Background and Objectives: This study aimed to histologically evaluate the effects of local melatonin application at different doses on bone fracture healing. Materials and Methods: Thirty rats were divided into three groups, with ten rats in each group. In the control group (n = 10), a fracture line was created in the tibial bones, and fracture osteosynthesis was performed without any additional procedure. In the local melatonin dose 1 (MLT D-1) group (n = 10), a fracture line was created in the tibial bones, and 1.2 mg of lyophilized powder melatonin was applied locally before fracture osteosynthesis. In the local melatonin dose 2 (MLT D-2) group (n = 10), a fracture line was created in the tibial bones, and 3 mg of lyophilized powder melatonin was applied locally before fracture osteosynthesis. After a 12-week healing period, all subjects were sacrificed, and tibial bones were collected for histomorphometric analysis. Results: The percentage of bone formation was significantly higher in the MLT D-1 and MLT D-2 groups than in the control group. There was no statistically significant difference between the MLT D-1 and MLT D-2 groups. Conclusions: In conclusion, the study demonstrated that local melatonin application supports bone fracture by increasing bone formation, although different doses of melatonin did not lead to significant variations in fracture healing.

Resin-bonded fixed dental prostheses (RBFDPs) are a commonly used precision treatment, such as fixed dental prosthesis (FDP) and implant-supported dentures. Full crown preparation of vital teeth, which is required for traditional FDPs, may result in a risk of pulp reaction as a large portion of the coronal tooth structure must be removed. RBFDP has been recognized as a non-invasive or minimally invasive treatment modality for the replacement of single missing teeth. RBFDPs require much less tooth preparation than conventional FDPs. These dental treatments are restorative solutions used to cover missing teeth and achieve an aesthetic smile. The biomechanical rules, aesthetics, polishability, and bond strength have been emphasized in RBFDP treatments. Polyetheretherketone (PEEK) is one of the most widely used biomaterials in dentistry. The material, which stands out especially with its acceptable aesthetics, biocompatibility and modulus of elasticity close to dentin, has enabled it to be used in RBFDP treatments. Since PEEK is lighter than metal alloys, patients experience less discomfort and a feeling closer to natural teeth. Furthermore, the thermoplastic properties of PEEK are claimed to provide a precise fit, allowing the restoration to better integrate into the natural tooth structure. In addition, its ability to be customized using different modern manufacturing techniques is thought to offer dentists and patients a reliable option for successful long-term treatment. Our review is about the use of PEEK material as an alternative material in RBFDPs with low negative effects on periodontal tissues and their bonding with resins.

Background This study aimed to conduct a biomechanical investigation of the effects of stem cell enhancer (SCE) application on osseointegration of titanium implants in rat tibias. Methods After surgical implantation of titanium implants in the metaphyseal part of the tibiae of rats, the rats were randomly divided into three equal groups (n = 10): control group, SCE Dosage group 1 (SCE1), and SCE Dosage group 2 (SCE2). Each group consisted of 10 rats. The rats in the SCE1 and SCE2 groups were administered 6 mg and 12 mg SCE (Stemregen®), respectively, every day during the four-week of experimental period after surgery. Implants and surrounding bone tissues were collected for biomechanical bone-implant connection analysis at the end of the experimental procedures. One-way ANOVA was used for statistical analysis. Results There was no significant difference in the biomechanical osseointegration values of the groups; however, the osseointegration of the SCE group was better than that of the control group. Conclusions Stem cell enhancers have the potential to improve the biomechanical bone-implant interface.

Purpose: The aim of this study was to compare oral hygiene, trauma incidence, DMFT and dmft index, PUFA, pufa and PUFA/pufa index of children with special educational needs according to disability status. Materials and Methods: This cross-sectional study was conducted in special education institutions in Elazig. Age, gender, disability, presence of dental caries, dental trauma, dental abrasions, oral hygiene and cooperation status of the children were recorded. DMFT/dmft and PUFA/pufa index were used for dental caries scoring. One-way ANOVA and Chi-square tests were used to analyze the data and the significance level was determined as 0.05. Results: There was a statistically significant difference (p

Objective: To describe oral health status and its relationship with glycemic control in children with type 1 diabetes mellitus (T1DM) using standardized indices. Materials and Methods: A comparative cross-sectional study was conducted with 30 children aged 6-14 years with T1DM and 30 healthy controls. Oral examinations recorded DMFS/ dfs (Decayed, Missing, Filled Surfaces), PUFA/pufa (Pulpal involvement,Ulceration, Fistula, Abscess), Plaque Index (PI), Gingival Index (GI), and Simplified Oral Hygiene Index (OHI-S). Glycated hemoglobin (HbA1c) levels were categorized as ≤7% or >7%. Non-parametric tests, Spearman’s correlation analyses were performed. The level of statistical significance was set at P < .05. Results: The T1DM group had significantly lower DMFS/dfs and PUFA/pufa scores than controls (P < .001 and P = .004, respectively), and no significant differences were found in PI, GI, and OHI-S values. In the T1DM group, correlation analyses between HbA1c levels and oral health indices (DMFS/dfs, PUFA/pufa, PI, GI, and OHI-S) revealed no statistically significant associations (P > .05). No statistically significant correlations were found between HbA1c and any of the oral health indices (P > .05). Conclusion: Children with T1DM showed lower caries experience, possibly due to regular medicalfollow-up, nutritional counseling, and improved oral hygiene. Routine oral health monitoringshould be integrated into pediatric diabetes care.