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Dr. Dimitrios Gkiliopoulos
Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece

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0 Biomaterials
0 Drug Delivery
0 Green Chemistry
0 Polymer (nano)composites
0 Polymer chemistry & technology

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Journal article
Published: 26 August 2021 in Nanomaterials
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Ion doping has rendered mesoporous structures important materials in the field of tissue engineering, as apart from drug carriers, they can additionally serve as regenerative materials. The purpose of the present study was the synthesis, characterization and evaluation of the effect of artemisinin (ART)-loaded cerium-doped mesoporous calcium silicate nanopowders (NPs) on the hemocompatibility and cell proliferation of human periodontal ligament fibroblasts (hPDLFs). Mesoporous NPs were synthesized in a basic environment via a surfactant assisted cooperative self-assembly process and were characterized using Scanning Electron Microscopy (SEM), X-ray Fluorescence Spectroscopy (XRF), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction Analysis (XRD) and N2 Porosimetry. The loading capacity of NPs was evaluated using Ultrahigh Performance Liquid Chromatography/High resolution Mass Spectrometry (UHPLC/HRMS). Their biocompatibility was evaluated with the MTT assay, and the analysis of reactive oxygen species was performed using the cell-permeable ROS-sensitive probe 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA). The synthesized NPs presented a mesoporous structure with a surface area ranging from 1312 m2/g for undoped silica to 495 m2/g for the Ce-doped NPs, excellent bioactivity after a 1-day immersion in c-SBF, hemocompatibility and a high loading capacity (around 80%). They presented ROS scavenging properties, and both the unloaded and ART-loaded NPs significantly promoted cell proliferation even at high concentrations of NPs (125 μg/mL). The ART-loaded Ce-doped NPs with the highest amount of cerium slightly restricted cell proliferation after 7 days of culture, but the difference was not significant compared with the control untreated cells.

ACS Style

Ioannis Tsamesidis; Dimitrios Gkiliopoulos; Georgia K. Pouroutzidou; Evgenia Lymperaki; Chrysanthi Papoulia; Karine Reybier; Pierre Perio; Konstantinos M. Paraskevopoulos; Eleana Kontonasaki; Anna Theocharidou. Effect of Artemisinin-Loaded Mesoporous Cerium-Doped Calcium Silicate Nanopowder on Cell Proliferation of Human Periodontal Ligament Fibroblasts. Nanomaterials 2021, 11, 2189 .

AMA Style

Ioannis Tsamesidis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Evgenia Lymperaki, Chrysanthi Papoulia, Karine Reybier, Pierre Perio, Konstantinos M. Paraskevopoulos, Eleana Kontonasaki, Anna Theocharidou. Effect of Artemisinin-Loaded Mesoporous Cerium-Doped Calcium Silicate Nanopowder on Cell Proliferation of Human Periodontal Ligament Fibroblasts. Nanomaterials. 2021; 11 (9):2189.

Chicago/Turabian Style

Ioannis Tsamesidis; Dimitrios Gkiliopoulos; Georgia K. Pouroutzidou; Evgenia Lymperaki; Chrysanthi Papoulia; Karine Reybier; Pierre Perio; Konstantinos M. Paraskevopoulos; Eleana Kontonasaki; Anna Theocharidou. 2021. "Effect of Artemisinin-Loaded Mesoporous Cerium-Doped Calcium Silicate Nanopowder on Cell Proliferation of Human Periodontal Ligament Fibroblasts." Nanomaterials 11, no. 9: 2189.

Journal article
Published: 07 May 2021 in Micro
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Polystyrene (PS)/silicate composites were prepared with the addition of two organoclays (orgMMT and orgZenith) and two mesoporous silicas (SBA-15 and MCF) via (i) solution casting and (ii) melt compounding methods. X-ray diffraction (XRD) analysis evidenced an intercalated structure for PS/organoclay nanocomposites. Thermogravimetric analysis indicated improvement in the thermal stability of PS-nanocomposites compared to the pristine polymer. This enhancement was more prevalent for the nanocomposites prepared with a lab-made organoclay (orgZenith). Tensile measurement results indicated that elastic modulus increment was more prevalent (up to 50%) for microcomposites prepared using mesoporous silicas as filler. Organoclay addition led to a decrease in oxygen transmission rate (OTR) values. This decrement reached up to 50% for high organoclay content films in comparison to pristine PS film. Decrement above 80% was measured for microcomposites with mesoporous silicas and 5 wt% filler content obtained via melt compounding.

ACS Style

Athanasios Ladavos; Aris Giannakas; Panagiotis Xidas; Dimitrios Giliopoulos; Maria Baikousi; Dimitrios Gournis; Michael Karakassides; Konstantinos Triantafyllidis. Preparation and Characterization of Polystyrene Hybrid Composites Reinforced with 2D and 3D Inorganic Fillers. Micro 2021, 1, 3 -14.

AMA Style

Athanasios Ladavos, Aris Giannakas, Panagiotis Xidas, Dimitrios Giliopoulos, Maria Baikousi, Dimitrios Gournis, Michael Karakassides, Konstantinos Triantafyllidis. Preparation and Characterization of Polystyrene Hybrid Composites Reinforced with 2D and 3D Inorganic Fillers. Micro. 2021; 1 (1):3-14.

