Background: The objective of this study is to evaluate the application of National guidelines for prevention and clinical management of traumatic dental injuries (NGPCMTDI) in developmental age published by the Italian Ministry of Health. Methods: In the present retrospective and multicenter study, 246 patients who underwent dental injury were selected to assess the management of the traumatic event compiled with the protocol provided by the National guidelines. Each health worker involved completed a form related to the dental injury in order to standardize the collected data. Two reference centers have been identified for data collection. Analyses for comparisons between groups were performed using the _X² test for categorical variables or by Fisher exact test as appropriate. Statistical significance was assumed at p < 0.05. Results: Evaluating the distribution by age we concluded that: 27.24% of the enrolled patients were aged 1–5 years, 51.63% 6–10 years, and 19.92% 11–17 years. The dental injuries occurred in 10.16% of the situations at home, 50.81% at school, 28.86% during recreation, and 9.35% at the gym. The deciduous dentition is involved in 34.96% of the traumas while the permanent dentition is involved in 69.51%. Conclusion: From the present study it emerged that the National guidelines are not uniformly applied.

Background: This proof-of-concept clinical study evaluated the feasibility, applicability, tolerability, and preliminary response of a customised 3D-printed, thermoformed intraoral device for gingival topical treatment. Immune-mediated conditions, including oral lichen planus, mucous membrane pemphigoid, and pemphigus vulgaris often cause desquamative gingivitis. Topical corticosteroids are often ineffective in the oral environment, and frequent reapplication may increase systemic absorption. Methods: Two adults with immune-mediated gingival disease—oral lichen planus and mucous membrane pemphigoid—were unresponsive to topical corticosteroids. Following intraoral scanning, digital design, 3D printing, and thermoforming, each received a custom device with reservoirs over the lesions. They applied the corticosteroid gel and wore the device for 30 minutes, three times daily, in four cycles of five treatment days and two rest days. Results: Both cases completed the digital workflow successfully, with high compliance and no device-related mucosal irritation or pressure lesions. Mean pain scores fell from 8.5 at T0 to 4 at T1 (day 20) and 1.5 at T2 (day 40). Erythema and erosive areas decreased markedly, while symptoms nearly resolved. Conclusions: Device-mediated clobetasol was feasible, well tolerated, and effective in two topical treatment–resistant patients, but is currently limited to keratinized, dentition-supported sites (gingiva and palate). Randomized controlled trials must confirm efficacy versus conventional application.