This page has only limited features, please log in for full access.
The presented study showed the relationship between dopamine receptor gene polymorphism and personality traits in athletes training in martial arts. Behavioral modulation resulting from a balance of the neurotransmitters dopamine and norepinephrine to inactivation of the dorsolateral prefrontal cortex and dysregulation of various pathways involved in attention and impulse control processes; Methods: The study was conducted among martial arts athletes. The study group included 258 volunteers and 284 controls. The genetic test was performed using the real-time PCR method; psychological tests were performed using standardized TCI questionnaires. All analyses were performed using STATISTICA 13. Results: Interaction between martial arts and DRD2 rs1799732 (manual) G/-(VIC/FAM)-ins/del and RD- Harm avoidance and Reward Dependence scale were demonstrated. In athletes, a lower Reward Dependence scale score was associated with the DRD2 rs1799732 (manual)-/-polymorphism compared to the control group. Conclusions: It seems justified to study not only genetic aspects related to brain transmission dopamine in martial arts athletes. In the studied athletes, the features related to reward addiction and harm avoidance are particularly important in connection with the dopaminergic reward system in the brain.
Krzysztof Chmielowiec; Monika Michałowska-Sawczyn; Jolanta Masiak; Jolanta Chmielowiec; Grzegorz Trybek; Marta Niewczas; Wojciech Czarny; Paweł Cieszczyk; Myosotis Massidda; Patrizia Proia; Anna Grzywacz. Analysis of DRD2 Gene Polymorphism in the Context of Personality Traits in a Group of Athletes. Genes 2021, 12, 1219 .
AMA StyleKrzysztof Chmielowiec, Monika Michałowska-Sawczyn, Jolanta Masiak, Jolanta Chmielowiec, Grzegorz Trybek, Marta Niewczas, Wojciech Czarny, Paweł Cieszczyk, Myosotis Massidda, Patrizia Proia, Anna Grzywacz. Analysis of DRD2 Gene Polymorphism in the Context of Personality Traits in a Group of Athletes. Genes. 2021; 12 (8):1219.
Chicago/Turabian StyleKrzysztof Chmielowiec; Monika Michałowska-Sawczyn; Jolanta Masiak; Jolanta Chmielowiec; Grzegorz Trybek; Marta Niewczas; Wojciech Czarny; Paweł Cieszczyk; Myosotis Massidda; Patrizia Proia; Anna Grzywacz. 2021. "Analysis of DRD2 Gene Polymorphism in the Context of Personality Traits in a Group of Athletes." Genes 12, no. 8: 1219.
Neuroblastoma (NB) is a common malignant solid tumor in children and accounts for 15% of childhood cancer mortality. Amplification of the N-Myc oncogene is a well-established poor prognostic marker in NB patients and strongly correlates with higher tumor aggression and resistance to treatment. New therapies for patients with N-Myc-amplified NB need to be developed. After treating NB cells with BSAO/SPM, the detection of apoptosis was determined after annexin V-FITC labeling and DNA staining with propidium iodide. The mitochondrial membrane potential activity was checked, labeling cells with the probe JC-1 dye. We analyzed, by real-time RT-PCR, the transcript of genes involved in the apoptotic process, to determine possible down- or upregulation of mRNAs after the treatment on SJNKP and the N-Myc-amplified IMR5 cell lines with BSAO/SPM. The experiments were carried out considering the proapoptotic genes Tp53 and caspase-3. After treatment with BSAO/SPM, both cell lines displayed increased mRNA levels for all these proapoptotic genes. Western blotting analysis with PARP and caspase-3 antibody support that BSAO/SPM treatment induces high levels of apoptosis in cells. The major conclusion is that BSAO/SPM treatment leads to antiproliferative and cytotoxic activity of both NB cell lines, associated with activation of apoptosis.
Yuta Kanamori; Alessia Finotti; Laura Magno; Gianluca Canettieri; Tomoaki Tahara; Fabio Timeus; Antonio Greco; Paola Tirassa; Jessica Gasparello; Pasquale Fino; Carlo Di Liegro; Patrizia Proia; Gabriella Schiera; Italia Di Liegro; Roberto Gambari; Enzo Agostinelli. Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5. Cells 2021, 10, 1950 .
AMA StyleYuta Kanamori, Alessia Finotti, Laura Magno, Gianluca Canettieri, Tomoaki Tahara, Fabio Timeus, Antonio Greco, Paola Tirassa, Jessica Gasparello, Pasquale Fino, Carlo Di Liegro, Patrizia Proia, Gabriella Schiera, Italia Di Liegro, Roberto Gambari, Enzo Agostinelli. Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5. Cells. 2021; 10 (8):1950.
