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The aim of this study was to analyze the effects of a multicomponent exercise program on the physical and hemodynamic functions of community-dwelling older adults with low schooling levels in relation to simple multicomponent group exercises. Twenty-one older people were randomly assigned to two groups: G1 (n = 11) and G2 (n = 10); sixteen of whom completed the sixteen sessions over a six-week period, three times a week. During eight sessions, G1 performed adapted dual-task multicomponent exercises (strengthening, balance, and cognition) and G2 simple multicomponent exercises (strengthening and balance), and both groups engaged in eight additional sessions of simple multicomponent exercises. The dual-task multicomponent exercises exhibited similar effects to those of their simple multicomponent counterparts. The older adults from both groups improved mobility, frailty, static postural control, balance, and hemodynamic stability. The adapted program was beneficial to the community-dwelling older people with low schooling in the group intervention.
Neildja Maria da Silva; Monalisa Silva de França; Dellis Kariny Freitas Holanda de Almeida; Evelin Suyany Guedes de Lima; Vinícius Hugley Brito dos Santos; João Victor De Araújo Souza; Ana Rodriguez Larrad; Débora De Almeida Aloise; Núbia Maria Freire Vieira Lima. Effects of a Multicomponent Exercise Program on Groups of Community-Dwelling Older Adults with Low Schooling: A Pilot Study. Journal of Aging Research 2021, 2021, 1 -12.
AMA StyleNeildja Maria da Silva, Monalisa Silva de França, Dellis Kariny Freitas Holanda de Almeida, Evelin Suyany Guedes de Lima, Vinícius Hugley Brito dos Santos, João Victor De Araújo Souza, Ana Rodriguez Larrad, Débora De Almeida Aloise, Núbia Maria Freire Vieira Lima. Effects of a Multicomponent Exercise Program on Groups of Community-Dwelling Older Adults with Low Schooling: A Pilot Study. Journal of Aging Research. 2021; 2021 ():1-12.
Chicago/Turabian StyleNeildja Maria da Silva; Monalisa Silva de França; Dellis Kariny Freitas Holanda de Almeida; Evelin Suyany Guedes de Lima; Vinícius Hugley Brito dos Santos; João Victor De Araújo Souza; Ana Rodriguez Larrad; Débora De Almeida Aloise; Núbia Maria Freire Vieira Lima. 2021. "Effects of a Multicomponent Exercise Program on Groups of Community-Dwelling Older Adults with Low Schooling: A Pilot Study." Journal of Aging Research 2021, no. : 1-12.
The aim of the study was to analyze the effect of social distancing on physical activity (PA) and Health-Related Quality of Life (HRQoL) in active Spanish older adults according to their physical functionality. The study included 58 older adults aged 76.24 ± 6.00 years who were enrolled in a supervised physical exercise program before the COVID-19 outbreak. Anthropometric, physical function, physical activity and HRQoL were measured at baseline (October 2019). After the two-month lockdown due to the COVID-19, questionnaires were collected again during de-escalation (May 2020). Participants were divided into high- (n = 29) and low-functionality (n = 29) groups. Total PA, walking and cleaning significantly decreased (p < 0.001) whilst exercising or dancing increased (p < 0.001). General health, social and emotional role functioning dimensions and overall mental component scores worsened (p < 0.01–p < 0.05). Low-functionality participants had significantly lower physical functioning scores at baseline (p < 0.01) and lower bodily pain scores at de-escalation (p < 0.01). Emotional role functioning dimension and overall mental component significantly decreased only in low-functionality participants (p < 0.05). Although PA levels decreased significantly, older adults continued being active regardless of their functionality. While mental HRQoL in participants with higher physical functionality remained unchanged, participants with lower functional capacity had a higher risk of mental health concerns. Therefore, attention should focus on strategies to mitigate the negative effects of distancing measures on older people’s mental health, especially in those with lower functionality.
Izaro Esain; Susana Gil; Iratxe Duñabeitia; Ana Rodriguez-Larrad; Iraia Bidaurrazaga-Letona. Effects of COVID-19 Lockdown on Physical Activity and Health-Related Quality of Life in Older Adults Who Regularly Exercise. Sustainability 2021, 13, 3771 .
AMA StyleIzaro Esain, Susana Gil, Iratxe Duñabeitia, Ana Rodriguez-Larrad, Iraia Bidaurrazaga-Letona. Effects of COVID-19 Lockdown on Physical Activity and Health-Related Quality of Life in Older Adults Who Regularly Exercise. Sustainability. 2021; 13 (7):3771.
Chicago/Turabian StyleIzaro Esain; Susana Gil; Iratxe Duñabeitia; Ana Rodriguez-Larrad; Iraia Bidaurrazaga-Letona. 2021. "Effects of COVID-19 Lockdown on Physical Activity and Health-Related Quality of Life in Older Adults Who Regularly Exercise." Sustainability 13, no. 7: 3771.
During the COVID-19 pandemic, entire populations were instructed to live in home-confinement to prevent the expansion of the disease. Spain was one of the countries with the strictest conditions, as outdoor physical activity was banned for nearly two months. This study aimed to analyse the changes in physical activity and sedentary behaviours in Spanish university students before and during the confinement by COVID-19 with special focus on gender. We also analysed enjoyment, the tools used and motivation and impediments for doing physical activity. An online questionnaire, which included the International Physical Activity Questionnaire Short Form and certain “ad hoc” questions, was designed. Students were recruited by distributing an invitation through the administrative channels of 16 universities and a total of 13,754 valid surveys were collected. Overall, university students reduced moderate (−29.5%) and vigorous (−18.3%) physical activity during the confinement and increased sedentary time (+52.7%). However, they spent more time on high intensity interval training (HIIT) (+18.2%) and mind-body activities (e.g., yoga) (+80.0%). Adaptation to the confinement, in terms of physical activity, was handled better by women than by men. These results will help design strategies for each gender to promote physical activity and reduce sedentary behaviour during confinement periods.
