Pieralberto Valpiana

Dr. Pieralberto Valpiana

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 April 2023 in Pathogens
Verified
Journal Article
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Pier Francesco IndelliPier Francesco Indelli
Pier Francesco Indelli
SGStefano Ghirardelli
Stefano Ghirardelli
PVPieralberto Valpiana
Pieralberto Valpiana
LBlorenzo bini
lorenzo bini
MCMichele Paolo Festini Capello
Michele Paolo Festini Capello
Ferdinando IannottiFerdinando Iannotti
Ferdinando Iannotti
Introduction: Periprosthetic joint infections (PJI) represent a devastating consequence following total joint arthroplasty (TJA). In this study, the authors describe a modified surgical technique developed to enhance the classical irrigation and debridement procedure (DAIR) to improve the possibilities of retaining an acutely infected TJA. Materials and Methods: This technique, debridement antibiotic pearls and retention of the implant (DAPRI), aims to remove the intra-articular biofilm allowing a higher and prolonged local antibiotic concentration by using calcium sulphate antibiotic-added beads in a setting of acute (<4 weeks from symptoms onset) PJI with pathogen identification. The combination of three different surgical techniques (tumor-like synovectomy, argon beam/acetic acid application and chlorhexidine gluconate brushing) aims to remove the bacterial biofilm from the implant without explanting the original hardware. Results: In total, 62 patients met the acute infection criteria (<4 weeks of symptoms); there were 57 males and five females. The patients’ average age at the time of treatment was 71 years (62–77) and the average BMI was 37 kg/m2. The micro-organism, always identified through synovial fluid analysis (culture, multiplex PCR or Next Generation Sequencing), was an aerobic Gram + in 76% (S. Coag-Neg 41%; S. aureus 16%), Gram—in 10% (E. coli 4%) and anaerobic Gram + in 4%. The DAPRI treatment was performed at an average of 3 days from symptoms onset (1–7 days). All patients underwent a 12-week course of post-operative antibiotic therapy (6 weeks I.V. and 6 weeks oral). All patients were available at the 2-year minimum FU (24–84 months). A total of 48 (77.5%) patients were infection-free at the final FU, while 14 patients underwent 2-stage revision for PJI recurrence. In total, four patients (6.4%) had a prolonged drainage from the wound after placement of the calcium sulphate beads. Conclusions: This study suggests that the DAPRI technique could represent a valid alternative to the classic DAIR procedure. The current authors do not recommend this procedure outside of the main inclusive criteria (acute scenario micro-organism identification).

18 July 2025 in Journal of Experimental Orthopaedics
Verified
Journal Article
Open access
FQFjorela Qordja
Fjorela Qordja
PVPieralberto Valpiana
Pieralberto Valpiana
LALuca Andriollo
Luca Andriollo
SRStefano Marco Paolo Rossi
Stefano Marco Paolo Rossi
ASAndrea Giordano Salvi
Andrea Giordano Salvi
Pier Francesco IndelliPier Francesco Indelli
Pier Francesco Indelli
Purpose: New alignment classifications based on phenotype reproduction have recently been introduced in total knee arthroplasty (TKA) as alternatives to traditional mechanical alignment. These classifications were designed according to the static hip–knee–ankle angle (sHKA) measurement from long leg radiographs (LLRs). This study aimed to understand whether and how the HKA varied throughout the knee's range of motion (ROM) during robot‐assisted TKA. Methods: This prospective, bi‐centric cohort study involved 107 consecutive patients undergoing primary robot‐assisted TKA. The surgical technique adhered to restricted kinematic alignment (HKA ± 3°) with asymmetric gap balancing principles. The HKA's dynamic variation (dHKA) was assessed intraoperatively at full extension, as well as at 30°, 45°, 60°, 90° and 120°, both before bone cuts and after the positioning of the trial components. The overall cohort was initially analyzed, followed by a subgroup analysis based on varus, neutral and valgus phenotypes. A descriptive analysis was conducted to evaluate dHKA trends. Collected data were then analyzed using one‐way repeated measures analysis of variance with Bonferroni correction and Bland–Altman plots to assess significant variations in dHKA across the ROM during flexion and to quantify outliers from the established safe boundaries of ±3°. Results: Out of 107 knees, the pre‐cut dHKA demonstrated a biphasic trend, decreasing in varus until 60° and then transitioning toward valgus, with significant differences primarily noted at 90° and 120°. Post‐cut, the dHKA exhibited an overall varus trend, increasing from full extension to 60° before experiencing a partial recovery. Significant differences were detected primarily at the initial flexion angles. Outlier rates increased with flexion: pre‐cut from 6.5% to 43.0%, and post‐cut from 1.9% to 30.8%, highlighting progressive inter‐individual variability throughout. Although the analysis was stratified by knee phenotype, the post‐cut dHKA trend did not differ among the various phenotypes or in comparison to the overall cohort trend. Conclusions: The main finding of the current study was that intraoperative dHKA differs significantly from sHKA during robot‐assisted TKA. Moreover, the sHKA was limited in predicting the actual kinematic HKA. Planning the final TKA alignment on static, standing LLRs may have limited value compared to intraoperative planning conducted with enabling technologies. Level of Evidence: Level 3.