Chicago/Turabian StyleYuta Kanamori; Alessia Finotti; Laura Magno; Gianluca Canettieri; Tomoaki Tahara; Fabio Timeus; Antonio Greco; Paola Tirassa; Jessica Gasparello; Pasquale Fino; Carlo Di Liegro; Patrizia Proia; Gabriella Schiera; Italia Di Liegro; Roberto Gambari; Enzo Agostinelli. 2021. "Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5." Cells 10, no. 8: 1950.
Even though scientific literature shows numerous heath complications and performance decrements associated with rapid weight loss (RWL), its prevalence remains exceedingly high across various combat sports. The aim of this study was to thoroughly search the existing literature to explore the influence of RWL on kidney function in Olympic and non-Olympic combat sport athletes. PubMed and Web of Science were searched for the relevant studies. Only original articles published from 2005 onwards, written in English, that included healthy males and females who prompted ~5% weight loss within a week or less, were included in the study. Retrieved studies showed that creatinine, blood urea nitrogen and urine specific gravity values were significantly increased after RWL in the majority of the included studies. This observation indicates that RWL caused dehydration and subsequent acute kidney damage despite various degrees of weight lost during the RWL phase, which can lead to adverse events in other body systems. Alternative methods of weight reduction that prioritize athletes’ health should be considered.
Nemanja Lakicevic; Antonio Paoli; Roberto Roklicer; Tatjana Trivic; Darinka Korovljev; Sergej Ostojic; Patrizia Proia; Antonino Bianco; Patrik Drid. Effects of Rapid Weight Loss on Kidney Function in Combat Sport Athletes. Medicina 2021, 57, 551 .
AMA StyleNemanja Lakicevic, Antonio Paoli, Roberto Roklicer, Tatjana Trivic, Darinka Korovljev, Sergej Ostojic, Patrizia Proia, Antonino Bianco, Patrik Drid. Effects of Rapid Weight Loss on Kidney Function in Combat Sport Athletes. Medicina. 2021; 57 (6):551.
Chicago/Turabian StyleNemanja Lakicevic; Antonio Paoli; Roberto Roklicer; Tatjana Trivic; Darinka Korovljev; Sergej Ostojic; Patrizia Proia; Antonino Bianco; Patrik Drid. 2021. "Effects of Rapid Weight Loss on Kidney Function in Combat Sport Athletes." Medicina 57, no. 6: 551.
The beneficial effects of physical activity on body image perception and bone are debated among artistic gymnasts. Gymnasts seem to be at greater risk of developing body dissatisfaction, eating disorders and osteoporosis due to inadequate nutrition and attention to the appearance of the body. The objective of this work was to investigate the association between the artistic gymnast and a more favorable body image compared to their sedentary peers and if a preworkout high-carbohydrate meal (HCM; 300 kcal, 88% carbohydrates, 9% protein, 3% fat) or high-protein meal (HPM; 300 kcal, 55% carbohydrates, 31% protein, 13% fat) is able to attenuate bone resorption in young rhythmic gymnasts. Twenty-eight preadolescent female gymnasts were examined. Self-esteem tests were used to analyze body image perception. Preworkout eating habits were examined by short food frequency questions (FFQ) validated for children. The biomarker of the bone resorption C-terminal telopeptide region of collagen type 1 (CTX) was measured in the urine (fasting, postmeal and postworkout). Gymnasts reported higher satisfaction with their body appearance compared to sedentary peers. Of the gymnasts, 30% did not have a preworkout meal regularly, and the timing of the consumption was variable. Bone resorption was decreased by the HCM, consumed 90 min before the training, with respect to the HPM. The study suggests that playing artistic gymnastics is associated with a positive body self-perception in a child. The variability in preworkout meal frequency and timing need attention to prevent inadequate eating habits in light of the ability of the HCM to reduce acute bone resorption.
Alessandra Amato; Patrizia Proia; Gaetano Caldara; Angelina Alongi; Vincenzo Ferrantelli; Sara Baldassano. Analysis of Body Perception, Preworkout Meal Habits and Bone Resorption in Child Gymnasts. International Journal of Environmental Research and Public Health 2021, 18, 2184 .
AMA StyleAlessandra Amato, Patrizia Proia, Gaetano Caldara, Angelina Alongi, Vincenzo Ferrantelli, Sara Baldassano. Analysis of Body Perception, Preworkout Meal Habits and Bone Resorption in Child Gymnasts. International Journal of Environmental Research and Public Health. 2021; 18 (4):2184.
Chicago/Turabian StyleAlessandra Amato; Patrizia Proia; Gaetano Caldara; Angelina Alongi; Vincenzo Ferrantelli; Sara Baldassano. 2021. "Analysis of Body Perception, Preworkout Meal Habits and Bone Resorption in Child Gymnasts." International Journal of Environmental Research and Public Health 18, no. 4: 2184.
