Mihaela Jana Țuculină

Dr. Mihaela Jana Țuculină

University of Medicine and Pharmacy of Craiova, Craiova, Dolj, Romania
orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 May 2022 in Diagnostics
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Journal Article
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Stelian-Mihai-Sever PetrescuStelian-Mihai-Sever Petrescu
Stelian-Mihai-Sever Petrescu
MȚMihaela Jana Țuculină
Mihaela Jana Țuculină
DPDragos-Laurentiu Popa
Dragos-Laurentiu Popa
ADAlina Duta
Alina Duta
ASAlex Ioan Sălan
Alex Ioan Sălan
IDIonela Teodora Dascălu
Ionela Teodora Dascălu
Cone beam computed tomography (CBCT) is a modern imaging technique that uses X-rays to investigate the structures of the dento-maxillary apparatus and obtain detailed images of those structures. The aim of this study was to determine a functional mathematical model able to evaluate the elastic force intensity on each bracket and tube type element and the ways in which those components act on the orthodontic system being used. To analyze a real orthodontic system, we studied the case of a 13-year-old female patient. To transfer geometric information from tomographic images, we used the InVesalius software. This software can generate three-dimensional reconstructions based on sequences and files in the DICOM format and was purchased from CBCT equipment. We analyzed and processed the geometries of the converted tissues in InVesalius using the Geomagic software. After using the Geomagic software, we exported the resulting model to the SolidWorks software used in computer-aided design. In this software, the model is transformed into a virtual solid. After making the geometric model, we analyzed the model using the Ansys Workbench software, which incorporates finite element analysis techniques. Following the simulations, we obtained result maps, which showed the complete mechanical behavior of the analyzed structures.

1 June 2023 in Medicina
Verified
Journal Article
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APAlexandru-Dan Popescu
Alexandru-Dan Popescu
MȚMihaela Jana Țuculină
Mihaela Jana Țuculină
ODOana Andreea Diaconu
Oana Andreea Diaconu
LGLelia Mihaela Gheorghita
Lelia Mihaela Gheorghita
Claudiu NicolicescuClaudiu Nicolicescu
Claudiu Nicolicescu
RVRuxandra Voinea-Georgescu
Ruxandra Voinea-Georgescu
Background and Objectives: This study aimed to evaluate the surface roughness evolution of several finished and polished composites when bleaching materials are applied. The research was conducted on four microhybrid or nanofilled composites that are used in dental restorations. Materials and Methods: For each composite type, 5 samples were selected for control, 5 samples were subjected to the bleaching protocol “office bleach” with 40% hydrogen peroxide, and 5 other samples were subjected to the “home bleach” protocol with 16% carbamide peroxide, resulting in a total number of 60 samples. The surfaces of all the samples were tested for roughness, and the values of the most relevant parameter (Ra), were collected. Comparisons between composites and samples were performed using one-way ANOVA (in Statistical Package for Social Sciences). Results: After the bleaching protocol with 40% hydrogen peroxide gel, it was found that the roughness of the group increased considerably compared to the control group, so the highest roughness was found at GC Gradia direct anterior group, and the lowest value was registered for the 3M ESPE Valux Plus group. Following the bleaching protocol with 16% carbamide peroxide (home bleach), it was noted that the sample surfaces were not as affected. In this case, the lowest roughness was found at 3M ESPE Valux Plus group, and the highest roughness was registered for the GC G-aenial anterior group. Following the interpretation of the results, all four types of dental composites tested showed significant surface roughness differences between the groups subjected to bleaching protocols and those kept as control (p < 0.05). Conclusions: The surfaces of the samples were affected by the bleaching protocols by increasing the roughness compared to the control samples.

