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Moustafa Moustafa
Department of Chemistry, Faculty of Science, Kuwait University, P.O. Box 12613, Safat,13060, Kuwait

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Journal article
Published: 16 July 2020 in Beilstein Journal of Organic Chemistry
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An efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamine derivatives was developed by reacting 5-amino-1,2,3,4-tetrazole with aromatic aldehydes and cyanamide in pyridine under controlled microwave heating with high yields. X-ray crystallography confirmed the structure of the obtained products.

ACS Style

Moustafa Sherief Moustafa; Ramadan Ahmed Mekheimer; Saleh Mohammed Al-Mousawi; Mohamed Abd-Elmonem; Hesham El-Zorba; Afaf Mohamed Abdel Hameed; Tahany Mahmoud Mohamed; Kamal Usef Sadek. Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines. Beilstein Journal of Organic Chemistry 2020, 16, 1706 -1712.

AMA Style

Moustafa Sherief Moustafa, Ramadan Ahmed Mekheimer, Saleh Mohammed Al-Mousawi, Mohamed Abd-Elmonem, Hesham El-Zorba, Afaf Mohamed Abdel Hameed, Tahany Mahmoud Mohamed, Kamal Usef Sadek. Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines. Beilstein Journal of Organic Chemistry. 2020; 16 (1):1706-1712.

Chicago/Turabian Style

Moustafa Sherief Moustafa; Ramadan Ahmed Mekheimer; Saleh Mohammed Al-Mousawi; Mohamed Abd-Elmonem; Hesham El-Zorba; Afaf Mohamed Abdel Hameed; Tahany Mahmoud Mohamed; Kamal Usef Sadek. 2020. "Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines." Beilstein Journal of Organic Chemistry 16, no. 1: 1706-1712.

Review
Published: 11 July 2020 in Toxins
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Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis mellifera L.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom’s observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.

ACS Style

Hesham El-Seedi; Aida Abd El-Wahed; Nermeen Yosri; Syed Ghulam Musharraf; Lei Chen; Moustafa Moustafa; Xiaobo Zou; Saleh Al-Mousawi; Zhiming Guo; Alfi Khatib; Shaden Khalifa. Antimicrobial Properties of Apis mellifera’s Bee Venom. Toxins 2020, 12, 451 .

AMA Style

Hesham El-Seedi, Aida Abd El-Wahed, Nermeen Yosri, Syed Ghulam Musharraf, Lei Chen, Moustafa Moustafa, Xiaobo Zou, Saleh Al-Mousawi, Zhiming Guo, Alfi Khatib, Shaden Khalifa. Antimicrobial Properties of Apis mellifera’s Bee Venom. Toxins. 2020; 12 (7):451.

Chicago/Turabian Style

Hesham El-Seedi; Aida Abd El-Wahed; Nermeen Yosri; Syed Ghulam Musharraf; Lei Chen; Moustafa Moustafa; Xiaobo Zou; Saleh Al-Mousawi; Zhiming Guo; Alfi Khatib; Shaden Khalifa. 2020. "Antimicrobial Properties of Apis mellifera’s Bee Venom." Toxins 12, no. 7: 451.

Preprint content
Published: 16 April 2020
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An efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamine derivatives was developed by reacting 5-amino-1,2,3,4-tetrazole with aromatic aldehydes and cyanamide in pyridine under controlled microwave heating with high yields. X-ray crystallography confirmed the structure of obtained products.

ACS Style

Moustafa Moustafa; Ramadan Mekheimer; Saleh Al-Mousawi; Mohamed Abd-Elmonem; Hesham El-Zorba; Afaf Abdel Hameed; Tahany Mohamed; Kamal Usef Sadek. Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-2,3-dihydro-1,3,5-triazine-2,4-diamines. 2020, 2020, 51 .

AMA Style

Moustafa Moustafa, Ramadan Mekheimer, Saleh Al-Mousawi, Mohamed Abd-Elmonem, Hesham El-Zorba, Afaf Abdel Hameed, Tahany Mohamed, Kamal Usef Sadek. Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-2,3-dihydro-1,3,5-triazine-2,4-diamines. . 2020; 2020 (1):51.

