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• To determine the effect of dietary agents with an emphasis on phenols and study their ability to prevent or remediate cellular stresses that lead to metabolic syndrome • To understand how synergistic natural compounds, modulate carbohydrate metabolism and/or molecular/orgenelle structures to maintain a healthy state • To evaluate the effects of farming practices environment and cooking processes on polyphenols compounds • To determine and analyze all food nutrients
Background: Citrullus colocynthis L. (C. colocynthis) is commonly known as colocynth. It belongs to the family Cucurbitaceae that is frequently used in alternative medicine in the north of Africa. The aim of the study: the present research was undertaken to investigate the chemical composition, antioxidant, antiproliferative, and antibacterial potentials of C. colocynthis seed extract. Material and methods: the chemical composition of C. colocynthis seed organic extract was characterized using gas chromatography/mass spectrometry (GC-MS). The antioxidant property was carried out using both β-carotene bleaching and DPPH assays. The antibacterial effect was effectuated using the agar disc diffusion method. The antiproliferative activity vs. human colorectal adenocarcinoma cell line (HT-29) and human breast adenocarcinoma cell line (MDA MB 231) were carried by WST-1 test. The chemical analysis showed the presence of interesting potentially bioactive compounds. The studied plant extract exhibited antioxidant potential with IC50 value of 2. 22 mg/mL (β-carotene bleaching) and 8.98 ± 0.619 mg/mL (DPPH). Concerning the antiproliferative activity, the seed extract was effective in MDA-MB-231 and HT-29 cancer cells with IC50 values 86.89 ± 3.395 and 242.1 ± 17.9 μg/mL, respectively, whilst the extract of Citrullus colocynthis seeds was non-toxic in healthy human dermal fibroblasts. Regarding the antibacterial test, the extract was effective in Gram-positive bacteria only. Conclusion: The outcome of this research indicated that the extracts from C. colocynthis seeds may compose a promising source with interesting compounds that can be used to fight cancer, free radicals damage, and bacterial infections.
Mohammed Bourhia; Kaoutar Bouothmany; Hanane Bakrim; Safaa Hadrach; Ahmad Salamatullah; Abdulhakeem Alzahrani; Heba Khalil Alyahya; Nawal Albadr; Said Gmouh; Amine Laglaoui; Mohammed El Mzibri; Laila Benbacer. Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds. Separations 2021, 8, 114 .
AMA StyleMohammed Bourhia, Kaoutar Bouothmany, Hanane Bakrim, Safaa Hadrach, Ahmad Salamatullah, Abdulhakeem Alzahrani, Heba Khalil Alyahya, Nawal Albadr, Said Gmouh, Amine Laglaoui, Mohammed El Mzibri, Laila Benbacer. Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds. Separations. 2021; 8 (8):114.
Chicago/Turabian StyleMohammed Bourhia; Kaoutar Bouothmany; Hanane Bakrim; Safaa Hadrach; Ahmad Salamatullah; Abdulhakeem Alzahrani; Heba Khalil Alyahya; Nawal Albadr; Said Gmouh; Amine Laglaoui; Mohammed El Mzibri; Laila Benbacer. 2021. "Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds." Separations 8, no. 8: 114.
The world is still in need of an effective therapy to treat coronavirus disease-19 (COVID-19). This cross-sectional study was conducted on COVID-19 survivors in Saudi Arabia to investigate the influence of a healthy diet on the recovery time from COVID-19. A questionnaire was developed to assess participants’ dietary habits, based on the 2015 Dutch food-based dietary guidelines. A total of 738 COVID-19 survivors participated in the study, of whom 237 (32.1%) were hospitalized for COVID-19 treatment while 501 (76.9%) were not hospitalized, and 320 (43.4%) were females and 418 (56.6%) were males. Overall, no significant difference was noted in healthy diet score between males and females; however, this score was significantly lower for Saudis compared to non-Saudis. Among the non-hospitalized patients, eating a more healthy diet was associated with a shorter duration of recovery (p< 0.05) and was significantly affected by gender (15.8 ± 9.3 male vs. 12.1 ± 8.9 female; p< 0.001) and marital status (12.1 ± 8.4 singles vs. 13.7 ± 9.3 married vs. 16.1 ± 11.8 divorced; p< 0.05). In contrast, no significant correlation was found with age or BMI. In this study, a more healthy diet was associated with a shorter duration of recovery from COVID-19. However, further studies are needed to thoroughly investigate the relationship between diet and recovery time from COVID-19.
Faisal Alamri; Aslam Khan; Abdulaziz Alshehri; Ahmed Assiri; Shahd Khan; Leen Aldwihi; Munirah Alkathiri; Omar Almohammed; Ahmad Salamatullah; Amer Alali; Waleed Badoghaish; Abdulmajeed Alshamrani; Yazed AlRuthia; Faleh Alqahtani. Association of Healthy Diet with Recovery Time from COVID-19: Results from a Nationwide Cross-Sectional Study. International Journal of Environmental Research and Public Health 2021, 18, 8248 .