The aims of this paper was to determine the effect of self-myofascial release (SMFR) on postural stability and to analyze if it can influence migraine condition. Twenty-five subjects (age 49.7± 12.5) affected by migraine were enrolled. Assessments included a stabilometric analysis in order to evaluate balance and plantar support, with eyes open (OE) and closed (CE); cervical ROM measurement; evaluation of upper limb strength through handgrip. All the analysis were carried out before and after the administration of a single SMFR protocol, using medium density small balls laid in the three most painful trigger points in migraine patients: trapezius, sternocleidomastoids and suboccipital muscles. Performing a T test for paired samples, there was a significant increase in two ranges of the stabilometric analysis: ellipse surface, both with open and closed eyes (p value EO = 0.05; p value EC = 0.04) and length of the sway path, but just with closed eyes (p value = 0.05). SMFR might have a positive impact on postural stability in subjects with migraine. Further investigation should be conducted to confirm the hypothesis.
Alessandra Amato; Giuseppe Messina; Valerio Giustino; Jessica Brusa; Filippo Brighina; Patrizia Proia. A pilot study on non-invasive treatment of migraine: The self-myofascial release. European Journal of Translational Myology 2021, 31, 1 .
AMA StyleAlessandra Amato, Giuseppe Messina, Valerio Giustino, Jessica Brusa, Filippo Brighina, Patrizia Proia. A pilot study on non-invasive treatment of migraine: The self-myofascial release. European Journal of Translational Myology. 2021; 31 (1):1.
Chicago/Turabian StyleAlessandra Amato; Giuseppe Messina; Valerio Giustino; Jessica Brusa; Filippo Brighina; Patrizia Proia. 2021. "A pilot study on non-invasive treatment of migraine: The self-myofascial release." European Journal of Translational Myology 31, no. 1: 1.
The aims of this paper was to determine the effect of self-myofascial release (SMFR) on postural stability and to analyze if it can influence migraine condition. Twenty-five subjects (age 49.7± 12.5) affected by migraine were enrolled. Assessments included a stabilometric analysis in order to evaluate balance and plantar support, with eyes open (OE) and closed (CE); cervical ROM measurement; evaluation of upper limb strength through handgrip. All the analysis were carried out before and after the administration of a single SMFR protocol, using medium density small balls laid in the three most painful trigger points in migraine patients: trapezius, sternocleidomastoids and suboccipital muscles. Performing a T test for paired samples, there was a significant increase in two ranges of the stabilometric analysis: ellipse surface, both with open and closed eyes (p value EO = 0.05; p value EC = 0.04) and length of the sway path, but just with closed eyes (p value = 0.05). SMFR might have a positive impact on postural stability in subjects with migraine. Further investigation should be conducted to confirm the hypothesis.
Alessandra Amato; Giuseppe Messina; Valerio Giustino; Jessica Brusa; Filippo Brighina; Patrizia Proia. A pilot study on non-invasive treatment of migraine: The self-myofascial release. European Journal of Translational Myology 2021, 1 .
AMA StyleAlessandra Amato, Giuseppe Messina, Valerio Giustino, Jessica Brusa, Filippo Brighina, Patrizia Proia. A pilot study on non-invasive treatment of migraine: The self-myofascial release. European Journal of Translational Myology. 2021; ():1.
Chicago/Turabian StyleAlessandra Amato; Giuseppe Messina; Valerio Giustino; Jessica Brusa; Filippo Brighina; Patrizia Proia. 2021. "A pilot study on non-invasive treatment of migraine: The self-myofascial release." European Journal of Translational Myology , no. : 1.
The purpose of this study was to investigate the intensity of SuperJump® workout as a home-based activity for fulfilling physical activity recommendations during COVID-19 home-confinement. Seventeen (males: n = 10; females: n = 7) college students (age: 25.8 ± 2.7 years; height: 1.7 ± 0.1 m; weight: 66.2 ± 12.1 kg) participated in the study. To assess the intensity of the activity (30-min), heart rate (HR), expressed as percentages of age-predicted maximal HR (%HRmax), and session ratings of perceived exertion (sRPE), collected on a CR10 scale, were used. %HRmax data were categorically separated in five classes of intensity according to the American College of Sport Science’s guidelines. Enjoyment was evaluated using the Physical Activity Enjoyment Scale (PACES). Repeated measures ANOVA was used to evaluate differences (p < 0.05) in relation to gender and exercise intensity. No gender difference emerged for %HRmax and sRPE. Significantly higher (p < 0.05) %HRmax were found for the moderate intensity (47.1 ± 34.4%) with respect to very light (3.6 ± 6.9%), light (14.5 ± 23.3%) and vigorous (34.6 ± 39.6%) and for the vigorous intensity with respect to very light; no near maximal to maximal values were observed. Subjects perceived SuperJump® as moderate (sRPE = 3.1 ± 1.2) while showing high levels of enjoyability (PACES = 86.6 ± 16.2%). SuperJump® can be classified as moderate-to-vigorous activity, representing an effective alternative and enjoyable home-based activity for preventing the effects of a sedentary lifestyle during home-confinement.
