This article presents a robust, fast, and fully automatic method for personalized cranial defect reconstruction and implant modeling. We propose a two-step deep learning-based method using a modified U-Net architecture to perform the defect reconstruction, and a dedicated iterative procedure to improve the implant geometry, followed by an automatic generation of models ready for 3-D printing. We propose a cross-case augmentation based on imperfect image registration combining cases from different datasets. Additional ablation studies compare different augmentation strategies and other state-of-the-art methods. We evaluate the method on three datasets introduced during the AutoImplant 2021 challenge, organized jointly with the MICCAI conference. We perform the quantitative evaluation using the Dice and boundary Dice coefficients, and the Hausdorff distance. The Dice coefficient, boundary Dice coefficient, and the 95th percentile of Hausdorff distance averaged across all test sets, are 0.91, 0.94, and 1.53 mm respectively. We perform an additional qualitative evaluation by 3-D printing and visualization in mixed reality to confirm the implant's usefulness. The article proposes a complete pipeline that enables one to create the cranial implant model ready for 3-D printing. The described method is a greatly extended version of the method that scored 1st place in all AutoImplant 2021 challenge tasks. We freely release the source code, which together with the open datasets, makes the results fully reproducible. The automatic reconstruction of cranial defects may enable manufacturing personalized implants in a significantly shorter time, possibly allowing one to perform the 3-D printing process directly during a given intervention. Moreover, we show the usability of the defect reconstruction in a mixed reality that may further reduce the surgery time.

This study explores an innovative approach to early Parkinson’s disease (PD) detection by analyzing speech data collected using a mixed reality (MR) system. A total of 57 Polish participants, including PD patients and healthy controls, performed five speech tasks while using an MR head-mounted display (HMD). Speech data were recorded and analyzed to extract acoustic and linguistic features, which were then evaluated using machine learning models, including logistic regression, support vector machines (SVMs), random forests, AdaBoost, and XGBoost. The XGBoost model achieved the best performance, with an F1-score of 0.90 ± 0.05 in the story-retelling task. Key features such as MFCCs (mel-frequency cepstral coefficients), spectral characteristics, RASTA-filtered auditory spectrum, and local shimmer were identified as significant in detecting PD-related speech alterations. Additionally, state-of-the-art deep learning models (wav2vec2, HuBERT, and WavLM) were fine-tuned for PD detection. HuBERT achieved the highest performance, with an F1-score of 0.94 ± 0.04 in the diadochokinetic task, demonstrating the potential of deep learning to capture complex speech patterns linked to neurodegenerative diseases. This study highlights the effectiveness of combining MR technology for speech data collection with advanced machine learning (ML) and deep learning (DL) techniques, offering a non-invasive and high-precision approach to PD diagnosis. The findings hold promise for broader clinical applications, advancing the diagnostic landscape for neurodegenerative disorders.

The need to protect road infrastructure makes it necessary to direct the mass enforcement control of motor vehicles. Such control, in order to fulfil its role, must be continuous and universal. The only tool currently known to achieve these goals are weigh-in-motion (WIM) systems. The implementation of mass enforcement WIM systems is possible only if the requirements for their metrological properties are formulated, followed by the implementation of administrative procedures for the type approval of WIM systems, rules for their metrological examination, and administrative regulations for their practical use. The AGH University of Krakow, in cooperation with the Central Office of Measures (Polish National Metrological Institute), has been conducting research in this direction for many years, and, now, as part of a research project financed by the Ministry of Education and Science. In this paper, we describe a unique WIM system located in the south of Poland and the results of over two years of our research. These studies are intended to lead to the formulation of requirements for metrological legalisation procedures for this type of system. Our efforts are focused on implementing WIM systems in Poland for direct mass enforcement. The tests carried out confirmed that the constructed system is fully functional. Its equipment with quartz and bending plate load sensors allows for the comparison of both technologies and the measurement of many parameters of the weighed vehicle and environmental parameters affecting weighing accuracy. The tests confirmed the stability of its metrological parameters. The GVW maximal measurement error does not exceed 5%, and the single axle load maximal measurement error does not exceed 12%. The sensors of the environmental parameters allow for the search for correlations between weighing accuracy and the intensity of these parameters.

Every year, thousands of people suffer from skull damage and require personalized implants to fill the cranial cavity. Unfortunately, the waiting time for reconstruction surgery can extend to several weeks or even months, especially in less developed countries. One factor contributing to the extended waiting period is the intricate process of personalized implant modeling. Currently, the preparation of these implants by experienced biomechanical experts is both costly and time-consuming. Recent advances in artificial intelligence, especially in deep learning, offer promising potential for automating the process. However, deep learning-based cranial reconstruction faces several challenges: (i) the limited size of training datasets, (ii) the high resolution of the volumetric data, and (iii) significant data heterogeneity. In this work, we propose a novel approach to address these challenges by enhancing the reconstruction through learnable symmetry enforcement. We demonstrate that it is possible to train a neural network dedicated to calculating skull symmetry, which can be utilized either as an additional objective function during training or as a post-reconstruction objective during the refinement step. We quantitatively evaluate the proposed method using open SkullBreak and SkullFix datasets, and qualitatively using real clinical cases. The results indicate that the symmetry-preserving reconstruction network achieves considerably better outcomes compared to the baseline (0.94/0.94/1.31 vs 0.84/0.76/2.43 in terms of DSC, bDSC, and HD95). Moreover, the results are comparable to the best-performing methods while requiring significantly fewer computational resources (< 500 vs > 100,000 GPU hours). Moreover, its relatively low computational complexity makes it scalable for reconstructing all symmetrical structures. The article introduces an automatic skull reconstruction method based on the enforcement of skull symmetry using a learnable deep learning network. The method requires significantly fewer computational resources compared to other well-performing methods and is able to improve the reconstruction for the out-of-distribution cases. The proposed method is a considerable contribution to the field of applied artificial intelligence in medicine and is a step towards automatic cranial defect reconstruction in clinical practice.