AMA StyleFaisal Alamri, Aslam Khan, Abdulaziz Alshehri, Ahmed Assiri, Shahd Khan, Leen Aldwihi, Munirah Alkathiri, Omar Almohammed, Ahmad Salamatullah, Amer Alali, Waleed Badoghaish, Abdulmajeed Alshamrani, Yazed AlRuthia, Faleh Alqahtani. Association of Healthy Diet with Recovery Time from COVID-19: Results from a Nationwide Cross-Sectional Study. International Journal of Environmental Research and Public Health. 2021; 18 (16):8248.
Chicago/Turabian StyleFaisal Alamri; Aslam Khan; Abdulaziz Alshehri; Ahmed Assiri; Shahd Khan; Leen Aldwihi; Munirah Alkathiri; Omar Almohammed; Ahmad Salamatullah; Amer Alali; Waleed Badoghaish; Abdulmajeed Alshamrani; Yazed AlRuthia; Faleh Alqahtani. 2021. "Association of Healthy Diet with Recovery Time from COVID-19: Results from a Nationwide Cross-Sectional Study." International Journal of Environmental Research and Public Health 18, no. 16: 8248.
Background: Stipa tenacissima L. (S. tenacissima), called Esparto grass, is a cultivated species used for industrial purposes, including textile production. This species has never been studied for its medical potential before, nor has it been used in traditional medicines. It is thus fitting that the present study aimed to investigate the pharmacological potential of S. tenacissima. To achieve this goal, this work was conducted to study the chemical composition, antioxidant properties, and antiproliferative effects of S. tenacissima against cancerous cell lines, including the human colorectal adenocarcinoma cell line (HT-29) and human breast adenocarcinoma cell line (MDA-MB-231). Fractionation and characterization of S. tenacissima extract showed the presence of promising bioactive fractions. The fractions obtained from S. tenacissima extract exhibited interesting antioxidant properties, with IC50 values ranging from 1.26 to 1.85 mg/mL. All fractions, such as F1, F2, F3, and F4, induced an important antiproliferative effect on the cancer cell lines MDA-MB-231, scoring IC50 values ranging from 63.58 ± 3.14 to 99.880 ± 0.061 µg/mL. These fractions (F1, F2, F3, and F4) also exhibited a potent antiproliferative effect versus HT-29 cell lines, with IC50 values ranging from 71.50 ± 4.97 to 87.500 ± 1.799 µg/mL. Therefore, S. tenacissima could constitute a new natural source of bioactive compounds that can be used for therapeutic purposes to fight cancer and free radical damage.
Mehdi El Bouchti; Mohammed Bourhia; Amal Alotaibi; Kaoutar Aghmih; Sanaa Majid; Riaz Ullah; Ahmad Salamatullah; Mounir El Achaby; Mina Oumam; Hassan Hannache; Omar Cherkaoui; Mohammed El Mzibri; Laila Benbacer; Said Gmouh. Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials. Life 2021, 11, 757 .
AMA StyleMehdi El Bouchti, Mohammed Bourhia, Amal Alotaibi, Kaoutar Aghmih, Sanaa Majid, Riaz Ullah, Ahmad Salamatullah, Mounir El Achaby, Mina Oumam, Hassan Hannache, Omar Cherkaoui, Mohammed El Mzibri, Laila Benbacer, Said Gmouh. Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials. Life. 2021; 11 (8):757.
Chicago/Turabian StyleMehdi El Bouchti; Mohammed Bourhia; Amal Alotaibi; Kaoutar Aghmih; Sanaa Majid; Riaz Ullah; Ahmad Salamatullah; Mounir El Achaby; Mina Oumam; Hassan Hannache; Omar Cherkaoui; Mohammed El Mzibri; Laila Benbacer; Said Gmouh. 2021. "Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials." Life 11, no. 8: 757.
The cyanobacterium Arthrospira platensis (A. platensis)—a genus of nonheterocystous filamentous cyanobacteria—is used in industrial applications and as a food supply. The current research work aims to study the physicochemical characteristics of A. platensis indigenous to the Moroccan Atlantic coast at Laayoune (Foum El Oued lagoon). The contents of proteins, carbohydrates, vitamins, lipids, minerals, heavy metals, energy value, humidity, ash, pigments, and tannins in A. platensis were investigated using protocols as described in the earlier literature. The values of protein, carbohydrate, and lipid contents in A. platensis were 58.9 ± 0.07, 14.67, and 45.54% respectively. The values of vitamins B2 and B3 dosed in A. platensis were 1.31 ± 0.19 and 30.8 ± 0.001 mg/kg, respectively. The values of heavy metals including lead and chromium were 70 ± 4.5 and 5 ± 0.5 PPB (parts-per-billion), respectively; however, no trace concerning cadmium was detected. The values of energy value, humidity, and ash content were 346.48 ± 0.21, 11.6 ± 0.17%, and 9.1 ± 0.21% kcal/100 g, respectively. The results of pigment content showed the presence of chlorophyll b, chlorophyll a, and carotenoids of 37.506 ± 3.38, 26.066 ± 3.08, and 9.52 ± 0.22 mg/g, respectively. The results obtained revealed that A. platensis indigenous to the Moroccan Atlantic coast at Laayoune was found to be very rich in proteins, carbohydrates, vitamins, minerals, ash, and pigments and lower in heavy metals and saturated fats when compared with species investigated in the literature. Thus, A. platensis indigenous to the Moroccan Atlantic coast at Laayoune fulfills the requirements for being used as dietary supplements.
