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Prof. Kannan RR Rengasamy
The International Consortium of Enzyme Inhibition Research (ICEIR)

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0 Functional Foods
0 Molecular Pharmacology
0 natural product chemistry
0 Biostimulants
0 marine pharmacology

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natural product chemistry

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Book chapter
Published: 10 August 2021 in Handbook of Dietary Phytochemicals
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Ellagitannins (ETs) are widely distributed secondary metabolites classified as hydrolyzable tannins found mainly in berries such as raspberries, blueberries (BBs), black raspberries (BRBs), strawberries, and pomegranates. A plethora of reports tend to show that ETs can impact positively on human health by promoting therapeutic activities such as being an antioxidant, antimicrobial, anti-inflammatory, and anticancer. Studies showed that ETs found in the seeds of black raspberries (BRBs) increase the functional activity of juices or wines which used BRBs as ingredients. It has been reported that berries have the potential to reduce the systolic and diastolic blood pressure and increase superoxide dismutase activity after the consumption of BBs. Numerous studies showed that ETs isolated from pomegranates possess good antimicrobial activities against a panel of microbes including human pathogens such as Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Yersinia enterocolitica, Listeria monocytogenes, and Candida albicans. Interestingly, it was shown that these therapeutic values are attributed to the presence of ETs. Furthermore, ETs are also distributed in various nuts, namely, pecans, cashews, walnuts, pistachios, or hazelnuts. It is known clinically that frequent nut intake is associated with protective effects against cardiovascular diseases. Although it is mentioned that ETs can also be found in vegetables, however as far as our literature search could establish, there are no scientific validation of ETs in vegetables. Thus, it is proposed that more scientific investigations be geared to shed light on the potential of ETs found in vegetables. Overall, foods containing ETs are recommended to be consumed on a regular basis since a panoply of scientific investigations showed that they are associated with promising health benefits.

ACS Style

Nabeelah Bibi Sadeer; Mohamad Fawzi Mahomoodally; Kannan R. R. Rengasamy. Dietary Ellagitannins. Handbook of Dietary Phytochemicals 2021, 1145 -1171.

AMA Style

Nabeelah Bibi Sadeer, Mohamad Fawzi Mahomoodally, Kannan R. R. Rengasamy. Dietary Ellagitannins. Handbook of Dietary Phytochemicals. 2021; ():1145-1171.

Chicago/Turabian Style

Nabeelah Bibi Sadeer; Mohamad Fawzi Mahomoodally; Kannan R. R. Rengasamy. 2021. "Dietary Ellagitannins." Handbook of Dietary Phytochemicals , no. : 1145-1171.

Journal article
Published: 28 July 2021 in Critical Reviews in Food Science and Nutrition
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The understanding of gut microbiota has emerged as a significant frontier in development of strategies to maintain normal human body's homeostasis and preventing the disease development over the last decade. The composition of the gut microbiota influences the clinical benefit of immune checkpoints in patients with advanced cancer, but the mechanisms underlying this relationship are unclear. Cancer is among the leading causes of mortality worldwide. So far, there is no universal treatment for cancer and despite significant advances, a lot of improvement on cancer therapy is required. Owing to its role in preserving the host’s health and maintaining cellular integrity, the human gut microbiome has recently drawn a lot of interest as a target for cancer treatment. Dietary fiber is fermented by the gut microbiota to generate short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, which are physiologically active metabolites. SCFAs can modulate the pathophysiology of the tumor environment through various critical signaling pathways. In addition, SCFAs can bind to carcinogens and other toxic chemicals, thus facilitating their biotransformation and elimination through different excretory mechanisms. This review discusses the mechanisms of action of short-chain fatty acids in modulating hematopoiesis of various immune system cells and the resultant beneficial anti-cancer effects. It also provides future perspectives on cancer therapy.

ACS Style

Muthu Thiruvengadam; Umadevi Subramanian; Baskar Venkidasamy; Prabhu Thirupathi; Ramkumar Samynathan; Mohammad Ali Shariati; Maksim Rebezov; Ill-Min Chung; Kannan R. R. Rengasamy. Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis. Critical Reviews in Food Science and Nutrition 2021, 1 -18.

AMA Style

Muthu Thiruvengadam, Umadevi Subramanian, Baskar Venkidasamy, Prabhu Thirupathi, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Ill-Min Chung, Kannan R. R. Rengasamy. Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis. Critical Reviews in Food Science and Nutrition. 2021; ():1-18.

Chicago/Turabian Style

Muthu Thiruvengadam; Umadevi Subramanian; Baskar Venkidasamy; Prabhu Thirupathi; Ramkumar Samynathan; Mohammad Ali Shariati; Maksim Rebezov; Ill-Min Chung; Kannan R. R. Rengasamy. 2021. "Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis." Critical Reviews in Food Science and Nutrition , no. : 1-18.

Journal article
Published: 19 July 2021 in Critical Reviews in Food Science and Nutrition
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Tartary buckwheat belongs to the family Polygonaceae, which is a traditionally edible and medicinal plant. Due to its various bioactive compounds, the consumption of Tartary buckwheat is correlated to a wide range of health benefits, and increasing attention has been paid to its potential as a functional food. This review summarizes the main bioactive compounds and important bioactivities and health benefits of Tartary buckwheat, emphasizing its protective effects on metabolic diseases and relevant molecular mechanisms. Tartary buckwheat contains a wide range of bioactive compounds, such as flavonoids, phenolic acids, triterpenoids, phenylpropanoid glycosides, bioactive polysaccharides, and bioactive proteins and peptides, as well as D-chiro-inositol and its derivatives. Consumption of Tartary buckwheat and Tartary buckwheat-enriched products is linked to multiple health benefits, e.g., antioxidant, anti-inflammatory, antihyperlipidemic, anticancer, antidiabetic, antiobesity, antihypertensive, and hepatoprotective activities. Especially, clinical studies indicate that Tartary buckwheat exhibits remarkable antidiabetic activities. Various tartary buckwheat -based foods presenting major health benefits as fat and blood glucose-lowering agents have been commercialized. Additionally, to address the safety concerns, i.e., allergic reactions, heavy metal and mycotoxin contaminations, the quality control standards for Tartary buckwheat and its products should be drafted and completed in the future.

