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Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
Tatjana Ruskovska; Irena Budić-Leto; Karla Corral-Jara; Vladimir Ajdžanović; Anna Arola-Arnal; Francisca Bravo; Georgia-Eirini Deligiannidou; Jaroslav Havlik; Milkica Janeva; Elena Kistanova; Christos Kontogiorgis; Irena Krga; Marika Massaro; Marko Miler; Verica Milosevic; Christine Morand; Egeria Scoditti; Manuel Suárez; David Vauzour; Dragan Milenkovic. Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies. Nutrients 2021, 13, 2326 .
AMA StyleTatjana Ruskovska, Irena Budić-Leto, Karla Corral-Jara, Vladimir Ajdžanović, Anna Arola-Arnal, Francisca Bravo, Georgia-Eirini Deligiannidou, Jaroslav Havlik, Milkica Janeva, Elena Kistanova, Christos Kontogiorgis, Irena Krga, Marika Massaro, Marko Miler, Verica Milosevic, Christine Morand, Egeria Scoditti, Manuel Suárez, David Vauzour, Dragan Milenkovic. Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies. Nutrients. 2021; 13 (7):2326.
Chicago/Turabian StyleTatjana Ruskovska; Irena Budić-Leto; Karla Corral-Jara; Vladimir Ajdžanović; Anna Arola-Arnal; Francisca Bravo; Georgia-Eirini Deligiannidou; Jaroslav Havlik; Milkica Janeva; Elena Kistanova; Christos Kontogiorgis; Irena Krga; Marika Massaro; Marko Miler; Verica Milosevic; Christine Morand; Egeria Scoditti; Manuel Suárez; David Vauzour; Dragan Milenkovic. 2021. "Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies." Nutrients 13, no. 7: 2326.
The Mediterranean diet (MD) has been sponsored worldwide as a healthy and sustainable diet. Our aim was to update and compare MD adherence and food choices across several Southern European countries: Spain (SP), Portugal (PT), Italy (IT), Greece (GR), and Cyprus (CY) (MED, Mediterranean), and Bulgaria (BG) and the Republic of North Macedonia (NMK) (non-MED, non-Mediterranean). Participants (N = 3145, ≥18 y) completed a survey (MeDiWeB) with sociodemographic, anthropometric, and food questions (14-item Mediterranean Diet Adherence Screener, 14-MEDAS). The MED and non-MED populations showed moderate (7.08 ± 1.96) and weak (5.58 ± 1.82) MD adherence, respectively, with significant yet small differences across countries (SP > PT > GR > IT > CY > BG > NMK, p-value < 0.001). The MED participants scored higher than the non-MED ones for most of the Mediterranean-typical foods, with the greatest differences found for olive oil (OO) and white meat preference. In most countries, ≥70% of the participants reported quantities of red meat, butter, sweet drinks, and desserts below the recommended cutoff points, whereas <50% achieved the targets for plant-based foods, OO, fish, and wine. Being a woman and increasing age were associated with superior adherence (p-value < 0.001), but differences were rather small. Our results suggest that the campaigns carried out to support and reinforce the MD and to promote plant-based foods have limited success across Southern Europe, and that more hard-hitting strategies are needed.
Stefano Quarta; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Rui Jorge; Vanda Andrade; Elena Philippou; Constantinos Zisimou; Viktorija Maksimova; Katarina Smilkov; Darinka Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Deligiannidou; Christos Kontogiorgis; Julio Sánchez-Meca; Paula Pinto; María-Teresa García-Conesa. Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations? Nutrients 2021, 13, 1432 .
AMA StyleStefano Quarta, Marika Massaro, Mihail Chervenkov, Teodora Ivanova, Dessislava Dimitrova, Rui Jorge, Vanda Andrade, Elena Philippou, Constantinos Zisimou, Viktorija Maksimova, Katarina Smilkov, Darinka Ackova, Lence Miloseva, Tatjana Ruskovska, Georgia Deligiannidou, Christos Kontogiorgis, Julio Sánchez-Meca, Paula Pinto, María-Teresa García-Conesa. Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations? Nutrients. 2021; 13 (5):1432.
Chicago/Turabian StyleStefano Quarta; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Rui Jorge; Vanda Andrade; Elena Philippou; Constantinos Zisimou; Viktorija Maksimova; Katarina Smilkov; Darinka Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Deligiannidou; Christos Kontogiorgis; Julio Sánchez-Meca; Paula Pinto; María-Teresa García-Conesa. 2021. "Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations?" Nutrients 13, no. 5: 1432.
