Leona S. Alizadeh

Dr. Leona S. Alizadeh

orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 June 2022 in Tomography
Verified
Journal Article
Open access
PDF file
SWStephan Waldeck
Stephan Waldeck
DODaniel Overhoff
Daniel Overhoff
Leona S. AlizadehLeona S. Alizadeh
Leona S. Alizadeh
BBBenjamin Becker
Benjamin Becker
MPMatthias Port
Matthias Port
SSSandra Schmidt
Sandra Schmidt
Cochlear implants (CIs) are the primary treatment method in patients with profound sensorineural hearing loss. Interpretation of postoperative imaging with conventional energy-integrating detector computed tomography (EID-CT) following CI surgery remains challenging due to metal artifacts. Still, the photon-counting detector (PCD-CT) is a new emerging technology with the potential to eliminate these problems. This study evaluated the performance of virtual monoenergetic (VME) EID-CT images versus PCD-CT in CI imaging. In this cadaveric study, two temporal bone specimens with implanted CIs were scanned with EID-CT and PCD-CT. The images were assessed according to the visibility of interelectrode wire, size of electrode contact, and diameter of halo artifacts. The visibility of interelectrode wire sections was significantly higher when reviewing PCD-CT images. The difference in diameter measurements for electrode contacts between the two CT scanner modalities showed that the PCD-CT technology generally led to significantly larger diameter readings. The larger measurements were closer to the manufacturer’s specifications for the CI electrode. The size of halo artifacts surrounding the electrode contacts did not differ significantly between the two imaging modalities. PCT-CT imaging is a promising technology for CI imaging with improved spatial resolution and better visibility of small structures than conventional EID-CT.

1 June 2022 in Academic Radiology
Verified
Journal Article
Closed access
VKVitali Koch
Vitali Koch
MAMoritz H. Albrecht
Moritz H. Albrecht
LGLeon David Gruenewald
Leon David Gruenewald
IYIbrahim Yel
Ibrahim Yel
KEKatrin Eichler
Katrin Eichler
CBChristian Booz
Christian Booz

7 June 2022 in Academic Radiology
Verified
Journal Article
Open access
Leona S. AlizadehLeona S. Alizadeh
Leona S. Alizadeh
MGMarcell Gyánó
Marcell Gyánó
IGIstván Góg
István Góg
KSKrisztián Szigeti
Krisztián Szigeti
SOSzabolcs Osváth
Szabolcs Osváth
CBChristian Booz
Christian Booz
In previous clinical studies digital variance angiography (DVA) provided higher contrast-to-noise ratio (CNR) and better image quality in lower extremity angiography than digital subtraction angiography (DSA). Our aim was to investigate whether DVA has similar quality reserve in prostatic artery embolization (PAE). The secondary aim was to explore the potential advantages of the color-coded DVA (ccDVA) technology in PAE. This retrospective study evaluated 108 angiographic acquisitions from 30 patients (mean ± SD age 68.0 ± 8.9, range 41-87) undergoing PAE between May and October 2020. DSA and DVA images were generated from the same unsubtracted acquisition, and their CNR was calculated. Visual evaluation of DVA and DSA image quality was performed by four experienced interventional radiologists in a randomized, blinded manner. The diagnostic value of DSA and ccDVA images was also evaluated using clinically relevant criteria (visibility of small [< 2.5 mm] and large arteries [> 2.5 mm], feeding arteries and tissue blush) in a paired comparison. Data were analysed by the Wilcoxon signed rank test or the binomial test, the interrater agreement was determined by the Kendall W or Fleiss Kappa analysis. DVA provided 4.11 times higher median CNR than DSA (IQR: 1.72). The visual score of DVA images (4.40 ± 0.05) was significantly higher than that of DSA (3.39 ± 0.07, p < 0.001). The Kendall W analysis showed moderate but significant agreement (WDVA = 0.38, WDSA = 0.53). The preference of ccDVA images was significantly higher in all criteria (63-89%) with an interrater agreement of 58-79%. The Fleiss Kappa range was 0.02-0.18, significant in all criteria except large vessels. Our data show that DVA provides higher CNR and better image quality in PAE. This quality reserve might be used for dose management (reduction of radiation dose and contrast agent volume), and ccDVA technology has also a high potential to assist PAE interventions in the future.