Chicago/Turabian Style

Athanasios Ladavos; Aris Giannakas; Panagiotis Xidas; Dimitrios Giliopoulos; Maria Baikousi; Dimitrios Gournis; Michael Karakassides; Konstantinos Triantafyllidis. 2021. "Preparation and Characterization of Polystyrene Hybrid Composites Reinforced with 2D and 3D Inorganic Fillers." Micro 1, no. 1: 3-14.

Journal article
Published: 11 March 2021 in Macromol
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In this work, polymer nanocomposite films based on poly(L-lactic acid) (PLLA) were reinforced with mesoporous silica nanoparticles, mesoporous cellular foam (MCF) and Santa Barbara amorphous-15 (SBA). PLLA is a biobased aliphatic polyester, that possesses excellent thermomechanical properties, and has already been commercialized for packaging applications. The aim was to utilize nanoparticles that have already been established as nanocarriers to enhance the mechanical and thermal properties of PLLA. Since the introduction of antibacterial properties has become an emerging trend in packaging applications, to achieve an effective antimicrobial activity, micro/nano 3D micropillars decorated with cone- and needle-shaped nanostructures were implemented on the surface of the films by means of thermal nanoimprint lithography (t-NIL), a novel and feasible fabrication technique with multiple industrial applications. The materials were characterized regarding their composition and crystallinity using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD), respectively, and their thermal properties using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Their mechanical properties were examined by the nanoindentation technique, while the films’ antimicrobial activity against the bacteria Escherichia coli and Staphylococcus aureus strains was tested in vitro. The results demonstrated the successful production of nanocomposite PLLA films, which exhibited improved mechanical and thermal properties compared to the pristine material, as well as notable antibacterial activity, setting new groundwork for the potential development of biobased smart packaging materials.

ACS Style

Eleni Psochia; Lazaros Papadopoulos; Dimitrios Gkiliopoulos; Achille Francone; Maria-Eirini Grigora; Dimitrios Tzetzis; Joana de Castro; Nuno Neves; Konstantinos Triantafyllidis; Clivia Torres; Nikolaos Kehagias; Dimitrios Bikiaris. Bottom-Up Development of Nanoimprinted PLLA Composite Films with Enhanced Antibacterial Properties for Smart Packaging Applications. Macromol 2021, 1, 49 -63.

AMA Style

Eleni Psochia, Lazaros Papadopoulos, Dimitrios Gkiliopoulos, Achille Francone, Maria-Eirini Grigora, Dimitrios Tzetzis, Joana de Castro, Nuno Neves, Konstantinos Triantafyllidis, Clivia Torres, Nikolaos Kehagias, Dimitrios Bikiaris. Bottom-Up Development of Nanoimprinted PLLA Composite Films with Enhanced Antibacterial Properties for Smart Packaging Applications. Macromol. 2021; 1 (1):49-63.

Chicago/Turabian Style

Eleni Psochia; Lazaros Papadopoulos; Dimitrios Gkiliopoulos; Achille Francone; Maria-Eirini Grigora; Dimitrios Tzetzis; Joana de Castro; Nuno Neves; Konstantinos Triantafyllidis; Clivia Torres; Nikolaos Kehagias; Dimitrios Bikiaris. 2021. "Bottom-Up Development of Nanoimprinted PLLA Composite Films with Enhanced Antibacterial Properties for Smart Packaging Applications." Macromol 1, no. 1: 49-63.

Journal article
Published: 01 February 2021 in Sustainability
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In water and wastewater, phosphate anions are considered critical contaminants because they cause algae blooms and eutrophication. The present work aims at studying the removal of phosphate anions from aqueous solutions using silica particles functionalized with polyethylenimine. The parameters affecting the adsorption process such as pH, initial concentration, adsorbent dose, and the presence of competitive anions, such as carbonate, nitrate, sulfate and chromate ions, were studied. Equilibrium studies were carried out to determine their sorption capacity and the rate of phosphate ions uptake. The adsorption isotherm data fitted well with the Langmuir and Sips model. The maximum sorption capacity was 41.1 mg/g at pH 5, which decreased slightly at pH 7. The efficiency of phosphate removal adsorption increased at lower pH values and by increasing the adsorbent dose. The maximum phosphate removal was 80% for pH 5 and decreased to 75% for pH 6, to 73% for pH 7 and to 70% for pH 8, for initial phosphate concentration at about 1 mg/L and for a dose of adsorbent 100 mg/L. The removal rate was increased with the increase of the adsorbent dose. For example, for initial phosphate concentration of 4 mg/L the removal rate increased from 40% to 80% by increasing the dose from 0.1 to 2.0 g/L at pH 7. The competitive anions adversely affected phosphate removal. Though they were also found to be removed to a certain extent. Their co-removal provided an adsorbent which might be very useful for treating waters with low-level multiple contaminant occurrence in natural or engineered aquatic systems.