14 January 2025 in Medicina
Verified
Journal Article
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MCMichele Paolo Festini Capello
Michele Paolo Festini Capello
PVPieralberto Valpiana
Pieralberto Valpiana
GAGiuseppe Aloisi
Giuseppe Aloisi
GCGiovanni Cristofolini
Giovanni Cristofolini
SMSvea Caren Misselwitz
Svea Caren Misselwitz
Pier Francesco IndelliPier Francesco Indelli
Pier Francesco Indelli
Background and Objectives: The objective of the study was to evaluate the epidemiology of slope-related accidents in a high-volume trauma center during the winter season. In addition, this study aims to analyze patient-related, equipment-related, and environment-related characteristics. Materials and Methods: A questionnaire containing 22 items was distributed to all adult patients admitted to the emergency department of the Brixen Hospital (Italy) during the 2023/24 winter season because of a ski/snowboard-related injury. Results: The final database included 579 questionnaires from 579 patients who ultimately entered the study: 285 were females and 294 were males. The analysis of risk factors for fractures revealed that patients with fractures were generally older (50.7 ± 16.0 years) compared to those without fractures (45.4 ± 17.2 years, p = 0.0021). Thirty-six percent of injuries were considered as joint sprain/ligament strain: patients in this group were younger (45.5 ± 16.2 years) compared to all patients (48.3 ± 17.3 years, p = 0.0151). Conclusions: In conclusion, this study identified significant risk factors associated with skiing and snowboarding injuries. Fractures were more common among older and more experienced skiers, particularly those who described themselves as experts. Ligamentous distortions were more common among younger and less experienced skiers. Fatigue is generally underestimated, and the general physical preparation is often lacking for sports like skiing and snowboarding. Additionally, the absence of significant correlations between weather conditions, snow quality, equipment type, and the difficulty of the slope with injury risk suggests that individual factors such as age and skill level are more critical determinants of injury risk than environmental or equipment-related factors.

28 January 2026 in Knee Surgery, Sports Traumatology, Arthroscopy
Verified
Journal Article
Open access
MEMichael Engl
Michael Engl
FQFjorela Qordja
Fjorela Qordja
GBGuido Bocchino
Guido Bocchino
GMGiulio Maccauro
Giulio Maccauro
SSSebastian Schaller
Sebastian Schaller
Pier Francesco IndelliPier Francesco Indelli
Pier Francesco Indelli
Purpose: Modern personalised total knee arthroplasty (TKA) techniques aim to mimic natural knee kinematics by focusing on soft‐tissue dynamics rather than static alignment. However, a consistent definition of the optimal ligamentous balance has not yet been established. This study had three aims: to assess intraoperative collateral ligament tension and the overall balance between the medial and lateral compartments; to evaluate postoperative gait analysis parameters and compare them with the healthy contralateral knee; and to determine whether the achieved intercompartmental balance affects the final coronal alignment of the knee. Methods: A prospective single‐cohort study was conducted to evaluate 102 primary AR‐assisted TKAs performed for end‐stage unilateral knee osteoarthritis between September 2021 and June 2024. A total of 17 patients out of 102 were ultimately included following the application of the study's inclusion and exclusion criteria. Intraoperative data were collected on MCL and LCL elongation patterns during passive ROM both before and after trial component placement. Additionally, the study examined differences in intercompartmental ligament balancing. Postoperative coronal alignment was radiographically evaluated using the hip‐knee‐ankle (HKA) angle. Functional outcomes were measured using 3D markerless gait analysis at least 9 months after surgery. A repeated‐measures analysis of variance (ANOVA) and a Pearson correlation were employed to examine trends in ligament asymmetry and their relationship with alignment. Results: The medial collateral ligament (MCL) exhibited nearly isometric behaviour throughout the range of motion (0.3 ± 1.11 at 0°, −2.4 ± 2.71 at 20°, −2.3 ± 3.96 at 40°, −2.3 ± 4.16 at 60°, −1.5 ± 4.03 at 80°, −0.7 ± 4.52 at 100°, −0.2 ± 4.97 at 120° preoperatively; 2.2 ± 2.98 at 0°, 2.1 ± 3.40 at 20°, 1.4 ± 4.02 at 40°, 1.2 ± 4.41 at 60°, 0.8 ± 4.48 at 80°, 1.5 ± 4.42 at 100°, 1.6 ± 5.09 at 120° postoperatively). Conversely, the LCL showed progressive detensioning (0.0 ± 2.03 at 0°, −3.1 ± 2.07 at 20°, −3.9 ± 2.72 at 40°, −4.9 ± 3.34 at 60°, −6.6 ± 3.63 at 80°, −8.5 ± 4.13 at 100°, −9.6 ± 4.40 at 120° preoperatively; −2.1 ± 5.16 at 0°, −3.1 ± 4.03 at 20°, −4.7 ± 3.80 at 40°, −5.8 ± 3.19 at 60°, −7.0 ± 3.86 at 80°, −6.6 ± 4.55 at 100°, −7.0 ± 5.08 at 120° postoperatively), leading to asymmetric ligament balancing with the opening of the lateral compartment. This trapezoidal soft‐tissue configuration persisted postoperatively. No significant differences were observed in gait parameters between the operated and contralateral limbs, all p ‐values being > 0.05. A notable negative correlation was seen between postoperative HKA and ligament asymmetry at early flexion angles (0°, 20°, 40°; r = −0.63, r = −0.67, r = −0.48, respectively), indicating that soft‐tissue balancing affects coronal alignment. Conclusions: Focusing on dynamic soft‐tissue boundaries rather than static alignment targets may preserve knee kinematics after TKA. Augmented reality‐assisted balancing techniques provide real‐time, personalised ligament management, which aligns with the patient's native kinematics and could be an encouraging direction in modern knee arthroplasty. More research is needed to confirm these findings across larger groups and different technologies. Level of Evidence: Level III.

