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Cyanotoxins (CTs) produced by cyanobacteria in surface freshwater are a major threat for public health and aquatic ecosystems. Cyanobacteria can also produce a wide variety of other understudied bioactive metabolites such as oligopeptides microginins (MGs), aeruginosins (AERs), aeruginosamides (AEGs) and anabaenopeptins (APs). This study reports on the co-occurrence of CTs and cyanopeptides (CPs) in Lake Vegoritis, Greece and presents their variant-specific profiles obtained during 3-years of monitoring (2018ā2020). Fifteen CTs (cylindrospermopsin (CYN), anatoxin (ATX), nodularin (NOD), and 12 microcystins (MCs)) and ten CPs (3 APs, 4 MGs, 2 AERs and aeruginosamide (AEG A)) were targeted using an extended and validated LC-MS/MS protocol for the simultaneous determination of multi-class CTs and CPs. Results showed the presence of MCs (MC-LR, MC-RR, MC-YR, dmMC-LR, dmMC-RR, MC-HtyR, and MC-HilR) and CYN at concentrations of <1 μg/L, with MC-LR (79%) and CYN (71%) being the most frequently occurring. Anabaenopeptins B (AP B) and F (AP F) were detected in almost all samples and microginin T1 (MG T1) was the most abundant CP, reaching 47.0 μg/L. This is the first report of the co-occurrence of CTs and CPs in Lake Vegoritis, which is used for irrigation, fishing and recreational activities. The findings support the need for further investigations of the occurrence of CTs and the less studied cyanobacterial metabolites in lakes, to promote risk assessment with relevance to human exposure.
Sevasti-Kiriaki Zervou; Kimon Moschandreou; Aikaterina Paraskevopoulou; Christophoros Christophoridis; Elpida Grigoriadou; Triantafyllos Kaloudis; Theodoros Triantis; Vasiliki Tsiaoussi; Anastasia Hiskia. Cyanobacterial Toxins and Peptides in Lake Vegoritis, Greece. Toxins 2021, 13, 394 .
AMA StyleSevasti-Kiriaki Zervou, Kimon Moschandreou, Aikaterina Paraskevopoulou, Christophoros Christophoridis, Elpida Grigoriadou, Triantafyllos Kaloudis, Theodoros Triantis, Vasiliki Tsiaoussi, Anastasia Hiskia. Cyanobacterial Toxins and Peptides in Lake Vegoritis, Greece. Toxins. 2021; 13 (6):394.
Chicago/Turabian StyleSevasti-Kiriaki Zervou; Kimon Moschandreou; Aikaterina Paraskevopoulou; Christophoros Christophoridis; Elpida Grigoriadou; Triantafyllos Kaloudis; Theodoros Triantis; Vasiliki Tsiaoussi; Anastasia Hiskia. 2021. "Cyanobacterial Toxins and Peptides in Lake Vegoritis, Greece." Toxins 13, no. 6: 394.
The production of β-Ī-methylamino-L-alanine (BMAA) in cyanobacteria is triggered by nitrogen-starvation conditions and its biological role, albeit unknown, is associated with nitrogen assimilation. In the present study, the effect of BMAA (773 μg Lā1) on nitrogen metabolism and physiology of the non-diazotrophic cyanobacterium and non-BMAA producer, Synechococcus sp. TAU-MAC 0499, was investigated. In order to study the combined effect of nitrogen availability and BMAA, nitrogen-starvation conditions were induced by transferring cells in nitrogen-free medium and subsequently exposing the cultures to BMAA. After short-term treatment (180 min) and in the presence of nitrogen, BMAA inhibited glutamine synthetase, which resulted in low concentration of glutamine. In the absence of nitrogen, although there was no effect on glutamine synthetase, a possible perturbation in nitrogen assimilation is reflected on the significant decrease in glutamate levels. During the long-term exposure (24ā96 h), growth, photosynthetic pigments and total protein were not affected by BMAA exposure, except for an increase in protein and phycocyanin levels at 48 h in nitrogen replete conditions. Results suggest that BMAA interferes with nitrogen assimilation, in a different way, depending on the presence or absence of combined nitrogen, providing novel data on the potential biological role of BMAA.
Yolanda Vergou; Maria Touraki; Aikaterina Paraskevopoulou; Theodoros M. Triantis; Anastasia Hiskia; Spyros Gkelis. β-Ī-Methylamino-L-alanine interferes with nitrogen assimilation in the cyanobacterium, non-BMAA producer, Synechococcus sp. TAU-MAC 0499. Toxicon 2020, 185, 147 -155.
