Mining potential drug-disease associations can speed up drug repositioning for pharmaceutical companies. Previous computational strategies focused on prior biological information for association inference. However, such information may not be comprehensively available and may contain errors. Different from previous research, two inference methods,ProbSandHeatS, were introduced in this paper to predict direct drug-disease associations based only on the basic network topology measure. Bipartite network topology was used to prioritize the potentially indicated diseases for a drug. Experimental results showed that both methods can receive reliable prediction performance and achieve AUC values of 0.9192 and 0.9079, respectively. Case studies on real drugs indicated that some of the strongly predicted associations were confirmed by results in the Comparative Toxicogenomics Database (CTD). Finally, a comprehensive prediction of drug-disease associations enables us to suggest many new drug indications for further studies.

The innovative bistatic synthetic aperture radar (BiSAR) mission LuTan-1 (LT-1) employs a non-interrupted synchronization scheme to achieve high-precision phase synchronization. While radio frequency interference (RFI) is a major factor in deteriorating phase synchronization performance. To present the effect of RFI on the synchronization phase clearly, the characteristics of RFI in the synchronization link are described in detail, and a precise analytic expression between the amplitude, frequency, and phase of RFI and synchronization phase error is established. Furthermore, a novel pulse compression-based notch (PCN) method is proposed to eliminate the phase error introduced by RFI. In the proposed method, the saturated distortion signals resulting from strong interferences are detected and discarded by the distribution features of their modes. Then, inspired by contrary thinking, the synchronization signal after pulse compression is notched instead of the RFI. A fast missing-data iterative adaptive approach (Fast MIAA) is performed to recover the gaped RFI signal and remove it from the compressed signal. Finally, the correct synchronization phases can be extracted from the peak positions of the remaining signals. Experimental results derived from using simulated and real synchronization data of the LT-1 system validate the performance of the proposed RFI mitigation method.

The challenging problem to realize high-resolution and wide-swath (HRWS) synthetic aperture radar (SAR) imaging is the ambiguity suppression in the azimuth and range directions. According to the spatial angle difference of each ambiguity component, the current technical approach is to design the spatial filter for achieving the ambiguity suppression based on the 2-D multichannel system. Along with the increasing of HRWS imaging requirements, the number of system channels also gradually increase and further result in the complex structure design of the phased array antenna system. Meanwhile, the traditional phased array antenna cannot effectively control the direction of the transmit beampattern in range. Unlike the traditional phased array, frequency diverse array (FDA) employs a small-frequency increment across the whole array elements and forms the range-angle-dependent S-shaped transmit beampattern, which can be utilized to separate the different range ambiguous region. Considering the above-mentioned characteristics and the range periodicity problem of transmit beampattern, this letter devises a scheme for spaceborne SAR HRWS imaging mode in the view of transmit beampattern utilizing 2-D planar array, i.e., the FDA in azimuth for removing the range nonperiodicity ambiguity and the conventional phased array in elevation for removing the range periodicity ambiguity. Simulation results have been presented to validate the effectiveness of the proposed scheme.

RGB-D cameras offer both color and depth images of the surrounding environment, making them an attractive option for robotic and vision applications. This work introduces the BRISK_D algorithm, which efficiently combines Features from Accelerated Segment Test (FAST) and Binary Robust Invariant Scalable Keypoints (BRISK) methods. In the BRISK_D algorithm, the keypoints are detected by the FAST algorithm and the location of the keypoint is refined in the scale and the space. The scale factor of the keypoint is directly computed with the depth information of the image. In the experiment, we have made a detailed comparative analysis of the three algorithms SURF, BRISK and BRISK_D from the aspects of scaling, rotation, perspective and blur. The BRISK_D algorithm combines depth information and has good algorithm performance.

Highly squint synthetic aperture radar (SAR) increases the flexibility and aspect-information of observation but poses several challenges to frequency-domain algorithms. The back-projection (BP) algorithm is recognized to produce the best results for highly squint mode but at high computational expense. Several fast BP algorithms have been developed to enhance the efficiency of the BP integral. The Cartesian factorized BP (CFBP) algorithm has been proposed to improve the performance. However, CFBP is ineffective in the highly squint case because its range model (RM) is imprecise. In this letter, we propose a modified CFBP (MCFBP) algorithm for highly squint spotlight SAR imaging. We employ a transformed Cartesian coordinate system to treat the transceiver mode as approximately side-looking mode. According to the transformed coordinate system, we propose a modified RM (MRM) to reduce the range error. Based on the MRM, we derive modified image spectrum compression steps and the Nyquist sampling rate of the subaperture image. MCFBP inherits CFBP's accuracy and efficiency advantages. Results of simulations and experiments performed by the X-band airborne SAR system with a maximum bandwidth of 1.2 GHz validate the improved performance of the proposed algorithm relative to BP and fast factorized BP.