ACS Style

Maria Xanthopoulou; Dimitrios Giliopoulos; Nikolaos Tzollas; Konstantinos Triantafyllidis; Margaritis Kostoglou; Ioannis Katsoyiannis. Phosphate Removal Using Polyethylenimine Functionalized Silica-Based Materials. Sustainability 2021, 13, 1502 .

AMA Style

Maria Xanthopoulou, Dimitrios Giliopoulos, Nikolaos Tzollas, Konstantinos Triantafyllidis, Margaritis Kostoglou, Ioannis Katsoyiannis. Phosphate Removal Using Polyethylenimine Functionalized Silica-Based Materials. Sustainability. 2021; 13 (3):1502.

Chicago/Turabian Style

Maria Xanthopoulou; Dimitrios Giliopoulos; Nikolaos Tzollas; Konstantinos Triantafyllidis; Margaritis Kostoglou; Ioannis Katsoyiannis. 2021. "Phosphate Removal Using Polyethylenimine Functionalized Silica-Based Materials." Sustainability 13, no. 3: 1502.

Journal article
Published: 21 January 2021 in Polymer
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In this article, we report effects imposed to polylactide (PLA) by fillers of different geometries and surface chemistry, namely mesoporous silicas, carbon nanotubes (CNT), mixtures of CNT and clays as well as new hybrid particle of the latter two, at low loadings (0.5–5 wt%). The initial scope for the nanocomposites preparation is the improvement of the rate of crystallization, being extremely slow in neat PLA and the study of structure - semicrystalline morphology - molecular mobility relationship. To that aim, Fourier transform infra red (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), polarized optical microscopy (POM) and broadband dielectric spectroscopy (BDS) were employed and evaluated by widely used analysis routes. All nanofillers were found to offer crystallization sites accelerating crystallization. The effect is systematically stronger for the silicas than the CNT-based fillers; moreover, was found to correlate with the weaker and stronger disturbance of the PLA carbonyls (FTIR), respectively, due to interfacial interactions. Comparing to clay/CNT mixture, the hybrid clay/CNT and neat CNTs were found more effective in improving the crystallization rate. Despite the crystallization rate improvement, the degree of crystallinity was not enhanced. Significant alternations in the semicrystalline morphology were recorded in the nanocomposites by POM. Regarding the main results on molecular mobility (DSC, BDS), a slight deceleration of segmental dynamics (glass transition, α relaxation) was recorded in the nanocomposites, accompanied by an increase in cooperativity. In general, results suggest complex phenomena affecting segmental dynamics, for example constraints imposed by the filler attractions (FTIR, DSC) and spatial confinement effects on the amorphous polymer between the fillers or crystals, that tend to decelerate and accelerate the dynamics, respectively. BDS enabled the recording of an additional clay-induced relaxation in the nanocomposites that shows cooperative characteristics and a quite high strength, most possibly arising from the interfacial polymer. Despite the lack of microscopy measurements for morphology, the combined data showed indirect although strong indications for the best dispersion in the PLA matrix at 1 wt% particle loading, independently from the type of the filler.

ACS Style

Lazaros Papadopoulos; Panagiotis A. Klonos; Zoi Terzopoulou; Eleni Psochia; Olawale Monsur Sanusi; Nourredine Aït Hocine; Abdelkibir Benelfellah; Dimitrios Giliopoulos; Konstantinos Triantafyllidis; Apostolos Kyritsis; Dimitrios N. Bikiaris. Comparative study of crystallization, semicrystalline morphology, and molecular mobility in nanocomposites based on polylactide and various inclusions at low filler loadings. Polymer 2021, 217, 123457 .

AMA Style

Lazaros Papadopoulos, Panagiotis A. Klonos, Zoi Terzopoulou, Eleni Psochia, Olawale Monsur Sanusi, Nourredine Aït Hocine, Abdelkibir Benelfellah, Dimitrios Giliopoulos, Konstantinos Triantafyllidis, Apostolos Kyritsis, Dimitrios N. Bikiaris. Comparative study of crystallization, semicrystalline morphology, and molecular mobility in nanocomposites based on polylactide and various inclusions at low filler loadings. Polymer. 2021; 217 ():123457.

Chicago/Turabian Style

Lazaros Papadopoulos; Panagiotis A. Klonos; Zoi Terzopoulou; Eleni Psochia; Olawale Monsur Sanusi; Nourredine Aït Hocine; Abdelkibir Benelfellah; Dimitrios Giliopoulos; Konstantinos Triantafyllidis; Apostolos Kyritsis; Dimitrios N. Bikiaris. 2021. "Comparative study of crystallization, semicrystalline morphology, and molecular mobility in nanocomposites based on polylactide and various inclusions at low filler loadings." Polymer 217, no. : 123457.