AMA StyleYolanda Vergou, Maria Touraki, Aikaterina Paraskevopoulou, Theodoros M. Triantis, Anastasia Hiskia, Spyros Gkelis. β-Ī-Methylamino-L-alanine interferes with nitrogen assimilation in the cyanobacterium, non-BMAA producer, Synechococcus sp. TAU-MAC 0499. Toxicon. 2020; 185 ():147-155.
Chicago/Turabian StyleYolanda Vergou; Maria Touraki; Aikaterina Paraskevopoulou; Theodoros M. Triantis; Anastasia Hiskia; Spyros Gkelis. 2020. "β-Ī-Methylamino-L-alanine interferes with nitrogen assimilation in the cyanobacterium, non-BMAA producer, Synechococcus sp. TAU-MAC 0499." Toxicon 185, no. : 147-155.
The present study was launched as a continuation of global efforts to tackle problems associated with two important aesthetic characteristics, taste and odor (T&O), of drinking water. The UV-A/Chlorine process, a promising advanced oxidation process (AOP), was evaluated for the first time for the removal of 2-isopropyl-3-methoxy pyrazine (IPMP), a widely reported compound in the literature that causes unpleasant taste and odor when present in water at or below the ng Lā1 level. It was found that the studied process was efficient for the removal of IPMP in both ultrapure and drinking water. The initial chlorine dosage influenced significantly the degradation efficiency under initial neutral pH values. Degradation efficiency of IPMP was slightly inhibited by using drinking water as matrix. Scavenging experiments highlighted the significant role of various reactive species (e.g. HO, ClO, Cl, Cl2ā) generated during the process that have not been studied comprehensively until now. In addition, the significant role of HO was further verified by Electron paramagnetic resonance spectroscopy (EPR) experiments. Overall, the formation of diverse radicals during the UV-A/Chlorine treatment enhanced the degradation of IPMP, promoting mainly the formation of hydroxy, hydroperoxy and dealkylated derivatives. In contrast, chlorinated by-products were only identified in traces.
Maria Antonopoulou; Nikolaos Ioannidis; Triantafyllos Kaloudis; Theodoros Triantis; Anastasia Hiskia. Kinetic and mechanistic investigation of water taste and odor compound 2-isopropyl-3-methoxy pyrazine degradation using UV-A/Chlorine process. Science of The Total Environment 2020, 732, 138404 .
AMA StyleMaria Antonopoulou, Nikolaos Ioannidis, Triantafyllos Kaloudis, Theodoros Triantis, Anastasia Hiskia. Kinetic and mechanistic investigation of water taste and odor compound 2-isopropyl-3-methoxy pyrazine degradation using UV-A/Chlorine process. Science of The Total Environment. 2020; 732 ():138404.
Chicago/Turabian StyleMaria Antonopoulou; Nikolaos Ioannidis; Triantafyllos Kaloudis; Theodoros Triantis; Anastasia Hiskia. 2020. "Kinetic and mechanistic investigation of water taste and odor compound 2-isopropyl-3-methoxy pyrazine degradation using UV-A/Chlorine process." Science of The Total Environment 732, no. : 138404.
Cyanobacteria are a diverse group of photosynthetic Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against a broad spectrum of organisms and cell lines. In this study, 29 strains isolated from freshwaters in Greece were classified using a polyphasic approach and assigned to Chroococcales, Synechococcales, and Nostocales, representing 11 genera and 17 taxa. There were good agreements between 16S ribosomal RNA (rRNA)ācpcBAāinternal genetic spacer (IGS) characterization and morphological features, except for the JaaginemaāLimnothrix group which appears intermixed and needs further elucidation. Methanol extracts of the strains were analyzed for cyanotoxin production and tested against pathogenic bacteria species and several cancer cell lines. We report for the first time a Nostoc oryzae strain isolated from rice fields capable of producing microcystins (MCs) and a Chlorogloeopsis fritschii strain isolated from the plankton of a lake, suggesting that this species may also occur in freshwater temperate habitats. Strains with very high or identical 16S rRNA gene sequences displayed different antibacterial and cytotoxic activities. Extracts from Synechococcus cf. nidulans showed the most potent antibacterial activity against Staphylococcus aureus, whereas Jaaginema sp. strains exhibited potent cytotoxic activities against human colorectal adenocarcinoma and hepatocellular carcinoma cells. Jaaginema Thessaloniki Aristotle University Microalgae and Cyanobacteria (TAU-MAC) 0110 and 0210 strains caused pronounced changes in the actin network and triggered the formation of numerous lipid droplets in hepatocellular carcinoma and green monkey kidney cells, suggesting oxidative stress and/or mitochondrial damage leading to apoptosis.