Rheumatoid arthritis (RA) is an autoimmune disorder affecting a vast variety of the population. The onset of RA as well as the development of systematic immunization is affected by both genetic and environmental risk factors. This review aims to point out the role of natural products in the management of RA, focusing on the reports of basic research (in vitro and animal studies) emphasizing the antioxidant and anti-inflammatory properties considered in the field of RA. A systematic screening of the relevant literature was carried out on PubMed, Google Scholar, and Scopus with the following criteria: publication date, 2015–2020; language, English; study design, in vitro or animal models; and the investigation of one or several natural products in the context of RA, including, when available, the molecular mechanisms implicated. A total of 211 papers were initially obtained and screened. In vitro and animal studies referring to 20 natural products and 15 pure compounds were ultimately included in this review. The outcomes of this work provide an overview of the methods employed in basic research over the past five years, with emphasis on the limitations presented, while demonstrating the potential benefits of utilizing natural products in the management of RA as supported by in vitro and animal studies.
Georgia-Eirini Deligiannidou; Vasiliki Gougoula; Eugenia Bezirtzoglou; Christos Kontogiorgis; Theodoros Constantinides. The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research. Antioxidants 2021, 10, 599 .
AMA StyleGeorgia-Eirini Deligiannidou, Vasiliki Gougoula, Eugenia Bezirtzoglou, Christos Kontogiorgis, Theodoros Constantinides. The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research. Antioxidants. 2021; 10 (4):599.
Chicago/Turabian StyleGeorgia-Eirini Deligiannidou; Vasiliki Gougoula; Eugenia Bezirtzoglou; Christos Kontogiorgis; Theodoros Constantinides. 2021. "The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research." Antioxidants 10, no. 4: 599.
The Mediterranean diet (MD) and other lifestyle characteristics have been associated with well-being, a broad multiparameter concept that includes individual’s subjective assessment of their own well-being (SWB). Some studies have suggested that diet influences SWB, thus, this work aimed to add novel information on the association of MD and SWB in a sample of Portuguese adults. Data on sociodemographic, economic, lifestyle, diet, and SWB were collected through a self-filled online questionnaire. MD adherence was assessed by the Mediterranean Diet Adherence Screener (MEDAS) score ]. Results showed a moderate adherence to the MD in 490 Portuguese adults (mean MEDAS of 7.4 ± 2.1). A higher MD adherence was found to be significantly positively associated with women, employed individuals, a higher number of meals per day, and those with frequent contact with nature (p-value < 0.0025, using Bonferroni adjustment). As a novelty, this study divided the participants into low SWB, medium SWB, and medium to high SWB profiles (3.9 ± 1.0; 6.2 ± 1.0; 8.2 ± 1.3, respectively; p-value < 0.05), which reported significantly increasing MEDAS scores (6.5 ± 2.1; 7.3 ± 2.1; 7.8 ± 1.9; respectively, p-value < 0.05).
Vanda Andrade; Rui Jorge; María-Teresa García-Conesa; Elena Philippou; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults. Nutrients 2020, 12, 3837 .
AMA StyleVanda Andrade, Rui Jorge, María-Teresa García-Conesa, Elena Philippou, Marika Massaro, Mihail Chervenkov, Teodora Ivanova, Viktorija Maksimova, Katarina Smilkov, Darinka Gjorgieva Ackova, Lence Miloseva, Tatjana Ruskovska, Georgia Eirini Deligiannidou, Christos A. Kontogiorgis, Paula Pinto. Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults. Nutrients. 2020; 12 (12):3837.
Chicago/Turabian StyleVanda Andrade; Rui Jorge; María-Teresa García-Conesa; Elena Philippou; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. 2020. "Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults." Nutrients 12, no. 12: 3837.
This study provides comprehensive validation of the 14-item Mediterranean Diet Adherence Screener (14-MEDAS) in an adult population from Greece (GR), Portugal (PT), Italy (IT), Spain (SP), Cyprus (CY), Republic of North Macedonia (NMK), and Bulgaria (BG). A moderate association between the 14-MEDAS and the reference food diary was estimated for the entire population (Pearson r = 0.573, p-value < 0.001; Intraclass Correlation Coefficient (ICC) = 0.692, p-value < 0.001) with the strongest correlation found in GR, followed by PT, IT, SP, and CY. These results were supported by kappa statistics in GR, PT, IT, and SP with ≥50% of food items exhibiting a fair or better agreement. Bland–Altman analyses showed an overestimation of the 14-MEDAS score in the whole population (0.79 ± 1.81, 95%Confidence Interval (CI) 0.61, 0.96), but this value was variable across countries, with GR, NMK, and BG exhibiting the lowest bias. Taking all analyses together, the validation achieved slightly better results in the Mediterranean countries but a definitive validation ranking order was not evident. Considering growing evidence of the shift from Mediterranean Diet (MD) adherence and of the importance of culture in making food choices it is crucial that we further improve validation protocols with specific applications to compare MD adherence across countries.
María-Teresa García-Conesa; Elena Philippou; Christos Pafilas; Marika Massaro; Stefano Quarta; Vanda Andrade; Rui Jorge; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region. Nutrients 2020, 12, 2960 .
