Iyyakkannu Sivanesan

Prof. Iyyakkannu Sivanesan

Konkuk University
orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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22 September 2016 in 3 Biotech
Verified
Journal Article
Open access
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Ramesh Kumar SainiRamesh Kumar Saini
Ramesh Kumar Saini
Iyyakkannu SivanesanIyyakkannu Sivanesan
Iyyakkannu Sivanesan
YKYoung-Soo Keum
Young-Soo Keum
Moringa oleifera Lam., also known as the ‘drumstick tree,’ is recognized as a vibrant and affordable source of phytochemicals, having potential applications in medicines, functional food preparations, water purification, and biodiesel production. The multiple biological activities including antiproliferation, hepatoprotective, anti-inflammatory, antinociceptive, antiatherosclerotic, oxidative DNA damage protective, antiperoxidative, cardioprotective, as well as folk medicinal uses of M. oleifera (MO) are attributed to the presence of functional bioactive compounds, such as phenolic acids, flavonoids, alkaloids, phytosterols, natural sugars, vitamins, minerals, and organic acids. The low molecular weight of M. oleifera cationic proteins (MOCP) extracted from the seeds is very useful and is used in water purification, because of its potent antimicrobial and coagulant properties. Also, the M. oleifera methyl esters (MOME) produced from the oil of the seeds meet the major specifications of the biodiesel standard of Germany, Europe, and United States (US). Thus, MO is emerging as one of the prominent industrial crops for sustainable biodiesel production in tropical and subtropical countries. In view of the high nutritional, nutraceutical, and industrial values, it is important to compile an updated comprehensive review on the related aspects of this multipurpose and miracle tree. Hence, the present study is focused on the nutritionally significant bioactives and medicinal and biological properties, to explore the potential applications of MO in nutritionally rich food preparations. Furthermore, water coagulation, proteins, and fatty acid methyl esters from the MO seeds are reviewed, to explore their possible industrial applications in biodiesel production and water purification. In addition, the future perspectives in these areas are suggested.

21 July 2017 in RSC Advances
Verified
Journal Article
Open access
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DKDoo Hwan Kim
Doo Hwan Kim
JGJudy Gopal
Judy Gopal
Iyyakkannu SivanesanIyyakkannu Sivanesan
Iyyakkannu Sivanesan
Plant tissue cultures are the core of plant biology, which is important for conservation, mass propagation, genetic manipulation, bioactive compound production and plant improvement. In recent years, the application of nanoparticles (NPs) has successfully led to the elimination of microbial contaminants from explants and demonstrated the positive role of NPs in callus induction, organogenesis, somatic embryogenesis, somaclonal variation, genetic transformation and secondary metabolite production. This review aims to consolidate all of the current achievements made through the integration of nanotechnology into plant tissue culture and highlight the positive attributes of using NPs in plant tissue culture. Both the positive and adverse effects of using NPs in the culture medium are discussed and presented. The toxicity aspects and the safety concerns of exposing plants and the associated environment to NPs are recorded. Finally, future prospects through the involvement of not merely Ag, TiO2, and ZnO NPs, but more recent innovations such as graphene, carbon nanotubes, SiO2, quantum dots, and dendrimers are proposed. The undisclosed shadows hanging in the background, including the repercussions of using nanomaterials without proper awareness, as well as dosage-based adverse effects and nanotoxicity aspects, are highlighted. The need for more research in the pursuit of discrete answers to unresolved questions regarding mechanisms is emphasized as the key to real progress in plant nanobiotechnology.

18 December 2024 in Pharmaceuticals
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Journal Article
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Arun KarnwalArun Karnwal
Arun Karnwal
AJAmar Yasser Jassim
Amar Yasser Jassim
AMAmeer Abbas Mohammed
Ameer Abbas Mohammed
VSVikas Sharma
Vikas Sharma
Abdel Razzaq Mohammad Al -TawahaAbdel Razzaq Mohammad Al -Tawaha
Abdel Razzaq Mohammad Al -Tawaha
Iyyakkannu SivanesanIyyakkannu Sivanesan
Iyyakkannu Sivanesan
Nanotechnology has revolutionised biomedical research, offering innovative healthcare solutions. Plant-based nanotechnology is emerging as a sustainable alternative, minimising environmental impacts and enhancing therapeutic effectiveness. This paper explores the potential of plant-derived nanoparticles (PNPs) in medicine, highlighting their biocompatibility, multifunctionality, and eco-friendliness. PNPs, synthesised through green methods, have demonstrated promising applications in drug delivery, cancer therapy, antimicrobial treatments, and tissue regeneration. Their unique properties, such as a high surface area and bioactive components, enable improved drug delivery, targeting, and controlled release, reducing side effects and enhancing treatment efficacy. Additionally, plant-derived compounds’ inherent antimicrobial and antioxidant properties, retained within platinum nanoparticles (PNPs), present innovative opportunities for combating antimicrobial resistance and promoting wound healing. Despite their potential, challenges remain in standardising PNP synthesis, ensuring consistency, and scaling up production for industrial applications. This review emphasises the need for further research on PNP toxicity, biocompatibility, and regulatory frameworks to fully harness their capabilities in clinical and commercial applications. Plant-based nanotechnology represents a promising, greener alternative for advancing healthcare solutions, aligning with global sustainability goals.