Hanane Ennaji; Mohammed Bourhia; Ikram Taouam; Aziz Falaq; Touria Ould Bellahcen; Ahmad Mohammad Salamatullah; Abdulhakeem Alzahrani; Heba Khalil Alyahya; Riaz Ullah; Samir Ibenmoussa; Naima Khlil; Mounia Cherki. Physicochemical Evaluation of Edible Cyanobacterium Arthrospira platensis Collected from the South Atlantic Coast of Morocco: A Promising Source of Dietary Supplements. Evidence-Based Complementary and Alternative Medicine 2021, 2021, 1 -11.
AMA StyleHanane Ennaji, Mohammed Bourhia, Ikram Taouam, Aziz Falaq, Touria Ould Bellahcen, Ahmad Mohammad Salamatullah, Abdulhakeem Alzahrani, Heba Khalil Alyahya, Riaz Ullah, Samir Ibenmoussa, Naima Khlil, Mounia Cherki. Physicochemical Evaluation of Edible Cyanobacterium Arthrospira platensis Collected from the South Atlantic Coast of Morocco: A Promising Source of Dietary Supplements. Evidence-Based Complementary and Alternative Medicine. 2021; 2021 ():1-11.
Chicago/Turabian StyleHanane Ennaji; Mohammed Bourhia; Ikram Taouam; Aziz Falaq; Touria Ould Bellahcen; Ahmad Mohammad Salamatullah; Abdulhakeem Alzahrani; Heba Khalil Alyahya; Riaz Ullah; Samir Ibenmoussa; Naima Khlil; Mounia Cherki. 2021. "Physicochemical Evaluation of Edible Cyanobacterium Arthrospira platensis Collected from the South Atlantic Coast of Morocco: A Promising Source of Dietary Supplements." Evidence-Based Complementary and Alternative Medicine 2021, no. : 1-11.
Cancer traits dependent chemo and radiotherapy display acute toxicity and long-term side effects. Since last two decades, researchers investigated a new anticancer agents derived from plants. Cassia alata (L.) is a medicinal herb distributed in the tropical and humid regions. In this study, C. alata flower methanol extract (CME) have been prepared using cold percolation method and the phytochemical components were identified using GC–MS analysis. CME have been used to study the antiproliferative and apoptosis properties against human colon cancer HT-115 colon cancer cells, its molecular mechanism have been explored. 0.2 mg/mL dose of CME, inhibited 50% of HT-115 colon cancer cell growth after 48hr was confirmed the significant antiproliferation effect. In normal cells such as Vero cells and hMSCs, 0.2 mg/mL dose of CME shown only 4% and 5% growth inhibition confirmed the HT-115 cell specific cytotoxic effect. This effect might be due to the availability of phytoactive biomolecules in CME such as, cyclotrisiloxan, beta-sitosterol and alpha-tocopherol have been confirmed by GC–MS. Most interestingly, PI and AO/ErBr staining of CME treated HT-115 cells shown early (25%), pro (17%) and late (8%) apoptotic and 3% necrotic cells after 48 hr. Treatment with CME extract showed potential effect on the inhibition of protumorigenic inflammatory and oxidative stress genes. Protumorigenic COX-2/PGE-2 and TNF-α/NF-κB immune axis were normalized after CME treatment. Amounts of both apoptosis related mRNA p53, Bax, caspase 3 and p21 genes were upregulated, whereas it resulted in significant reduction in the anti-apoptotic marker mdm2 and Bcl-2 genes. In conclusion, bioactive compounds present in CME potentially inhibit HT-115 colon cancer cell proliferation via an inhibition of protumorigenic immune axis and stimulation of mitochondria dependent apoptotic pathway without necrotic effect.
Ahmad Mohammad Salamatullah; P. Subash-Babu; Amr Nassrallah; Ali A. Alshatwi; Mohammed Saeed Alkaltham. Cyclotrisiloxan and β-Sitosterol rich Cassia alata (L.) flower inhibit HT-115 human colon cancer cell growth via mitochondrial dependent apoptotic stimulation. Saudi Journal of Biological Sciences 2021, 1 .
AMA StyleAhmad Mohammad Salamatullah, P. Subash-Babu, Amr Nassrallah, Ali A. Alshatwi, Mohammed Saeed Alkaltham. Cyclotrisiloxan and β-Sitosterol rich Cassia alata (L.) flower inhibit HT-115 human colon cancer cell growth via mitochondrial dependent apoptotic stimulation. Saudi Journal of Biological Sciences. 2021; ():1.
