This research study aims to investigate the effects of vaccination on reducing disease burden by analyzing a complex nonlinear ordinary differential equation system. The study focuses on five distinct sub-classes within the system to comprehensively explore the impact of vaccination. Specifically, the mathematical model employed in this investigation is a fractional representation of tuberculosis, utilizing the Atangana–Baleanu fractional derivative in the Caputo sense. The validity of the proposed model is established through a rigorous qualitative analysis. The existence and uniqueness of the solution are rigorously determined by applying the fundamental theorems of the fixed point approach. The stability analysis of the model is conducted using the Ulam–Hyers approach. Additionally, the study employs the widely recognized iterative Adams–Bashforth technique to obtain an approximate solution for the suggested model. The numerical simulation of the tuberculosis model is comprehensively discussed, with a particular focus on the assumptions made regarding vaccination. The model assumes that only a limited portion of the population is vaccinated at a steady rate, and the efficacy of the vaccine is a critical factor in reducing disease burden. The findings of the study indicate that the proposed model can effectively assess the impact of vaccination on mitigating the spread of tuberculosis. Furthermore, the numerical simulation underscores the significance of vaccination as an effective control measure against tuberculosis.

Fluid flow through porous spaces with variable porosity has wide-range applications, notably in biomedical and thermal engineering, where it plays a vital role in comprehending blood flow dynamics within cardiovascular systems, heat transfer and thermal management systems improve efficiency using porous materials with variable porosity. Keeping these important applications in view, in current study blood-based hybrid nanofluid flow has considered on a convectively heated sheet. The sheet exhibits the properties of a porous medium with variable porosity and extends in both the x and y directions. Blood has used as base fluid in which the nanoparticles of Cu and CuO have been mixed. Thermal radiation, space-dependent, and thermal-dependent heat sources have been incorporated into the energy equation, while magnetic effects have been integrated into the momentum equations. Dimensionless variables have employed to transform the modeled equations into dimensionless form and facilitating their solution using bvp4c approach. It has concluded in this study that, both the primary and secondary velocities augmented with upsurge in variable porous factor and declined with escalation in stretching ratio, Casson, magnetic, and slip factors along x- and y-axes. Thermal distribution has grown up with upsurge in Casson factor, magnetic factor, thermal Biot number, and thermal/space-dependent heat sources while has retarded with growth in variable porous and stretching ratio factors. The findings of this investigation have been compared with the existing literature, revealing a strong agreement among present and established results that ensured the validation of the model and method used in this work.

We propose a new generator for unit interval which is used to establish univariate and bivariate families of distributions. The univariate family can serve as an alternate to the Kumaraswamy-G univariate family proposed earlier by Cordeiro and de-Castro in 2011. Further, the new generator can also be used to develop more alternate univariate and bivariate G-classes such as beta-G, McDonald-G, Topp-Leone-G, Marshall-Olkin-G and Transmuted-G for support (0, 1). Some structural properties of the univariate family are derived and the estimation of parameters is dealt. The properties of a special model of this new univariate family called a New Kumaraswamy-Weibull (NKwW) distribution are obtained and parameter estimation is considered. A Monte Carlo simulation is reported to assess NKwW model parameters. The bivariate extension of the family is proposed and the estimation of parameters is described. The simulation study is also conducted for bivariate model. Finally, the usefulness of the univariate NKwW model is illustrated empirically by means of three real-life data sets on Air Conditioned Failures, Flood and Breaking Strength of Fibers, and one real-life data on UEFA Champion’s League for bivariate model.

In this study, we consider a general, flexible, parametric hazard-based regression model for censored lifetime data with covariates and term it the “general hazard (GH)” regression model. Some well-known models, such as the accelerated failure time (AFT), and the proportional hazard (PH) models, as well as the accelerated hazard (AH) model accounting for crossed survival curves, are sub-classes of this general hazard model. In the proposed class of hazard-based regression models, a covariate’s effect is identified as having two distinct components, namely a relative hazard ratio and a time-scale change on hazard progression. The new approach is more adaptive to modelling lifetime data and could give more accurate survival forecasts. The nested structure that includes the AFT, AH, and PH models in the general hazard model may offer a numerical tool for identifying which of them is most appropriate for a certain dataset. In this study, we propose a method for applying these various parametric hazard-based regression models that is based on a tractable parametric distribution for the baseline hazard, known as the generalized log-logistic (GLL) distribution. This distribution is closed under all the PH, AH, and AFT frameworks and can incorporate all of the basic hazard rate shapes of interest in practice, such as decreasing, constant, increasing, V-shaped, unimodal, and J-shaped hazard rates. The Bayesian and frequentist approaches were used to estimate the model parameters. Comprehensive simulation studies were used to evaluate the performance of the proposed model’s estimators and its nested structure. A right-censored cancer dataset is used to illustrate the application of the proposed approach. The proposed model performs well on both real and simulation datasets, demonstrating the importance of developing a flexible parametric general class of hazard-based regression models with both time-independent and time-dependent covariates for evaluating the hazard function and hazard ratio over time.