Ana Rodríguez-Larrad; Asier Mañas; Idoia Labayen; Marcela González-Gross; Ander Espin; Susana Aznar; José Antonio Serrano-Sánchez; Francisco J. Vera-Garcia; Domingo González-Lamuño; Ignacio Ara; Luis Carrasco-Páez; José Castro-Piñero; Mari Carmen Gómez-Cabrera; Sara Márquez; Josep A. Tur; Narcis Gusi; Pedro J. Benito; Diego Moliner-Urdiales; Jonatan R. Ruiz; Francisco B. Ortega; David Jiménez-Pavón; José Antonio Casajús; Jon Irazusta. Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender. International Journal of Environmental Research and Public Health 2021, 18, 369 .
AMA StyleAna Rodríguez-Larrad, Asier Mañas, Idoia Labayen, Marcela González-Gross, Ander Espin, Susana Aznar, José Antonio Serrano-Sánchez, Francisco J. Vera-Garcia, Domingo González-Lamuño, Ignacio Ara, Luis Carrasco-Páez, José Castro-Piñero, Mari Carmen Gómez-Cabrera, Sara Márquez, Josep A. Tur, Narcis Gusi, Pedro J. Benito, Diego Moliner-Urdiales, Jonatan R. Ruiz, Francisco B. Ortega, David Jiménez-Pavón, José Antonio Casajús, Jon Irazusta. Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender. International Journal of Environmental Research and Public Health. 2021; 18 (2):369.
Chicago/Turabian StyleAna Rodríguez-Larrad; Asier Mañas; Idoia Labayen; Marcela González-Gross; Ander Espin; Susana Aznar; José Antonio Serrano-Sánchez; Francisco J. Vera-Garcia; Domingo González-Lamuño; Ignacio Ara; Luis Carrasco-Páez; José Castro-Piñero; Mari Carmen Gómez-Cabrera; Sara Márquez; Josep A. Tur; Narcis Gusi; Pedro J. Benito; Diego Moliner-Urdiales; Jonatan R. Ruiz; Francisco B. Ortega; David Jiménez-Pavón; José Antonio Casajús; Jon Irazusta. 2021. "Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender." International Journal of Environmental Research and Public Health 18, no. 2: 369.
Objective To determine how overground robotic (OR) training added to ongoing rehabilitation affects gait speed, lower extremity function, functional mobility, and fatigue in individuals with multiple sclerosis (MS) and moderate to severe gait impairments. Design Randomized controlled trial. Setting Outpatient setting at the Multiple Sclerosis Association of Bizkaia, an association serving MS patients in Bizkaia, Spain. Participants Individuals with MS (N=36) participated in this interventional study. Inclusion criteria were age of 18 years or older, Expanded Disability Status Scale score between 4.5 and 7, and the need for assistive devices for walking outdoors. Interventions The control group (CG) engaged in an ongoing rehabilitation program consisting of weekly 1-hour individualized sessions. The intervention group (OR group) also participated in this program in addition to a twice-weekly individualized and progressive OR gait training intervention for 3 months, aiming to reach a maximum of 40 minutes by the end of the 3-month period. Main Outcome Measures Primary outcome was the 10-meter walking test (10MWT). Secondary variables included the Short Physical Performance Battery, the timed Up and Go (TUG) test, and the Modified Fatigue Impact Scale. Results The OR group maintained 10MWT performance and significantly improved on the TUG test (P=.049, medium effect size) without increasing fatigue perception. The CG demonstrated a decline on the 10MWT (P=.044, small effect size) and reduced fatigue (P=.024, medium effect size). No time per group interaction was observed for any variable. Conclusion The evaluated intervention could preserve gait speed and significantly improve functional mobility without increasing perceived fatigue in participants. Thus, OR exoskeletons could be considered a tool to deliver intensive practice of good-quality gait training in individuals with MS and moderate to severe gait impairments. Further studies are necessary to confirm these preliminary results.
Rakel Berriozabalgoitia; Iraia Bidaurrazaga-Letona; Erika Otxoa; Miriam Urquiza; Jon Irazusta; Ana Rodriguez-Larrad. Overground Robotic Program Preserves Gait in Individuals With Multiple Sclerosis and Moderate to Severe Impairments: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation 2020, 102, 932 -939.
AMA StyleRakel Berriozabalgoitia, Iraia Bidaurrazaga-Letona, Erika Otxoa, Miriam Urquiza, Jon Irazusta, Ana Rodriguez-Larrad. Overground Robotic Program Preserves Gait in Individuals With Multiple Sclerosis and Moderate to Severe Impairments: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation. 2020; 102 (5):932-939.
Chicago/Turabian StyleRakel Berriozabalgoitia; Iraia Bidaurrazaga-Letona; Erika Otxoa; Miriam Urquiza; Jon Irazusta; Ana Rodriguez-Larrad. 2020. "Overground Robotic Program Preserves Gait in Individuals With Multiple Sclerosis and Moderate to Severe Impairments: A Randomized Controlled Trial." Archives of Physical Medicine and Rehabilitation 102, no. 5: 932-939.
Background People with frailty and/or sarcopenia have an increased risk of negative health outcomes. However, their diagnosis is often difficult. Considering the potential value of myostatin and follistatin as biomarkers of these conditions, we aimed to compare the association between both myokines and frailty and/or sarcopenia in post‐hospitalised older people. In addition, the capability of myostatin and follistatin for identifying frailty and sarcopenia was compared with physical tests. Materials And Methods Participants in this cross‐sectional study consisted of 84 post‐hospitalised patients immediately after discharge. Participants met the following inclusion criteria: aged ≥70 years, score of ≥20 on the Mini‐Mental State Examination, and able to stand up and walk independently for at least 4 metres. Serum myostatin and follistatin concentrations were measured by enzyme‐linked immunosorbent assay. Body measures and results from 4 physical tests (hand grip, chair stand, 8‐foot timed Up‐and‐Go (8TUG) and gait speed (GS)) were also recorded. Frailty was evaluated by the Fried index, and sarcopenia by the criteria of the European Working Group on Sarcopenia in Older People. Results Myostatin concentration was lower and follistatin concentration higher in people with frailty or sarcopenia. Receiver operating characteristic curves indicated that GS and 8TUG tests had the greatest capability for identifying frailty. Myostatin was the only variable capable of identifying sarcopenia. Conclusion Myostatin may be a useful biomarker for sarcopenia in post‐hospitalised older adults. However, it has a lower capability for identifying frailty than physical tests. Further studies using larger samples and these myokines together with other biomarkers are warranted.