Review
Published: 01 January 2020 in Molecules
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The utilization of polymer/metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied due to their unique properties that arise from MOFs or hybrid composite systems. This review focuses on the types of polymer/MOF nanocomposites used in drug delivery and imaging applications. Initially, a comprehensive introduction to the synthesis and structure of MOFs and bio-MOFs is presented. Subsequently, the properties and the performance of polymer/MOF nanocomposites used in these applications are examined, in relation to the approach applied for their synthesis: (i) non-covalent attachment, (ii) covalent attachment, (iii) polymer coordination to metal ions, (iv) MOF encapsulation in polymers, and (v) other strategies. A critical comparison and discussion of the effectiveness of polymer/MOF nanocomposites regarding their synthesis methods and their structural characteristics is presented.

ACS Style

Dimitrios Giliopoulos; Alexandra Zamboulis; Dimitrios Giannakoudakis; Dimitrios Bikiaris; Konstantinos Triantafyllidis. Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications. Molecules 2020, 25, 185 .

AMA Style

Dimitrios Giliopoulos, Alexandra Zamboulis, Dimitrios Giannakoudakis, Dimitrios Bikiaris, Konstantinos Triantafyllidis. Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications. Molecules. 2020; 25 (1):185.

Chicago/Turabian Style

Dimitrios Giliopoulos; Alexandra Zamboulis; Dimitrios Giannakoudakis; Dimitrios Bikiaris; Konstantinos Triantafyllidis. 2020. "Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications." Molecules 25, no. 1: 185.

Journal article
Published: 15 January 2019 in Colloids and Interfaces
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Cleaning products have improved a lot in the last century. The reason for this improvement is not only the use of new surfactants, but also the use of additives that either increase the efficiency of surfactants or act as abrasive agents that increase the mechanical friction during the cleaning process. In this study mesoporous silica (SBA-15) particles are suggested as abrasive additives to a reference detergent as they have a quite soft structure and their shape can act as micro-sponge to collect large amounts of dirt. Indeed, SBA-15 performs very well when added to the detergent, decreasing the effort for primary cleaning of a surface. Furthermore, the properties of the coating layer left behind after primary cleaning with SBA-15 are also examined (i.e., secondary cleaning). It is found that SBA-15 offers no benefit for secondary cleaning. In order to explain this finding, the effect of SBA-15 on the wetting properties of different substrates is studied. It is seen that the SBA-15 coating layer is not uniform. Furthermore, it is seen that dirt is capable of pushing away the coating layer and occupying a large area on the substrate. Contact angle measurements indicate that the substrates become more omniphilic in the presence of SBA-15 coating.

ACS Style

Athanasios Plomaritis; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Thodoris D. Karapantsios. Mesoporous Silica SBA-15 Particles in a Detergent Solution as Abrasive and Coating Material for Household Care Cleaning Products. Colloids and Interfaces 2019, 3, 12 .

AMA Style

Athanasios Plomaritis, Dimitris Giliopoulos, Konstantinos Triantafyllidis, Margaritis Kostoglou, Thodoris D. Karapantsios. Mesoporous Silica SBA-15 Particles in a Detergent Solution as Abrasive and Coating Material for Household Care Cleaning Products. Colloids and Interfaces. 2019; 3 (1):12.

Chicago/Turabian Style

Athanasios Plomaritis; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Thodoris D. Karapantsios. 2019. "Mesoporous Silica SBA-15 Particles in a Detergent Solution as Abrasive and Coating Material for Household Care Cleaning Products." Colloids and Interfaces 3, no. 1: 12.

Journal article
Published: 15 May 2018 in Applied Sciences
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In this work, aprepitant (APR) was loaded in a high-molecular-weight poly(ethylene oxide) (PEO) and PEO/clay nanocomposites via the melt-mixing process in order to investigate the combined effect of the PEO and PEO/clay phases on the dissolution profile of APR. Various drug (5, 10, 20 wt %) and Cloisite-Na+ microgranuled nanoclay (5 and 10 wt %) loadings were used for the preparation of the solid dispersions using a twin screw melt mixer at temperatures below the drug’s melting point. X-ray diffraction (XRD) and infrared (FTIR) data of the prepared formulations confirmed that the semicrystalline structure of the PEO and the structure of APR have remained intact. The PEO chain intercalation in the intragallery space between the clay nanolayers was also confirmed by XRD, especially in the APR/PEO formulations containing 5 wt % microgranuled nanoclay. The in vitro release study demonstrated that in all formulations, the dissolution rate of APR was substantially enhanced compared to neat drug. Immediate release formulations have been prepared, and the combination of PEO/5 wt % clay nanocomposite phase with 5 or 10 wt % drug loading gives much higher maximum dissolution (reaching 98 and 85%, respectively) compared to the neat drug (40%). This improved performance was attributed to the highly intercalated/exfoliated state of clay nanolayers in the APR/PEO/5 wt % clay formulations. A model was also investigated to explain the physical mechanism of drug release in all formulations.

ACS Style

Christina Pappa; Stavroula Nanaki; Dimitrios Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Apostolos Avgeropoulos; Dimitrios Bikiaris. Nanostructured Composites of Sodium Montmorillonite Clay and PEO Used in Dissolution Improvement of Aprepitant Drug by Melt Mixing. Applied Sciences 2018, 8, 786 .

