Andre EL KHOURY

Prof. Dr. Andre EL KHOURY

Saint Joseph University, Beirut, Beyrouth, Lebanon
orcid

Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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29 March 2010 in Toxins
Verified
Journal Article
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Andre EL KHOURYAndre EL KHOURY
Andre EL KHOURY
AAAli Atoui
Ali Atoui
Ochratoxin A (OTA) is a mycotoxin produced by several species of Aspergillus and Penicillium fungi that structurally consists of a para-chlorophenolic group containing a dihydroisocoumarin moiety that is amide-linked to L-phenylalanine. OTA is detected worldwide in various food and feed sources. Studies show that this molecule can have several toxicological effects such as nephrotoxic, hepatotoxic, neurotoxic, teratogenic and immunotoxic. A role in the etiology of Balkan endemic nephropathy and its association to urinary tract tumors has been also proved. In this review, we will explore the general aspect of OTA: physico-chemical properties, toxicological profile, OTA producing fungi, contaminated food, regulation, legislation and analytical methods. Due to lack of sufficient information related to the molecular background, this paper will discuss in detail the recent advances in molecular biology of OTA biosynthesis, based on information and on new data about identification and characterization of ochratoxin biosynthetic genes in both Penicillium and Aspergillus species. This review will also cover the development of the molecular methods for the detection and quantification of OTA producing fungi in various foodstuffs.

28 February 2020 in Toxins
Verified
Journal Article
Open access
PDF file
ICIsaura Caceres
Isaura Caceres
AKAnthony Al Khoury
Anthony Al Khoury
RKRhoda El Khoury
Rhoda El Khoury
LSLORBER Sophie
LORBER Sophie
Isabelle OswaldIsabelle Oswald
Isabelle Oswald
Jean-Denis BaillyJean-Denis Bailly
Jean-Denis Bailly
The study of fungal species evolved radically with the development of molecular techniques and produced new evidence to understand specific fungal mechanisms such as the production of toxic secondary metabolites. Taking advantage of these technologies to improve food safety, the molecular study of toxinogenic species can help elucidate the mechanisms underlying toxin production and enable the development of new effective strategies to control fungal toxicity. Numerous studies have been made on genes involved in aflatoxin B1 (AFB1) production, one of the most hazardous carcinogenic toxins for humans and animals. The current review presents the roles of these different genes and their possible impact on AFB1 production. We focus on the toxinogenic strains Aspergillus flavus and A. parasiticus, primary contaminants and major producers of AFB1 in crops. However, genetic reports on A. nidulans are also included because of the capacity of this fungus to produce sterigmatocystin, the penultimate stable metabolite during AFB1 production. The aim of this review is to provide a general overview of the AFB1 enzymatic biosynthesis pathway and its link with the genes belonging to the AFB1 cluster. It also aims to illustrate the role of global environmental factors on aflatoxin production and the recent data that demonstrate an interconnection between genes regulated by these environmental signals and aflatoxin biosynthetic pathway.

1 January 2021 in AIMS Agriculture and Food
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Journal Article
Open access
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RDRouaa Daou
Rouaa Daou
KJKarine Joubrane
Karine Joubrane
Richard G. MarounRichard G. Maroun
Richard G. Maroun
LKLydia Rabbaa Khabbaz
Lydia Rabbaa Khabbaz
AIAli Ismail
Ali Ismail
Andre EL KHOURYAndre EL KHOURY
Andre EL KHOURY
Mycotoxins are secondary metabolites produced by filamentous fungi in food and feed due to several conditions that affect fungal growth and mycotoxin production in different ways. This review aims to explore the different factors that affect mycotoxin production and their control methods. Environmental conditions such as high temperature and humidity increase the risk of fungal growth and mycotoxin production. Other factors that affect contamination include pH, fungal strain, and substrate. To control mycotoxin contamination an integrated approach that starts in the field prior to planting and continues throughout the whole food chain is required, so good practices help minimize contamination at every step to deliver safe products. Good practices include proper practices on the field before and after planting, good harvest practices, appropriate drying measures, and good storage practices. Mycotoxin contamination is inevitable in food and once present they tend to remain as they are very stable compounds, although several physical, chemical and biological techniques could be applied to help minimize contamination. Food processing may also play a minimal role in controlling mycotoxins. Finally, regulations serve to keep food markets free from highly contaminated products, while proper sampling procedures and analytical methods ensure regulations endorsement.

1 October 2014 in International Journal of Food Microbiology
Verified
Journal Article
Closed access
Joanna TannousJoanna Tannous
Joanna Tannous
RKRhoda El Khoury
Rhoda El Khoury
SSSelma Pascale Snini
Selma Pascale Snini
YLYannick Lippi
Yannick Lippi
Andre EL KHOURYAndre EL KHOURY
Andre EL KHOURY
OPOlivier Puel
Olivier Puel

1 October 2011 in Food Control
Verified
Journal Article
Closed access
Andre EL KHOURYAndre EL KHOURY
Andre EL KHOURY
AAAli Atoui
Ali Atoui
JYJoseph Yaghi
Joseph Yaghi

1 August 2019 in LWT
Verified
Journal Article
Closed access
Hiba N. RAJHAHiba N. RAJHA
Hiba N. RAJHA
TMTania Mhanna
Tania Mhanna
SKSally El Kantar
Sally El Kantar
Andre EL KHOURYAndre EL KHOURY
Andre EL KHOURY
Nicolas LOUKANicolas LOUKA
Nicolas LOUKA
Richard G. MarounRichard G. Maroun
Richard G. Maroun