28 August 2022 in Diagnostics
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Journal Article
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BMBugala Narcis Mihaita
Bugala Narcis Mihaita
Mara CarsoteMara Carsote
Mara Carsote
LSLoredana Elena Stoica
Loredana Elena Stoica
DADana Albulescu
Dana Albulescu
MȚMihaela Jana Țuculină
Mihaela Jana Țuculină
DADragos Ovidiu Alexandru
Dragos Ovidiu Alexandru
This review highlights oral anomalies with major clinical impact in Addison disease (AD), including dental health and dermatologic features, through a dual perspective: pigmentation issues and AD comorbidities with oral manifestations. Affecting 92% of AD patients, cutaneomucosal hyperpigmentation is synchronous with or precedes general manifestations by up to a decade, underlying melanocytic infiltration of the basal epidermal layer; melanophages in the superficial dermis; and, rarely, acanthosis, perivascular lymphocytic infiltrate, and hyperkeratosis. Intraoral pigmentation might be the only sign of AD; thus, early recognition is mandatory, and biopsy is helpful in selected cases. The buccal area is the most affected location; other sites are palatine arches, lips, gums, and tongue. Pigmented oral lesions are patchy or diffuse; mostly asymptomatic; and occasionally accompanied by pain, itchiness, and burn-like lesions. Pigmented lingual patches are isolated or multiple, located on dorsal and lateral areas; fungiform pigmented papillae are also reported in AD individuals. Dermoscopy examination is particularly indicated for fungal etiology; yet, it is not routinely performed. AD’s comorbidity burden includes the cluster of autoimmune polyglandular syndrome (APS) type 1 underlying AIRE gene malfunction. Chronic cutaneomucosal candidiasis (CMC), including oral CMC, represents the first sign of APS1 in 70–80% of cases, displaying autoantibodies against interleukin (IL)-17A, IL-17F ± IL-22, and probably a high mucosal concentration of interferon (IFN)-γ. CMC is prone to systemic candidiasis, representing a procarcinogenic status due to Th17 cell anomalies. In APS1, the first cause of mortality is infections (24%), followed by oral and esophageal cancers (15%). Autoimmune hypoparathyroidism (HyP) is the earliest endocrine element in APS1; a combination of CMC by the age of 5 years and dental enamel hypoplasia (the most frequent dental complication of pediatric HyP) by the age of 15 is an indication for HyP assessment. Children with HyP might experience short dental roots, enamel opacities, hypodontia, and eruption dysfunctions. Copresence of APS-related type 1 diabetes mellitus (DM) enhances the risk of CMC, as well as periodontal disease (PD). Anemia-related mucosal pallor is related to DM, hypothyroidism, hypogonadism, corresponding gastroenterological diseases (Crohn’s disease also presents oral ulceration (OU), mucogingivitis, and a 2–3 times higher risk of PD; Biermer anemia might cause hyperpigmentation by itself), and rheumatologic diseases (lupus induces OU, honeycomb plaques, keratotic plaques, angular cheilitis, buccal petechial lesions, and PD). In more than half of the patients, associated vitiligo involves depigmentation of oral mucosa at different levels (palatal, gingival, alveolar, buccal mucosa, and lips). Celiac disease may manifest xerostomia, dry lips, OU, sialadenitis, recurrent aphthous stomatitis and dental enamel defects in children, a higher prevalence of caries and dentin sensitivity, and gingival bleeding. Oral pigmented lesions might provide a useful index of suspicion for AD in apparently healthy individuals, and thus an adrenocorticotropic hormone (ACTH) stimulation is useful. The spectrum of autoimmune AD comorbidities massively complicates the overall picture of oral manifestations.