Chicago/Turabian Style

Moustafa Moustafa; Ramadan Mekheimer; Saleh Al-Mousawi; Mohamed Abd-Elmonem; Hesham El-Zorba; Afaf Abdel Hameed; Tahany Mohamed; Kamal Usef Sadek. 2020. "Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-2,3-dihydro-1,3,5-triazine-2,4-diamines." 2020, no. 1: 51.

Review
Published: 23 August 2019 in Marine Drugs
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Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

ACS Style

Shaden A. M. Khalifa; Nizar Elias; Mohamed A. Farag; Lei Chen; Aamer Saeed; Mohamed-Elamir F. Hegazy; Moustafa S. Moustafa; Aida Abd El-Wahed; Saleh M. Al-Mousawi; Syed G. Musharraf; Fang-Rong Chang; Arihiro Iwasaki; Kiyotake Suenaga; Muaaz Alajlani; Ulf Göransson; Hesham R. El-Seedi. Marine Natural Products: A Source of Novel Anticancer Drugs. Marine Drugs 2019, 17, 491 .

AMA Style

Shaden A. M. Khalifa, Nizar Elias, Mohamed A. Farag, Lei Chen, Aamer Saeed, Mohamed-Elamir F. Hegazy, Moustafa S. Moustafa, Aida Abd El-Wahed, Saleh M. Al-Mousawi, Syed G. Musharraf, Fang-Rong Chang, Arihiro Iwasaki, Kiyotake Suenaga, Muaaz Alajlani, Ulf Göransson, Hesham R. El-Seedi. Marine Natural Products: A Source of Novel Anticancer Drugs. Marine Drugs. 2019; 17 (9):491.

Chicago/Turabian Style

Shaden A. M. Khalifa; Nizar Elias; Mohamed A. Farag; Lei Chen; Aamer Saeed; Mohamed-Elamir F. Hegazy; Moustafa S. Moustafa; Aida Abd El-Wahed; Saleh M. Al-Mousawi; Syed G. Musharraf; Fang-Rong Chang; Arihiro Iwasaki; Kiyotake Suenaga; Muaaz Alajlani; Ulf Göransson; Hesham R. El-Seedi. 2019. "Marine Natural Products: A Source of Novel Anticancer Drugs." Marine Drugs 17, no. 9: 491.

Journal article
Published: 27 December 2012 in Molecules
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Reaction of enaminones 1a–d with 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2) in the presence of AcOH/NH4OAc afforded 7-amino-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbonitrile derivatives 9a–d. On the other hand, 2-aminopyrano[4,3,2-de] [1,6]naphthyridine-3-carbonitriles 20a–c,e were the only obtained products from the reactions of 1a–d with 2 in the presence of AcOH/NaOAc, while 1d afforded [3,5-bis-(4-chloro-benzoyl)-phenyl]-(4-chloro-phenyl)-methanone 21 under the same condition. The reaction of 2 with diethyl acetylenedicarboxylate in the presence of AcOH/NH4OAc afforded (4-cyano-5-dicyanomethylene-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-acetic acid ethyl ester 15B.

ACS Style

Moustafa Sherief Moustafa; Saleh Mohammed Al-Mousawi; Noha Mohamed Hilmy; Yehia A. Ibrahim; Johannes C. Liermann; Herbert Meier; Mohamed Hilmy Elnagdi. Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines. Molecules 2012, 18, 276 -286.

AMA Style

Moustafa Sherief Moustafa, Saleh Mohammed Al-Mousawi, Noha Mohamed Hilmy, Yehia A. Ibrahim, Johannes C. Liermann, Herbert Meier, Mohamed Hilmy Elnagdi. Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines. Molecules. 2012; 18 (1):276-286.

Chicago/Turabian Style

Moustafa Sherief Moustafa; Saleh Mohammed Al-Mousawi; Noha Mohamed Hilmy; Yehia A. Ibrahim; Johannes C. Liermann; Herbert Meier; Mohamed Hilmy Elnagdi. 2012. "Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines." Molecules 18, no. 1: 276-286.