Chicago/Turabian StyleAhmad Mohammad Salamatullah; P. Subash-Babu; Amr Nassrallah; Ali A. Alshatwi; Mohammed Saeed Alkaltham. 2021. "Cyclotrisiloxan and β-Sitosterol rich Cassia alata (L.) flower inhibit HT-115 human colon cancer cell growth via mitochondrial dependent apoptotic stimulation." Saudi Journal of Biological Sciences , no. : 1.
Resistance to drugs is reaching alarming levels and is placing human health at risk. With the lack of new antimicrobials drugs, infectious diseases are becoming harder to treat. Hence, there is an increasing awareness of active phytochemicals with therapeutic functions. The tremendous research interest on the Cistus L. genus includes numerous plants used in traditional medicine by people living around the Mediterranean Sea, also resulted in some interesting discoveries and written literature. This review aimed at gathering scientific literature about Cistus species, describing phytochemical profiles and the various pharmacological activities. We also extensively reviewed the antimicrobial activities, including antiviral, antiparasitic, antifungal, and antibacterial potentials of Essential Oils (EO), raw extracts as well as isolated compounds. Mechanisms of action along with methods used are also investigated in this review. Considering the findings of the Cistus species extracts, this genus offers an adequate reserve of active phytochemicals since many have been used to create drugs. Therefore, this review work can serve society by providing a global view on Cistus L. sp. regarding pharmacological potentials and their chemical profiles.
Imane Zalegh; Mohamed Akssira; Mohammed Bourhia; Fouad Mellouki; Naima Rhallabi; Ahmad Salamatullah; Mohammed Alkaltham; Heba Khalil Alyahya; Rajaa Mhand. A Review on Cistus sp.: Phytochemical and Antimicrobial Activities. Plants 2021, 10, 1214 .
AMA StyleImane Zalegh, Mohamed Akssira, Mohammed Bourhia, Fouad Mellouki, Naima Rhallabi, Ahmad Salamatullah, Mohammed Alkaltham, Heba Khalil Alyahya, Rajaa Mhand. A Review on Cistus sp.: Phytochemical and Antimicrobial Activities. Plants. 2021; 10 (6):1214.
Chicago/Turabian StyleImane Zalegh; Mohamed Akssira; Mohammed Bourhia; Fouad Mellouki; Naima Rhallabi; Ahmad Salamatullah; Mohammed Alkaltham; Heba Khalil Alyahya; Rajaa Mhand. 2021. "A Review on Cistus sp.: Phytochemical and Antimicrobial Activities." Plants 10, no. 6: 1214.
This work was conducted to study the chemical composition, antioxidant, antibacterial, and antifungal activities of essential oil and hydrolat from Withania frutescens. The essential oil was extracted by hydrodistillation. The chemical characterization was performed using gas chromatography-mass spectrometry (GC/MS). The antioxidant activity was studied using four different assays (DPPH, TAC, FRAP, and β-carotene bleaching). The antibacterial activity test was carried out on multidrug-resistant bacteria including Gram-negative and Gram-positive strains. Antifungal activity was tested on Candida albicans and Saccharomyces cerevisiae. The yield of essential oil (EO) obtained by hydrodistillation of W. frutescens was 0.31% majorly composed of camphor, α-thujone, carvacrol, and thymol. Regarding the antioxidant activities, the concentration of the sample required to inhibit 50% of radicals (IC50) of EO and hydrolat were 14.031 ± 0.012 and 232.081 ± 3.047 µg/mL (DPPH), 4.618 ± 0.045 and 8.997 ± 0.147 µg/mL (FRAP), 0.091 ± 0.007 and 0.131 ± 0.004 mg AAE/mg (TAC), 74.141 ± 1.040% and 40.850 ± 0.083% (β-carotene), respectively. Concerning the antibacterial activity of essential oil and hydrolat, the minimum inhibitory concentration (MIC) values found were 0.006 ± 0.001 and 6.125 ± 0.541 µg/mL (Escherichia coli 57), 0.003 ± 0.001 and 6.125 ± 0.068 µg/mL (Klebsiella pneumoniae), 0.001 ± 0.0 and 6.125 ± 0.046 µg/mL (Pseudomonas aeruginosa) and 0.012 ± 0.003 and 6.125 ± 0.571 µg/mL (Staphylococcus aureus), respectively. MIC values of essential oil and hydrolat vs. both C. albicans and S. cerevisiae were lower than 1/20,480 µg/mL. Based on the findings obtained, essential oils of Withania frutescens can be used as promising natural agents to fight free radical damage and nosocomial antibiotic-resistant microbes.
Abdelfattah EL Moussaoui; Mohammed Bourhia; Fatima Jawhari; Ahmad Salamatullah; Riaz Ullah; Ahmed Bari; Hafiz Majid Mahmood; Muhammad Sohaib; Bohza Serhii; Alexander Rozhenko; Mourad Aboul-Soud; Essam Ezzeldin; Gamal Mostafa; Dalila Bousta; Amina Bari. Chemical Profiling, Antioxidant, and Antimicrobial Activity against Drug-Resistant Microbes of Essential Oil from Withania frutescens L. Applied Sciences 2021, 11, 5168 .
