The SARS-CoV-2 set off a pandemic involving millions of people around the world. The topic of discussion is the possible viral detection in different body fluids than respiratory droplets. Therefore, we evaluated the possible presence of SARS-CoV-2 in semen and urine samples. Thirty patients were included in the study aged 35.67 ± 6.84 years. The day after the pharyngeal and/or nose swab of SARS-CoV-2 was positive, urine and semen samples were taken from patients, and the presence of SARS-CoV-2 was investigated. Laboratory tests and chest CT findings were evaluated simultaneously. SARS-CoV-2 was detected in four (13.3%) patients’ semen samples and in seven (23.3%) patients’ urine samples. White blood cell (WBC), neutrophil, C-reactive protein (CRP), ferritin, alanine transaminase (ALT), lactate dehydrogenase (LDH) and procalcitonin were significantly higher in patients with SARS-CoV-2 in semen (p < .05), though no statistical difference was found in urine (p > .05). Patients with severe pneumonia findings in Chest CT images are likely to be PCR positive in semen and urine samples (p = .005, p = .001). SARS-CoV-2 was not detected in urine and semen samples of patients after they had recovered (average duration 23 ± 4 days). SARS-CoV-2 can be detected in the urogenıtal fluıds of patients with severe clinical conditions and high viral load.

Ticks are obligate blood-sucking arthropods that exist worldwide. Their targets include all vertebrates and humans. Ticks are harmful to people with regard to transmission in many viral, bacterial, and parasitic infections. In addition to these diseases and toxin-induced neurological complications, tick-induced paralysis is a syndrome related to neurotoxin production, and its mortality ratio in the literature is reported to be approximately 10%. Tick-induced isolated facial paralysis is a rare form of the disease developing because of attachment to the external auditory canal or attachment behind the ear. Our country and region are under risk in terms of included tick habitat for tick-induced paralysis that is responsible particularly for hard ticks. In our article, we aimed to present a case with isolated facial paralysis that occurred after the internal auditory canal was bitten by Hyalomma margintum species belonging to the hard ticks group and to probe the management of this disease.

Carbapenem-resistant Klebsiella pneumoniae (CRKP) and difficult-to-treat resistant Pseudomonas aeruginosa (DTRPA) are major public health concerns due to r

Background: Candidaemia remains a common, life‐threatening infection among intensive care unit (ICU) patients, with high mortality, particularly in patients with delayed diagnosis and treatment. Objectives: This international, multicentre, prospective, observational study aimed to identify risk factors for candidaemia in ICU patients and to develop an easy‐to‐use predictive tool, the CanDi‐Score, for early initiation of empirical antifungal treatment. Patients/Methods: All adults over 18 years hospitalised for more than 48 h in the ICUs were included in the study and followed for 30 days. Data on demographics, comorbidities, clinical severity scores including APACHE II and SOFA scores, Charlson comorbidity index (CCI), established risk factors for candidaemia and their time‐dependent effects such as total parenteral nutrition (TPN), mechanical ventilation (MV), and central venous catheter (CVC) were collected. Univariate and multivariate logistic regression analyses were used to identify factors associated with candidaemia development, and fast backwards variable selection was used. To account for between‐centre heterogeneity, sensitivity analyses were performed using mixed‐effects logistic regression models including centre‐specific random intercepts. A nomogram model was constructed using independent risk factors identified in multivariable analysis, and its predictive performance was evaluated with Area Under the Curve (AUC), sensitivity, and specificity. Results: A total of 2,704 ICU patients, including 204 with candidaemia, were enrolled. Patients with candidaemia had higher APACHE II (19 vs. 13) and CCI scores (6 vs. 5; both p < 0.001), and more frequently had chronic renal failure, haemodialysis, malignancy, recent gastrointestinal surgery, and neutropenia (all p ≤ 0.05). Patients were randomly split into development (80%) and validation (20%) cohorts. Multivariate analysis identified higher CCI, concurrent infection, neutropenia, ICU stay > 14 days, MV > 3 days, CVC duration and TPN > 14 days as independent risk factors. The risk associated with CVC increased substantially with prolonged use (OR: 0–7 days: 3.69; 8–21 days: 8.58; > 21 days: 17.21). The model demonstrated good performance in both the development and validation cohorts, with sensitivity, specificity, and AUC values of 79.6%, 76.5%, and 0.86 (95% CI: 0.83–0.88) in the development cohort, respectively, and comparable predictive performance in the validation cohort. The score model was demonstrated by a nomogram. Conclusions: Given the high mortality of candidaemia in ICU patients, the CanDi‐Score may serve as a valuable tool for early prediction and timely empirical antifungal treatment. Key predictors include CCI, presence of concurrent infections, the duration of CVC use, and TPN administration. CanDi‐Score provides clinicians with a practical approach to identify high‐risk patients and guides decision‐making for the early initiation of antifungal treatment.

Increased tetanus cases, particularly after natural disasters such as earthquakes, have been documented in the literature. Factors like multiple injuries, poor environmental hygiene, and delayed medical interventions create favorable conditions for tetanus. We present a case of tetanus in a 55-year-old male earthquake victim injured by a metal object on his foot. Upon admission, he exhibited trismus, opisthotonus, generalized tonic-clonic contractions, and a low Glasgow Coma Scale. Laboratory findings revealed markers of infection, kidney dysfunction, and muscle damage. Treatment included tetanus immunoglobulin, antibiotics (ampicillin-sulbactam and metronidazole), mechanical ventilation, magnesium sulfate infusion, and dialysis. After 55 days of intensive care, including physical therapy and tracheostomy, the patient was discharged. This case underscores that despite vaccination programs, tetanus remains a significant public health threat. Early vaccination, immune globulin administration, wound debridement, and cleaning are critical in managing tetanus, especially in post-disaster settings.