Alice Iannaccone; Andrea Fusco; Salvador Jaime; Sara Baldassano; Jill Cooper; Patrizia Proia; Cristina Cortis. Stay Home, Stay Active with SuperJump®: A Home-Based Activity to Prevent Sedentary Lifestyle during COVID-19 Outbreak. Sustainability 2020, 12, 10135 .
AMA StyleAlice Iannaccone, Andrea Fusco, Salvador Jaime, Sara Baldassano, Jill Cooper, Patrizia Proia, Cristina Cortis. Stay Home, Stay Active with SuperJump®: A Home-Based Activity to Prevent Sedentary Lifestyle during COVID-19 Outbreak. Sustainability. 2020; 12 (23):10135.
Chicago/Turabian StyleAlice Iannaccone; Andrea Fusco; Salvador Jaime; Sara Baldassano; Jill Cooper; Patrizia Proia; Cristina Cortis. 2020. "Stay Home, Stay Active with SuperJump®: A Home-Based Activity to Prevent Sedentary Lifestyle during COVID-19 Outbreak." Sustainability 12, no. 23: 10135.
Tumorigenesis is a multiphasic process in which genetic alterations guide the progressive transformation in cancer cells1. In order to evaluate the possible correlation between some gene variants and the risk of the toxicity development onset, two of the polymorphisms of the thymidylate synthase (TYMS), rs34743033 (2R/3R) and rs16430 (DEL/INS) were investigated. We enrolled in our study 47 patients from the Hospital of Sicily. Our preliminary findings suggest that there could be a linkage between the genotypes discussed and the development of the toxicity following the chemotherapy treatment. These results need to be confirmed by further studies, however this short paper offers some initial insight into the relationships between genetic background and the better outcome for patients.
Stefano Vitello; Italia Di Liegro; Maria Rita Ricciardi; Chiara Verga; Alessandra Amato; Gabriella Schiera; Carlo Di Liegro; Giuseppe Messina; Patrizia Proia. Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine. European Journal of Translational Myology 2020, 30, 8970 .
AMA StyleStefano Vitello, Italia Di Liegro, Maria Rita Ricciardi, Chiara Verga, Alessandra Amato, Gabriella Schiera, Carlo Di Liegro, Giuseppe Messina, Patrizia Proia. Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine. European Journal of Translational Myology. 2020; 30 (3):8970.
Chicago/Turabian StyleStefano Vitello; Italia Di Liegro; Maria Rita Ricciardi; Chiara Verga; Alessandra Amato; Gabriella Schiera; Carlo Di Liegro; Giuseppe Messina; Patrizia Proia. 2020. "Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine." European Journal of Translational Myology 30, no. 3: 8970.
Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution. However, only recently the health consequences of a sedentary lifestyle, and of highly energetic diets, are becoming clear. It has been also acknowledged that lifestyle and diet can induce epigenetic modifications which modify chromatin structure and gene expression, thus causing even heritable metabolic outcomes. Many studies have shown that PA can reverse at least some of the unwanted effects of sedentary lifestyle, and can also contribute in delaying brain aging and degenerative pathologies such as Alzheimer’s Disease, diabetes, and multiple sclerosis. Most importantly, PA improves cognitive processes and memory, has analgesic and antidepressant effects, and even induces a sense of wellbeing, giving strength to the ancient principle of “mens sana in corpore sano” (i.e., a sound mind in a sound body). In this review we will discuss the potential mechanisms underlying the effects of PA on brain health, focusing on hormones, neurotrophins, and neurotransmitters, the release of which is modulated by PA, as well as on the intra- and extra-cellular pathways that regulate the expression of some of the genes involved.
Di Liegro; Gabriella Schiera; Patrizia Proia; Carlo Maria Di Liegro; Italia Di Liegro. Physical Activity and Brain Health. Genes 2019, 10, 720 .
AMA StyleDi Liegro, Gabriella Schiera, Patrizia Proia, Carlo Maria Di Liegro, Italia Di Liegro. Physical Activity and Brain Health. Genes. 2019; 10 (9):720.
Chicago/Turabian StyleDi Liegro; Gabriella Schiera; Patrizia Proia; Carlo Maria Di Liegro; Italia Di Liegro. 2019. "Physical Activity and Brain Health." Genes 10, no. 9: 720.