3 February 2021 in Antioxidants
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Journal Article
Open access
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MMManikandan Muthu
Manikandan Muthu
JGJudy Gopal
Judy Gopal
Se Chul ChunSe Chul Chun
Se Chul Chun
ADAnna Jacintha Prameela Devadoss
Anna Jacintha Prameela Devadoss
Nazim HasanNazim Hasan
Nazim Hasan
Iyyakkannu SivanesanIyyakkannu Sivanesan
Iyyakkannu Sivanesan
Chitosan is obtained from chitin that in turn is recovered from marine crustacean wastes. The recovery methods and their varying types and the advantages of the recovery methods are briefly discussed. The bioactive properties of chitosan, which emphasize the unequivocal deliverables contained by this biopolymer, have been concisely presented. The variations of chitosan and its derivatives and their unique properties are discussed. The antioxidant properties of chitosan have been presented and the need for more work targeted towards harnessing the antioxidant property of chitosan has been emphasized. Some portions of the crustacean waste are being converted to chitosan; the possibility that all of the waste can be used for harnessing this versatile multifaceted product chitosan is projected in this review. The future of chitosan recovery from marine crustacean wastes and the need to improve in this area of research, through the inclusion of nanotechnological inputs have been listed under future perspective.

14 February 2023 in Plants
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Journal Article
Open access
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RSRam Kumar Samynathan
Ram Kumar Samynathan
Baskar VenkidasamyBaskar Venkidasamy
Baskar Venkidasamy
KRKarthikeyan Ramya
Karthikeyan Ramya
Pandiyan MuthuramalingamPandiyan Muthuramalingam
Pandiyan Muthuramalingam
Hyunsuk ShinHyunsuk Shin
Hyunsuk Shin
Iyyakkannu SivanesanIyyakkannu Sivanesan
Iyyakkannu Sivanesan
Selenium (Se) is a microelement that plays an important nutrient role by influencing various physiological and biochemical traits in plants. It has been shown to stimulate plant metabolism, enhancing secondary metabolites and lowering abiotic and biotic stress in plants. Globally, the enormous applications of nanotechnology in the food and agricultural sectors have vastly expanded. Nanoselenium is more active than bulk materials, and various routes of synthesis of Se nanoparticles (Se-NPs) have been reported in which green synthesis using plants is more attractive due to a reduction in ecological issues and an increase in biological activities. The Se-NP-based biofortification is more significant because it increases plant stress tolerance and positively impacts their metabolism. Se-NPs can enhance plant resistance to various oxidative stresses, promote growth, enhance soil nutrient status, enhance plant antioxidant levels, and participate in the transpiration process. Additionally, they use a readily available, biodegradable reducing agent and are ecologically friendly. This review concentrates on notable information on the different modes of Se-NPs’ synthesis and characterization, their applications in plant growth, yield, and stress tolerance, and their influence on the metabolic process.

20 November 2022 in Metabolites
Verified
Journal Article
Open access
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NMNandakumar Muruganathan
Nandakumar Muruganathan
ADAnand Raj Dhanapal
Anand Raj Dhanapal
Baskar VenkidasamyBaskar Venkidasamy
Baskar Venkidasamy
Pandiyan MuthuramalingamPandiyan Muthuramalingam
Pandiyan Muthuramalingam
DSDhivya Selvaraj
Dhivya Selvaraj
Iyyakkannu SivanesanIyyakkannu Sivanesan
Iyyakkannu Sivanesan
Nature gives immense resources that are beneficial to humankind. The natural compounds present in plants provide primary nutritional values to our diet. Apart from food, plants also provide chemical compounds with therapeutic values. The importance of these plant secondary metabolites is increasing due to more studies revealing their beneficial properties in treating and managing various diseases and their symptoms. Among them, flavonoids are crucial secondary metabolite compounds present in most plants. Of the reported 8000 flavonoid compounds, luteolin is an essential dietary compound. This review discusses the source of the essential flavonoid luteolin in various plants and its biosynthesis. Furthermore, the potential health benefits of luteolins such as anti-cancer, anti-microbial, anti-inflammatory, antioxidant, and anti-diabetic effects and their mechanisms are discussed in detail. The activity of luteolin and its derivatives are diverse, as they help to prevent and control many diseases and their life-threatening effects. This review will enhance the knowledge and recent findings regarding luteolin and its therapeutic effects, which are certainly useful in potentially utilizing this natural metabolite.