Iñaki Echeverria; Ariadna Besga; Begoña Sanz; María Amasene; Gotzone Hervás; Julia Barroso; Ana Rodriguez‐Larrad; Jon Irazusta. Identification of frailty and sarcopenia in hospitalised older people. European Journal of Clinical Investigation 2020, 51, e13420 .
AMA StyleIñaki Echeverria, Ariadna Besga, Begoña Sanz, María Amasene, Gotzone Hervás, Julia Barroso, Ana Rodriguez‐Larrad, Jon Irazusta. Identification of frailty and sarcopenia in hospitalised older people. European Journal of Clinical Investigation. 2020; 51 (4):e13420.
Chicago/Turabian StyleIñaki Echeverria; Ariadna Besga; Begoña Sanz; María Amasene; Gotzone Hervás; Julia Barroso; Ana Rodriguez‐Larrad; Jon Irazusta. 2020. "Identification of frailty and sarcopenia in hospitalised older people." European Journal of Clinical Investigation 51, no. 4: e13420.
Nutritional status is relevant to functional recovery in patients after an acute process requiring rehabilitation. Nevertheless, little is known about the impact of malnutrition on geriatric rehabilitation. This study aimed to determine the association between nutritional status at admission and the evolution of functional and physical outcomes, as well as the capability of nutritional status to identify fallers among patients admitted to geriatric rehabilitation for different reasons. This was a retrospective cohort study of 375 patients. Data collected included age, gender, diagnosis at admission, comorbidities, cognitive and nutritional status, functional and physical measurements, length of stay, mortality and falls. Orthogeriatric patients with worse nutritional status according to the Mini Nutritional Assessment-Short Form (MNA-SF) had a significantly lower Barthel Index at admission and discharge with worse functional gain and poorer outcomes in the Short Physical Performance Battery (SPPB). However, in hospital-deconditioned patients, the MNA-SF score was not significantly associated with functional and physical recovery. Poor nutritional status at admission increased the risk of experiencing at least one fall during rehabilitation in orthogeriatric patients. However, hospital-deconditioned patients who fell had better SPPB scores than those who did not fall. Our results demonstrate the importance of nutritional status in the clinical evolution of orthogeriatric patients throughout the rehabilitation process.
Miriam Urquiza; Naiara Fernandez; Ismene Arrinda; Irati Sierra; Jon Irazusta; Ana Rodriguez Larrad. Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study. Nutrients 2020, 12, 2855 .
AMA StyleMiriam Urquiza, Naiara Fernandez, Ismene Arrinda, Irati Sierra, Jon Irazusta, Ana Rodriguez Larrad. Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study. Nutrients. 2020; 12 (9):2855.
Chicago/Turabian StyleMiriam Urquiza; Naiara Fernandez; Ismene Arrinda; Irati Sierra; Jon Irazusta; Ana Rodriguez Larrad. 2020. "Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study." Nutrients 12, no. 9: 2855.
The determination of the objectives of gait rehabilitation therapies is usually based on partial data provided by clinical tests carried out in specific scenarios and the subjective perception of both the therapist and the patient. However, recent studies have shown that individualization is mandatory to maximize the effect of the therapy on the patient. This requires monitoring the Activities of Daily Living of the patient using objective indicators and measurements, which can be achieved using instrumented devices or wearable sensors. In this work, a smart crutch tip is proposed, which integrates a novel neural-network based intelligent Activities of Daily Living classifier. Based on the sensors integrated on the tip, the classifier is able to detect four typical activities (walking, standing still, going up stairs and going down stairs). In order to design the classifier, data from a group of 13 volunteers is used and different network architectures are evaluated in order to consider the most computationally efficient design, obtaining a success rate of 95%.
Asier Brull; Asier Zubizarreta; Itziar Cabanes; Jon Torres-Unda; Ana Rodriguez-Larrad. A Smart Crutch Tip for Monitoring the Activities of Daily Living Based on a Novel Neural-Network Intelligent Classifier. Advances in Intelligent Systems and Computing 2020, 113 -122.
AMA StyleAsier Brull, Asier Zubizarreta, Itziar Cabanes, Jon Torres-Unda, Ana Rodriguez-Larrad. A Smart Crutch Tip for Monitoring the Activities of Daily Living Based on a Novel Neural-Network Intelligent Classifier. Advances in Intelligent Systems and Computing. 2020; ():113-122.
Chicago/Turabian StyleAsier Brull; Asier Zubizarreta; Itziar Cabanes; Jon Torres-Unda; Ana Rodriguez-Larrad. 2020. "A Smart Crutch Tip for Monitoring the Activities of Daily Living Based on a Novel Neural-Network Intelligent Classifier." Advances in Intelligent Systems and Computing , no. : 113-122.
Multiple Sclerosis (MS) is a neurological degenerative disease with high impact on our society. In order to mitigate its effects, proper rehabilitation therapy is mandatory, in which individualisation is a key factor. Technological solutions can provide the information required for this purpose, by monitoring patients and extracting relevant indicators. In this work, a novel Sensorized Tip is proposed for monitoring People with Multiple Sclerosis (PwMS) that require Assistive Devices for Walking (ADW) such as canes or crutches. The developed Sensorized Tip can be adapted to the personal ADW of each patient to reduce its impact, and provides sensor data while naturally walking in the everyday activities. This data that can be processed to obtain relevant indicators that helps assessing the status of the patient. Different from other approaches, a full validation of the proposed processing algorithms is carried out in this work, and a preliminary study-case is carried out with PwMS considering a set of indicators obtained from the Sensorized Tip’s processed data. Results of the preliminary study-case demonstrate the potential of the device to monitor and characterise patient status.