Spyros Gkelis; Manthos Panou; Despoina Konstantinou; Panagiotis Apostolidis; Antonia Kasampali; Sofia Papadimitriou; Dominiki Kati; Giorgia Maria Di Lorenzo; Stamatia Ioakeim; Sevasti-Kiriaki Zervou; Christophoros Christophoridis; Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia; Minas Arsenakis. Diversity, Cyanotoxin Production, and Bioactivities of Cyanobacteria Isolated from Freshwaters of Greece. Toxins 2019, 11, 436 .
AMA StyleSpyros Gkelis, Manthos Panou, Despoina Konstantinou, Panagiotis Apostolidis, Antonia Kasampali, Sofia Papadimitriou, Dominiki Kati, Giorgia Maria Di Lorenzo, Stamatia Ioakeim, Sevasti-Kiriaki Zervou, Christophoros Christophoridis, Theodoros M. Triantis, Triantafyllos Kaloudis, Anastasia Hiskia, Minas Arsenakis. Diversity, Cyanotoxin Production, and Bioactivities of Cyanobacteria Isolated from Freshwaters of Greece. Toxins. 2019; 11 (8):436.
Chicago/Turabian StyleSpyros Gkelis; Manthos Panou; Despoina Konstantinou; Panagiotis Apostolidis; Antonia Kasampali; Sofia Papadimitriou; Dominiki Kati; Giorgia Maria Di Lorenzo; Stamatia Ioakeim; Sevasti-Kiriaki Zervou; Christophoros Christophoridis; Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia; Minas Arsenakis. 2019. "Diversity, Cyanotoxin Production, and Bioactivities of Cyanobacteria Isolated from Freshwaters of Greece." Toxins 11, no. 8: 436.
Toxic cyanobacteria occur in Greek surface water bodies. However, studies on the occurrence of cyanotoxins (CTs) are often limited to mainly microcystins (MCs), with use of screening methods, such as ELISA, that are not conclusive of the chemical structure of the CT variants and can be subject to false positive results. A multi-lake survey in Greece (14 lakes) was conducted in water and biomass, targeted to a wide range of multi-class CTs including MCs, nodularin-R (NOD), cylindrospermopsin (CYN), anatoxin-a (ANA-a) and saxitoxins (STXs), using multi-class/variant LC-MS/MS analytical workflows, achieving sensitive detection, definitive identification and accurate quantitation. A wide variety of CTs (CYN, ANA-a, STX, neoSTX, dmMC-RR, MC-RR, MC-YR, MC-HtyR, dm3MC-LR, MC-LR, MC-HilR, MC-WR, MC-LA, MC-LY, MC-LW and MC-LF), were detected, with MCs being the most commonly occurring. In biomass, MC-RR was the most abundant toxin, reaching 754 ng mgā1 dw, followed by MC-LR (458 ng mgā1 dw). CYN and ANA-a were detected for the first time in the biomass of Greek lakes at low concentrations and STXs in lakes Trichonis, Vistonis and Petron. The abundance and diversity of CTs were also evaluated in relation to recreational health risks, in a case study with a proven history of MCs (Lake Kastoria).
Christophoros Christophoridis; Sevasti-Kiriaki Zervou; Korina Manolidi; Matina Katsiapi; Maria Moustaka-Gouni; Triantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. Occurrence and diversity of cyanotoxins in Greek lakes. Scientific Reports 2018, 8, 1 -22.
AMA StyleChristophoros Christophoridis, Sevasti-Kiriaki Zervou, Korina Manolidi, Matina Katsiapi, Maria Moustaka-Gouni, Triantafyllos Kaloudis, Theodoros M. Triantis, Anastasia Hiskia. Occurrence and diversity of cyanotoxins in Greek lakes. Scientific Reports. 2018; 8 (1):1-22.
Chicago/Turabian StyleChristophoros Christophoridis; Sevasti-Kiriaki Zervou; Korina Manolidi; Matina Katsiapi; Maria Moustaka-Gouni; Triantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. 2018. "Occurrence and diversity of cyanotoxins in Greek lakes." Scientific Reports 8, no. 1: 1-22.
