling rate was the most effective parameter. The PSD was reduced when paracetamol crystallized from the controlled crystallization in the presence of less than 3 mol% of both additives. These smaller particles increased almost four-fold the compressibility of paracetamol in comparison to the commercial material. Moreover, tablets were prepared for each formulation using a direct compaction method. The results illustrated that a higher tablet hardness of paracetamol was achieved by tailoring the paracetamol crystal size distribution. In addition, the tablet disintegration time was higher for the formulation with increased hardness. Overall, this work presents the potential use of structurally similar compounds as additives to alter the mechanical properties of an API.
Leila Keshavarz; Mahboubeh Pishnamazi; U.B. Rao Khandavilli; Saeed Shirazian; Maurice N. Collins; Gavin M. Walker; Patrick J. Frawley. Tailoring crystal size distributions for product performance, compaction of paracetamol. Arabian Journal of Chemistry 2021, 14, 103089 .
AMA StyleLeila Keshavarz, Mahboubeh Pishnamazi, U.B. Rao Khandavilli, Saeed Shirazian, Maurice N. Collins, Gavin M. Walker, Patrick J. Frawley. Tailoring crystal size distributions for product performance, compaction of paracetamol. Arabian Journal of Chemistry. 2021; 14 (4):103089.
Chicago/Turabian StyleLeila Keshavarz; Mahboubeh Pishnamazi; U.B. Rao Khandavilli; Saeed Shirazian; Maurice N. Collins; Gavin M. Walker; Patrick J. Frawley. 2021. "Tailoring crystal size distributions for product performance, compaction of paracetamol." Arabian Journal of Chemistry 14, no. 4: 103089.
The influence of lignin modification on drug release and pH-dependent releasing behavior of oral solid dosage forms was investigated using three different formulations. The first formulation contains microcrystalline cellulose (MCC 101) as the excipient and paracetamol as the active pharmaceutical ingredient (API). The second formulation includes Alcell lignin and MCC 101 as the excipient and paracetamol, and the third formulation consists of carboxylated Alcell lignin, MCC 101 and paracetamol. Direct compaction was carried out in order to prepare the tablets. Lignin can be readily chemically modified due to the existence of different functional groups in its structure. The focus of this investigation is on lignin carboxylation and its influence on paracetamol control release behavior at varying pH. Results suggest that carboxylated lignin tablets had the highest drug release, which is linked to their faster disintegration and lower tablet hardness.
Mahboubeh Pishnamazi; Hamid Hafizi; Saeed Shirazian; Mario Culebras; Gavin M. Walker; Maurice N. Collins. Design of Controlled Release System for Paracetamol Based on Modified Lignin. Polymers 2019, 11, 1059 .
AMA StyleMahboubeh Pishnamazi, Hamid Hafizi, Saeed Shirazian, Mario Culebras, Gavin M. Walker, Maurice N. Collins. Design of Controlled Release System for Paracetamol Based on Modified Lignin. Polymers. 2019; 11 (6):1059.
Chicago/Turabian StyleMahboubeh Pishnamazi; Hamid Hafizi; Saeed Shirazian; Mario Culebras; Gavin M. Walker; Maurice N. Collins. 2019. "Design of Controlled Release System for Paracetamol Based on Modified Lignin." Polymers 11, no. 6: 1059.
The influence of lignin modification on drug release and pH-dependent releasing behaviour of oral solid dosage form was investigated using three different formulations. The first formulation contains microcrystalline cellulose (MCC101) as excipient and paracetamol as active pharmaceutical ingredient (API). The second formulation includes Alcell lignin and MCC 101 as excipient and paracetamol, and the third formulation consists of carboxylated Alcell lignin, MCC 101 and paracetamol. Direct compaction was carried out in order to prepare the tablets. Lignin can be readily chemically modified due to the existence of different functional groups in its structure. The focus of this investigation is on lignin carboxylation and its influence on paracetamol control release behaviour at varying pH. Results suggest that carboxylated lignin tablets had the highest drug release, which is linked to their faster disintegration and lower tablet hardness.
Mahboubeh Pishnamazi; Hamid Hafizi; Shirazian Shirazian; Mario Culebras; Gavin M. Walker; Maurice N. Collins. Design of Controlled Release System for Paracetamol Based on Modified Lignin. 2019, 1 .
AMA StyleMahboubeh Pishnamazi, Hamid Hafizi, Shirazian Shirazian, Mario Culebras, Gavin M. Walker, Maurice N. Collins. Design of Controlled Release System for Paracetamol Based on Modified Lignin. . 2019; ():1.
Chicago/Turabian StyleMahboubeh Pishnamazi; Hamid Hafizi; Shirazian Shirazian; Mario Culebras; Gavin M. Walker; Maurice N. Collins. 2019. "Design of Controlled Release System for Paracetamol Based on Modified Lignin." , no. : 1.
In this study, a process map was developed in an effort to improve the understanding of dry granulation of pharmaceutical excipients by roll compaction process, and to implement the quality-by-design (QbD) approach. Through development of the process map, a correlation was made between the critical process parameters (roll pressure, screw speed), and critical quality attributes (density of ribbons and granule size). This method reduces development time, quantity of materials required and cost. A new excipient formulation based on natural polymers (lignin and cellulose) was utilised to improve the properties and reduce costs associated with tablets production. A variety of lignin, microcrystalline cellulose (MCC) and lactose monohydrate formulations were compacted followed by milling to obtain granules. Formulations were also characterised in terms of compressibility and flowability. Density of ribbons as well as granule size distribution were mapped versus critical process parameters. Based on this work as initial study, roll pressure was found to be a critical process parameter, higher ribbon density and larger granule size obtained with higher roll pressure. It was also revealed that the process map is a powerful tool in understanding the dry granulation, and can be used to construct a design space for pharmaceutical manufacturing.
Mahboubeh Pishnamazi; Stephanie Casilagan; Cian Clancy; Saeed Shirazian; Javed Iqbal; David Egan; Chris Edlin; Denise M. Croker; Gavin M. Walker; Maurice N. Collins. Microcrystalline cellulose, lactose and lignin blends: Process mapping of dry granulation via roll compaction. Powder Technology 2018, 341, 38 -50.
AMA StyleMahboubeh Pishnamazi, Stephanie Casilagan, Cian Clancy, Saeed Shirazian, Javed Iqbal, David Egan, Chris Edlin, Denise M. Croker, Gavin M. Walker, Maurice N. Collins. Microcrystalline cellulose, lactose and lignin blends: Process mapping of dry granulation via roll compaction. Powder Technology. 2018; 341 ():38-50.
Chicago/Turabian StyleMahboubeh Pishnamazi; Stephanie Casilagan; Cian Clancy; Saeed Shirazian; Javed Iqbal; David Egan; Chris Edlin; Denise M. Croker; Gavin M. Walker; Maurice N. Collins. 2018. "Microcrystalline cellulose, lactose and lignin blends: Process mapping of dry granulation via roll compaction." Powder Technology 341, no. : 38-50.