20 November 2021 in Diagnostic and Interventional Radiology
Verified
Journal Article
Closed access
Thomas Josef VoglThomas Josef Vogl
Thomas Josef Vogl
AZAnnette Zinn
Annette Zinn
EEElsayed Elhawash
Elsayed Elhawash
Leona S. AlizadehLeona S. Alizadeh
Leona S. Alizadeh
Nour-Eldin A. Nour-EldinNour-Eldin A. Nour-Eldin
Nour-Eldin A. Nour-Eldin
NNNaguib Nagy
Naguib Nagy
We aimed to evaluate the advantages of magnetic resonance angiography (MRA)-planned prostatic artery embolization (PAE) for benign prostatic hyperplasia (BPH). In this retrospective study, MRAs of 56 patients (mean age, 67.23±7.73 years; age range, 47–82 years) who underwent PAE between 2017 and 2018 were evaluated. For inclusion, full information about procedure time and radiation values must have been available. To identify prostatic artery (PA) origin, three-dimensional MRA reconstruction with maximum intensity projection was conducted in every patient. In total, 33 patients completed clinical and imaging follow-up and were included in clinical evaluation. There were 131 PAs with a second PA in 19 pelvic sides. PA origin was correctly identified via MRA in 108 of 131 PAs (82.44%). In patients in which MRA allowed a PA analysis, a significant reduction of the fluoroscopy time (−27.0%, p = 0.028) and of the dose area product (−38.0%, p = 0.003) was detected versus those with no PA analysis prior to PAE. Intervention time was reduced by 13.2%, (p = 0.25). Mean fluoroscopy time was 30.1 min, mean dose area product 27,749 μGy·m2, and mean entrance dose 1553 mGy. Technical success was achieved in all 56 patients (100.0%); all patients were embolized on both pelvic sides. The evaluated data documented a significant reduction in international prostate symptom scores (p < 0.001; mean 9.67 points). MRA prior to PAE allowed the identification of PA in 82.44% of the cases. MRA-planned PAE is an effective treatment for patients with BPH.

2 February 2023 in Diagnostics
Verified
Journal Article
Open access
PDF file
CBChristian Booz
Christian Booz
IYIbrahim Yel
Ibrahim Yel
JWJulian L. Wichmann
Julian L. Wichmann
SMSimon S. Martin
Simon S. Martin
VKVitali Koch
Vitali Koch
TDTommaso D'Angelo
Tommaso D'Angelo
Urine sedimentation in the bladder can occur in various circumstances and can lead to urinary obstruction/stasis with associated pain. It is usually diagnosed with an ultrasound; however, CT is also used to assess the amount and to further check for urinary stones. Depending on the composition, urine sedimentation and stones can be treated medically by alkalinisation of the urine with potassium sodium hydrogen citrate in the case of uric acid-based sedimentation/stones. Due to technical developments and improved material differentiation and characterisation in CT imaging, dual-energy CT allows for differentiation of uric acid from calcium, which can be used for sedimentation/stone composition analysis. Subsequently, treatment decisions can be made based on the findings in dual-energy CT.

12 June 2024 in Academic Radiology
Verified
Journal Article
Closed access
Leona S. AlizadehLeona S. Alizadeh
Leona S. Alizadeh
DRDavid Radek
David Radek
CBChristian Booz
Christian Booz
NVNiklas Verloh
Niklas Verloh
IYIbrahim Yel
Ibrahim Yel
TVThomas J. Vogl
Thomas J. Vogl