AMA Style

Christina Pappa, Stavroula Nanaki, Dimitrios Giliopoulos, Konstantinos Triantafyllidis, Margaritis Kostoglou, Apostolos Avgeropoulos, Dimitrios Bikiaris. Nanostructured Composites of Sodium Montmorillonite Clay and PEO Used in Dissolution Improvement of Aprepitant Drug by Melt Mixing. Applied Sciences. 2018; 8 (5):786.

Chicago/Turabian Style

Christina Pappa; Stavroula Nanaki; Dimitrios Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Apostolos Avgeropoulos; Dimitrios Bikiaris. 2018. "Nanostructured Composites of Sodium Montmorillonite Clay and PEO Used in Dissolution Improvement of Aprepitant Drug by Melt Mixing." Applied Sciences 8, no. 5: 786.

Journal article
Published: 01 August 2017 in European Journal of Pharmaceutics and Biopharmaceutics
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In this study, high surface area mesoporous silica foam with cellular pore morphology (MCF) was used for injectable delivery of paliperidone, an antipsychotic drug used in patients suffering from bipolar disorder. The aim was to enhance paliperidone solubility and simultaneously to prepare long active intractable microspheres. For this reason paliperidone was first loaded in MCF silica, and the whole system was further encapsulated into PLA and PLGA 75/25w/w copolymer in the form of microspheres. It was found that paliperidone, after its adsorption into MCF, was transformed in its amorphous state, thus leading to enhanced in vitro dissolution profile. Furthermore, incorporation of the drug-loaded MCF to polymeric microparticles (PLA and PLGA) prolonged the release time of paliperidone from 10 to 15days.

ACS Style

Stavroula Nanaki; Maria Tseklima; Zoi Terzopoulou; Maria Nerantzaki; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Dimitrios N. Bikiaris. Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug. European Journal of Pharmaceutics and Biopharmaceutics 2017, 117, 77 -90.

AMA Style

Stavroula Nanaki, Maria Tseklima, Zoi Terzopoulou, Maria Nerantzaki, Dimitris Giliopoulos, Konstantinos Triantafyllidis, Margaritis Kostoglou, Dimitrios N. Bikiaris. Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug. European Journal of Pharmaceutics and Biopharmaceutics. 2017; 117 ():77-90.

Chicago/Turabian Style

Stavroula Nanaki; Maria Tseklima; Zoi Terzopoulou; Maria Nerantzaki; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Dimitrios N. Bikiaris. 2017. "Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug." European Journal of Pharmaceutics and Biopharmaceutics 117, no. : 77-90.

Journal article
Published: 01 March 2017 in European Journal of Pharmaceutical Sciences
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In this work, high surface area mesoporous silica (SBA-15) was loaded with paclitaxel (taxol, PTX) and was further entrapped into poly(lactic acid-co-glycolic acid) (PLGA) microparticles (MPs). A modified solvent evaporation-emulsion method was used in order to formulate the composite microparticles with sizes of 8-12μm. PTX loaded SBA-15 as well as the PLGA/PTX-SBA-15 composites were characterized in terms of their morphology, crystal structure and thermal properties. Drug content, loading efficiency, particle size and the in-vitro drug release kinetics of the PLGA/PTΧ-SBA-15 microspheres were also investigated. The in vitro release studies were carried out using Simulated Body Fluid (SBF) at 37°C revealing that the prepared formulations present higher dissolution rate than pure PTX and sustained pattern which is ideal for anticancer carriers. Modeling and data analysis of the in vitro drug release was also investigated. It was also shown that all microparticles have low cytotoxicity in HUVE cells. Finally, it was found that drug loaded microparticles are very effective in Human Cervical Adenocarcinoma (HeLa) cells.

ACS Style

Stavroula Nanaki; Panoraia I. Siafaka; Dorothea Zachariadou; Maria Nerantzaki; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Eleni Nikolakaki; Dimitrios N. Bikiaris. PLGA/SBA-15 mesoporous silica composite microparticles loaded with paclitaxel for local chemotherapy. European Journal of Pharmaceutical Sciences 2017, 99, 32 -44.

AMA Style

Stavroula Nanaki, Panoraia I. Siafaka, Dorothea Zachariadou, Maria Nerantzaki, Dimitris Giliopoulos, Konstantinos Triantafyllidis, Margaritis Kostoglou, Eleni Nikolakaki, Dimitrios N. Bikiaris. PLGA/SBA-15 mesoporous silica composite microparticles loaded with paclitaxel for local chemotherapy. European Journal of Pharmaceutical Sciences. 2017; 99 ():32-44.

Chicago/Turabian Style

Stavroula Nanaki; Panoraia I. Siafaka; Dorothea Zachariadou; Maria Nerantzaki; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Eleni Nikolakaki; Dimitrios N. Bikiaris. 2017. "PLGA/SBA-15 mesoporous silica composite microparticles loaded with paclitaxel for local chemotherapy." European Journal of Pharmaceutical Sciences 99, no. : 32-44.

Journal article
Published: 01 August 2016 in European Polymer Journal
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ACS Style

Dimitris Achilias; Kostas Gerakis; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Dimitrios Bikiaris. Effect of high surface area mesoporous silica fillers (MCF and SBA-15) on solid state polymerization of PET. European Polymer Journal 2016, 81, 347 -364.

