Deborah J Hall

Ms. Deborah J Hall

orcid

Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 December 2004 in The Journal of Arthroplasty
Verified
Journal Article
Closed access
RURobert M. Urban
Robert M. Urban
MTMichael J. Tomlinson
Michael J. Tomlinson
DHDeborah J Hall
Deborah J Hall
JJJoshua J. Jacobs
Joshua J. Jacobs

16 June 2012 in Journal of Biomedical Materials Research Part B: Applied Biomaterials
Verified
Journal Article
Closed access
PDF file
MMMathew Mathew
Mathew Mathew
SASavithri Abbey
Savithri Abbey
NHNadim J. Hallab
Nadim J. Hallab
DHDeborah J Hall
Deborah J Hall
CSCortino Sukotjo
Cortino Sukotjo
Markus A. A WimmerMarkus A. A Wimmer
Markus A. A Wimmer

1 June 2007 in Clinical Orthopaedics and Related Research
Verified
Journal Article
Closed access
RURobert M Urban
Robert M Urban
TTThomas M Turner
Thomas M Turner
DHDeborah J Hall
Deborah J Hall
NINozomu Inoue
Nozomu Inoue
SGSteven Gitelis
Steven Gitelis
Calcium phosphates (CaPO4) and faster-resorbing calcium sulfate (CaSO4) are successfully employed as synthetic bone grafts for treatment of contained defects. We used a canine critical-sized bone defect model to study an injectable CaSO4/CaPO4 composite graft that incorporated a matrix of CaSO4 and dicalcium phosphate dihydrate into which beta-tricalcium phosphate granules were distributed. The area fraction, ultimate compressive stress, and elastic modulus of restored bone and the relative rates of material resorption were compared between the CaSO4/CaPO4 composite graft and pure CaSO4 pellets and to normal canine bone. The area fraction of bone in stained sections and the ultimate compressive stress of the regenerated bone were greater using the CaSO4/CaPO4 composite graft compared to pure CaSO4 pellets after 13 and 26 weeks and were greater than normal bone. The elastic modulus of restored bone in defects treated with CaSO4/CaPO4 composite graft was greater than in defects treated with CaSO4 pellets after 26 weeks, but similar to specimens of normal bone. A small amount of CaSO4/CaPO4 composite graft and no CaSO4 pellets remained after 13 or 26 weeks. This novel CaSO4/CaPO4 composite holds promise for clinical applications where a strong, injectable, slower-resorbing, and biocompatible bone graft substitute would be advantageous.

26 August 2017 in Journal of Biomedical Materials Research Part B: Applied Biomaterials
Verified
Journal Article
Closed access
PDF file
DHDeborah J Hall
Deborah J Hall
RPRobin Pourzal
Robin Pourzal
HLHannah J. Lundberg
Hannah J. Lundberg
MMMathew T. Mathew
Mathew T. Mathew
JJJoshua J. Jacobs
Joshua J. Jacobs
RURobert M. Urban
Robert M. Urban

1 August 2005 in Clinical Orthopaedics and Related Research
Verified
Journal Article
Closed access
TTThomas M Turner
Thomas M Turner
RURobert M Urban
Robert M Urban
DHDeborah J Hall
Deborah J Hall
PCPing C Chye
Ping C Chye
JSJohn Segreti
John Segreti
SGSteven Gitelis
Steven Gitelis
We asked if tobramycin-loaded calcium sulfate pellets could be used to maintain high local site antibiotic concentrations for an extended period with minimal systemic levels and without adverse effects on vital organs. Calcium sulfate pellets loaded with 10% tobramycin were implanted in contained medullary defects in the proximal humeri of canines. The number of pellets implanted was calculated to yield an equivalent human maximum prescribed dose, and 1.8-fold this dose. These doses converted to approximately 20 mg/kg, and 36 mg/kg, respectively, for the canine. Local and systemic tobramycin levels, pellet resorption, bone response, clinical pathology parameters, and histopathologic responses of potential target organs were analyzed to determine if there was any adverse response for a 28-day period. Serum tobramycin was elevated for less than one day while local levels remained elevated for at least 14 days, and in some animals, 28 days. Tobramycin delivered locally from calcium sulfate pellets had no apparent adverse effect on clinical pathology parameters or on any of the organs that were analyzed. In addition, bone formation and pellet resorption followed patterns typically seen with calcium sulfate materials.

1 September 2017 in The Journal of Arthroplasty
Verified
Journal Article
Closed access
YFYale A. Fillingham
Yale A. Fillingham
CVCraig J. Della Valle
Craig J. Della Valle
DBDaniel D. Bohl
Daniel D. Bohl
MKMick P. Kelly
Mick P. Kelly
DHDeborah J Hall
Deborah J Hall
JJJoshua J. Jacobs
Joshua J. Jacobs