ACS Style

Liang Zou; Dingtao Wu; Guixing Ren; Yichen Hu; Lianxin Peng; Jianglin Zhao; Pascual Garcia-Perez; Maria Carpena; Miguel A. Prieto; Hui Cao; Ka-Wing Cheng; Mingfu Wang; Jesus Simal-Gandara; Oliver D. John; Kannan R. R. Rengasamy; Gang Zhao; Jianbo Xiao. Bioactive compounds, health benefits, and industrial applications of Tartary buckwheat (Fagopyrum tataricum). Critical Reviews in Food Science and Nutrition 2021, 1 -17.

AMA Style

Liang Zou, Dingtao Wu, Guixing Ren, Yichen Hu, Lianxin Peng, Jianglin Zhao, Pascual Garcia-Perez, Maria Carpena, Miguel A. Prieto, Hui Cao, Ka-Wing Cheng, Mingfu Wang, Jesus Simal-Gandara, Oliver D. John, Kannan R. R. Rengasamy, Gang Zhao, Jianbo Xiao. Bioactive compounds, health benefits, and industrial applications of Tartary buckwheat (Fagopyrum tataricum). Critical Reviews in Food Science and Nutrition. 2021; ():1-17.

Chicago/Turabian Style

Liang Zou; Dingtao Wu; Guixing Ren; Yichen Hu; Lianxin Peng; Jianglin Zhao; Pascual Garcia-Perez; Maria Carpena; Miguel A. Prieto; Hui Cao; Ka-Wing Cheng; Mingfu Wang; Jesus Simal-Gandara; Oliver D. John; Kannan R. R. Rengasamy; Gang Zhao; Jianbo Xiao. 2021. "Bioactive compounds, health benefits, and industrial applications of Tartary buckwheat (Fagopyrum tataricum)." Critical Reviews in Food Science and Nutrition , no. : 1-17.

Journal article
Published: 13 July 2021 in Critical Reviews in Food Science and Nutrition
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Alginates are linear polymers comprising 40% of the dry weight of algae possess various applications in food and biomedical industries. Alginate oligosaccharides (AOS), a degradation product of alginate, is now gaining much attention for their beneficial role in food, pharmaceutical and agricultural industries. Hence this review was aimed to compile the information on alginate and AOS (prepared from seaweeds) during 1994–2020. As per our knowledge, this is the first review on the potential use of alginate oligosaccharides in different fields. The alginate derivatives are grouped according to their applications. They are involved in the isolation process and show antimicrobial, antioxidant, anti-inflammatory, antihypertension, anticancer, and immunostimulatory properties. AOS also have significant applications in prebiotics, nutritional supplements, plant growth development and others products.

ACS Style

Chunhua Zhang; Mingxi Li; Abdur Rauf; Anees Ahmed Khalil; Zhiguo Shan; Chuying Chen; Kannan R. R. Rengasamy; Chunpeng Wan. Process and applications of alginate oligosaccharides with emphasis on health beneficial perspectives. Critical Reviews in Food Science and Nutrition 2021, 1 -27.

AMA Style

Chunhua Zhang, Mingxi Li, Abdur Rauf, Anees Ahmed Khalil, Zhiguo Shan, Chuying Chen, Kannan R. R. Rengasamy, Chunpeng Wan. Process and applications of alginate oligosaccharides with emphasis on health beneficial perspectives. Critical Reviews in Food Science and Nutrition. 2021; ():1-27.

Chicago/Turabian Style

Chunhua Zhang; Mingxi Li; Abdur Rauf; Anees Ahmed Khalil; Zhiguo Shan; Chuying Chen; Kannan R. R. Rengasamy; Chunpeng Wan. 2021. "Process and applications of alginate oligosaccharides with emphasis on health beneficial perspectives." Critical Reviews in Food Science and Nutrition , no. : 1-27.

Journal article
Published: 09 July 2021 in South African Journal of Botany
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To isolate four phytochemicals (Lapachol, Peshawarquinone- a novel Naphthoquinone, Indanone derivatives and Lapachone), from the methanolic fraction of Heterophragma Adenophyllum Seem, were screened for possible inhibitory potential against urease, a key enzyme involved in gastrointestinal pathologies. To provide additional insights, in Silico docking studies were carried out to study the mechanism of inhibition by using Molecular Operating Environment (MOE). The studied phytochemicals inhibited urease, lapachone (4) inhibition was weak (IC50 = 87.3 + 2.17 μM), while the peshawarquinone (2) and indanone derivatives (3) significantly inhibited with IC50 = 19.8 + 0.56 and 21.9 + 1.12 μM, respectively. Interestingly, lapachol (1) showed potent activity (IC50 = 23.1 + 0.14 μM) as compared to the positive control thiourea (IC50 = 21 + 0.23 μM). In silico docking studies were carried out to study the mechanism of inhibition of Jack-beans urease (JBU) by using Molecular Operating Environment (MOE). Docking results showed that inactivation of the JBU is due to the interaction of compounds with Ni atom and the entrance flap-residues especially with CME592 (a modified cysteine residue). Phytochemicals isolated from H. adenophyllum show promising results to be exploited as a urease inhibitor in managing Helicobacter pylori infection implicated in gastrointestinal diseases.

ACS Style

Abdur Rauf; Yahya S. Al-Awthan; Omar Bahattab; Zafar Ali Shah; Umer Rashid; Saud Bawazeer; Mohammad Ali Shariati; Mohamad Fawzi Mahomoodally; Sirajudheen Anwar; Kannan Rr Rengasamy. Potent urease inhibition and in Silico docking study of four secondary metabolites isolated from Heterophragma adenophyllum Seem. South African Journal of Botany 2021, 142, 201 -205.