27 April 2023 in Diagnostics
Verified
Journal Article
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MKMahmoud KATTA Katta
Mahmoud KATTA Katta
Stelian-Mihai-Sever PetrescuStelian-Mihai-Sever Petrescu
Stelian-Mihai-Sever Petrescu
LDLucian Paul Dragomir
Lucian Paul Dragomir
MPMihai Raul Popescu
Mihai Raul Popescu
RGRuxandra Voinea Georgescu
Ruxandra Voinea Georgescu
IDIonela Teodora Dascălu
Ionela Teodora Dascălu
The finite element method (FEM) is a computational method that can solve all biomechanical problems, including the field of orthodontics. The purpose of this virtual experimental study is to determine the behavior of a real orthodontic system subjected to different systems of loads. To analyze the real orthodontic system, we studied the case of a 21-year-old female patient. We used the InVesalius program, which can transform a set of DICOM-type images taken from cone beam computed tomography (CBCT) into three-dimensional structures. These structures were edited, modified, completed, and analyzed from a geometric point of view with the help of the Geomagic software. The final result of these operations must be a three-dimensional model made up of perfectly closed surfaces so that they can be transformed into virtual solids. The model consisting of perfectly closed surfaces is loaded into computer-aided design (CAD) programs. Bracket and tube components, as well as orthodontic wires, can be added to these models, similar to the analyzed patient’s tissues. When the model is complete and geometrically correct, it is exported to a program that uses FEM, such as Ansys Workbench. The simulation was performed for the forces of 0.5, 0.6, 0.7, 0.8, 0.9, and 1 N. The intention was to determine the behavior of the entire orthodontic system for these force values. After running the simulations, result maps were obtained that were composed of displacement, strain, and stress diagrams. It was also found that, in addition to the known rigidity, the orthodontic system has some elasticity due to the orthodontic wires, as well as the periodontal ligaments. Thus, a virtual analysis study can be carried out starting from a real patient with pre-treatment CBCT images and the virtual models of the bracket and tube elements and of the orthodontic wires.

1 December 2021 in Experimental and Therapeutic Medicine
Verified
Journal Article
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IBIulia Bailescu
Iulia Bailescu
MPMihai Popescu
Mihai Popescu
LSLavinia Raluca Sarafoleanu
Lavinia Raluca Sarafoleanu
SBSimona Bondari
Simona Bondari
CSCorneliu Sabetay
Corneliu Sabetay
DADana-Maria Albulescu
Dana-Maria Albulescu
Osteochondroma represents a bone outgrowth covered by cartilaginous tissue and localized on the external surface of the bone. The incidence of osteochondroma is 20‑35% of all pediatric benign tumors. Osteochondromas can be present in solitary or multiple forms and usually occur in the metaphysis of long bones in immature skeletons. The present study aimed to retrospectively determine the association between imaging diagnostic accuracy and histopathological examinations, which are the main methods of diagnosis for this type of tumor. A total of 66 patients presenting with radiological aspects of osteochondroma were initially selected; however, only the 56 patients who had a positive histopathological diagnosis of osteochondroma were eventually included in this study. Patient characteristics were taken into consideration and included age, sex, lesion localization, lesion imaging semiotics and histopathological aspects. Osteochondromas are generally asymptomatic lesions that are often incidentally diagnosed after trauma, which makes it difficult to determine the exact incidence of this pathology.

16 May 2023 in Diagnostics
Verified
Journal Article
Open access
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ASAdrian Ștefan Stănuși
Adrian Ștefan Stănuși
DPDragos-Laurentiu Popa
Dragos-Laurentiu Popa
MIMihaela Ionescu
Mihaela Ionescu
CCCristian Niky Cumpătă
Cristian Niky Cumpătă
GPGabriel Sebastian Petrescu
Gabriel Sebastian Petrescu
ASAndreea Stanusi
Andreea Stanusi
The success of endodontic treatment is dependent on the removal of bacteria. A modern strategy to reduce bacterial load is laser irradiation. During this procedure, there is a local increase in temperature with possible side effects. The aim of this study was to determine the thermal behavior of a maxillary first molar when performing the conventional irradiation technique using a diode laser. For this study, a 3D virtual model of a maxillary first molar was created. The preparation of the access cavity, the rotary instrumentation of the palatal root canal and the laser irradiation protocol were simulated. The model was exported in a finite element analysis program where the temperature and heat flux were studied. Temperature and heat flux maps were obtained, and the temperature increase on the internal wall of the root canal was analyzed. The maximum temperature value exceeded 400 °C and was maintained for less than 0.5 s. The obtained temperature maps support the bactericidal effect of diode laser and the limitation of damage to surrounding tissues. On internal root walls, the temperature reached several hundred degrees Celsius, but for very short durations. Conventional laser irradiation is an adjuvant method of decontamination of the endodontic system.