Background: Osteosarcoma is a rare but aggressive bone malignancy. Despite advances in multimodal therapy, survival remains suboptimal, highlighting the need for prognostic markers to guide treatment. Methods: This study included 162 osteosarcoma patients who received neoadjuvant chemotherapy followed by surgery between January 2009 and March 2024. Patients received either double (cisplatin + doxorubicin) or triple (MAP or PEI) chemotherapy. Survival analyses were conducted using Kaplan–Meier curves, log-rank tests, and Cox proportional hazards models. Results: The median age was 20 years (IQR: 18–29), and 53.1% were male. Patients who received triple chemotherapy regimens demonstrated significantly longer overall survival (OS) compared to those on doublet regimens. High tumor necrosis rates (>90%) and negative surgical margins were strongly associated with improved OS, while metastatic disease at diagnosis, elevated alkaline phosphatase (ALP), and male gender were linked to poorer survival. Multivariate analysis identified adjuvant therapy, age under 18, high necrosis rate, negative margins, and normal ALP as significant OS predictors. Conclusions: Triple-agent chemotherapy, necrosis rate ≥90 and negative surgical margins are strongly associated with prolonged survival in osteosarcoma. The key prognostic indicators such as ALP levels, surgical margins and age at diagnosis should guide personalized treatment strategies to improve outcomes in curable patients.

Paratesticular Well-differentiated Liposarcoma: A Case Report - Journal of Oncological Sciences

Tiroid Kanserlerinde Epidemiyoloji Emine Bihter ENİSELER Tiroid Kanserlerinde Patoloji Zübeyde YILDIRIM Tiroid Kanserlerinde Radyolojik Tanı Yontemleri Bartu ÇETİN Tiroid Nodullerine Klinik Yaklaşım Mustafa DEMİRPENCE Tiroid Kanserlerinde Cerrahi Seda BAŞTÜRK Diferansiye Tiroid Karsinomlarında Radyoaktif İyot Tedavisi Selda YILMAZ TATAR Tiroid Kanserlerine Genel Bakış Mehmet Alper YILMAZ Papiller Tiroid Kanseri Emir Gökhan KAHRAMAN Folikuler Tiroid Kanseri Emir Gökhan KAHRAMAN Tiroid Onkositik Karsinomu Gürkan GÜL Meduller Tiroid Kanseri Gürkan GÜL Anaplastik Tiroid Kanseri Kıvanç MERCAN Herediter Non-Meduller Tiroid Kanserleri Kıvanç MERCAN Tiroid Kanserlerinde Radyoterapi Endikasyonları Fatma SERT Tiroid Kanserlerinde İzlem Selda YILMAZ TATAR

PURPOSE: Early-onset gastrointestinal cancers are concerning entities globally, yet early-onset biliary tract cancers (EOBTCs) are understudied. Early-stage disease is crucial for young patients' survival. METHODS: TOG/GI-SAFRADJU (ClinicalTrials.gov identifier: NCT06975917 ) is a multicenter, hospital-based, registry initiative of the Turkish Oncology Group, including patients with resected BTCs. Early-onset was defined as a diagnosis at age <50 years. Characteristics and survival of EOBTC and non-EOBTC were compared. Among patients with EOBTC, prognostic factors for recurrence-free survival (RFS) and overall survival (OS) were analyzed. Risk scores were assigned on the basis of hazard ratios. RESULTS: Six hundred seventeen patients from 44 centers were included. 12.6% (n = 78) were EOBTC. R1 resection rate was significantly higher among EOBTC (37.1% v 25.7%, P = .038). Adjuvant treatments did not differ between EOBTC and non-EOBTC. Among patients who received adjuvant chemotherapy, RFS (13.9 months [95% CI, 11.4 to 22.1] v 15.9 months [95% CI, 13.6 to 18.9], P = .947) and OS (35.6 months [95% CI, 28.0 to 81.4] v 31.3 months [95% CI, 27.8 to 44.3], P = .670) were similar between EOBTC and non-EOBTC groups. Among patients with EOBTC, R1-resection and high CA19-9 levels were associated with shorter RFS, and gallbladder localization and high CA19-9 were associated with shorter OS in adjusted analyses. Using these factors, risk scores early-stage EOBTC RFS score (EOB-RS) for RFS and early-stage EOBTC OS score (EOB-OS) for OS were formed, each including three ranks. Both scores significantly ordered the prognosis of patients with EOBTC (EOB-RS, [0 points]: 22.7 months, [1 or 2]: 10.3 months, [3]: 5.7 months, P < .001, EOB-OS: [0]: 110.9 months, [1 or 2]: 29.6 months, [3]: 10.1 months, P < .001). CONCLUSION: Resected EOBTC patients showed survival comparable to older counterparts receiving surgery/adjuvant therapy. This study suggests a potential risk scoring system for early-stage EOBTC, pending validation.

Background and Objectives: Although perioperative FLOT improves outcomes in locally advanced gastric cancer, postoperative recurrence remains frequent. This study evaluated the prognostic value of a PET-derived SUVmax/albumin ratio integrating tumor metabolism and nutritional status in patients treated with neoadjuvant FLOT. Materials and Methods: This retrospective single-center study included patients with gastric adenocarcinoma treated with neoadjuvant FLOT followed by curative gastrectomy between January 2017 and May 2025, using data obtained from existing medical records after ethical approval. Pre-treatment SUVmax from ¹⁸F-FDG PET/CT and serum albumin were recorded to calculate the SUVmax/albumin ratio. Progression-free survival (PFS) was the primary endpoint. Prognostic factors were analyzed using Cox regression, and discriminatory performance was assessed using receiver operating characteristic (ROC) analysis. Results: A total of 104 patients were included. During a median follow-up of 28 months (IQR, 16–46 months), 46 patients (44.2%) developed recurrence. Patients with recurrence had significantly lower serum albumin levels and higher PET SUVmax values and PET SUVmax/albumin ratios (all p < 0.001). In multivariable analysis, the PET SUVmax/albumin ratio remained significantly associated with PFS (HR 1.71; 95% CI 1.33–2.21; p < 0.001). ROC analysis demonstrated moderate discriminatory performance (AUC 0.733; 95% CI 0.638–0.815), while additional time-dependent ROC analyses yielded AUC values of 0.732 (95% CI 0.611–0.836) at 1 year and 0.829 (95% CI 0.694–0.947) at 3 years. Exploratory comparative analyses demonstrated that both PET SUVmax and serum albumin retained statistical significance when evaluated simultaneously in the same multivariable model. Conclusions: The pre-treatment PET SUVmax/albumin ratio was significantly associated with PFS in patients with gastric cancer treated with neoadjuvant FLOT and may represent an exploratory composite prognostic biomarker requiring further prospective validation.