AMA Style

Abdur Rauf, Yahya S. Al-Awthan, Omar Bahattab, Zafar Ali Shah, Umer Rashid, Saud Bawazeer, Mohammad Ali Shariati, Mohamad Fawzi Mahomoodally, Sirajudheen Anwar, Kannan Rr Rengasamy. Potent urease inhibition and in Silico docking study of four secondary metabolites isolated from Heterophragma adenophyllum Seem. South African Journal of Botany. 2021; 142 ():201-205.

Chicago/Turabian Style

Abdur Rauf; Yahya S. Al-Awthan; Omar Bahattab; Zafar Ali Shah; Umer Rashid; Saud Bawazeer; Mohammad Ali Shariati; Mohamad Fawzi Mahomoodally; Sirajudheen Anwar; Kannan Rr Rengasamy. 2021. "Potent urease inhibition and in Silico docking study of four secondary metabolites isolated from Heterophragma adenophyllum Seem." South African Journal of Botany 142, no. : 201-205.

Journal article
Published: 01 July 2021 in South African Journal of Botany
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COVID-19 (SARS-CoV-2) is a viral disease that causes acute respiratory syndrome, which has increased the morbidity and mortality rate throughout the world. World Health Organization has declared this COVID-19 outbreak as pandemic and classified health emergency throughout the world. In the recent past, outbreaks of SARS and MERS have shown the interspecies transmission potential of coronaviruses and limitations of already prescribed drugs to overcome this global public health issue. Therefore, there is a dire need to identify a new regimen of targeted drugs from natural compounds having anti-COVID19 potential. This study aimed at screening 1018 brown algal natural compounds (many of them previously reported to have immunomodulatory effects) having probable anti-COVID19 potentials. The source compounds were extracted from MarinLit, a database dedicated to marine natural products and screened against COVID-19 main protease. The top seven compounds were further analysed, and their interactions with the active site were visualized. This study will further warrant screening the potent compounds against the virus in-vitro conditions.

ACS Style

Abdur Rauf; Umer Rashid; Anees Ahmed Khalil; Shahid Ali Khan; Sirajudheen Anwar; Ahmed Alafnan; Abdulhakeem Alamri; Kannan Rr Rengasamy. Docking-based virtual screening and identification of potential COVID-19 main protease inhibitors from brown algae. South African Journal of Botany 2021, 1 .

AMA Style

Abdur Rauf, Umer Rashid, Anees Ahmed Khalil, Shahid Ali Khan, Sirajudheen Anwar, Ahmed Alafnan, Abdulhakeem Alamri, Kannan Rr Rengasamy. Docking-based virtual screening and identification of potential COVID-19 main protease inhibitors from brown algae. South African Journal of Botany. 2021; ():1.

Chicago/Turabian Style

Abdur Rauf; Umer Rashid; Anees Ahmed Khalil; Shahid Ali Khan; Sirajudheen Anwar; Ahmed Alafnan; Abdulhakeem Alamri; Kannan Rr Rengasamy. 2021. "Docking-based virtual screening and identification of potential COVID-19 main protease inhibitors from brown algae." South African Journal of Botany , no. : 1.

Review
Published: 10 June 2021 in Critical Reviews in Food Science and Nutrition
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The COVID-19 pandemic has damaged the world’s economy during 2020-2021, reduced the purchasing power of households, partially restricted international movements and trade (including food products) and damaged horticultural production. This resulted in uncertainty in the food business and caused food supply shocks. According to some scientists, business people, and politicians, this situation is a forerunner and warning for humanity to change its lifestyle by focusing on sustainable measures to prevent natural ecosystems damage. In line with this, the present review article focused on the significant impacts of the COVID-19 pandemic on horticultural production and some prevention measures. It has been scientifically confirmed that the postharvest losses of fruits and vegetables reach around 10-15% in developed countries and about 20-40% in developing countries, higher in some specific crops. It is believed that reducing these losses can help the world fight food supply shocks during the COVID-19 pandemic and customary conditions to reduce the pressure on natural resources. Therefore, the present paper aimed to highlight some critical handling practices against food supply shocks.

ACS Style

Ibrahim Kahramanoğlu; Kannan R. R. Rengasamy; Serhat Usanmaz; Turgut Alas; Murat Helvacı; Volkan Okatan; Mehmet A. Aşkın; Chunpeng Wan. Improving the safety and security of fruits and vegetables during COVID-19 pandemic with postharvest handling. Critical Reviews in Food Science and Nutrition 2021, 1 -11.

AMA Style

Ibrahim Kahramanoğlu, Kannan R. R. Rengasamy, Serhat Usanmaz, Turgut Alas, Murat Helvacı, Volkan Okatan, Mehmet A. Aşkın, Chunpeng Wan. Improving the safety and security of fruits and vegetables during COVID-19 pandemic with postharvest handling. Critical Reviews in Food Science and Nutrition. 2021; ():1-11.

Chicago/Turabian Style

Ibrahim Kahramanoğlu; Kannan R. R. Rengasamy; Serhat Usanmaz; Turgut Alas; Murat Helvacı; Volkan Okatan; Mehmet A. Aşkın; Chunpeng Wan. 2021. "Improving the safety and security of fruits and vegetables during COVID-19 pandemic with postharvest handling." Critical Reviews in Food Science and Nutrition , no. : 1-11.

Journal article
Published: 08 June 2021 in Food and Chemical Toxicology
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Carotenoids in food substances are believed to have health benefits by lowering the risk of diseases. Lutein, a carotenoid compound, is one of the essential nutrients available in green leafy vegetables (kale, broccoli, spinach, lettuce, and peas), along with other foods, such as eggs. As nutrition plays a pivotal role in maintaining human health, lutein, as a nutritional substance, confers promising benefits against numerous health issues, including neurological disorders, eye diseases, skin irritation, etc. This review describes the in-depth health beneficial effects of lutein. As yet, a minimal amount of literature has been undertaken to consider all its promising bioactivities. The step-by-step biosynthesis of lutein has also been taken into account in this review. Besides, this review demonstrates the drug interactions of lutein with β-carotene, as well as safety concerns and dosage. The potential benefits of lutein have been assessed against neurological disorders, eye diseases, cardiac complications, microbial infections, skin irritation, bone decay, etc. Additionally, recent studies ascertained the significance of lutein nanoformulations in the amelioration of eye disorders, which are also considered in this review. Moreover, a possible approach for the use of lutein in bioactive functional foods will be discussed.