AMA StyleMaría-Teresa García-Conesa, Elena Philippou, Christos Pafilas, Marika Massaro, Stefano Quarta, Vanda Andrade, Rui Jorge, Mihail Chervenkov, Teodora Ivanova, Dessislava Dimitrova, Viktorija Maksimova, Katarina Smilkov, Darinka Gjorgieva Ackova, Lence Miloseva, Tatjana Ruskovska, Georgia Eirini Deligiannidou, Christos A. Kontogiorgis, Paula Pinto. Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region. Nutrients. 2020; 12 (10):2960.
Chicago/Turabian StyleMaría-Teresa García-Conesa; Elena Philippou; Christos Pafilas; Marika Massaro; Stefano Quarta; Vanda Andrade; Rui Jorge; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. 2020. "Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region." Nutrients 12, no. 10: 2960.
The natural process of aging gradually causes changes in living organisms, leading to the deterioration of organs, tissues, and cells. In the case of osteoarthritis (OA), the degradation of cartilage is a result of both mechanical stress and biochemical factors. Natural products have already been evaluated for their potential role in the prevention and treatment of OA, providing a safe and effective adjunctive therapeutic approach. This review aimed to assess the therapeutic potential of natural products and their derivatives in osteoarthritis via a systematic search of literature after 2008, including in vitro, in vivo, ex vivo, and animal models, along with clinical trials and meta-analysis. Overall, 170 papers were obtained and screened. Here, we presented findings referring to the preventative and therapeutic potential of 17 natural products and 14 naturally occurring compounds, underlining, when available, the mechanisms implicated. The nature of OA calls to initially focus on the management of symptoms, and, in that context, several naturally occurring compounds have been utilized. Underlying a global need for more sustainable natural sources for treatment, the evidence supporting their chondroprotective potential is still building up. However, arriving at that kind of solution requires more clinical research, targeting the implications of long-term treatment, adverse effects, and epigenetic implications.
Georgia-Eirini Deligiannidou; Rafail-Efraim Papadopoulos; Christos Kontogiorgis; Anastasia Detsi; Eugenia Bezirtzoglou; Theodoros Constantinides. Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview. Antioxidants 2020, 9, 348 .
AMA StyleGeorgia-Eirini Deligiannidou, Rafail-Efraim Papadopoulos, Christos Kontogiorgis, Anastasia Detsi, Eugenia Bezirtzoglou, Theodoros Constantinides. Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview. Antioxidants. 2020; 9 (4):348.
Chicago/Turabian StyleGeorgia-Eirini Deligiannidou; Rafail-Efraim Papadopoulos; Christos Kontogiorgis; Anastasia Detsi; Eugenia Bezirtzoglou; Theodoros Constantinides. 2020. "Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview." Antioxidants 9, no. 4: 348.
Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.
Daniela Martini; Laura Chiavaroli; Antonio González-Sarrías; Letizia Bresciani; Susana A. Palma-Duran; Margherita Dall’Asta; Georgia-Eirini Deligiannidou; Marika Massaro; Egeria Scoditti; Emilie Combet; Viktorija Maksimova; Mireia Urpi-Sarda; Christos A. Kontogiorgis; Cristina Andrés-Lacueva; Eileen R. Gibney; Daniele Del Rio; Christine Morand; Mar Garcia-Aloy; Ana Rodriguez-Mateos; Pedro Mena. Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability. Nutrients 2019, 11, 1805 .
AMA StyleDaniela Martini, Laura Chiavaroli, Antonio González-Sarrías, Letizia Bresciani, Susana A. Palma-Duran, Margherita Dall’Asta, Georgia-Eirini Deligiannidou, Marika Massaro, Egeria Scoditti, Emilie Combet, Viktorija Maksimova, Mireia Urpi-Sarda, Christos A. Kontogiorgis, Cristina Andrés-Lacueva, Eileen R. Gibney, Daniele Del Rio, Christine Morand, Mar Garcia-Aloy, Ana Rodriguez-Mateos, Pedro Mena. Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability. Nutrients. 2019; 11 (8):1805.
Chicago/Turabian StyleDaniela Martini; Laura Chiavaroli; Antonio González-Sarrías; Letizia Bresciani; Susana A. Palma-Duran; Margherita Dall’Asta; Georgia-Eirini Deligiannidou; Marika Massaro; Egeria Scoditti; Emilie Combet; Viktorija Maksimova; Mireia Urpi-Sarda; Christos A. Kontogiorgis; Cristina Andrés-Lacueva; Eileen R. Gibney; Daniele Del Rio; Christine Morand; Mar Garcia-Aloy; Ana Rodriguez-Mateos; Pedro Mena. 2019. "Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability." Nutrients 11, no. 8: 1805.