Asier Brull; Asier Zubizarreta; Itziar Cabanes; Ana Rodriguez-Larrad. Sensorized Tip for Monitoring People with Multiple Sclerosis that require Assistive Devices for Walking. Sensors 2020, 20, 4329 .
AMA StyleAsier Brull, Asier Zubizarreta, Itziar Cabanes, Ana Rodriguez-Larrad. Sensorized Tip for Monitoring People with Multiple Sclerosis that require Assistive Devices for Walking. Sensors. 2020; 20 (15):4329.
Chicago/Turabian StyleAsier Brull; Asier Zubizarreta; Itziar Cabanes; Ana Rodriguez-Larrad. 2020. "Sensorized Tip for Monitoring People with Multiple Sclerosis that require Assistive Devices for Walking." Sensors 20, no. 15: 4329.
Physical exercise protects against age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) may mediate some of the cognitive benefits of physical exercise, but the effect of physical exercise on serum BDNF is unclear. Indeed, differential findings have been reported depending on the characteristics of the participants and the intensity, duration, and type of exercise. The aim of this study was to determine whether three different physical exercise interventions alter serum BDNF levels in older adults living in long-term nursing homes (LTNHs) and whether changes in physical, cognitive, and dual-task performance are related to changes in serum BDNF. LTNH study participants (n = 126) were randomly assigned to multicomponent or dual-task training or a walking program and serum BDNF levels were analyzed by ELISA. We also assessed physical, cognitive, and dual-task parameters. Neither the multicomponent, dual-task, nor walking exercise programs caused changes in serum BDNF concentration in older adults living in LTNHs. Changes in BDNF during the interventions were not significantly associated with modifications in physical, cognitive or dual-task performance parameters. Our results provide new evidence clarifying the relationship between physical and cognitive exercise and BDNF.
Chloe Rezola-Pardo; Gotzone Hervás; Haritz Arrieta; Alejandra Hernández-De Diego; Fatima Ruiz-Litago; Susana Maria Gil; Ana Rodriguez-Larrad; Jon Irazusta. Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes. Experimental Gerontology 2020, 139, 111024 .
AMA StyleChloe Rezola-Pardo, Gotzone Hervás, Haritz Arrieta, Alejandra Hernández-De Diego, Fatima Ruiz-Litago, Susana Maria Gil, Ana Rodriguez-Larrad, Jon Irazusta. Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes. Experimental Gerontology. 2020; 139 ():111024.
Chicago/Turabian StyleChloe Rezola-Pardo; Gotzone Hervás; Haritz Arrieta; Alejandra Hernández-De Diego; Fatima Ruiz-Litago; Susana Maria Gil; Ana Rodriguez-Larrad; Jon Irazusta. 2020. "Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes." Experimental Gerontology 139, no. : 111024.
Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable exoskeletons are promising tools for gait rehabilitation, but currently there is no evidence of their clinical effects on patients with MS. The present study aims to determine the effects of an OR intervention in people with MS and moderate to severe walking disabilities and ascertain if benefits are maintained over a follow-up period of 3 months. This randomized controlled trial will include 36 participants with MS. Inclusion criteria are: older than 18 years, definitive diagnosis of MS, 4.5–7 points on the EDSS (Expanded Disability Status Scale), and needing one or two canes or crutches for walking outdoors. Subjects in the control group will receive conventional physiotherapy sessions at ADEMBI (Asociación de Esclerosis Múltiple de Bizkaia) provided to control spasticity, maintain articular range and exercise balance. Subjects in the intervention group will receive the same physiotherapy but also participate in a progressive OR gait training program assisted by the EksoTM exoskeleton. The program consists of twice a week individually supervised sessions in two setting modalities: PreGait and ProStepPlus. The training parameters (duration, speed, cadence, length of steps) will be set during the first session and the progression and intensity of the intervention will be adapted to the tolerance of each participant. The primary outcome of this study is gait speed. Secondary outcomes will include physical and cognitive performance tests, clinical, fatigue and quality of life assessments, and changes in the plasma levels of inflammatory cytokines. The present trial is the first analyzing the effectiveness of an OR intervention for gait training in patients with MS. It will help clarify the applicability of robotic technologies to clinical practice, extending the functionality and quality of life of people with MS to face a successful aging process. (ACTRN12619000014156; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376548).
Rakel Berriozabalgoitia; Begoña Sanz; Ana Belén Fraile-Bermúdez; Erika Otxoa; Izaskun Yeregui; Iraia Bidaurrazaga-Letona; Iratxe Duñabeitia; Alfredo Antigüedad; Maria Domercq; Jon Irazusta; Ana Rodriguez-Larrad. An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial. Frontiers in Medicine 2020, 7, 1 .
AMA StyleRakel Berriozabalgoitia, Begoña Sanz, Ana Belén Fraile-Bermúdez, Erika Otxoa, Izaskun Yeregui, Iraia Bidaurrazaga-Letona, Iratxe Duñabeitia, Alfredo Antigüedad, Maria Domercq, Jon Irazusta, Ana Rodriguez-Larrad. An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial. Frontiers in Medicine. 2020; 7 ():1.
Chicago/Turabian StyleRakel Berriozabalgoitia; Begoña Sanz; Ana Belén Fraile-Bermúdez; Erika Otxoa; Izaskun Yeregui; Iraia Bidaurrazaga-Letona; Iratxe Duñabeitia; Alfredo Antigüedad; Maria Domercq; Jon Irazusta; Ana Rodriguez-Larrad. 2020. "An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial." Frontiers in Medicine 7, no. : 1.
