Francesco Pegreffi

Prof. Dr. Francesco Pegreffi

Medicina e Chirurgia, Università degli Studi di Enna Kore, Enna, Italy
orcid

Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2009 in Journal of Bone and Joint Surgery
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Journal Article
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GPGiuseppe Porcellini
Giuseppe Porcellini
FCFabrizio Campi
Fabrizio Campi
Francesco PegreffiFrancesco Pegreffi
Francesco Pegreffi
Alessandro CastagnaAlessandro Castagna
Alessandro Castagna
PPPaolo Paladini
Paolo Paladini
Background: Arthroscopic repair of anterior dislocation of the shoulder can fail. We hypothesized that patients who are at higher risk for redislocation following repair could be recognized preoperatively on the basis of their clinical history. The purpose of the present study was to identify the risk factors for recurrence in a community-based population of patients with traumatic unidirectional instability that was treated with a single arthroscopic technique. Methods: From January 2000 to December 2003, 625 patients with anterior unidirectional instability were managed with an arthroscopic Bankart technique, and 385 met the criteria for inclusion in the study. Demographic data were collected, and clinical follow-up was performed at three, six, twelve, twenty-four, and thirty-six months. Results: At thirty-six months, thirty-one patients (8.1%) had experienced a redislocation; the rate was 13.3% among patients who were twenty-two years of age and younger and 6.3% among older patients. Age at the time of the first dislocation, male sex, and the time from the first dislocation until surgery were significant risk factors for recurrence (p < 0.05 for all). Conclusions: Patients who are more likely to have a redislocation following arthroscopic repair of an anterior shoulder dislocation can be identified preoperatively on the basis of sex, age, and the time from the first dislocation to surgery. Level of Evidence: Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence.

1 March 2011 in Injury
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Journal Article
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AHA. Hoang-Kim
A. Hoang-Kim
Francesco PegreffiFrancesco Pegreffi
Francesco Pegreffi
AMA. Moroni
A. Moroni
ALAmy L. Ladd
Amy L. Ladd

1 April 2006 in The International Journal of Artificial Organs
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Carla Renata ArciolaCarla Renata Arciola
Carla Renata Arciola
DCDavide Campoccia
Davide Campoccia
YAY.H. An
Y.H. An
LBL. Baldassarri
L. Baldassarri
VPV. Pirini
V. Pirini
Lorenzo MontanaroLorenzo Montanaro
Lorenzo Montanaro
Several species belonging to Staphylococcus genus (nonSau/nonSep species) exhibit increasing abilities as opportunistic pathogens in colonisation of periprosthesis tissues. Here we report on antibiotic resistance of 193 strains, belonging to nonSau/nonSep species, consecutively collected from orthopedic implant infections in a period of about 40 months. The 193 strains (representing 17% of all staphylococci isolated) were analysed for their antibiotic resistance to 16 different drugs. Five species turned out more prevalent, ranging from 1 to 5%: S. hominis (4.2%), S. haemolyticus (3.7%), S. capitis (2.7%), S. warneri (2.6%), and S. cohnii (1.6%). Among these, the prevalence of antibiotic resistance to penicillins was similar, ranging from 51% to 66%. Conversely, significant differences were observed for all the remaining antibiotics. For S. haemolyticus the resistances to oxacillin and imipenem, the four aminoglycosides and erythromycin were at least twice that of the other three species which were compared. S. warneri was on the contrary the species with the lowest occurrence of resistant strains. Ten species appeared only rarely at the infection sites: S. lugdunensis, S. caprae, S. equorum, S. intermedius, S. xylosus, S. simulans, S. saprophyticus, S. pasteuri, S. sciuri, and S. schleiferi. The behaviours of these species, often resistant to penicillins, were individually analysed. Differences in both the frequencies and the panels of antibiotic resistances observed among the nonSau/nonSep species: i) suggest that horizontal spreading of resistance factors, if acting, was not sufficient per se to level their bio-diversities; ii) highlight and confirm the worrisome appearance within the Staphylococcus genus of emerging “new pathogens”, not homogeneous for their virulence and antibiotic resistance prevalence, which deserve to be recognised and treated individually.