AMA Style

Dimitris Achilias, Kostas Gerakis, Dimitris Giliopoulos, Konstantinos Triantafyllidis, Dimitrios Bikiaris. Effect of high surface area mesoporous silica fillers (MCF and SBA-15) on solid state polymerization of PET. European Polymer Journal. 2016; 81 ():347-364.

Chicago/Turabian Style

Dimitris Achilias; Kostas Gerakis; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Dimitrios Bikiaris. 2016. "Effect of high surface area mesoporous silica fillers (MCF and SBA-15) on solid state polymerization of PET." European Polymer Journal 81, no. : 347-364.

Journal article
Published: 01 January 2014 in Thermochimica Acta
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ACS Style

George Z. Papageorgiou; Eva Karandrea; Dimitris Giliopoulos; Dimitrios Papageorgiou; Athanasios Ladavos; Aikaterini Katerinopoulou; Dimitris Achilias; Konstantinos Triantafyllidis; Dimitrios N. Bikiaris. Effect of clay structure and type of organomodifier on the thermal properties of poly(ethylene terephthalate) based nanocomposites. Thermochimica Acta 2014, 576, 84 -96.

AMA Style

George Z. Papageorgiou, Eva Karandrea, Dimitris Giliopoulos, Dimitrios Papageorgiou, Athanasios Ladavos, Aikaterini Katerinopoulou, Dimitris Achilias, Konstantinos Triantafyllidis, Dimitrios N. Bikiaris. Effect of clay structure and type of organomodifier on the thermal properties of poly(ethylene terephthalate) based nanocomposites. Thermochimica Acta. 2014; 576 ():84-96.

Chicago/Turabian Style

George Z. Papageorgiou; Eva Karandrea; Dimitris Giliopoulos; Dimitrios Papageorgiou; Athanasios Ladavos; Aikaterini Katerinopoulou; Dimitris Achilias; Konstantinos Triantafyllidis; Dimitrios N. Bikiaris. 2014. "Effect of clay structure and type of organomodifier on the thermal properties of poly(ethylene terephthalate) based nanocomposites." Thermochimica Acta 576, no. : 84-96.

Journal article
Published: 21 May 2013 in Journal of Thermal Analysis and Calorimetry
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In this study, composites of high-density polyethylene (HDPE) with mesostructured cellular foam (MCF) silicas have been prepared by melt mixing and studied for the first time. Two different MCF silica analogues having different pore size were used, i.e., 12 nm (MCF-12) and 50 nm (MCF-50). The MCF content in the mesocomposites was 1, 2.5, 5, and 10 mass%. All HDPE/MCF-50 mesocomposites exhibited improved mechanical properties compared with neat HDPE, indicating that the mesocellular silica foam particles with the large mesopore size can act as efficient reinforcing agents. On the other hand, the MCF-12 silica with the smaller size mesopores induced inferior mechanical properties, mainly due to the poorer dispersion of the silica particles and the formation of large aggregates. The mesocellular silica foam particles also affected the thermal properties and the crystallization characteristics of HDPE. Crystallization of mesocomposites was faster than that of neat HDPE. Crystallization kinetics was analyzed with the Avrami equation for both isothermal and non-isothermal conditions. For isothermal crystallization, the Avrami exponent increased with increasing crystallization temperature from 2 to 3. In non-isothermal crystallization, the values of the Avrami exponent increased from 3 to 6.3 with decreasing cooling rate. Lower activation energy values of non-isothermal crystallization were calculated using the isoconversional method of Friedman, as well as using the Kissinger’s equation. Finally, the nucleation efficiency of the mesocellular silica foam particles was estimated from data associated with non-isothermal crystallization, according to the method of Dobreva.

ACS Style

George Z. Papageorgiou; Aikaterini Palani; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Dimitrios N. Bikiaris. Mechanical properties and crystallization of high-density polyethylene composites with mesostructured cellular silica foam. Journal of Thermal Analysis and Calorimetry 2013, 113, 1651 -1665.

AMA Style

George Z. Papageorgiou, Aikaterini Palani, Dimitris Giliopoulos, Konstantinos Triantafyllidis, Dimitrios N. Bikiaris. Mechanical properties and crystallization of high-density polyethylene composites with mesostructured cellular silica foam. Journal of Thermal Analysis and Calorimetry. 2013; 113 (3):1651-1665.

Chicago/Turabian Style

George Z. Papageorgiou; Aikaterini Palani; Dimitris Giliopoulos; Konstantinos Triantafyllidis; Dimitrios N. Bikiaris. 2013. "Mechanical properties and crystallization of high-density polyethylene composites with mesostructured cellular silica foam." Journal of Thermal Analysis and Calorimetry 113, no. 3: 1651-1665.