ACS Style

Saikat Mitra; Abdur Rauf; Abu Montakim Tareq; Shamima Jahan; Talha Bin Emran; Talukder Galeeb Shahriar; Kuldeep Dhama; Fahad A. Alhumaydhi; Abdullah S.M. Aljohani; Maksim Rebezov; Sahab Uddin; Philippe Jeandet; Zafar Ali Shah; Mohammad Ali Shariati; Kannan Rr. Rengasamy. Potential health benefits of carotenoid lutein: An updated review. Food and Chemical Toxicology 2021, 154, 112328 .

AMA Style

Saikat Mitra, Abdur Rauf, Abu Montakim Tareq, Shamima Jahan, Talha Bin Emran, Talukder Galeeb Shahriar, Kuldeep Dhama, Fahad A. Alhumaydhi, Abdullah S.M. Aljohani, Maksim Rebezov, Sahab Uddin, Philippe Jeandet, Zafar Ali Shah, Mohammad Ali Shariati, Kannan Rr. Rengasamy. Potential health benefits of carotenoid lutein: An updated review. Food and Chemical Toxicology. 2021; 154 ():112328.

Chicago/Turabian Style

Saikat Mitra; Abdur Rauf; Abu Montakim Tareq; Shamima Jahan; Talha Bin Emran; Talukder Galeeb Shahriar; Kuldeep Dhama; Fahad A. Alhumaydhi; Abdullah S.M. Aljohani; Maksim Rebezov; Sahab Uddin; Philippe Jeandet; Zafar Ali Shah; Mohammad Ali Shariati; Kannan Rr. Rengasamy. 2021. "Potential health benefits of carotenoid lutein: An updated review." Food and Chemical Toxicology 154, no. : 112328.

Journal article
Published: 06 June 2021 in South African Journal of Botany
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Mushrooms are well-known for their richness of health-beneficial bioactive metabolites. In recent years, consumer interests regarding fatty acid compositions of different foods are increasing. Thus, the present study was designed to characterize sterols and fatty acid compositions of fifteen types of edible mushrooms marketed in Korea utilizing gas chromatography (GC)-flame ionization detection (FID) and GC-mass spectrometry (MS). Among all studied samples, significant variations were recorded for contents of sterols. Among all sterols identified and quantified, ergosterol (ergosta-5,7,22-trien- 3β-ol) was found to be the most abundant (774.2–82.1 mg/100 g dry weight (DW)), with minor presence of ergosta-5,7-dien-3β-ol, ergosta-7-3β-ol, and ergosta-7,22-dien-3β-ol. Regarding fatty acid compositions, linoleic (C18:2n6c) was recorded in the highest quantity (79.5% of total fatty acids), followed by palmitic, oleic, and stearic acid. These four fatty acids together accounted for 64.8% (Santali; No 3) to 96.6% (‘DDL01’ ferulae; No 9) of total fatty acids. Exceptionally, in ‘Nolu’ Lion's mane (No. 5) mushrooms, palmitic acid had the highest quantity (34.9% of total fatty acids), followed by linoleic (24.5% of total), oleic, and stearic acid. Fat quality indices such as the ratio of hypocholesterolemic/hypercholesterolemic fatty acids, atherogenic index, and thrombogenic index from these studied mushrooms indicate that mushroom fats are beneficial for health.

ACS Style

Ramesh Kumar Saini; Abdur Rauf; Anees Ahmed Khalil; Eun-Young Ko; Young-Soo Keum; Sirajudheen Anwar; Abdulwahab Alamri; Kannan R.R. Rengasamy. Edible mushrooms show significant differences in sterols and fatty acid compositions. South African Journal of Botany 2021, 141, 344 -356.

AMA Style

Ramesh Kumar Saini, Abdur Rauf, Anees Ahmed Khalil, Eun-Young Ko, Young-Soo Keum, Sirajudheen Anwar, Abdulwahab Alamri, Kannan R.R. Rengasamy. Edible mushrooms show significant differences in sterols and fatty acid compositions. South African Journal of Botany. 2021; 141 ():344-356.

Chicago/Turabian Style

Ramesh Kumar Saini; Abdur Rauf; Anees Ahmed Khalil; Eun-Young Ko; Young-Soo Keum; Sirajudheen Anwar; Abdulwahab Alamri; Kannan R.R. Rengasamy. 2021. "Edible mushrooms show significant differences in sterols and fatty acid compositions." South African Journal of Botany 141, no. : 344-356.

Review
Published: 13 May 2021 in Critical Reviews in Food Science and Nutrition
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Iturin, a metabolite produced by Bacillus subtilis, has a broad-spectrum antibacterial effect, and because they are secreted in the rhizosphere of plants, iturins are often mixed with many organic molecules. In recent years, people have improved their separation and purification methods but still cannot achieve simple and effective procedures, making Iturins an ideal biological control agent for insects and bacteria; commercial value still cannot be realized. With the in-depth studies of Iturins, its anti-cancer, hemolysis and other biological activities have gradually been discovered. This article reviews the branches of the Iturin family, structural features of these metabolite, separation and purification methods used for producing it, culture optimization, and various biological activities of the Iturin family, such as insecticidal, antibacterial, hemolytic and anticarcinogenic properties, among others have been summarized. Furthermore, this review revealed some commercial applications of Iturins and their relevance in research works. For example, in food packaging, clean water has good development potential.This can promote the commercial application of Iturins instead of other chemical and biological control agents that are environmentally friendly, pollution-free and have no side effects on humans. Furthermore, work documented anticancer, hemolytic and other biological activities of Iturin.