Multicomponent physical exercise is effective in curbing the effect of hospitalization in older adults. However, it is not well established which characteristics of the exercise interventions would optimize intervention sustainability and efficacy. This study compared the effects of two group-based multicomponent exercise interventions of different lengths in older adults after hospitalization. Fifty-five participants were randomly assigned to a short-term group-based branch (SGB, n = 27) or to a long-term group-based branch (LGB, n = 28). The SGB participated in a six-week multicomponent group-based exercise-training program followed by 18 weeks of home-based exercise. The LGB completed 12 weeks of each phase. Physical function, physical activity, quality of life, anthropometrics, and nutritional status were assessed at baseline, after 12 weeks, and after 24 weeks of intervention. Both groups improved physical function and nutritional status and increased physical activity after 12 weeks of intervention (paired student’s t-test, p < 0.01), and maintained the positive effects during the following 12 weeks. No group-by-time interaction was observed in any of the studied variables using mixed-model ANOVA. Based on these findings, we determined that 6 weeks of a group-based exercise intervention caused similar functional and nutritional benefits to a longer group-based intervention of 12 weeks when both are continued at home until 24 weeks.
Iñaki Echeverria; Maria Amasene; Miriam Urquiza; Idoia Labayen; Pilar Anaut; Ana Rodriguez-Larrad; Jon Irazusta; Ariadna Besga. Multicomponent Physical Exercise in Older Adults after Hospitalization: A Randomized Controlled Trial Comparing Short- vs. Long-Term Group-Based Interventions. International Journal of Environmental Research and Public Health 2020, 17, 666 .
AMA StyleIñaki Echeverria, Maria Amasene, Miriam Urquiza, Idoia Labayen, Pilar Anaut, Ana Rodriguez-Larrad, Jon Irazusta, Ariadna Besga. Multicomponent Physical Exercise in Older Adults after Hospitalization: A Randomized Controlled Trial Comparing Short- vs. Long-Term Group-Based Interventions. International Journal of Environmental Research and Public Health. 2020; 17 (2):666.
Chicago/Turabian StyleIñaki Echeverria; Maria Amasene; Miriam Urquiza; Idoia Labayen; Pilar Anaut; Ana Rodriguez-Larrad; Jon Irazusta; Ariadna Besga. 2020. "Multicomponent Physical Exercise in Older Adults after Hospitalization: A Randomized Controlled Trial Comparing Short- vs. Long-Term Group-Based Interventions." International Journal of Environmental Research and Public Health 17, no. 2: 666.
The quality of life and functional mobility of patients with Multiple Sclerosis (MS) can significantly improve with exercise and a rehabilitation therapy adjusted to the needs of each patient. The assessment of gait and functional mobility of patients with MS is usually done based on clinical scales and tests, which have various limitations. This work presents the preliminary results of a clinical study carried out with patients with MS walking with a sensorized crutch tip. This tip allows to define new indicators that can be correlated with the clinical assessment scales and provide further objective and quantitative information to assess gait performance and level of impairment of patients with MS, and characterize their gait patterns. The results suggest that parameters such as the average cycle time and the average percentage of body weight might be useful to evaluate the gait performance and level of disability. Moreover, parameters related with the pitch angle of the crutch allow to determine crutch usage patterns and spot differences between patients with similar functional performance.
Iñigo Sesar; Asier Zubizarreta; Itziar Cabanes; Asier Brull; Jon Torres-Unda; Ana Rodriguez-Larrad. A preliminary analysis of gait performance of patients with multiple sclerosis using a sensorized crutch tip. IFAC-PapersOnLine 2020, 53, 16462 -16467.
AMA StyleIñigo Sesar, Asier Zubizarreta, Itziar Cabanes, Asier Brull, Jon Torres-Unda, Ana Rodriguez-Larrad. A preliminary analysis of gait performance of patients with multiple sclerosis using a sensorized crutch tip. IFAC-PapersOnLine. 2020; 53 (2):16462-16467.
Chicago/Turabian StyleIñigo Sesar; Asier Zubizarreta; Itziar Cabanes; Asier Brull; Jon Torres-Unda; Ana Rodriguez-Larrad. 2020. "A preliminary analysis of gait performance of patients with multiple sclerosis using a sensorized crutch tip." IFAC-PapersOnLine 53, no. 2: 16462-16467.
Age-related strength and muscle mass loss is further increased after acute periods of inactivity. To avoid this, resistance training has been proposed as an effective countermeasure, but the additional effect of a protein supplement is not so clear. The aim of this study was to examine the effect of a whey protein supplement enriched with leucine after resistance training on muscle mass and strength gains in a post-hospitalized elderly population. A total of 28 participants were included and allocated to either protein supplementation or placebo supplementation following resistance training for 12 weeks (2 days/week). Physical function (lower and upper body strength, aerobic capacity and the Short Physical Performance Battery (SPPB) test), mini nutritional assessment (MNA) and body composition (Dual X-ray Absorptiometry) were assessed at baseline and after 12 weeks of resistance training. Both groups showed improvements in physical function after the intervention (p < 0.01), but there were no further effects for the protein group (p > 0.05). Muscle mass did not improve after resistance training in either group (p > 0.05). In conclusion, 12 weeks of resistance training are enough to improve physical function in a post-hospitalized elderly population with no further benefits for the protein-supplemented group.
Maria Amasene; Ariadna Besga; Iñaki Echeverria; Miriam Urquiza; Jonatan R. Ruiz; Ana Rodriguez-Larrad; Mikel Aldamiz; Pilar Anaut; Jon Irazusta; Idoia Labayen. Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial. Nutrients 2019, 11, 2337 .
AMA StyleMaria Amasene, Ariadna Besga, Iñaki Echeverria, Miriam Urquiza, Jonatan R. Ruiz, Ana Rodriguez-Larrad, Mikel Aldamiz, Pilar Anaut, Jon Irazusta, Idoia Labayen. Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial. Nutrients. 2019; 11 (10):2337.
Chicago/Turabian StyleMaria Amasene; Ariadna Besga; Iñaki Echeverria; Miriam Urquiza; Jonatan R. Ruiz; Ana Rodriguez-Larrad; Mikel Aldamiz; Pilar Anaut; Jon Irazusta; Idoia Labayen. 2019. "Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial." Nutrients 11, no. 10: 2337.