The aim of this study was to determine the blood lactate levels in healthy and pathological subjects, particularly with migraine and fibromyalgia. Moreover we investigated the possible correlation between lactate concentration, postural stability and balance disorders; the composition of the groups were: migraine (n = 25; age 49.7 ± 12.5), fibromyalgia (n = 10; age 43.7 ± 21.2), control group (n = 16 age 28.52 ± 2.4). The results showed that patients with fibromyalgia (FG) had higher lactate levels compared to migraine (MG) and control group (CG) (mean ± sd: FG = 1.78 ± 0.9 mmol/L; MG = 1.45±1 mmol/L; CG = 0,85 ± 0,07 mmol/L). The same situation was highlighted about the sway path length with eyes closed (FG = 518 ± 195 mm; MG = 465 ± 165 mm; CG = 405 ± 94,72 mm) and with eyes open (FG = 430 ± 220 mm; MG = 411 ± 143 mm; CG = 389 ± 107 mm). This can be explained by the fact that energy-intensive postural strategies must be used to optimize both static and dynamic coordination, in particular with repeated contractions of tonic oxidative muscle cells responsible for postural control.
Patrizia Proia; Alessandra Amato; Valentina Contrò; Alessandra Lo Monaco; Jessica Brusa; Filippo Brighina; Giuseppe Messina. Relevance of lactate level detection in migrane and fibromyalgia. European Journal of Translational Myology 2019, 29, 8202 .
AMA StylePatrizia Proia, Alessandra Amato, Valentina Contrò, Alessandra Lo Monaco, Jessica Brusa, Filippo Brighina, Giuseppe Messina. Relevance of lactate level detection in migrane and fibromyalgia. European Journal of Translational Myology. 2019; 29 (2):8202.
Chicago/Turabian StylePatrizia Proia; Alessandra Amato; Valentina Contrò; Alessandra Lo Monaco; Jessica Brusa; Filippo Brighina; Giuseppe Messina. 2019. "Relevance of lactate level detection in migrane and fibromyalgia." European Journal of Translational Myology 29, no. 2: 8202.
Patrizia Proia; Alessandra Amato; Rosalia Puleo; Francesco Arnetta; Federica Rizzo; Licia Di Grigoli; Daniele Zangla; Giuseppe Schirò; Paolo Ragonese; Giuseppe Messina. Efficacy of 12 weeks of proprioceptive training in patients with multiple sclerosis. Journal of Human Sport and Exercise - 2019 - Summer Conferences of Sports Science 2019, 1 .
AMA StylePatrizia Proia, Alessandra Amato, Rosalia Puleo, Francesco Arnetta, Federica Rizzo, Licia Di Grigoli, Daniele Zangla, Giuseppe Schirò, Paolo Ragonese, Giuseppe Messina. Efficacy of 12 weeks of proprioceptive training in patients with multiple sclerosis. Journal of Human Sport and Exercise - 2019 - Summer Conferences of Sports Science. 2019; ():1.
Chicago/Turabian StylePatrizia Proia; Alessandra Amato; Rosalia Puleo; Francesco Arnetta; Federica Rizzo; Licia Di Grigoli; Daniele Zangla; Giuseppe Schirò; Paolo Ragonese; Giuseppe Messina. 2019. "Efficacy of 12 weeks of proprioceptive training in patients with multiple sclerosis." Journal of Human Sport and Exercise - 2019 - Summer Conferences of Sports Science , no. : 1.
Giuseppe Messina; Alessandra Amato; Filippo Brighina; Alessandra Lo Monaco; Valerio Giustino; Jessica Brusa; Angelo Iovane; Patrizia Proia. Lactate level and handgrip test in migraine and fibromyalgia after self-myofascial release treatment. Journal of Human Sport and Exercise - 2019 - Summer Conferences of Sports Science 2019, 1 .
AMA StyleGiuseppe Messina, Alessandra Amato, Filippo Brighina, Alessandra Lo Monaco, Valerio Giustino, Jessica Brusa, Angelo Iovane, Patrizia Proia. Lactate level and handgrip test in migraine and fibromyalgia after self-myofascial release treatment. Journal of Human Sport and Exercise - 2019 - Summer Conferences of Sports Science. 2019; ():1.
Chicago/Turabian StyleGiuseppe Messina; Alessandra Amato; Filippo Brighina; Alessandra Lo Monaco; Valerio Giustino; Jessica Brusa; Angelo Iovane; Patrizia Proia. 2019. "Lactate level and handgrip test in migraine and fibromyalgia after self-myofascial release treatment." Journal of Human Sport and Exercise - 2019 - Summer Conferences of Sports Science , no. : 1.