28 March 2026 in Medicina
Verified
Journal Article
Open access
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VCVittorio Castoldi
Vittorio Castoldi
ASAndrea Giordano Salvi
Andrea Giordano Salvi
GPGiuseppe Petralia
Giuseppe Petralia
GAGiuseppe Aloisi
Giuseppe Aloisi
PVPieralberto Valpiana
Pieralberto Valpiana
SRSalvatore Risitano
Salvatore Risitano
Gait analysis study comparing unicompartmental vs. total knee arthroplasty, differences in knee kinematics: a retrospective cohort study. Background and Objectives: Total knee arthroplasty (TKA) is an effective treatment for advanced knee osteoarthritis, although functional outcomes may remain suboptimal in many patients. Unicompartmental knee arthroplasty (UKA) often provides better functional recovery but shows lower long-term implant survival. Recently, personalized TKA approaches have been developed to improve kinematic restoration and patient satisfaction. This study aimed to compare knee kinematics among patients who underwent personalized TKA, medial UKA, and healthy controls. Materials and Methods: This retrospective cohort study included 9 patients treated with robotic-assisted personalized TKA, 9 patients treated with medial UKA, and 9 healthy controls matched for age, sex, and BMI. Inclusion criteria were age 60–80 years, Kellgren–Lawrence grade III–IV, a minimum follow-up of 12 months, deviation from neutral HKA < 15°, healthy contralateral knee, and high postoperative functional scores. Exclusion criteria included valgus knees (HKA > 180°), postoperative complications, and neuromotor disorders. In the TKA group, a Medial Congruent implant was implanted with ROSA robotic assistance using a restricted kinematic alignment (±5° HKA) and asymmetric intercompartmental balancing. In the UKA group, a fixed-bearing medial implant (Physica ZUK) was used. Gait analysis was performed on a markerless instrumented treadmill (WalkerView™; Dalmine, Italy). Differences between groups were analyzed using one-way ANOVA and Tukey’s post-hoc test (p < 0.05). Results: UKA patients walked with a stiffer knee during stance. Knee range of motion during stance increased from UKA (6.3° ± 7.2°) to TKA (13.6° ± 8.8°, p = 0.045) and to controls (16.6° ± 4.5°, p = 0.02). During loading response, UKA patients showed lower flexion (10.2° ± 6.1°) than TKA (19.4° ± 7.9°, p = 0.049) and controls (19.6° ± 2.8°, p = 0.004). Knee flexion during swing was comparable between UKA and TKA. Conclusions: UKA patients demonstrated reduced knee flexion during early stance compared with robotic-assisted TKA and healthy controls. The observed differences may reflect multiple factors, including surgical technique, implant design, and patient-related characteristics. Because preoperative functional data were not available, potential selection bias cannot be excluded. These findings should be interpreted cautiously and warrant confirmation in larger prospective studies.