Nanocrystalline cellulose is an abundant and inexhaustible organic material on Earth. It can be derived from many lignocellulosic plants and also from agricultural residues. They endowed exceptional physicochemical properties, which have promoted their intensive exploration in biomedical application, especially for tissue engineering scaffolds. Nanocrystalline cellulose has been acknowledged due to its low toxicity and low ecotoxicological risks towards living cells. To explore this field, this review provides an overview of nanocrystalline cellulose in designing materials of bone scaffolds. An introduction to nanocrystalline cellulose and its isolation method of acid hydrolysis are discussed following by the application of nanocrystalline cellulose in bone tissue engineering scaffolds. This review also provides comprehensive knowledge and highlights the contribution of nanocrystalline cellulose in terms of mechanical properties, biocompatibility and biodegradability of bone tissue engineering scaffolds. Lastly, the challenges for future scaffold development using nanocrystalline cellulose are also included.

Green Lean Six Sigma has emerged in the Industry 4.0 era as a business strategy contributing to the circular economy by adopting the 3R concept, i.e., reduce, reuse, and recycle. Despite its broadly acknowledged capabilities in the manufacturing industry, practitioners continue to be cautious about its implementation, owing to insufficient knowledge and culture. Hence, there is a need to systematize the existing knowledge regarding this green initiative and also to recognize the key factors enabling its implementation. In the Malaysian manufacturing context, the enabling factors have yet to be identified and evaluated. This current study is the first of its kind to identify and examine these factors and to create a structural model to conceptualize and operationalize this business strategy. The implemented methodological approach includes two steps. Firstly, it performs a systematic review of leading studies on the topic, which are rather scarce in the current context. The second step entails a principal component factor analysis using varimax rotation to finalize the findings. The theoretical and empirical results revealed a structural model with five interconnected key factors, including twenty-seven enablers, that can be used to narrow the existing knowledge gap in the understudied context.

Downsizing energy consumption during the machining of metals is vital for sustainable manufacturing. As a prerequisite, energy consumption should be determined, through direct or indirect measurement. The manufacturing process of interest is the finish turning which has been explored to generate (near) net shapes, particularly for hardened steels. In this paper, we propose using measured cutting forces to calculate the electrical energy consumption during the finish turning process of metals where typically the depth of cut is lower than the cutting tool nose radius. In this approach, the resultant cutting force should be used for calculating the energy consumption, instead of only the main (tangential) cutting force as used in the conventional approach. A case study was carried out where a hardened stainless steel (AISI 420, hardness of 47–48 HRC) was turned using a coated carbide tool, with a nose radius of 0.8 mm, without cutting fluid, and at 0.4 mm depth of cut. The experimental design varied the cutting speed (100, 130, and 170 m/min) and feed (0.10, 0.125, and 0.16 mm) while other parameters were kept constant. The results indicate that the electrical energy consumption during the particular dry turning of hardened steel can be calculated using cutting force data as proposed. This generally means machining studies that measure cutting forces can also present energy consumption during the finish or hard turning of metals, without specifically measuring the power consumption of the machining process. For this particular dry turning of hardened stainless steel, cutting parameters optimization in terms of machining responses (i.e., low surface roughness, long tool life, low cutting force, and low energy consumption) was also determined to provide an insight on how energy consumption can be integrated with other machining responses towards sustainable machining process of metals.

Commercial grade sulfonated-Polyethersulfone (S-PES) and functionalized multiwall carbon nanotube (f-MWCNT)/polyvinylpyrrolidone (PVP) nanocomposites (NCs) were used to enhance and optimize the antifouling, protein resistance and protein separation properties of the S-PES ultrafiltration membranes. The polarities of sulfonic groups of S-PES, carbonyl carbon of pyrrolidone, hydroxyl and carboxyl groups of f-MWCNT in the membrane composition helped to strongly bind each other through hydrogen bonding, as shown by Fourier-transform infrared spectroscopy (FTIR). These binding forces greatly reduced the leaching of NCs and developed long finger-like projection, as confirmed by elution ratio and cross-sectional studies of the membranes via field emission scanning electron microscope (FESEM). The contact angle was reduced up to 48% more than pristine PES. Atomic force microscopy (AFM) was employed to study the various parameters of surface roughness with 3d diagrams, while grain analysis of membrane surface provided a quantitative estimation about volume, area, perimeter, length, radius and diameter. The NCs/S-PES enhanced the flux rate with an impressive (80–84%) flux recovery ratio and (58–62%) reversible resistance (R_r) value in situ, with 60% and 54.4% lesser dynamic and static protein adsorption. The best performing membrane were reported to remove 31.8%, 66.3%, 83.6% and 99.9% for lysozyme-(14.6 kDa), trypsin-(20 kDa), pepsin-(34.6 kDa) and bovine serum albumin (BSA-66 kDa), respectively.

The use of soft tissue engineering scaffolds is an advanced approach to repairing damaged soft tissue. To ensure the success of this technique, proper mechanical and biocompatibility properties must be taken into consideration. In this study, a three-dimensional (3D) scaffold was developed using digital light processing (DLP) and ultra-hard and tough (UHT) bio-resin. The 3D scaffold structure consisted of thermoplastic polyurethane (TPU) and maghemite (ϒ-Fe₂O₃) nanoparticles mixed with UHT bio-resin. The solution sample for fabricating the scaffolds was varied with the concentration of the TPU (10, 12.5, and 15% wt/v) and the amount of ϒ-Fe₂O₃ (1, 3, and 5% v/v) added to 15% wt/v of TPU. Before developing the real geometry of the sample, a pre-run of the DLP 3D printing process was done to determine the optimum curing time of the structure to be perfectly cured, which resulted in 30 s of curing time. Then, this study proceeded with a tensile test to determine the mechanical properties of the developed structure in terms of elasticity. It was found that the highest Young’s Modulus of the scaffold was obtained with 15% wt/v TPU/UHT with 1% ϒ-Fe₂O₃. Furthermore, for the biocompatibility study, the degradation rate of the scaffold containing TPU/UHT was found to be higher compared to the TPU/UHT containing ϒ-Fe₂O₃ particles. However, the MTT assay results revealed that the existence of ϒ-Fe₂O₃ in the scaffold improved the proliferation rate of the cells.

This study investigated the influence of dope extrusion rate (DER) and post-treatment effect on the morphology, permeation, and metal ion rejection by polyethersulfone/lithium bromide (PES/LiBr)-based hollow fiber (HF) membranes. HF fibers were spun with 2.25, 2.5, and 3.1 ratios of DER to bore fluid rate (BFR), wherein DER varied from 11.35, 12.5, to 15.6 mL/min with a fixed BFR (5 mL/min). Molecular weight cutoff (MWCO), pore size, water flux, and flux recovery ratio were determined, whereas lake water was used to observe the rejection rate of dissolved metallic ions. Results showed that with the increase of the DER wall thickness (WT), HFs increased from 401.5 to 419.5 um, and furthermore by the post-treatments up to 548.2 um, as confirmed by field emission scanning electron microscope (FESEM) analysis. Moreover, MWCO, pore size, and the pure water permeation (PWP) of the HF membranes decreased, while the separation performance for polyethylene glycol (PEG) solute increased with increasing DER. Post-treated HFs from 11.35 mL/min of DER showed 93.8% of MWCO value with up to 90% and 70% rejection of the arsenic and chromium metallic ions, respectively, in comparison with all other formulated HFs.