The aim of this study was to investigate the association between the MCT1 (monocarboxylate transporter 1) A1470T polymorphism and positional roles in a large cohort of professional football players from five different countries. We compared genotype distributions of the MCT1 A1470T polymorphism between football players (n=694) and non-athlete controls (n=781) from Italy, Poland, Lithuania, Ukraine and Malta, and we analyzed the MCT1 genotype distributions with respect to the players’ positions in the field (e. g. forwards, midfielders, defenders and goalkeepers). Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. In the pooled cohort of Italian, Polish, Lithuanian and Ukrainian football players, forwards (n=148) were more likely than controls (n=781) to possess the A allele (χ2=7.067, p=0.029, FDR q value 0.116), with a greater likelihood of having the AA genotype compared with the TT genotype (OR=1.97; C.I.=1.07-3.64; p=0.021, FDR q value 0.086). The MCT1 AA genotype was significantly more frequent in forwards then in controls. Further studies are needed to confirm these findings in other professional football player cohorts.
Paweł Cięszczyk; Carla Maria Calò; Myosotis Massidda; Alberto Mendez-Villanueva; Valentina Ginevičienė; Patrizia Proia; Svitlana B. Drozdovska; Victor Dosenko; Marco Scorcu; Aleksander Stula; Marek Sawczuk. Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status. International Journal of Sports Medicine 2018, 39, 1028 -1034.
AMA StylePaweł Cięszczyk, Carla Maria Calò, Myosotis Massidda, Alberto Mendez-Villanueva, Valentina Ginevičienė, Patrizia Proia, Svitlana B. Drozdovska, Victor Dosenko, Marco Scorcu, Aleksander Stula, Marek Sawczuk. Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status. International Journal of Sports Medicine. 2018; 39 (13):1028-1034.
Chicago/Turabian StylePaweł Cięszczyk; Carla Maria Calò; Myosotis Massidda; Alberto Mendez-Villanueva; Valentina Ginevičienė; Patrizia Proia; Svitlana B. Drozdovska; Victor Dosenko; Marco Scorcu; Aleksander Stula; Marek Sawczuk. 2018. "Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status." International Journal of Sports Medicine 39, no. 13: 1028-1034.
The purpose of this study was to determine the probability of soccer players having the best genetic background that could increase performance, evaluating the polymorphism that are considered Performance Enhancing Polymorphism (PEPs) distributed on five genes: PPARα, PPARGC1A, NRF2, ACE e CKMM. Particularly, we investigated how each polymorphism works directly or through another polymorphism to distinguish elite athletes from non-athletic population. Sixty professional soccer players (age 22.5 ± 2.2) and sixty healthy volunteers (age 21.2± 2.3) were enrolled. Samples of venous blood was used to prepare genomic DNA. The polymorphic sites were scanned using PCR-RFLP protocols with different enzyme. We used a multivariate logistic regression analysis to demonstrate an association between the five PEPs and elite phenotype. We found statistical significance in NRF2 (AG/GG genotype) polymorphism/soccer players association (p
Valentina Contrò; Gabriella Schiera; Antonino Abbruzzo; Antonino Bianco; Alessandra Amato; Alessia Sacco; Alessandra Macchiarella; Antonio Palma; Patrizia Proia. An innovative way to highlight the power of each polymorphism on elite athletes phenotype expression. European Journal of Translational Myology 2018, 28, 7186 .
AMA StyleValentina Contrò, Gabriella Schiera, Antonino Abbruzzo, Antonino Bianco, Alessandra Amato, Alessia Sacco, Alessandra Macchiarella, Antonio Palma, Patrizia Proia. An innovative way to highlight the power of each polymorphism on elite athletes phenotype expression. European Journal of Translational Myology. 2018; 28 (1):7186.
Chicago/Turabian StyleValentina Contrò; Gabriella Schiera; Antonino Abbruzzo; Antonino Bianco; Alessandra Amato; Alessia Sacco; Alessandra Macchiarella; Antonio Palma; Patrizia Proia. 2018. "An innovative way to highlight the power of each polymorphism on elite athletes phenotype expression." European Journal of Translational Myology 28, no. 1: 7186.
Benefits of exercise are known for a long time, but mechanisms underlying the exercise mode recommendations for specific chronic cardiovascular diseases remain unclear. The aim of this study was to compare the effects of different circuit training protocols in order to determine which is the best for weight loss and for specific overweight- related disorders. Forty-five female sedentary overweight participants from 20 to 50 years (average 31.8±11.2) were enrolled and assigned to three different groups; each group was compared with a control normal-weight group. Three different circuit protocols were randomly assigned to each overweight group: aerobictone- aerobic (ATA), aerobic-circuit-aerobic (ACA) and mini-trampoline circuit (MTC), while control group performed a classic circuit weight training (CWT). Every group trained three times per week, for 12 weeks. The results show that ATA group reduced body fat and total body mass more than other groups (P<0.001; P=0.007). ACA group reduced total body mass in significant statistical way (P=0.032), as well as body fat (P<0.001) and low-density lipoprotein cholesterol (P=0.013). In MTC group there was a significant reduction in every parameter we analyzed (total body mass, body fat and lipid profile: P<0.001). CWT group has shown a significant loss only in body fat (P<0.001). Every circuit protocol is optimal for reducing body fat and total body mass: however, MTC protocol has shown the best results on lipid profile.