Journal article
Published: 18 May 2012 in Molecules
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The reaction of 3-oxo-3-phenyl-2-phenylhydrazonal with functionally substituted and heteroaromatic substituted acetonitrile to yield arylazonicotinic acid derivatives and 5-arylsubstituted pyridines was established. In some cases the produced nicotinates could not be isolated as they underwent thermally induced 6π-electrocyclization yielding polynuclear pyridine derivatives.

ACS Style

Omniya Sayed Zaky; Moustafa Sherief Moustafa; Maghraby Ali Selim; Awatef Mohamed El-Maghraby; Mohamed Hilmy Elnagdi. Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates. Molecules 2012, 17, 5924 -5934.

AMA Style

Omniya Sayed Zaky, Moustafa Sherief Moustafa, Maghraby Ali Selim, Awatef Mohamed El-Maghraby, Mohamed Hilmy Elnagdi. Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates. Molecules. 2012; 17 (5):5924-5934.

Chicago/Turabian Style

Omniya Sayed Zaky; Moustafa Sherief Moustafa; Maghraby Ali Selim; Awatef Mohamed El-Maghraby; Mohamed Hilmy Elnagdi. 2012. "Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates." Molecules 17, no. 5: 5924-5934.

Journal article
Published: 04 January 2012 in Beilstein Journal of Organic Chemistry
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The multicomponent reaction of 5-aminopyrazole derivatives with cyclic 1,3-dicarbonyl compounds and dimethylformamide dimethylacetal (DMFDMA) in DMF at 150 °C under controlled microwave heating afforded regioselectively 8,9-dihydropyrazolo[1,5-a]quinazolin-6(7H)-ones 6 rather than the corresponding dihydropyrazolo[5,1-b]quinazolin-8(5H)-ones 4.

ACS Style

Kamal Usef Sadek; Ramadan Ahmed Mekheimer; Tahany Mahmoud Mohamed; Moustafa Sherief Moustafa; Mohamed Hilmy Elnagdi. Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating. Beilstein Journal of Organic Chemistry 2012, 8, 18 -24.

AMA Style

Kamal Usef Sadek, Ramadan Ahmed Mekheimer, Tahany Mahmoud Mohamed, Moustafa Sherief Moustafa, Mohamed Hilmy Elnagdi. Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating. Beilstein Journal of Organic Chemistry. 2012; 8 (1):18-24.

Chicago/Turabian Style

Kamal Usef Sadek; Ramadan Ahmed Mekheimer; Tahany Mahmoud Mohamed; Moustafa Sherief Moustafa; Mohamed Hilmy Elnagdi. 2012. "Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating." Beilstein Journal of Organic Chemistry 8, no. 1: 18-24.

Journal article
Published: 13 March 2007 in Beilstein Journal of Organic Chemistry
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2-Arylhydrazononitriles as building blocks in heterocyclic synthesis: A novel route to 2-substituted-1,2,3-triazoles and 1,2,3-triazolo[4,5-b]pyridines

ACS Style

Saleh M. Al-Mousawi; Moustafa Sh. Moustafa. 2-Arylhydrazononitriles as building blocks in heterocyclic synthesis: A novel route to 2-substituted-1,2,3-triazoles and 1,2,3-triazolo[4,5-b]pyridines. Beilstein Journal of Organic Chemistry 2007, 3, 12 -12.

AMA Style

Saleh M. Al-Mousawi, Moustafa Sh. Moustafa. 2-Arylhydrazononitriles as building blocks in heterocyclic synthesis: A novel route to 2-substituted-1,2,3-triazoles and 1,2,3-triazolo[4,5-b]pyridines. Beilstein Journal of Organic Chemistry. 2007; 3 (1):12-12.

Chicago/Turabian Style

Saleh M. Al-Mousawi; Moustafa Sh. Moustafa. 2007. "2-Arylhydrazononitriles as building blocks in heterocyclic synthesis: A novel route to 2-substituted-1,2,3-triazoles and 1,2,3-triazolo[4,5-b]pyridines." Beilstein Journal of Organic Chemistry 3, no. 1: 12-12.