Book chapter
Published: 01 August 2012 in Internal Variables in Thermoelasticity
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The remarkable physical properties of carbon nanotubes and their versatile chemical reactivity leading to various types of surface organo-functionalization were the main reasons why CNTs have become one of the most important types of nano-additives for the development of novel polymer (including epoxy) nanocomposites with improved and sometimes unique properties. The present chapter deals with the organo-functionalization of carbon nanotubes and the preparation of the respective epoxy – CNT nanocomposites. The effect of functionalization on dispersion of CNTs and on the final properties of the nanocomposites is discussed, while emphasis is given on the reactivity of the functional groups and their participation in the curing process of epoxy resins.

ACS Style

Dimitris Giliopoulos; Kostas S. Triantafyllidis; Dimitrios Gournis. Chemical Functionalization of Carbon Nanotubes for Dispersion in Epoxy Matrices. Internal Variables in Thermoelasticity 2012, 155 -183.

AMA Style

Dimitris Giliopoulos, Kostas S. Triantafyllidis, Dimitrios Gournis. Chemical Functionalization of Carbon Nanotubes for Dispersion in Epoxy Matrices. Internal Variables in Thermoelasticity. 2012; ():155-183.

Chicago/Turabian Style

Dimitris Giliopoulos; Kostas S. Triantafyllidis; Dimitrios Gournis. 2012. "Chemical Functionalization of Carbon Nanotubes for Dispersion in Epoxy Matrices." Internal Variables in Thermoelasticity , no. : 155-183.

Journal article
Published: 01 November 2011 in International Journal of Nanomedicine
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Peer reviewed article authored by (Karavelidis V, Karavas E, Giliopoulos D, Papadimitriou S, Bikiaris D). Read article or submit your manuscript for publishing.

ACS Style

Dimitrios Bikiaris; Vassilios Karavelidis; Evangelos Karavas; Dimitris Giliopoulos; Sofia Papadimitriou. Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior. International Journal of Nanomedicine 2011, 6, 3021 -32.

AMA Style

Dimitrios Bikiaris, Vassilios Karavelidis, Evangelos Karavas, Dimitris Giliopoulos, Sofia Papadimitriou. Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior. International Journal of Nanomedicine. 2011; 6 ():3021-32.

Chicago/Turabian Style

Dimitrios Bikiaris; Vassilios Karavelidis; Evangelos Karavas; Dimitris Giliopoulos; Sofia Papadimitriou. 2011. "Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior." International Journal of Nanomedicine 6, no. : 3021-32.

Journal article
Published: 23 December 2010 in European Journal of Pharmaceutical Sciences
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Five polyesters based on 1,3-propanediol or ethylene glycol and an aliphatic dicarboxylic acid were used for the preparation of Ropinirole HCl-loaded nanoparticles. The advantage of the present study is that the used polyesters – as well as poly(lactic acid) (PLA) – have similar degree of crystallinity but different melting points, varying from 46.7 to 166.4 °C. Based on polymer toxicity on HUVEC, the biocompatibility of these aliphatic polyesters was found comparable to that of PLA and thus the studied polyesters could be used as drug carriers. Drug encapsulation in polyesters was performed via emulsification/solvent evaporation method. Particle size of drug-loaded nanoparticles was between 140 and 190 nm, as measured by light scattering. Drug loading content for all the polyesters varies between 10 and 16% and their entrapment efficiency is relatively high (32–48%). WAXD patterns of nanoparticles show that Ropinirole HCl lies in amorphous state within polymer matrices. Drug release diagrams reveal that the higher percentage of Ropinirole HCl is released during the first 6 h after its insertion in the dissolution medium. Fast release rates of the drug are attributed to high hydrophilicity of Ropinirole HCl. Melting point (Tm) and glass transition temperature (Tg) of the host polymer matrices seem to be important parameters, since higher drug release rates are observed in polyesters with low Tm and Tg.

ACS Style

Vassilios Karavelidis; Dimitris Giliopoulos; Evangelos Karavas; Dimitrios Bikiaris. Nanoencapsulation of a water soluble drug in biocompatible polyesters. Effect of polyesters melting point and glass transition temperature on drug release behavior. European Journal of Pharmaceutical Sciences 2010, 41, 636 -643.

AMA Style

Vassilios Karavelidis, Dimitris Giliopoulos, Evangelos Karavas, Dimitrios Bikiaris. Nanoencapsulation of a water soluble drug in biocompatible polyesters. Effect of polyesters melting point and glass transition temperature on drug release behavior. European Journal of Pharmaceutical Sciences. 2010; 41 (5):636-643.

Chicago/Turabian Style

Vassilios Karavelidis; Dimitris Giliopoulos; Evangelos Karavas; Dimitrios Bikiaris. 2010. "Nanoencapsulation of a water soluble drug in biocompatible polyesters. Effect of polyesters melting point and glass transition temperature on drug release behavior." European Journal of Pharmaceutical Sciences 41, no. 5: 636-643.

Journal article
Published: 17 November 2009 in Macromolecular Chemistry and Physics
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ACS Style

Dimitris S. Achilias; Dimitrios N. Bikiaris; Efthimios Papastergiadis; Dimitris Giliopoulos; George Z. Papageorgiou. Characterization and Crystallization Kinetics of in situ Prepared Poly(propylene terephthalate)/SiO2 Nanocomposites. Macromolecular Chemistry and Physics 2009, 211, 66 -79.

