This article discusses the problem of vibrations during machining. The manufacturing process of generator turbine blades is highly complex. Machining using Computerized Numerical Control (CNC) requires low cutting parameters in order to avoid vibration problems. However, even under these conditions, the surface quality and accuracy of the manufactured objects suffer from high levels of vibrations. Hence, the aim of this research is to counteract this phenomenon. Basic issues related to vibration problems will also be also discussed and a short review of currently available solutions for both active and passive vibration monitoring during machining will be presented. The authors developed a method which does not require any additional equipment other than modified CNC code. The proposed method can be applied to any CNC machine, and is especially suitable for lathes. The method seeks to eradicate the phenomenon of vibrations by providing enhanced control through Input Shaping Control (ISC). For this purpose, the authors present a method for modeling the machining process and design an ISC filter; the model is then implemented in the Matlab and Simulink environment. The last part of the article presents the results, together with a discussion, and includes a brief summary.

The paper presents experimental studies of an asymmetric multi-bolted connection at the preloading state. Design assumptions and structure of a stand for testing forces in bolts in a multi-bolted connection were introduced. The tightening process was conducted with a wrench, monitoring the values of the forces in the bolts using a calibrated measuring system based on resistance strain gauges. The measurement data was processed using the Matlab R2018b Simulink program. Single-pass and multi-pass tightening was tested. The influence of the method and sequence of bolt tightening on the distribution of force values in bolts during and at the end of the preloading state was investigated. The results were statistically processed and summarized in the form of diagrams showing the distributions of normalized force values in the bolts for all the considered tightening cases. The tests were carried out for the selected connection and an assembly method was proposed which would make it possible to achieve the most even distribution of the force values in the bolts at its end, and thus before the connection exploitation state.

This article describes the experimental studies of a preloaded asymmetric multi-bolted connection in the exploitation state. The construction of two stands were introduced: for bolt calibration and for evaluating the bolt forces in a multi-bolted connection. The bolts were tightened in a specific optimal sequence, in three passes, monitoring the force values in the bolts using a calibrated strain gauge measuring system. The studies were conducted for the selected multi-bolted connection on an Instron 8850 testing machine. The measurement data were saved in MATLAB R2018b Simulink. The measurement results were analysed statistically and are presented via charts showing the distributions of the normalised values of the bolt forces as a function of the linearly increasing and decreasing exploitation loads. We show that the forces in individual bolts, after unloading the multi-bolted connection, change in relation to the initial values of their preload.

Miniaturization is a dominant trend in machine building which requires the use of advanced techniques of manufacturing and control. Apart from dimensional and shape precision of miniaturized components, surface geometry, particularly roughness and so-called microroughness that results from the use of advanced treatment techniques, plays an important role in correct assembly, reliable operation and durability of the whole machine. The selection of filtration method in surface geometry of micro-objects can be a substantial problem. The authors of the paper propose to use wavelet filtration in digital processing of a point cloud to remove measurement noise and not to change the surface character of the measured object. Also, the authors propose, in this paper, some criteria for selecting the number of wavelet filtration levels based on minimalization of the RMS value. It is supposed to improve the efficiency of low-pass filtration of small areas of the surface, particularly compared to traditional λs Gaussian filtration.

Hepatic drug metabolizing enzymes (DMEs), whose activity may be affected by liver diseases, are major determinants of drug pharmacokinetics. Hepatitis C liver samples in different functional states, i.e., the Child–Pugh class A (n = 30), B (n = 21) and C (n = 7) were analyzed for protein abundances (LC-MS/MS) and mRNA levels (qRT-PCR) of 9 CYPs and 4 UGTs enzymes. The protein levels of CYP1A1, CYP2B6, CYP2C8, CYP2C9, and CYP2D6 were not affected by the disease. In the Child–Pugh class A livers, a significant up-regulation of UGT1A1 (to 163% of the controls) was observed. The Child–Pugh class B was associated with down-regulation of the protein abundance of CYP2C19 (to 38% of the controls), CYP2E1 (to 54%), CYP3A4 (to 33%), UGT1A3 (to 69%), and UGT2B7 (to 56%). In the Child–Pugh class C livers, CYP1A2 was found to be reduced (to 52%). A significant trend in down-regulation of the protein abundance was documented for CYP1A2, CYP2C9, CYP3A4, CYP2E1, UGT2B7, and UGT2B15. The results of the study demonstrate that DMEs protein abundances in the liver are affected by hepatitis C virus infection and depend on the severity of the disease.

Modern technology allows ductile cast iron parts to be efficiently machined while ensuring a relatively long tool life. One of the basic indices describing the susceptibility of ductile cast irons to change in volume, shape, and dimensions under machining conditions is their machinability. Machinability can be expressed directly in terms of the values of basic quantities such as periodic cutting speed and roughness. At the same time, machinability is a relative quantity evaluated alternatively. This means that the machinability of ductile cast iron can be good, allowing high cutting speeds to be achieved, but it can also be poor, expressed in terms of poor surface quality. In the experimental research carried out, an attempt was made to determine the limit values of the cutting speed, beyond which one should not exceed, in order to increase the efficiency of the machining process. The surface roughness, unlike the periodic cutting speed, is a quantity defined in the product design documentation, so its limits must be observed. In addition to the usual indices of surface geometric texture, the research analysed alternative indices for determining the condition of surface geometric texture and the influence of periodic cutting speed on their values. In the conclusions, valuable recommendations are given for designers and technologists on the purpose and functionality of product surfaces and how to define them. Methods of specifying tribological characteristics, hydrophobic or hydrophilic properties, as well as the ability to retain fluids and maintain protective coatings of ductile cast iron parts after machining are described, for which relative values, depending on the machining parameters used, can vary from about 10 to even 30%.