ACS Style

Chunpeng Wan; Xiaoyuan Fan; Zaixiang Lou; Hongxin Wang; Ahmed Olatunde; Kannan R. R. Rengasamy. Iturin: cyclic lipopeptide with multifunction biological potential. Critical Reviews in Food Science and Nutrition 2021, 1 -13.

AMA Style

Chunpeng Wan, Xiaoyuan Fan, Zaixiang Lou, Hongxin Wang, Ahmed Olatunde, Kannan R. R. Rengasamy. Iturin: cyclic lipopeptide with multifunction biological potential. Critical Reviews in Food Science and Nutrition. 2021; ():1-13.

Chicago/Turabian Style

Chunpeng Wan; Xiaoyuan Fan; Zaixiang Lou; Hongxin Wang; Ahmed Olatunde; Kannan R. R. Rengasamy. 2021. "Iturin: cyclic lipopeptide with multifunction biological potential." Critical Reviews in Food Science and Nutrition , no. : 1-13.

Review
Published: 27 April 2021 in Critical Reviews in Food Science and Nutrition
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Many short-lived and highly reactive oxygen species, such as superoxide anion (O2-) and hydrogen peroxide (H2O2), are toxic or can create oxidative stress in cells, a response involved in the pathogenesis of numerous diseases depending on their concentration, location, and cellular conditions. Superoxide dismutase (SOD) activities as an endogenous and exogenous cell defense mechanism include the potential use in treating various diseases, improving the potential use in treating various diseases, and improving food-stuffs preparation dietary supplements human nutrition. Published work indicates that SOD regulates oxidative stress, lipid metabolism, inflammation, and oxidation in cells. It can prevent lipid peroxidation, the oxidation of low-density lipoprotein in macrophages, lipid droplets' formation, and the adhesion of inflammatory cells into endothelial monolayers. It also expresses antioxidant effects in numerous cancer-related processes. Additionally, different forms of SOD may also augment food processing and pharmaceutical applications, exhibit anticancer, antioxidant, and anti-inflammatory effects, and prevent arterial problems by protecting the proliferation of vascular smooth muscle cells. Many investigations in this review have reported the therapeutic ability and physiological importance of SOD. Because of their antioxidative effects, SODs are of great potential in the medicinal, cosmetic, food, farming and chemical industries. This review discusses the findings of human and animal studies that support the advantages of SOD enzyme regulations to reduce the formation of oxidative stress in various ways.

ACS Style

Mohammad Nazmul Islam; Abdur Rauf; Fowzul Islam Fahad; Talha Bin Emran; Saikat Mitra; Ahmed Olatunde; Mohammad Ali Shariati; Maksim Rebezov; Kannan R. R. Rengasamy; Mohammad S. Mubarak. Superoxide dismutase: an updated review on its health benefits and industrial applications. Critical Reviews in Food Science and Nutrition 2021, 1 -19.

AMA Style

Mohammad Nazmul Islam, Abdur Rauf, Fowzul Islam Fahad, Talha Bin Emran, Saikat Mitra, Ahmed Olatunde, Mohammad Ali Shariati, Maksim Rebezov, Kannan R. R. Rengasamy, Mohammad S. Mubarak. Superoxide dismutase: an updated review on its health benefits and industrial applications. Critical Reviews in Food Science and Nutrition. 2021; ():1-19.

Chicago/Turabian Style

Mohammad Nazmul Islam; Abdur Rauf; Fowzul Islam Fahad; Talha Bin Emran; Saikat Mitra; Ahmed Olatunde; Mohammad Ali Shariati; Maksim Rebezov; Kannan R. R. Rengasamy; Mohammad S. Mubarak. 2021. "Superoxide dismutase: an updated review on its health benefits and industrial applications." Critical Reviews in Food Science and Nutrition , no. : 1-19.

Review
Published: 10 April 2021 in Critical Reviews in Food Science and Nutrition
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Marine organisms are considered a cache of biologically active metabolites with pharmaceutical, functional, and nutraceutical properties. Among these, marine bioactive peptides (MBAs) present in diverse marine species (fish, sponges, cyanobacteria, fungi, ascidians, seaweeds, & mollusks) have acquired attention owing to their broad-spectrum health-promoting benefits. Nowadays, scientists are keener exploring marine bioactive peptides precisely due to their unique structural and biological properties. These MBAs have reported ameliorating potential against different diseases like hypertension, diabetes, obesity, HIV, cancer, oxidation, and inflammation. Furthermore, MBAs isolated from various marine organisms may also have a beneficial role in the cosmetic, nutraceutical, and food industries. Few marine peptides and their derivative are approved for commercial use, while many MBAs are in various pre-clinical and clinical trials. This review mainly focuses on the diversity of marine bioactive peptides in marine organisms and their production procedures, such as chemical and enzymatic hydrolysis. Moreover, MBAs' therapeutic and biological potential has also been critically discussed herein, along with their status in drug discovery, pre-clinical and clinical trials.

ACS Style

Abdur Rauf; Anees Ahmed Khalil; Muneeb Khan; Sirajudheen Anwar; Abdulwahab Alamri; Abdulmalik M. Alqarni; Adel Alghamdi; Farhan Alshammari; Kannan R. R. Rengasamy; Chunpeng Wan. Can be marine bioactive peptides (MBAs) lead the future of foodomics for human health? Critical Reviews in Food Science and Nutrition 2021, 1 -79.

AMA Style

Abdur Rauf, Anees Ahmed Khalil, Muneeb Khan, Sirajudheen Anwar, Abdulwahab Alamri, Abdulmalik M. Alqarni, Adel Alghamdi, Farhan Alshammari, Kannan R. R. Rengasamy, Chunpeng Wan. Can be marine bioactive peptides (MBAs) lead the future of foodomics for human health? Critical Reviews in Food Science and Nutrition. 2021; ():1-79.

Chicago/Turabian Style

Abdur Rauf; Anees Ahmed Khalil; Muneeb Khan; Sirajudheen Anwar; Abdulwahab Alamri; Abdulmalik M. Alqarni; Adel Alghamdi; Farhan Alshammari; Kannan R. R. Rengasamy; Chunpeng Wan. 2021. "Can be marine bioactive peptides (MBAs) lead the future of foodomics for human health?" Critical Reviews in Food Science and Nutrition , no. : 1-79.