Valentina Contrò; Antonino Bianco; Jill Cooper; Alessia Sacco; Alessandra Macchiarella; Marcello Traina; Patrizia Proia. Effects of different circuit training protocols on body mass, fat mass and blood parameters in overweight adults. Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale 2017, 90, 1 .
AMA StyleValentina Contrò, Antonino Bianco, Jill Cooper, Alessia Sacco, Alessandra Macchiarella, Marcello Traina, Patrizia Proia. Effects of different circuit training protocols on body mass, fat mass and blood parameters in overweight adults. Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale. 2017; 90 (1):1.
Chicago/Turabian StyleValentina Contrò; Antonino Bianco; Jill Cooper; Alessia Sacco; Alessandra Macchiarella; Marcello Traina; Patrizia Proia. 2017. "Effects of different circuit training protocols on body mass, fat mass and blood parameters in overweight adults." Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale 90, no. 1: 1.
Eukaryotic genomes transcribe up to 90% of the genomic DNA but only 1-2% of these transcripts encode for proteins, whereas the vast majority are transcribed as non-coding RNAs (ncRNAs). They are divided into short ncRNA, particularly micro-RNA (miRNA) and small interference RNA (siRNA), and long ncRNAs. Noteworthy, they are unexpectedly stable since they are protected from degradation through different mechanisms: package in exosomes/microvesicles structures, in apoptotic bodies, in HDL lipoprotein, or by RNA binding proteins. For several years already, biomarkers have been used to detect biological disease; in the last years, a requirement appeared to find some of them to unearth the signs of doping. The potential of ncRNAs as a biological candidate is strongly debated and it seems to have become the right tool in the anti-doping hands. In the recent years, the next-generation sequencing (NGS) technology was used by the World Anti-Doping Agency to draft the athlete biological passport (ABP), measuring the circulating miRNAs and applying these new biomarkers in anti-doping. NGS technology does not require any prior knowledge of ncRNAs, but the limit to employ this biomarker to detect performance-enhancing drug use must consider the intrinsic and extrinsic factors that might affect measurements.
Gabriella Schiera; Valentina Contro; Alessia Sacco; Alessandra Macchiarella; Pawel Cięszczyk; Patrizia Proia. From Epigenetics to Anti-Doping Application: A New Tool of Detection. Human Movement 2017, 18, 1 .
AMA StyleGabriella Schiera, Valentina Contro, Alessia Sacco, Alessandra Macchiarella, Pawel Cięszczyk, Patrizia Proia. From Epigenetics to Anti-Doping Application: A New Tool of Detection. Human Movement. 2017; 18 (1):1.
Chicago/Turabian StyleGabriella Schiera; Valentina Contro; Alessia Sacco; Alessandra Macchiarella; Pawel Cięszczyk; Patrizia Proia. 2017. "From Epigenetics to Anti-Doping Application: A New Tool of Detection." Human Movement 18, no. 1: 1.
Purpose. Energy requirements in sports performance are affected by numerous factors: physical characteristics, age, genetic basis, sports discipline. The Food and Nutrition Board recommended nutrition based on age, height, and body weight gain in relation to physical activity. Some genetic factors, such as the PPAR-encoding gene, play a key role in metabolism. The aim of the study was to investigate the effect of specific snacks on performance. Methods. Seventeen girls aged 10-14 years practising artistic gymnastics were enrolled. A carb or protein/carb snack was provided before the training, and a questionnaire was administered at the end. In addition, saliva samples were collected for genetic analyses. Results. Most girls represented the CC genotype (65%), while a small part had the GC (23%) and GG (12%). The average BMI equalled 20.05 ± 2.8 kg/m
Alessandra Amato; Alessia Sacco; Alessandra Macchiarella; Valentina Contro; Emilia Sabatino; Claudia Galassi; Patrizia Proia. Influence of Nutrition and Genetics on Performance: A Pilot Study in a Group of Gymnasts. Human Movement 2017, 18, 12 -16.
AMA StyleAlessandra Amato, Alessia Sacco, Alessandra Macchiarella, Valentina Contro, Emilia Sabatino, Claudia Galassi, Patrizia Proia. Influence of Nutrition and Genetics on Performance: A Pilot Study in a Group of Gymnasts. Human Movement. 2017; 18 (3):12-16.
Chicago/Turabian StyleAlessandra Amato; Alessia Sacco; Alessandra Macchiarella; Valentina Contro; Emilia Sabatino; Claudia Galassi; Patrizia Proia. 2017. "Influence of Nutrition and Genetics on Performance: A Pilot Study in a Group of Gymnasts." Human Movement 18, no. 3: 12-16.