AMA Style

Dimitris S. Achilias, Dimitrios N. Bikiaris, Efthimios Papastergiadis, Dimitris Giliopoulos, George Z. Papageorgiou. Characterization and Crystallization Kinetics of in situ Prepared Poly(propylene terephthalate)/SiO2 Nanocomposites. Macromolecular Chemistry and Physics. 2009; 211 (1):66-79.

Chicago/Turabian Style

Dimitris S. Achilias; Dimitrios N. Bikiaris; Efthimios Papastergiadis; Dimitris Giliopoulos; George Z. Papageorgiou. 2009. "Characterization and Crystallization Kinetics of in situ Prepared Poly(propylene terephthalate)/SiO2 Nanocomposites." Macromolecular Chemistry and Physics 211, no. 1: 66-79.

Journal article
Published: 11 August 2008 in Macromolecular Bioscience
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A series of seven fast-biodegrading aliphatic polyesters were prepared from 1,3-propanediol and aliphatic diacids with increasing number of methylene units (x). Melting points decreased from PPSu to PPAd and then increased again to PPAz and PPSeb. Crystallization rates and thermal stability increased steadily with increasing x. Glass transition temperatures decreased steadily to PPPim and subsequently increased. Enzymatic degradation of the polymers in the presence of a mixture of Rhizopus delemar and Pseudomonas cepacia lipases was much faster than that of poly(epsilon-caprolactone). All the polyester specimens were almost disintegrated within 36 h. PPSub exhibited the fastest enzymatic hydrolysis rates, PPAd and PPSuc the slowest.

ACS Style

Dimitrios N. Bikiaris; George Z. Papageorgiou; Dimitris Giliopoulos; Charalampos A. Stergiou. Correlation between Chemical and Solid-State Structures and Enzymatic Hydrolysis in Novel Biodegradable Polyesters. The Case of Poly(propylene alkanedicarboxylate)s. Macromolecular Bioscience 2008, 8, 728 -740.

AMA Style

Dimitrios N. Bikiaris, George Z. Papageorgiou, Dimitris Giliopoulos, Charalampos A. Stergiou. Correlation between Chemical and Solid-State Structures and Enzymatic Hydrolysis in Novel Biodegradable Polyesters. The Case of Poly(propylene alkanedicarboxylate)s. Macromolecular Bioscience. 2008; 8 (8):728-740.

Chicago/Turabian Style

Dimitrios N. Bikiaris; George Z. Papageorgiou; Dimitris Giliopoulos; Charalampos A. Stergiou. 2008. "Correlation between Chemical and Solid-State Structures and Enzymatic Hydrolysis in Novel Biodegradable Polyesters. The Case of Poly(propylene alkanedicarboxylate)s." Macromolecular Bioscience 8, no. 8: 728-740.

Journal article
Published: 31 December 2006 in European Polymer Journal
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Solid state polycondensation (SSP) is a conventional method used to increase the molecular weight of poly(ethylene terephthalate) (PET) in order to become more suitable for applications as carbonated soft drink bottles, etc. In the present study, the effect of activated carbon black (ACB) nanoparticles, on the SSP kinetics is examined. TEM micrographs revealed that ACB was finely dispersed into PET matrix as individual nanoparticles without creating agglomerates. Intrinsic viscosity (IV) measurements revealed that at temperatures 210 and 220 °C the activated carbon black does not influence the IV increase. However, at 230 and 240 °C an accelerating effect was found and higher intrinsic viscosity values were measured, compared to neat PET. Furthermore, a simple kinetic model was employed to predict the time evolution of IV, as well as the carboxyl and hydroxyl content during SSP. The kinetic parameters of the transesterification and esterification reactions were estimated at different temperatures with or without the addition of ACB. From the experimental measurements and the theoretical simulation results it was proved that ACB enhances the esterification reaction at all studied temperatures acting as a co-catalyst. However, the transesterification reaction remains unaffected by the presence of ACB at elevated temperatures (230 or 240 °C), while it is reduced at lower values (210 and 220 °C). Finally, the activation energies of both transesterification and esterification were determined together with the concentration of inactive end-groups.

ACS Style

D.N. Bikiaris; Dimitris Achilias; Dimitris Giliopoulos; G.P. Karayannidis. Effect of activated carbon black nanoparticles on solid state polymerization of poly(ethylene terephthalate). European Polymer Journal 2006, 42, 3190 -3201.

AMA Style

D.N. Bikiaris, Dimitris Achilias, Dimitris Giliopoulos, G.P. Karayannidis. Effect of activated carbon black nanoparticles on solid state polymerization of poly(ethylene terephthalate). European Polymer Journal. 2006; 42 (12):3190-3201.

Chicago/Turabian Style

D.N. Bikiaris; Dimitris Achilias; Dimitris Giliopoulos; G.P. Karayannidis. 2006. "Effect of activated carbon black nanoparticles on solid state polymerization of poly(ethylene terephthalate)." European Polymer Journal 42, no. 12: 3190-3201.