In rehabilitation procedures related to the lower limbs, gait monitoring is an important source of information for the therapist. However, many of the approaches proposed in the literature require the use of uncomfortable and invasive devices. In this work, an instrumented tip is developed and detailed, which can be connected to any crutch. The instrumented tip provides objective data of the crutch motion, which, combined with patient movement data, might be used to monitor the daily activities or assess the recovery status of the patient. For that purpose, the tip integrates a two-axis inclinometer, a tri-axial gyroscope, and a force sensor to measure the force exerted on the crutch. In addition, a novel algorithm to estimate the pitch angle of the crutch is developed. The proposed approach is tested experimentally, obtaining acceptable accuracies and demonstrating the validity of the proposed lightweight, portable solution for gait monitoring.
Iñigo Sesar; Asier Zubizarreta; Itziar Cabanes; Eva Portillo; Jon Torres-Unda; Ana Rodriguez-Larrad. Instrumented Crutch Tip for Monitoring Force and Crutch Pitch Angle. Sensors 2019, 19, 2944 .
AMA StyleIñigo Sesar, Asier Zubizarreta, Itziar Cabanes, Eva Portillo, Jon Torres-Unda, Ana Rodriguez-Larrad. Instrumented Crutch Tip for Monitoring Force and Crutch Pitch Angle. Sensors. 2019; 19 (13):2944.
Chicago/Turabian StyleIñigo Sesar; Asier Zubizarreta; Itziar Cabanes; Eva Portillo; Jon Torres-Unda; Ana Rodriguez-Larrad. 2019. "Instrumented Crutch Tip for Monitoring Force and Crutch Pitch Angle." Sensors 19, no. 13: 2944.
Frailty is a geriatric syndrome characterized by decreasing functional reserves and increasing vulnerability to falls, injuries and declining health, leading to dependence upon caregivers. Frailty is associated not only with physical decline, but also with cognitive and psychological impairments in aging people. Higher serum adiponectin concentration has been linked to better performance on frailty measures but also to worse cognitive status. Nonetheless, several studies have proposed adiponectin as a frailty biomarker. To further delineate the relationship between adiponectin serum levels and frailty-related parameters, we studied a population of 112 long-term nursing home residents (aged 84.9 ± 6.7) and analyzed their serum adiponectin levels in conjunction with frailty-related parameters including body composition, physical fitness, cognitive function, psychological parameters and quality of life. Frailty was assessed following the Fried Frailty Criteria, the Clinical Frailty Scale and the Tilburg Frailty Indicator. In women, higher serum adiponectin levels were associated with lower body weight, body mass index, body fat mass, fat mass/height2, lean mass, lean mass/height2 and smaller waist circumference and hip circumference (p < 0.05). In men, the association was positive (p < 0.05) between serum adiponectin and percentage of fat mass and negative between serum adiponectin and percentage of lean mass. Interestingly, in men, better cognitive function was inversely related to adiponectin (p < 0.05) while decreased anxiety was linked to a higher concentration of adiponectin in women (p < 0.05). According to the Tilburg Frailty Indicator, frail men had lower levels of adiponectin than those who were not frail (p < 0.05). Variables that predicted adiponectin concentration in multiple regression models were different for women and men. In women, lean mass and anxiety were independent negative predictors of blood adiponectin (β = −0.363, p = 0.002; β = −0.204, p = 0.067, respectively). In men, the Montreal Cognitive Assessment (MOCA) test was the only parameter to remain significant in the regression model (β = −439, p = 0.015). The results of our study show that adiponectin is linked to body composition, cognitive function and anxiety in long-term nursing home residents with differential relationships by sex. Further studies should be conducted to determine whether adiponectin is a valid and reliable frailty biomarker.
B. Sanz; H. Arrieta; G. Hervás; C. Rezola-Pardo; F. Ruiz-Litago; M. Iturburu; S.M. Gil; A. Rodríguez-Larrad; J. Irazusta. Serum adiponectin is associated with body composition and cognitive and psychological status in older adults living in long-term nursing homes. Experimental Gerontology 2019, 121, 1 -9.
AMA StyleB. Sanz, H. Arrieta, G. Hervás, C. Rezola-Pardo, F. Ruiz-Litago, M. Iturburu, S.M. Gil, A. Rodríguez-Larrad, J. Irazusta. Serum adiponectin is associated with body composition and cognitive and psychological status in older adults living in long-term nursing homes. Experimental Gerontology. 2019; 121 ():1-9.
Chicago/Turabian StyleB. Sanz; H. Arrieta; G. Hervás; C. Rezola-Pardo; F. Ruiz-Litago; M. Iturburu; S.M. Gil; A. Rodríguez-Larrad; J. Irazusta. 2019. "Serum adiponectin is associated with body composition and cognitive and psychological status in older adults living in long-term nursing homes." Experimental Gerontology 121, no. : 1-9.
The purpose of the Aging-ONDUAL-TASK study is to determine if a supervised dual-task program carried out in long-term nursing homes is able to attenuate frailty in a greater extent than the same multicomponent exercise program alone. This multicenter randomized controlled trial will include 188 participants who will be randomly allocated to either a multicomponent exercise program or to the same multicomponent program with simultaneous cognitive training (dual-task training). Inclusion criteria are as follows: ≥ 70 years, ≥ 50 on the Barthel Index, ≥ 20 on the Mini Examen Cognoscitivo (MEC-35) who are able to stand up and walk independently for 10 m. Subjects in the multicomponent group will attend a twice-a-week multicomponent exercise program of 1-h duration per session, consisting of strength and balance exercises. Participants in the dual-task group will perform the same multicomponent exercise program with concurrent individually tailored cognitive tasks. Study assessments will be conducted at baseline and at 3 months. The primary outcome measure will be gait speed under dual-task conditions and secondary outcomes will include physical fitness measurements, gait spatiotemporal parameters, cognition and emotional assessments, several frailty scales and objectively measured physical activity. The present research will add valuable information to the knowledge around the effects of the dual-task program in long-term nursing home residents, taking altogether physical, cognitive and emotional variables linked to frailty. Australian and New Zealand Clinical Trials Registry (ANZCTR) with the identifier: ACTRN12618000536268. Registration date: 11/04/2018.