AMA StyleAbdelfattah EL Moussaoui, Mohammed Bourhia, Fatima Jawhari, Ahmad Salamatullah, Riaz Ullah, Ahmed Bari, Hafiz Majid Mahmood, Muhammad Sohaib, Bohza Serhii, Alexander Rozhenko, Mourad Aboul-Soud, Essam Ezzeldin, Gamal Mostafa, Dalila Bousta, Amina Bari. Chemical Profiling, Antioxidant, and Antimicrobial Activity against Drug-Resistant Microbes of Essential Oil from Withania frutescens L. Applied Sciences. 2021; 11 (11):5168.
Chicago/Turabian StyleAbdelfattah EL Moussaoui; Mohammed Bourhia; Fatima Jawhari; Ahmad Salamatullah; Riaz Ullah; Ahmed Bari; Hafiz Majid Mahmood; Muhammad Sohaib; Bohza Serhii; Alexander Rozhenko; Mourad Aboul-Soud; Essam Ezzeldin; Gamal Mostafa; Dalila Bousta; Amina Bari. 2021. "Chemical Profiling, Antioxidant, and Antimicrobial Activity against Drug-Resistant Microbes of Essential Oil from Withania frutescens L." Applied Sciences 11, no. 11: 5168.
Cucumbers have a limited shelf-life, from 10 to 14 days at commercial temperatures with relative humidity (80%). The aim of the work was to evaluate the postharvest physicochemical properties and fungal populations of cucumber treated with sodium tripolyphosphate/titanium dioxide nanoparticles during storage at 10 °C to prolong the shelf-life to 21 days. Cucumber samples treated with chitosan/sodium tripolyphosphate/titanium dioxide nanoparticles (Cu-CHS-TDN-ST) and (Cu-CHS-TDN-ST) were found to be in a well-hydrated state and with a green-colored appearance upon day 21, with excellent quality for consumption. Chitosan coating (Cu-CHS) alone prolonged the cucumber shelf-life for 14 days of storage. The Cu-CHS coating was less evident in reducing the respiration rate of cucumbers on day 14 than both nanocoatings, which were reported at the end of the storage period to be 5.09 and 5.38 mg·kg−1 h−1 for Cu-CHS-TDN-ST and Cu-CHS-TDN, respectively. The Cu-CHS-TDN-ST treatment reduced the loss of ascorbic acid content to 13.17 mg/100 g, delayed chilling injury, and had the highest chlorophyll contents during the whole storage period. The presence of sodium tripolyphosphate with the nanocoating delayed tissue damage. Peroxidase enzyme activity reached the maximum of 54.65 Ug−1 for Cu-CHS-TDN-ST on day 21, followed by Cu-CHS-TDN 50.1 Ug−1. On day 21, the fungal populations of Cu-CHS-TDN samples (3.77 log CFU/g) were more than that of Cu-CHS-TDN-ST (3.15 log CFU/g) against Cu-Control (100 % spoiled). It was noted that the Cu-CHS-TDN-ST and CHS-TDN-ST coating treatments were capable of preserving the cucumber samples’ quality during storage. The addition of sodium tripolyphosphate as a crosslinker for stabilizing the nanoparticle polymers in the coating treatments prolonged the shelf-life and achieved excellent quality for the cucumbers.
Ebtihal Khojah; Rokayya Sami; Mahmoud Helal; Abeer Elhakem; Nada Benajiba; Mohammed Alkaltham; Ahmad Salamatullah. Postharvest Physicochemical Properties and Fungal Populations of Treated Cucumber with Sodium Tripolyphosphate/Titanium Dioxide Nanoparticles during Storage. Coatings 2021, 11, 613 .
AMA StyleEbtihal Khojah, Rokayya Sami, Mahmoud Helal, Abeer Elhakem, Nada Benajiba, Mohammed Alkaltham, Ahmad Salamatullah. Postharvest Physicochemical Properties and Fungal Populations of Treated Cucumber with Sodium Tripolyphosphate/Titanium Dioxide Nanoparticles during Storage. Coatings. 2021; 11 (6):613.
Chicago/Turabian StyleEbtihal Khojah; Rokayya Sami; Mahmoud Helal; Abeer Elhakem; Nada Benajiba; Mohammed Alkaltham; Ahmad Salamatullah. 2021. "Postharvest Physicochemical Properties and Fungal Populations of Treated Cucumber with Sodium Tripolyphosphate/Titanium Dioxide Nanoparticles during Storage." Coatings 11, no. 6: 613.
Background: Gramineae damping-off disease is a growing problem worldwide, which affects a large range of seedlings in nurseries, glasshouses, gardens, crops, forests and untimely generates a heavy economic impact on the agriculture and related sectors. Objectives: The present study was conducted to evaluate the preventive potential of carvacrol on germination of Fusarium oxysporum, Neocosmospora solani, and Microdochium nivale spores as responsible agents for Lolium perenne seeds damping-off disease. Material and methods: Macrodilution method in agar medium, spore germination, spore destruction, and preventive treatment bioassays were used to achieve this goal. Results: The minimum inhibitory concentration (MIC) of carvacrol vs. tested strains existed in the range of 0.25–0.5 mg/mL. Carvacrol used in concentrations ranging from 0.2 to 0.4 mg/mL inhibited the germination of all fungal spores in a dose-dependent manner. Carvacrol showed a very strong sporicidal effect against all studied fungal strains, and this effect was well confirmed by microscopic observations. The percentage of growth inhibition was found to be strictly correlated to carvacrol dose up vs. all strains. Carvacrol increased the emergence of L. perenne seeds when compared to both uninfested and infested seeds. Conclusion: Based on the results obtained, carvacrol fulfills the requirement for being a natural alternative agent to fight Gramineae seedlings’ damping-off caused by fungal species without adverse effects on the plants.
