In smart cities, effective traffic congestion management hinges on adept pedestrian and vehicle detection. Unmanned Aerial Vehicles (UAVs) offer a solution with mobility, cost-effectiveness, and a wide field of view, and yet, optimizing recognition models is crucial to surmounting challenges posed by small and occluded objects. To address these issues, we utilize the YOLOv8s model and a Swin Transformer block and introduce the PVswin-YOLOv8s model for pedestrian and vehicle detection based on UAVs. Firstly, the backbone network of YOLOv8s incorporates the Swin Transformer model for global feature extraction for small object detection. Secondly, to address the challenge of missed detections, we opt to integrate the CBAM into the neck of the YOLOv8. Both the channel and the spatial attention modules are used in this addition because of how well they extract feature information flow across the network. Finally, we employ Soft-NMS to improve the accuracy of pedestrian and vehicle detection in occlusion situations. Soft-NMS increases performance and manages overlapped boundary boxes well. The proposed network reduced the fraction of small objects overlooked and enhanced model detection performance. Performance comparisons with different YOLO versions ( for example YOLOv3 extremely small, YOLOv5, YOLOv6, and YOLOv7), YOLOv8 variants (YOLOv8n, YOLOv8s, YOLOv8m, and YOLOv8l), and classical object detectors (Faster-RCNN, Cascade R-CNN, RetinaNet, and CenterNet) were used to validate the superiority of the proposed PVswin-YOLOv8s model. The efficiency of the PVswin-YOLOv8s model was confirmed by the experimental findings, which showed a 4.8% increase in average detection accuracy (mAP) compared to YOLOv8s on the VisDrone2019 dataset.

Enhancing the environmental perception of autonomous vehicles (AVs) in intelligent transportation systems requires computer vision technology to be effective in detecting objects and obstacles, particularly in adverse weather conditions. Adverse weather circumstances present serious difficulties for object-detecting systems, which are essential to contemporary safety procedures, infrastructure for monitoring, and intelligent transportation. AVs primarily depend on image processing algorithms that utilize a wide range of onboard visual sensors for guidance and decisionmaking. Ensuring the consistent identification of critical elements such as vehicles, pedestrians, and road lanes, even in adverse weather, is a paramount objective. This paper not only provides a comprehensive review of the literature on object detection (OD) under adverse weather conditions but also delves into the ever-evolving realm of the architecture of AVs, challenges for automated vehicles in adverse weather, the basic structure of OD, and explores the landscape of traditional and deep learning (DL) approaches for OD within the realm of AVs. These approaches are essential for advancing the capabilities of AVs in recognizing and responding to objects in their surroundings. This paper further investigates previous research that has employed both traditional and DL methodologies for the detection of vehicles, pedestrians, and road lanes, effectively linking these approaches with the evolving field of AVs. Moreover, this paper offers an in-depth analysis of the datasets commonly employed in AV research, with a specific focus on the detection of key elements in various environmental conditions, and then summarizes the evaluation matrix. We expect that this review paper will help scholars to gain a better understanding of this area of research.

Computational prediction of interactions between drugs and their target proteins is of great importance for drug discovery and design. The difficulties of developing computational methods for the prediction of such potential interactions lie in the rarity of known drug-protein interactions and no experimentally verified negative drug-target interaction sample. Furthermore, target proteins need also to be predicted for some new drugs without any known target interaction information. In this paper, a semi-supervised learning method NetCBP is presented to address this problem by using labeled and unlabeled interaction information. Assuming coherent interactions between the drugs ranked by their relevance to a query drug, and the target proteins ranked by their relevance to the hidden target proteins of the query drug, we formulate a learning framework maximizing the rank coherence with respect to the known drug-target interactions. When applied to four classes of important drug-target interaction networks, our method improves previous methods in terms of cross-validation and some strongly predicted interactions are confirmed by the publicly accessible drug target databases, which indicates the usefulness of our method. Finally, a comprehensive prediction of drug–target interactions enables us to suggest many new potential drug–target interactions for further studies.

The identification of microRNA-disease associations is critical for understanding the molecular mechanisms of diseases. However, experimental determination of associations between microRNAs and diseases remains challenging. Meanwhile, target diseases need to be revealed for some new microRNAs without any known target disease association information as new microRNAs are discovered each year. Therefore, computational methods for microRNA-disease association prediction have gained a lot of research interest.

Accumulating experimental evidence has indicated that long non-coding RNAs (lncRNAs) are critical for the regulation of cellular biological processes implicated in many human diseases. However, only relatively few experimentally supported lncRNA-disease associations have been reported. Developing effective computational methods to infer lncRNA-disease associations is becoming increasingly important. Current network-based algorithms typically use a network representation to identify novel associations between lncRNAs and diseases. But these methods are concentrated on specific entities of interest (lncRNAs and diseases) and they do not allow to consider networks with more than two types of entities. Considering the limitations in previous computational methods, we develop a new global network-based framework, LncRDNetFlow, to prioritize disease-related lncRNAs. LncRDNetFlow utilizes a flow propagation algorithm to integrate multiple networks based on a variety of biological information including lncRNA similarity, protein-protein interactions, disease similarity, and the associations between them to infer lncRNA-disease associations. We show that LncRDNetFlow performs significantly better than the existing state-of-the-art approaches in cross-validation. To further validate the reproducibility of the performance, we use the proposed method to identify the related lncRNAs for ovarian cancer, glioma, and cervical cancer. The results are encouraging. Many predicted lncRNAs in the top list have been verified by the biological studies.

In recent years, autonomous vehicles have become more and more popular due to their broad influence over society, as they increase passenger safety and convenience, lower fuel consumption, reduce traffic blockage and accidents, save costs, and enhance reliability. However, autonomous vehicles suffer from some functionality errors which need to be minimized before they are completely deployed onto main roads. Pedestrian detection is one of the most considerable tasks (functionality errors) in autonomous vehicles to prevent accidents. However, accurate pedestrian detection is a very challenging task due to the following issues: (i) occlusion and deformation and (ii) low-quality and multi-spectral images. Recently, deep learning (DL) technologies have exhibited great potential for addressing the aforementioned pedestrian detection issues in autonomous vehicles. This survey paper provides an overview of pedestrian detection issues and the recent advances made in addressing them with the help of DL techniques. Informative discussions and future research works are also presented, with the aim of offering insights to the readers and motivating new research directions.