Review
Published: 07 April 2021 in Current Neuropharmacology
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Pain is a distressing but fundamental manifestation that prepares the body for potentially detrimental stimuli while ensuring its protection. Plant and animal products have traditionally been used to relieve pain for centuries. However, no attempt has been made to compile a single report of plant and animal products possessing analgesic properties. This review enadeavours to recover data from published articles to establish a collective literature review on folk remedies from plant and animal sources used as analgesics and in the treatment of pain-related conditions, identifying gaps in existing knowledge and future works. Relevant information was systematically retrieved using the PRISMA method. In this review, in total, 209 plants were found to be either used raw or prepared by decoctions or maceration. Administration was either oral or topical, and they were predominantly used in Asian countries. In vivo studies of plants with analgesic properties, which were tested using different methods including acetic-induced writhing test, hotplate test, tail-flick test, and formalin-induced pain test, were compiled. Animal products with analgesic properties were obtained mainly from compounds present in venom; their bioactive compounds were also identified. In the literature search, certain gaps were noted, which could be reviewed in future studies. For instance, there was a disparity of information regarding the traditional uses of medicinal plants. In this review, an attempt was made to critically assess and describe the pharmacological properties and bioactive composition of indigenous plants, some animal species, and animal venom by scrutinizing databases and looking for published articles. Therefore, it can be concluded that the compounds obtained from these sources can serve as important ingredients in therapeutic agents to alleviate pain once their limitations are assessed and improved upon. In the literature search, certain gaps were noted, which could be reviewed in future studies.

ACS Style

Kannan Rr Rengasamy; Mohamad Fawzi Mahomoodally; Teshika Joaheer; Yansheng Zhang. A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics. Current Neuropharmacology 2021, 19, 553 -588.

AMA Style

Kannan Rr Rengasamy, Mohamad Fawzi Mahomoodally, Teshika Joaheer, Yansheng Zhang. A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics. Current Neuropharmacology. 2021; 19 (4):553-588.

Chicago/Turabian Style

Kannan Rr Rengasamy; Mohamad Fawzi Mahomoodally; Teshika Joaheer; Yansheng Zhang. 2021. "A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics." Current Neuropharmacology 19, no. 4: 553-588.

Journal article
Published: 15 March 2021 in Food and Chemical Toxicology
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Camel Urine (CU) is composed of components that have antitumor properties and other therapeutic benefits. Regardless of short-term preliminary CU genotoxicity is reported, comprehensive genotoxic studies are limited. In this study, sensitive in vitro and in vivo genotoxic bioassays such as mitotic index (MI), chromosomal aberrations (CA), micronucleated polychromatic erythrocytes (MPE), and analysis of primary spermatocytes were employed. The adventitious roots of Allium cepa L. and mice (Mus musculus), as an experimental mammalian system, were employed to assess the MI and CA of CU induced by sodium nitrate and cyclophosphamide respectively. In contrast, other clastogenic assays were studied in mice (Mus musculus). Twenty-eight days of four repeated doses (2.5, 5, 25, and 50 mL/kg BW) of CU were tested and compared with three doses (10, 25, and 50 mg/kg BW) cyclophosphamide as a positive control and deionized water as the negative control. The results proved that cytological examination of CU was cytotoxic since a decrease in mitotic activity (16.8–1.1) was observed, since the significant reduction in cell proliferation in A. cepa L. and also in mice bone marrow cells. On the other hand, CU did not induce a clastogenic effect since no significant stickiness, fragment, multinucleoli were observed compared to the control group. Additionally, the data showed that CU decreased the CA when mice had received cyclophosphamide (25 mg BW) followed by CU doses. CU was found to be cytotoxic but no clastogenic effect. Furthermore, it possesses anticlastogenic properties. The observed results suggest that CU in whole or the metabolites present in CU could be a potent drug target. Further research is warranted to study the complete metabolites profiling and to study the molecular mechanisms.

ACS Style

Sirajudheen Anwar; Siddique Akber Ansari; Abdulwahab Alamri; Abdulhakeem Alamri; Aali Alqarni; Saleh Alghamdi; Mohamed E. Wagih; Akbar Ahmad; Kannan Rr. Rengasamy. Clastogenic, anti-clastogenic profile and safety assessment of Camel urine towards the development of new drug target. Food and Chemical Toxicology 2021, 151, 112131 .

AMA Style

Sirajudheen Anwar, Siddique Akber Ansari, Abdulwahab Alamri, Abdulhakeem Alamri, Aali Alqarni, Saleh Alghamdi, Mohamed E. Wagih, Akbar Ahmad, Kannan Rr. Rengasamy. Clastogenic, anti-clastogenic profile and safety assessment of Camel urine towards the development of new drug target. Food and Chemical Toxicology. 2021; 151 ():112131.

Chicago/Turabian Style

Sirajudheen Anwar; Siddique Akber Ansari; Abdulwahab Alamri; Abdulhakeem Alamri; Aali Alqarni; Saleh Alghamdi; Mohamed E. Wagih; Akbar Ahmad; Kannan Rr. Rengasamy. 2021. "Clastogenic, anti-clastogenic profile and safety assessment of Camel urine towards the development of new drug target." Food and Chemical Toxicology 151, no. : 112131.

Journal article
Published: 11 March 2021 in Critical Reviews in Food Science and Nutrition
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Over the past decade, the gut microbiota has emerged as an important frontier in understanding the human body's homeostasis and the development of diseases. Gut flora in human beings regulates various metabolic functionalities, including enzymes, amino acid synthesis, bio-transformation of bile acid, fermentation of non-digestible carbohydrates (NDCs), generation of indoles and polyamines (PAs), and production of short-chain fatty acids (SCFAs). Among all the metabolites produced by gut microbiota, SCFAs, the final product of fermentation of dietary fibers by gut microbiota, receive lots of attention from scientists due to their pharmacological and physiological characteristics. However, the molecular mechanisms underlying the role of SCFAs in the interaction between diet, gut microbiota, and host energy metabolism is still needed in-depth research. This review highlights the recent biotechnological advances in applying SCFAs as important metabolites to treat various diseases and maintain colonic health.

