Multifunctional nanocomposite coatings were synthesized by reinforcing a polymeric matrix with halloysite nanotubes (HNTs) loaded with corrosion inhibitor (NaNO₃) and urea formaldehyde microcapsules (UFMCs) encapsulated with a self-healing agent (linseed oil (LO)). The developed polymeric nanocomposite coatings were applied on the polished mild steel substrate using the doctor’s blade technique. The structural (FTIR, XPS) and thermogravimetric (TGA) analyses reveal the loading of HNTs with NaNO₃ and encapsulation of UFMCs with linseed oil. It was observed that self-release of the inhibitor from HNTs in response to pH change was a time dependent process. Nanocomposite coatings demonstrate decent self-healing effects in response to the external controlled mechanical damage. Electrochemical impedance spectroscopic analysis (EIS) indicates promising anticorrosive performance of novel nanocomposite coatings. Observed corrosion resistance of the developed smart coatings may be attributed to the efficient release of inhibitor and self-healing agent in response to the external stimuli. Polymeric nanocomposite coatings modified with multifunctional species may offer suitable corrosion protection of steel in the oil and gas industry.

In the present study, nanocomposite ultrafiltration membranes were prepared by incorporating nanotubes clay halloysite (HNTs) into polysulfone (PSF) and PSF/polyvinylpyrrolidone (PVP) dope solutions followed by membrane casting using phase inversion method. Characterization of HNTs were conducted using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), and thermogravimetric (TGA) analysis. The pore structure, morphology, hydrophilicity and mechanical properties of the composite membranes were characterized by using SEM, water contact angle (WCA) measurements, and dynamic mechanical analysis. It was shown that the incorporation of HNTs enhanced hydrophilicity and mechanical properties of the prepared PSF membranes. Compared to the pristine PSF membrane, results show that the total porosity and pore size of PSF/HNTs composite membranes increased when HNTs loadings were more than 0.5 wt % and 1.0 wt %, respectively. These findings correlate well with changes in water flux of the prepared membranes. It was observed that HNTs were homogenously dispersed within the PSF membrane matrix at HNTs content of 0.1 to 0.5 wt % and the PSF/HNTs membranes prepared by incorporating 0.2 wt % HNTs loading possess the optimal mechanical properties in terms of elastic modulus and yield stress. In the case of the PSF/PVP matrix, the optimal mechanical properties were obtained with 0.3 wt % of HNTs because PVP enhances the HNTs distribution. Results of bovine serum albumin (BSA) filtration tests indicated that PSF/0.2 wt % HNTs membrane exhibited high BSA rejection and notable anti-fouling properties.

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The application of nanoscale materials such as nanoparticles in biomedicine has opened new horizons in the treatment of CVDs. We have previously shown that the iron metal–organic framework nanoparticle, Materials Institut Lavoisier-89 (nanoMIL-89) represents a viable vehicle for future drug delivery of pulmonary arterial hypertension. In this study, we have assessed the cellular uptake of nanoMIL-89 in pulmonary artery endothelial and smooth muscle cells using microscopy imaging techniques. We also tested the cellular responses to nanoMIL-89 using molecular and cellular assays. Microscopic images showed cellular internalization of nanoMIL-89, packaging into endocytic vesicles, and passing to daughter cells during mitosis. Moreover, nanoMIL-89 showed anti-inflammatory activity without any significant cytotoxicity. Our results indicate that nanoMIL-89 formulation may offer promising therapeutic opportunities and set forth a new prototype for drug delivery not only in CVDs, but also for other diseases yet incurable, such as diabetes and cancer.