Hamza Saghrouchni; Azeddin El Barnossi; Ahmad Salamatullah; Mohammed Bourhia; Abdulhakeem Alzahrani; Mohammed Alkaltham; Heba Alyahya; Nour Tahiri; Hamada Imtara; Işıl Var. Carvacrol: A Promising Environmentally Friendly Agent to Fight Seeds Damping-Off Diseases Induced by Fungal Species. Agronomy 2021, 11, 985 .
AMA StyleHamza Saghrouchni, Azeddin El Barnossi, Ahmad Salamatullah, Mohammed Bourhia, Abdulhakeem Alzahrani, Mohammed Alkaltham, Heba Alyahya, Nour Tahiri, Hamada Imtara, Işıl Var. Carvacrol: A Promising Environmentally Friendly Agent to Fight Seeds Damping-Off Diseases Induced by Fungal Species. Agronomy. 2021; 11 (5):985.
Chicago/Turabian StyleHamza Saghrouchni; Azeddin El Barnossi; Ahmad Salamatullah; Mohammed Bourhia; Abdulhakeem Alzahrani; Mohammed Alkaltham; Heba Alyahya; Nour Tahiri; Hamada Imtara; Işıl Var. 2021. "Carvacrol: A Promising Environmentally Friendly Agent to Fight Seeds Damping-Off Diseases Induced by Fungal Species." Agronomy 11, no. 5: 985.
Diabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives to fight this lethal disease. This modest study aims to investigate the chemical composition, antidiabetic and antihyperglycemic potentials along with subacute toxicity (bodyweight change and biochemical parameters) of hydroethanol extract from Withania frutescens L. roots (WFRE). The chemical analysis was carried out using GC–MS after extract silylation. The chemical analysis identified many potentially active compounds that may determine the antidiabetic results of WFRE. The antidiabetic effect of WFRE was evaluated in mice with severe diabetes using oral administration of doses up to 400 mg/kg for 28 days. The results of the antidiabetic and antihyperglycemic tests indicate that WFRE possesses promising glucose-lowering effects and, as a result, it may serve as an antidiabetic alternative for long-term use. The 4-week treatments with different doses of plant extract did not alter the bodyweight appearance of the diabetic mice nor their biochemical parameters (AST and ALT). The findings obtained indicate that the studied plant extract controlled severe diabetes in mice. Therefore, Withania frutescens L. can serve society as it provides natural agents to control diabetes.
Abdelfattah El Moussaoui; Hamza Mechchate; Mohammed Bourhia; Imane Es-Safi; Ahmad Salamatullah; Mohammed Alkaltham; Heba Alyahya; Dalila Bousta; Amina Bari. Glycemic Control Potential of Chemically Characterized Extract from Withania frutescens L. Roots in Severe Diabetes-Induced Mice. Applied Sciences 2021, 11, 3998 .
AMA StyleAbdelfattah El Moussaoui, Hamza Mechchate, Mohammed Bourhia, Imane Es-Safi, Ahmad Salamatullah, Mohammed Alkaltham, Heba Alyahya, Dalila Bousta, Amina Bari. Glycemic Control Potential of Chemically Characterized Extract from Withania frutescens L. Roots in Severe Diabetes-Induced Mice. Applied Sciences. 2021; 11 (9):3998.
Chicago/Turabian StyleAbdelfattah El Moussaoui; Hamza Mechchate; Mohammed Bourhia; Imane Es-Safi; Ahmad Salamatullah; Mohammed Alkaltham; Heba Alyahya; Dalila Bousta; Amina Bari. 2021. "Glycemic Control Potential of Chemically Characterized Extract from Withania frutescens L. Roots in Severe Diabetes-Induced Mice." Applied Sciences 11, no. 9: 3998.
Beetroot is a widely consumed crop all over the world and contains plenty of bioactive compounds. In this study, we analyzed the bioactive as well as the antimicrobial properties of the oven-dried beetroot (pulp and peel) using different solvents. The 50% methanolic extract yielded the highest content of total polyphenols and total flavonoids as well as the reducing power of the beetroot. The beetroot peel exhibited a higher content of total polyphenols, total flavonoids, and reducing power activity under all the extraction solvents. Mixture of methanol and water (50% v/v) extracted the highest chlorogenic acid (78.24 mg/100 g) of the dried beetroot peel, while 1,2-dihydroxybenzene was the most noteworthy phenolic compound (42.52 mg/100 g) in beetroot peel methanolic extract. The 50% methanolic extract of both peel and pulp demonstrated the highest antibacterial and anticandidal potential. These results can be helpful for beetroot consumption.