15 February 2023 in Journal of Clinical Medicine
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Francesco PegreffiFrancesco Pegreffi
Francesco Pegreffi
ABAlice Balestra
Alice Balestra
OLOrazio De Lucia
Orazio De Lucia
Lee SmithLee Smith
Lee Smith
MBMARIO BARBAGALLO
MARIO BARBAGALLO
Nicola VeroneseNicola Veronese
Nicola Veronese
An association between knee osteoarthritis (OA) and sarcopenia has been proposed, but the evidence is controversial, with the recent literature showing disparate results. Therefore, we aimed to perform a systematic review and meta-analysis to evaluate the prevalence of sarcopenia in knee OA patients compared to people not affected by this condition. We searched several databases until 22 February 2022. The data regarding prevalence were summarized using odds ratios (ORs) with their 95% confidence intervals (CIs). Among the 504 papers initially screened, 4 were included for a total of 7495 participants with a mean age of 68.4 years, who were mainly females (72.4%). The prevalence of sarcopenia in people with knee OA was 45.2%, whilst, in the controls, it was 31.2%. Pooling the data of the studies included that the prevalence of sarcopenia in knee OA was more than two times higher than in the control group (OR = 2.07; 95%CI: 1.43–3.00; I2 = 85%). This outcome did not suffer any publication bias. However, after removing an outlier study, the recalculated OR was 1.88. In conclusion, the presence of sarcopenia in knee OA patients was high, affecting one person in every two persons and was higher than in the control groups included.

1 April 2005 in Journal of Bone and Joint Surgery
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AMAntonio Moroni
Antonio Moroni
CFCesare Faldini
Cesare Faldini
Francesco PegreffiFrancesco Pegreffi
Francesco Pegreffi
AHAmy Hoang-Kim
Amy Hoang-Kim
FVFrancesca Vannini
Francesca Vannini
SGSandro Giannini
Sandro Giannini
Background: Although the use of a sliding hip screw is considered to be the preferred treatment for pertrochanteric femoral fractures, we theorized that external fixation could produce clinical outcomes equal to, if not better than, the outcomes obtained with conventional treatment. Furthermore, because external fixation is minimally invasive, we expected a lower rate of morbidity and a reduced need for blood transfusions. Therefore, we compared the two treatments in a clinical trial of elderly patients with pertrochanteric fracture. Methods: Forty consecutive elderly female patients who had a pertrochanteric fracture were randomized to be treated with either fixation with a 135° four-hole sliding hip screw (Group A) or an external fixation device with hydroxyapatite-coated pins (Group B). The inclusion criteria were female gender, an age of at least sixty-five years, an AO/OTA type-A1 or A2 fracture, and a bone mineral density T-score of less than -2.5. There were no differences in patient age, fracture type, bone mineral density, comorbidities, length of hospital stay, or quality of reduction between the two groups. Results: The average intraoperative time (and standard deviation) was 64 ± 6 minutes in Group A and 34 ± 5 minutes in Group B (p < 0.005). The average number of units of blood transfused postoperatively was 2.0 ± 0.1 in Group A and none in Group B (p < 0.0001). Group B had less pain five days postoperatively (p < 0.05). Varus collapse of the fracture at six months averaged 6° ± 8° in Group A and 2° ± 1° in Group B (p < 0.002). No pin-track infections occurred in Group B. The average Harris hip score at six months was 62 ± 19 points in Group A and 63 ± 17 points in Group B. Conclusions: This study showed that external fixation with hydroxyapatite-coated pins is an effective treatment for this fracture in this patient population. The operative time is brief, the blood loss is minimal, the fixation is adequate, and the reduction is maintained over time. Level of Evidence: Therapeutic Level I. See Instructions to Authors for a complete description of levels of evidence.

15 September 2022 in Drugs & Aging
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Journal Article
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LMLisa McCarthy
Lisa McCarthy
RSRachel Savage
Rachel Savage
KDKieran Dalton
Kieran Dalton
RMRobin Mason
Robin Mason
JLJoyce Li
Joyce Li
PRPaula A. Rochon
Paula A. Rochon