ACS Style

Abdur Rauf; Anees Ahmed Khalil; Ubaid-Ur- Rahman; Ahood Khalid; Saima Naz; Mohammad Ali Shariati; Maksim Rebezov; Ewaldo Zavala Urtecho; Ricardo Diego Duarte Galhardo de Albuquerque; Sirajudheen Anwar; Abdulwahab Alamri; Ramesh Kumar Saini; Kannan R. R Rengasamy. Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review. Critical Reviews in Food Science and Nutrition 2021, 1 -21.

AMA Style

Abdur Rauf, Anees Ahmed Khalil, Ubaid-Ur- Rahman, Ahood Khalid, Saima Naz, Mohammad Ali Shariati, Maksim Rebezov, Ewaldo Zavala Urtecho, Ricardo Diego Duarte Galhardo de Albuquerque, Sirajudheen Anwar, Abdulwahab Alamri, Ramesh Kumar Saini, Kannan R. R Rengasamy. Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review. Critical Reviews in Food Science and Nutrition. 2021; ():1-21.

Chicago/Turabian Style

Abdur Rauf; Anees Ahmed Khalil; Ubaid-Ur- Rahman; Ahood Khalid; Saima Naz; Mohammad Ali Shariati; Maksim Rebezov; Ewaldo Zavala Urtecho; Ricardo Diego Duarte Galhardo de Albuquerque; Sirajudheen Anwar; Abdulwahab Alamri; Ramesh Kumar Saini; Kannan R. R Rengasamy. 2021. "Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review." Critical Reviews in Food Science and Nutrition , no. : 1-21.

Review
Published: 01 March 2021 in Pharmacological Research
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Marine habitats are well-known for their diverse life forms that are potential sources of novel bioactive compounds. Evidence from existing studies suggests that these compounds contribute significantly to the field of pharmaceuticals, nutraceuticals, and cosmeceuticals. The isolation of natural compounds from a marine environment with protease inhibitory activity has gained importance due to drug discovery potential. Despite the increasing research endeavours focusing on protease inhibitors' design and characterization, many of these compounds have failed to reach final phases of clinical trials. As a result, the search for new sources for the development of protease inhibitors remains pertinent. This review focuses on the diverse marine protease inhibitors and their structure-activity relationships. Furthermore, the potential of marine protease inhibitors in drug discovery and molecular mechanism inhibitor binding are critically discussed.

ACS Style

Abdur Rauf; Anees Ahmed Khalil; Ahmed Olatunde; Muneeb Khan; Sirajudheen Anwar; Ahmed Alafnan; Kannan Rr Rengasamy. Diversity, molecular mechanisms and structure-activity relationships of marine protease inhibitors—A review. Pharmacological Research 2021, 166, 105521 .

AMA Style

Abdur Rauf, Anees Ahmed Khalil, Ahmed Olatunde, Muneeb Khan, Sirajudheen Anwar, Ahmed Alafnan, Kannan Rr Rengasamy. Diversity, molecular mechanisms and structure-activity relationships of marine protease inhibitors—A review. Pharmacological Research. 2021; 166 ():105521.

Chicago/Turabian Style

Abdur Rauf; Anees Ahmed Khalil; Ahmed Olatunde; Muneeb Khan; Sirajudheen Anwar; Ahmed Alafnan; Kannan Rr Rengasamy. 2021. "Diversity, molecular mechanisms and structure-activity relationships of marine protease inhibitors—A review." Pharmacological Research 166, no. : 105521.

Review
Published: 01 February 2021 in Biomedicine & Pharmacotherapy
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Medicinal plants are being used for therapeutic purposes since the dawn of human civilization. The therapeutic efficacy of medicinal plants is due to the presence of wide range phytochemical constituents or secondary metabolites. The medicinal plants are traditionally used for several types of ailments. Even in those pathological conditions where other methods of treatment fail to work. Curcuma longa Linn is very common ingredient used as spice in foods as preservative and coloring material in different part of the world. It has been used as a home remedy for a variety of diseases. Curcuma longa and its isolated constituent curcumin are widely evaluated for anticancer activity. Curcumin possesses broad remedial potential due to its multi-targeting effect against many different carcinoma including leukemia, genitourinary cancers, gastrointestinal cancers and breast cancer etc. Hence, Curcumin has potential for the development of new medicine for the treatment of several diseases.

ACS Style

Sabira Sultana; Naveed Munir; Zahed Mahmood; Muhammad Riaz; Muhammad Akram; Maksim Rebezov; Nazira Kuderinova; Zhanar Moldabayeva; Mohammad Ali Shariati; Abdur Rauf; Kannan R.R. Rengasamy. Molecular targets for the management of cancer using Curcuma longa Linn. phytoconstituents: A Review. Biomedicine & Pharmacotherapy 2021, 135, 111078 .

AMA Style

Sabira Sultana, Naveed Munir, Zahed Mahmood, Muhammad Riaz, Muhammad Akram, Maksim Rebezov, Nazira Kuderinova, Zhanar Moldabayeva, Mohammad Ali Shariati, Abdur Rauf, Kannan R.R. Rengasamy. Molecular targets for the management of cancer using Curcuma longa Linn. phytoconstituents: A Review. Biomedicine & Pharmacotherapy. 2021; 135 ():111078.

Chicago/Turabian Style

Sabira Sultana; Naveed Munir; Zahed Mahmood; Muhammad Riaz; Muhammad Akram; Maksim Rebezov; Nazira Kuderinova; Zhanar Moldabayeva; Mohammad Ali Shariati; Abdur Rauf; Kannan R.R. Rengasamy. 2021. "Molecular targets for the management of cancer using Curcuma longa Linn. phytoconstituents: A Review." Biomedicine & Pharmacotherapy 135, no. : 111078.