Ahmad Salamatullah; Khizar Hayat; Mohammed Alkaltham; Mohammed Ahmed; Shaista Arzoo; Fohad Husain; Alhanouf Al-Dossari; Ghalia Shamlan; Laila Al-Harbi. Bioactive and Antimicrobial Properties of Oven-Dried Beetroot (Pulp and Peel) Using Different Solvents. Processes 2021, 9, 588 .
AMA StyleAhmad Salamatullah, Khizar Hayat, Mohammed Alkaltham, Mohammed Ahmed, Shaista Arzoo, Fohad Husain, Alhanouf Al-Dossari, Ghalia Shamlan, Laila Al-Harbi. Bioactive and Antimicrobial Properties of Oven-Dried Beetroot (Pulp and Peel) Using Different Solvents. Processes. 2021; 9 (4):588.
Chicago/Turabian StyleAhmad Salamatullah; Khizar Hayat; Mohammed Alkaltham; Mohammed Ahmed; Shaista Arzoo; Fohad Husain; Alhanouf Al-Dossari; Ghalia Shamlan; Laila Al-Harbi. 2021. "Bioactive and Antimicrobial Properties of Oven-Dried Beetroot (Pulp and Peel) Using Different Solvents." Processes 9, no. 4: 588.
The eggplant is an important vegetable that is used all over the world and it contains valuable bioactive properties. Cooking methods affect the nutritional value as well as the functional characteristics of vegetables. This study investigated the effect of air-frying at different temperatures and the extraction solvents on the bioactive properties of eggplant. The eggplant air-fried for 25 min and extracted with 50% ethanol exhibited the highest total flavonoid content (35.10 mg catechin equivalent per gram dry weight), while its total polyphenol content was found as 87.81 mg gallic acid equivalent per gram dry weight. The uncooked sample exhibited the lowest DPPH scavenging (IC50: 422.12 mg/mL reducing power: 0.914), while the highest DPPH scavenging activity (IC50: 2.87 mg/mL; reducing power: 0.936) was recorded for the sample air-fried for 25 min and extracted with 50% ethanol. The highest amount of tannic acid was found in medium-cooked eggplant, while chlorogenic acid was the highest in the high-cooked sample. These results might be helpful for functional food processors.
Ahmad Salamatullah; Mohammed Ahmed; Mohammed Alkaltham; Khizar Hayat; Najla Aloumi; Alhanouf Al-Dossari; Laila Al-Harbi; Shaista Arzoo. Effect of Air-Frying on the Bioactive Properties of Eggplant (Solanum melongena L.). Processes 2021, 9, 435 .
AMA StyleAhmad Salamatullah, Mohammed Ahmed, Mohammed Alkaltham, Khizar Hayat, Najla Aloumi, Alhanouf Al-Dossari, Laila Al-Harbi, Shaista Arzoo. Effect of Air-Frying on the Bioactive Properties of Eggplant (Solanum melongena L.). Processes. 2021; 9 (3):435.
Chicago/Turabian StyleAhmad Salamatullah; Mohammed Ahmed; Mohammed Alkaltham; Khizar Hayat; Najla Aloumi; Alhanouf Al-Dossari; Laila Al-Harbi; Shaista Arzoo. 2021. "Effect of Air-Frying on the Bioactive Properties of Eggplant (Solanum melongena L.)." Processes 9, no. 3: 435.
Fruits and vegetables constitute a considerable amount of antioxidants and among them eggplant is a rich source of polyphenol compounds. This study investigated the bioactive and antimicrobial properties of eggplant under different degree of microwave cooking. The eggplant was cooked for 7 min (light cooked), 10 min (medium cooked), and 15 min (high cooked). The highest total polyphenol content was observed in the light cooked eggplant sample (27.35 mg gallic acid equivalent (GAE)/g dry weight (DW)) followed by high cooked sample (26.10 mg GAE/g DW), while the lowest total polyphenol content (2.79 mg GAE/g DW) was obtained for the uncooked (control) sample. The total polyphenol content of the samples ranged in the following order; light cooked > high cooked > medium cooked > uncooked. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging of eggplant ranged between 16.16% (control) and 47.88% (high cooked). The highest reducing power was exhibited by the light cooked (absorbance 1.708) eggplant sample followed by the high cooked (absorbance 1.597), while the lowest reducing power was shown by uncooked sample (absorbance 0.389). Moreover, antimicrobial studies showed that light cooked eggplant sample demonstrated broad-spectrum inhibition of growth in Gram-positive as well as Gram-negative bacteria and Candida albicans. Slightly lower antimicrobial potential was exhibited by medium cooked eggplant sample while no antibacterial or antifungal activity was recorded for the extract of high cooked eggplant sample. Microwave cooking might be a method to enhance the antioxidant and antimicrobial potential of eggplant.