Chloe Rezola-Pardo; Haritz Arrieta; Susana Maria Gil; Jose Javier Yanguas; Miren Iturburu; Jon Irazusta; Begoña Sanz; Ana Rodriguez-Larrad. A randomized controlled trial protocol to test the efficacy of a dual-task multicomponent exercise program in the attenuation of frailty in long-term nursing home residents: Aging-ONDUAL-TASK study. BMC Geriatrics 2019, 19, 1 -9.
AMA StyleChloe Rezola-Pardo, Haritz Arrieta, Susana Maria Gil, Jose Javier Yanguas, Miren Iturburu, Jon Irazusta, Begoña Sanz, Ana Rodriguez-Larrad. A randomized controlled trial protocol to test the efficacy of a dual-task multicomponent exercise program in the attenuation of frailty in long-term nursing home residents: Aging-ONDUAL-TASK study. BMC Geriatrics. 2019; 19 (1):1-9.
Chicago/Turabian StyleChloe Rezola-Pardo; Haritz Arrieta; Susana Maria Gil; Jose Javier Yanguas; Miren Iturburu; Jon Irazusta; Begoña Sanz; Ana Rodriguez-Larrad. 2019. "A randomized controlled trial protocol to test the efficacy of a dual-task multicomponent exercise program in the attenuation of frailty in long-term nursing home residents: Aging-ONDUAL-TASK study." BMC Geriatrics 19, no. 1: 1-9.
Background: Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. Objective: To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing home residents. We also aimed to ascertain the effect of an exercise program on myostatin levels. Methods: We obtained study data on 112 participants from long-term nursing homes. Participants were randomly assigned to a control or an intervention group and performed a 6-month multicomponent exercise program. Serum myostatin levels were analyzed by ELISA. Assessments also included body composition (anthropometry and bioelectrical impedance), physical fitness (Senior Fitness Test), physical activity level (accelerometry), and frailty (Fried frailty criteria, Clinical Frailty Scale, and Tilburg frailty indicator). Results: The concentration of myostatin at baseline was positively correlated with: a leaner body composition (p < 0.05), and a higher number of steps per day and light and moderate-vigorous physical activity in women (p < 0.005); greater upper and lower limb strength, endurance, and poorer flexibility (p < 0.05) in men; and better performance (less time) in the 8-ft timed up-and-go test in both women (p < 0.01) and men (p < 0.005). We observed higher concentrations of serum myostatin in non-frail than in frail participants (p < 0.05). Additionally, we found that the implemented physical exercise intervention, which was effective to improve physical fitness, increased myostatin concentration in men (p < 0.05) but not in women. The improvements in physical condition were related with increases in serum myostatin only in men (p < 0.05–0.01). Conclusions: Higher serum levels of myostatin were found to be associated with better physical fitness. The improvements in physical fitness after the intervention were positively related to increases in myostatin concentrations in men. These results seem to rule out the idea that high serum myostatin levels are indicative of frailty in long-term nursing home residents. However, although the direction of association was opposite to that expected for the function of myostatin, the use of this protein as a biomarker for physical fitness, rather than frailty, merits further study.
Haritz Arrieta; Gotzone Hervás; Chloe Rezola Pardo; Fátima Ruiz-Litago; Miren Iturburu; José Javier Yanguas; Susana María Gil; Ana Rodriguez-Larrad; Jon Irazusta. Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention. Gerontology 2018, 65, 229 -239.
AMA StyleHaritz Arrieta, Gotzone Hervás, Chloe Rezola Pardo, Fátima Ruiz-Litago, Miren Iturburu, José Javier Yanguas, Susana María Gil, Ana Rodriguez-Larrad, Jon Irazusta. Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention. Gerontology. 2018; 65 (3):229-239.
Chicago/Turabian StyleHaritz Arrieta; Gotzone Hervás; Chloe Rezola Pardo; Fátima Ruiz-Litago; Miren Iturburu; José Javier Yanguas; Susana María Gil; Ana Rodriguez-Larrad; Jon Irazusta. 2018. "Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention." Gerontology 65, no. 3: 229-239.
Little is known about the effects of detraining in older adults, particularly those who regularly exercise. To determine the consequences of 3 months of cessation of a habitual supervised exercise on functional fitness and quality of life in aged adults and to explore the associations among those parameters. Thirty-eight women and 11 men (mean age 75.5 ± 5.7 years) took part in a physical exercise program for 9 months, followed by a 3-month detraining period. Participants completed physical function tests and questionnaires regarding the quality of life and leisure-time physical activity at the end of the exercise program (baseline) and 3 months later (detraining). After the detraining period, performance in the 8 Foot Up and Go test (p < 0.001) and the physical and mental components of the quality of life (p < 0.001) declined. Significant correlations were observed when comparing the 8 Foot Up and Go test (p < 0.05), Chair Stand test (p < 0.05), and the 6-min Walk test (p < 0.001) to the physical component of the quality of life after the detraining period. Three months of a detraining period in older people who habitually undertake supervised activities is enough to produce a decline in dynamic balance and also quality of life. To avoid the deleterious effect of periods of cessation of supervised exercise, as a suggestion, specifically designed exercises could be prescribed for an older population, with emphasis on balance exercises.
Izaro Esain; Susana M. Gil; Iraia Bidaurrazaga-Letona; Ana Rodriguez-Larrad. Effects of 3 months of detraining on functional fitness and quality of life in older adults who regularly exercise. Aging Clinical and Experimental Research 2018, 31, 503 -510.
AMA StyleIzaro Esain, Susana M. Gil, Iraia Bidaurrazaga-Letona, Ana Rodriguez-Larrad. Effects of 3 months of detraining on functional fitness and quality of life in older adults who regularly exercise. Aging Clinical and Experimental Research. 2018; 31 (4):503-510.
Chicago/Turabian StyleIzaro Esain; Susana M. Gil; Iraia Bidaurrazaga-Letona; Ana Rodriguez-Larrad. 2018. "Effects of 3 months of detraining on functional fitness and quality of life in older adults who regularly exercise." Aging Clinical and Experimental Research 31, no. 4: 503-510.