Review
Published: 01 February 2021 in Seminars in Cancer Biology
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Ginger is a spice that is renowned for its characteristic aromatic fragrance and pungent taste, with documented healing properties. Field studies conducted in several Asian and African countries revealed that ginger is used traditionally in the management of cancer. The scientific community has probed into the biological validation of its extracts and isolated compounds including the gingerols, shogaols, zingiberene, and zingerone, through in-vitro and in-vivo studies. Nonetheless, an updated compilation of these data together with a deep mechanistic approach is yet to be provided. Accordingly, this review highlights the mechanisms and therapeutics of ginger and its bioactive compounds focused on a cancer context and these evidence are based on the (i) cytotoxic effect against cancer cell lines, (ii) enzyme inhibitory action, (iii) combination therapy with chemotherapeutic and phenolic compounds, (iv) possible links to the microbiome and (v) the use of nano-formulations of ginger bioactive compounds as a more effective drug delivery strategy in cancer therapy.

ACS Style

M.F. Mahomoodally; M.Z. Aumeeruddy; Kannan R.R. Rengasamy; S. Roshan; S. Hammad; Jessica Pandohee; Xuebo Hu; G. Zengin. Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications. Seminars in Cancer Biology 2021, 69, 140 -149.

AMA Style

M.F. Mahomoodally, M.Z. Aumeeruddy, Kannan R.R. Rengasamy, S. Roshan, S. Hammad, Jessica Pandohee, Xuebo Hu, G. Zengin. Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications. Seminars in Cancer Biology. 2021; 69 ():140-149.

Chicago/Turabian Style

M.F. Mahomoodally; M.Z. Aumeeruddy; Kannan R.R. Rengasamy; S. Roshan; S. Hammad; Jessica Pandohee; Xuebo Hu; G. Zengin. 2021. "Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications." Seminars in Cancer Biology 69, no. : 140-149.

Review article
Published: 28 January 2021 in Biomedicine & Pharmacotherapy
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The SARS-CoV-2, previously called a novel coronavirus, that broke out in the Wuhan city of China caused a significant number of morbidity and mortality in the world. It is spreading at peak levels since the first case reported and the need for vaccines is in immense demand globally. Numerous treatment and vaccination strategies that were previously employed for other pathogens including coronaviruses are now being been adopted to guide the formulation of new SARS-CoV-2 vaccines. Several vaccine targets can be utilized for the development of the SARS-CoV-2 vaccine. In this review, we highlighted the potential of various antigenic targets and other modes for formulating an effective vaccine against SARS-CoV-2. There are a varying number of challenges encountered during developing the most effective vaccines, and measures for tackling such challenges will assist in fast pace development of vaccines. This review will give a concise overview of various aspects of the vaccine development process against SARS-CoV-2, including 1) potential antigen targets 2) different vaccination strategies from conventional to novel platforms, 3) ongoing clinical trials, 4) varying challenges encountered during developing the most effective vaccine and the futuristic approaches.

ACS Style

Jonaid Ahmad Malik; Almas Hanif Mulla; Tahmeena Farooqi; Faheem Hyder Pottoo; Sirajudheen Anwar; Kannan R.R. Rengasamy. Targets and strategies for vaccine development against SARS-CoV-2. Biomedicine & Pharmacotherapy 2021, 137, 111254 -111254.

AMA Style

Jonaid Ahmad Malik, Almas Hanif Mulla, Tahmeena Farooqi, Faheem Hyder Pottoo, Sirajudheen Anwar, Kannan R.R. Rengasamy. Targets and strategies for vaccine development against SARS-CoV-2. Biomedicine & Pharmacotherapy. 2021; 137 ():111254-111254.

Chicago/Turabian Style

Jonaid Ahmad Malik; Almas Hanif Mulla; Tahmeena Farooqi; Faheem Hyder Pottoo; Sirajudheen Anwar; Kannan R.R. Rengasamy. 2021. "Targets and strategies for vaccine development against SARS-CoV-2." Biomedicine & Pharmacotherapy 137, no. : 111254-111254.

Journal article
Published: 26 January 2021 in South African Journal of Botany
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Thalictrum foliolosum DC. is a perennial herb of the Ranunculaceae family that has been used to cure high fever, inflammation, stomachache, and malaria in traditional Chinese medicines for centuries. The present study aims at the optimization of a hydro-alcoholic ultrasound-assisted extraction (UAE) for antifungal extracts from dry T. foliolosum roots (TFr) in vitro and their antifungal activity against Penicillium italicum by applying response surface methodology (RSM). Based on a Box-Behnken design (BBD), the obtained results Results showed that the suitable conditions of UAE method were as follows: extraction time of 70 min, ethanol concentration of 55%, liquid-to-solid ratio of 34 mL/g and extraction temperature of 75 °C. Under these conditions,the experimental inhibitory zone (59.33 ± 0.55 mm diameter) of TFr extract against P. italicum was well-matched with the predicted value (59.46 mm). The mycelial growth assay showed that TFr extract possessed a broad antifungal spectrum against thirteen phytopathogens. Both in vitro and in situ antifungal assays indicated that TFr extract as a natural antifungal agent can be potentially applied to control postharvest blue mold disease in citrus fruits.

ACS Style

Chuying Chen; Qiang Huang; Jinyin Chen; Kannan Rr Rengasamy; Chunpeng Wan. Extraction optimization of antifungal compounds from Thalictrum foliolosum DC. roots. South African Journal of Botany 2021, 138, 328 -336.

AMA Style

Chuying Chen, Qiang Huang, Jinyin Chen, Kannan Rr Rengasamy, Chunpeng Wan. Extraction optimization of antifungal compounds from Thalictrum foliolosum DC. roots. South African Journal of Botany. 2021; 138 ():328-336.

Chicago/Turabian Style

Chuying Chen; Qiang Huang; Jinyin Chen; Kannan Rr Rengasamy; Chunpeng Wan. 2021. "Extraction optimization of antifungal compounds from Thalictrum foliolosum DC. roots." South African Journal of Botany 138, no. : 328-336.