Ahmad Salamatullah; Mohammed Alkaltham; Khizar Hayat; Mohammed Ahmed; Shaista Arzoo; Fohad Husain; Abdulhakeem Alzahrani. Bioactive and Antimicrobial Properties of Eggplant (Solanum melongena L.) under Microwave Cooking. Sustainability 2021, 13, 1519 .
AMA StyleAhmad Salamatullah, Mohammed Alkaltham, Khizar Hayat, Mohammed Ahmed, Shaista Arzoo, Fohad Husain, Abdulhakeem Alzahrani. Bioactive and Antimicrobial Properties of Eggplant (Solanum melongena L.) under Microwave Cooking. Sustainability. 2021; 13 (3):1519.
Chicago/Turabian StyleAhmad Salamatullah; Mohammed Alkaltham; Khizar Hayat; Mohammed Ahmed; Shaista Arzoo; Fohad Husain; Abdulhakeem Alzahrani. 2021. "Bioactive and Antimicrobial Properties of Eggplant (Solanum melongena L.) under Microwave Cooking." Sustainability 13, no. 3: 1519.
It was investigated effects of roasting temperature and time on color, crude oil, acrylamide, total phenols, antioxidant activity, and trans fatty acid and phenolic contents in white and brown sesame seeds. Samples were roasted in a microwave oven (360, 540, 720 W; 5, 10, 15 min) and an electric oven (180 °C, 200 °C, 220 °C; 10, 20, 30 min). Phenolic and antioxidant contents changed significantly. Maximum total phenolic content and antioxidant activity values were noted for samples roasted in the electric oven at 220 °C for 30 min (white, 264.17 mg/100 g, 74.76%; brown, 289.79 mg/100 g, 74.32%, respectively). Dominant fatty acids did not change significantly following electric oven roasting. Roasting at 200 °C and 220 °C caused trans fatty acid formation. Elaidic, linolelaidic acid content were 0.05–0.36%, 0.06–0.33% in white sesame and 0.22–0.41%, 0.06–0.23% in brown sesame, respectively. Acrylamide formation was not detected.
Ahmad Mohammed Salamatullah; Mohammed Saeed Alkaltham; Nurhan Uslu; Mehmet Musa Özcan; Khizar Hayat. The effects of different roasting temperatures and times on some physicochemical properties and phenolic compounds in sesame seeds. Journal of Food Processing and Preservation 2021, 45, 1 .
AMA StyleAhmad Mohammed Salamatullah, Mohammed Saeed Alkaltham, Nurhan Uslu, Mehmet Musa Özcan, Khizar Hayat. The effects of different roasting temperatures and times on some physicochemical properties and phenolic compounds in sesame seeds. Journal of Food Processing and Preservation. 2021; 45 (3):1.
Chicago/Turabian StyleAhmad Mohammed Salamatullah; Mohammed Saeed Alkaltham; Nurhan Uslu; Mehmet Musa Özcan; Khizar Hayat. 2021. "The effects of different roasting temperatures and times on some physicochemical properties and phenolic compounds in sesame seeds." Journal of Food Processing and Preservation 45, no. 3: 1.
The boiling process caused decrease from 22.22 mg/100g to 3.01 mg/100g in total phenolic content of celery root. Similarly, after boiling process, antioxidant activity of sample reduced from 2.67% to 0.53%. The main phenolic compounds of celery were found as catechin (50.93 mg/100g), 3,4‐dihydroxybenzoic acid (39.81 mg/100g), 1,2‐dihydroxybenzene (35.19 mg7100g) and gallic acid (19.21 mg/100g), respectively. Generally, the reduction in phenolic compounds was observed with boiling process. The highest reduction was determined in 3,4‐dihydroxybenzoic acid from 39.81 mg/100g to 30.62 mg/100g. Additionally, gallic acid and quercetin contents of celery decreased from 19.21 mg/100g to 15.75 mg/100g and from 17.28 mg/100g to 13.08 mg/100g, respectively, while catechin content of sample increased from 50.93 mg/100g to 54.77 mg/100g after boiling process. A significant decrease in the total phenol and antioxidant activity values of boiled samples was observed.
Ahmad Mohammed Salamatullah; Mehmet Musa Özcan; Mohammed Saeed Alkaltham; Nurhan Uslu; Khizar Hayat. Influence of boiling on total phenol, antioxidant activity, and phenolic compounds of celery ( Apium graveolens L) root. Journal of Food Processing and Preservation 2020, 45, 1 .
AMA StyleAhmad Mohammed Salamatullah, Mehmet Musa Özcan, Mohammed Saeed Alkaltham, Nurhan Uslu, Khizar Hayat. Influence of boiling on total phenol, antioxidant activity, and phenolic compounds of celery ( Apium graveolens L) root. Journal of Food Processing and Preservation. 2020; 45 (2):1.
Chicago/Turabian StyleAhmad Mohammed Salamatullah; Mehmet Musa Özcan; Mohammed Saeed Alkaltham; Nurhan Uslu; Khizar Hayat. 2020. "Influence of boiling on total phenol, antioxidant activity, and phenolic compounds of celery ( Apium graveolens L) root." Journal of Food Processing and Preservation 45, no. 2: 1.