Few studies have simultaneously examined changes in physical, cognitive and emotional performance throughout the aging process. Baseline data from an ongoing experimental randomized study were analyzed. Physical activity, handgrip, the Senior Fitness Test, Trail Making Test A, Rey Auditory-Verbal Learning Test, Quality of Life-Alzheimer's Disease Scale (QoL-AD) and the Goldberg Depression Scale were used to assess study participants. Logistic regression models were applied. ACTRN12616001044415 (04/08/2016). The study enrolled 114 participants with a mean age of 84.9 (standard deviation 6.9) years from ten different nursing homes. After adjusting for age, gender and education level, upper limb muscle strength was found to be associated with Rey Auditory-Verbal Learning Test [EXP(B): 1.16, 95% confidence interval (CI): 1.04-1.30] and QoL-AD [EXP(B): 1.18, 95% CI: 1.06-1.31]. Similarly, the number of steps taken per day was negatively associated with the risk of depression according to the Goldberg Depression Scale [EXP(B): 1.14, 95% CI: 1.000-1.003]. Additional analyses suggest that the factors associated with these variables are different according to the need for using an assistive device for walking. In those participants who used it, upper limb muscle strength remained associated with Rey Auditory-Verbal Learning Test [EXP(B): 1.21, 95% CI: 1.01-1.44] and QoL-AD tests [EXP(B): 1.19, 95% CI: 1.02-1.40]. In those individuals who did not need an assistive device for walking, lower limb muscle strength was associated with Rey Auditory-Verbal Learning Test [EXP(B): 1.35, 95% CI: 1.07-1.69], time spent in light physical activity was associated with QoL-AD test [EXP(B): 1.13, 95% CI: 1.00-1.02], and the number of steps walked per day was negatively associated with the risk of depression according to the Goldberg Depression Scale [EXP(B): 1.27, 95% CI: 1.000-1.004]. Muscle strength and physical activity are factors positively associated with a better performance on the Rey Auditory-Verbal Learning Test, QoL-AD and Goldberg Depression Scale in older adults with mild to moderate cognitive impairment living in nursing homes. These associations appeared to differ according to the use of an assistive device for walking. Our findings support the need for the implementation of interventions directed to increase the strength and physical activity of individuals living in nursing homes to promote physical, cognitive and emotional benefits. ACTRN12616001044415 (04/08/2016).
Haritz Arrieta; Chloe Rezola-Pardo; Iñaki Echeverría; Miren Iturburu; Susana María Gil; José Javier Yanguas; Jon Irazusta; Ana Rodriguez-Larrad. Physical activity and fitness are associated with verbal memory, quality of life and depression among nursing home residents: preliminary data of a randomized controlled trial. BMC Geriatrics 2018, 18, 80 .
AMA StyleHaritz Arrieta, Chloe Rezola-Pardo, Iñaki Echeverría, Miren Iturburu, Susana María Gil, José Javier Yanguas, Jon Irazusta, Ana Rodriguez-Larrad. Physical activity and fitness are associated with verbal memory, quality of life and depression among nursing home residents: preliminary data of a randomized controlled trial. BMC Geriatrics. 2018; 18 (1):80.
Chicago/Turabian StyleHaritz Arrieta; Chloe Rezola-Pardo; Iñaki Echeverría; Miren Iturburu; Susana María Gil; José Javier Yanguas; Jon Irazusta; Ana Rodriguez-Larrad. 2018. "Physical activity and fitness are associated with verbal memory, quality of life and depression among nursing home residents: preliminary data of a randomized controlled trial." BMC Geriatrics 18, no. 1: 80.
To investigate the impact of a multicomponent exercise program on anthropometry, physical function, and physical activity on older adults living in long-term nursing homes (LTNH), we conducted a randomized controlled trial involving 112 participants aged 84.9 ± 6.9 years. Participants were randomly assigned to an intervention (IG) or control group (CG). The IG participated in a 3-month multicomponent exercise intervention focused on strength, balance, stretching exercises, and walking recommendations. Subjects in the CG participated in routine activities. Analyses of outcome parameters were performed in the entire sample and in two subgroups, classified according to participants' physical function score at baseline. The group-by-time interaction, favoring the IG, was significant for the entire sample and for the participants in the low physical function subgroup for the following parameters: waist circumference, 30-s chair-stand, arm-curl, 8-ft timed up-and-go, SPPB score, gait speed, and Berg scale (p < .05). In participants with higher physical function at baseline, significant group-by-time interaction was observed in the SPPB score and Berg scale (p < .05). When differences were analyzed within groups, the IG maintained or improved in all assessed parameters, while participants in the CG showed a marked decline. Our study showed that a multicomponent exercise program is effective for older people living in LTNH. This is especially relevant in those with lower physical function scores. The lower efficacy of the program in participants with better function might be due to the insufficient exercise demands of our intervention for more fit residents. Future studies should analyze the effects of programs with higher intensities in older people with intermediate to high physical function.
Haritz Arrieta; Chloe Rezola-Pardo; Idoia Zarrazquin; Iñaki Echeverria; Jose Javier Yanguas; Miren Iturburu; Susana Maria Gil; Ana Rodriguez-Larrad; Jon Irazusta. A multicomponent exercise program improves physical function in long-term nursing home residents: A randomized controlled trial. Experimental Gerontology 2018, 103, 94 -100.
AMA StyleHaritz Arrieta, Chloe Rezola-Pardo, Idoia Zarrazquin, Iñaki Echeverria, Jose Javier Yanguas, Miren Iturburu, Susana Maria Gil, Ana Rodriguez-Larrad, Jon Irazusta. A multicomponent exercise program improves physical function in long-term nursing home residents: A randomized controlled trial. Experimental Gerontology. 2018; 103 ():94-100.
Chicago/Turabian StyleHaritz Arrieta; Chloe Rezola-Pardo; Idoia Zarrazquin; Iñaki Echeverria; Jose Javier Yanguas; Miren Iturburu; Susana Maria Gil; Ana Rodriguez-Larrad; Jon Irazusta. 2018. "A multicomponent exercise program improves physical function in long-term nursing home residents: A randomized controlled trial." Experimental Gerontology 103, no. : 94-100.