Doping, although was born as a medication and not with the purpose of enhancing performance, is a widespread practice in all sports, between amateur and gym-goers. The Italian sports federations were in second place worldwide for positive doping-test, after Russia. This review focuses on the analysis of data collected by Italian National Olympic Committee (CONI) in the 2012–2014 period, showing that the most commonly used substances were anabolic androgenic agents, glucocorticoids, diuretics and stimulants. Prevention in doping could be a key to limit the damage caused by this harmful practice both, for the physical health and the athlete’s moral integrity and anti-doping campaigns should be direct as much as possible to young people, since about two-thirds of adolescents appear to be dissatisfied with their body. Even coordination between the various professionals that surround athletes could help fight doping by planning specific training and adapted to the individual athlete, taking into account the actual physical limitations and physical features of each.
Alessia Sacco; Alessandra Macchiarella; Alessandra Amato; Daniele La Commare; Valentina Contrò; Patrizia Proia. Trend of Drug Abuse in 2011– 2014 in Italy. Central European Journal of Sport Sciences and Medicine 2017, 19, 77 -84.
AMA StyleAlessia Sacco, Alessandra Macchiarella, Alessandra Amato, Daniele La Commare, Valentina Contrò, Patrizia Proia. Trend of Drug Abuse in 2011– 2014 in Italy. Central European Journal of Sport Sciences and Medicine. 2017; 19 ():77-84.
Chicago/Turabian StyleAlessia Sacco; Alessandra Macchiarella; Alessandra Amato; Daniele La Commare; Valentina Contrò; Patrizia Proia. 2017. "Trend of Drug Abuse in 2011– 2014 in Italy." Central European Journal of Sport Sciences and Medicine 19, no. : 77-84.
More than two hundred years after its discovery, lactate still remains an intriguing molecule. Considered for a long time as a waste product of metabolism and the culprit behind muscular fatigue, it was then recognized as an important fuel for many cells. In particular, in the nervous system, it has been proposed that lactate, released by astrocytes in response to neuronal activation, is taken up by neurons, oxidized to pyruvate and used for synthesizing acetyl-CoA to be used for the tricarboxylic acid cycle. More recently, in addition to this metabolic role, the discovery of a specific receptor prompted a reconsideration of its role, and lactate is now seen as a sort of hormone, even involved in processes as complex as memory formation and neuroprotection. As a matter of fact, exercise offers many benefits for our organisms, and seems to delay brain aging and neurodegeneration. Now, exercise induces the production and release of lactate into the blood which can reach the liver, the heart, and also the brain. Can lactate be a beneficial molecule produced during exercise, and offer neuroprotection? In this review, we summarize what we have known on lactate, discussing the roles that have been attributed to this molecule over time.
Patrizia Proia; Carlo Maria Di Liegro; Gabriella Schiera; Anna Fricano; Italia Di Liegro. Lactate as a Metabolite and a Regulator in the Central Nervous System. International Journal of Molecular Sciences 2016, 17, 1450 .
AMA StylePatrizia Proia, Carlo Maria Di Liegro, Gabriella Schiera, Anna Fricano, Italia Di Liegro. Lactate as a Metabolite and a Regulator in the Central Nervous System. International Journal of Molecular Sciences. 2016; 17 (9):1450.
Chicago/Turabian StylePatrizia Proia; Carlo Maria Di Liegro; Gabriella Schiera; Anna Fricano; Italia Di Liegro. 2016. "Lactate as a Metabolite and a Regulator in the Central Nervous System." International Journal of Molecular Sciences 17, no. 9: 1450.
The ability of a cell to respond to a particular hormone depends on the presence of specific receptors for those hormones. Once the hormone has bound to its receptor, and following structural and biochemical modifications to the receptor, it separates from cytoplasmic chaperone proteins, thereby exposing the nuclear localization sequences that result in the activation of the receptor and initiation of the biological actions of the hormone on the target cell. In addition, recent work has demonstrated new pathways of steroid signaling through orphan and cell surface receptors that contribute to more rapid, “non-nuclear” or non-transcriptional effects of steroid hormones, often involving G-protein-mediated pathways. This review will summarize some of these studies for estrogens, androgens and progestins
Valentina Contrò; John R. Basile; Patrizia Proia. Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways. AIMS Molecular Science 2015, 2, 294 -310.
AMA StyleValentina Contrò, John R. Basile, Patrizia Proia. Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways. AIMS Molecular Science. 2015; 2 (3):294-310.
Chicago/Turabian StyleValentina Contrò; John R. Basile; Patrizia Proia. 2015. "Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways." AIMS Molecular Science 2, no. 3: 294-310.