Cyanobacteria are photosynthetic microorganisms distributed globally in aquatic and terrestrial environments. They are also industrially cultivated to be used as dietary supplements, as they have a high nutritional value; however, they are also known to produce a wide range of toxic secondary metabolites, called cyanotoxins. BMAA (β-methylamino-L-alanine) and its most common structural isomers, DAB (2,4-diaminobutyric acid) and AEG (N-2-aminoethylglycine) produced by cyanobacteria, are non-proteinogenic amino acids that have been associated with neurodegenerative diseases. A possible route of exposure to those amino acids is through consumption of food supplements based on cyanobacteria. The review critically discusses existing reports regarding the occurrence of BMAA, DAB and AEG in cyanobacteria and cyanobacteria-based food supplements. It is shown that inconsistencies in reported results could be attributed to performance of different methods of extraction and analysis applied and in ambiguities regarding determination of soluble and bound fractions of the compounds. The critical aspect of this review aims to grow awareness of human intake of neurotoxic amino acids, while results presented in literature concerning dietary supplements aim to promote further research, quality control as well as development of guidelines for cyanotoxins in food products.
Korina Manolidi; Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. Neurotoxin BMAA and its isomeric amino acids in cyanobacteria and cyanobacteria-based food supplements. Journal of Hazardous Materials 2018, 365, 346 -365.
AMA StyleKorina Manolidi, Theodoros M. Triantis, Triantafyllos Kaloudis, Anastasia Hiskia. Neurotoxin BMAA and its isomeric amino acids in cyanobacteria and cyanobacteria-based food supplements. Journal of Hazardous Materials. 2018; 365 ():346-365.
Chicago/Turabian StyleKorina Manolidi; Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. 2018. "Neurotoxin BMAA and its isomeric amino acids in cyanobacteria and cyanobacteria-based food supplements." Journal of Hazardous Materials 365, no. : 346-365.
Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment. Machine-accessible metadata file describing the reported data (ISA-Tab format)
Evanthia Mantzouki; James Campbell; Emiel van Loon; Petra Visser; Iosif Konstantinou; Maria Antoniou; Gregory Giuliani; Danielle Machado-Vieira; Alinne GurjĆ£o de Oliveira; Dubravka Å poljariÄ MaroniÄ; Filip SteviÄ; Tanja Žuna Pfeiffer; Itana Bokan VuceliÄ; Petar ŽutiniÄ; Marija Gligora UdoviÄ; AnÄelka PlenkoviÄ-Moraj; Nikoletta Tsiarta; LudÄk BlĆ”ha; Rodan GeriÅ”; MarkĆ©ta FrĆ”nkovĆ”; Kirsten Seestern Christoffersen; Trine Perlt Warming; TƵnu Feldmann; Alo Laas; Kristel Panksep; Lea Tuvikene; Kersti Kangro; Kerstin HƤggqvist; Pauliina Salmi; Lauri Arvola; Jutta Fastner; Dietmar Straile; Karl-Otto Rothhaupt; Jeremy Fonvielle; Hans-Peter Grossart; Christos Avagianos; Triantafyllos Kaloudis; Theodoros Triantis; Sevasti-Kiriaki Zervou; Anastasia Hiskia; Spyros Gkelis; Manthos Panou; Valerie McCarthy; Victor C. Perello; Ulrike Obertegger; Adriano Boscaini; Giovanna Flaim; Nico Salmaso; Leonardo Cerasino; Judita KoreivienÄ; JÅ«ratÄ KarosienÄ; JÅ«ratÄ KasperoviÄienÄ; Ksenija Savadova; Irma VitonytÄ; Sigrid Haande; Birger Skjelbred; Magdalena Grabowska; Maciej Karpowicz; Damian Chmura; Lidia Nawrocka; Justyna Kobos; Hanna Mazur-Marzec; Pablo Alcaraz-PĆ”rraga; Elzbieta Wilk-Wozniak; Wojciech KrztoÅ; Edward Walusiak; Ilona Gagala; Joanna Mankiewicz-Boczek; Magdalena Toporowska; Barbara Pawlik-Skowronska; MichaÅ NiedÅŗwiecki; Wojciech PÄczuÅa; Agnieszka Napiórkowska-Krzebietke; Julita Dunalska; Justyna SieÅska; Daniel SzymaÅski; Marek Kruk; Agnieszka BudzyÅska; Ryszard Goldyn; Anna Kozak; Joanna RosiÅska; Elżbieta SzelÄ g-Wasielewska; Piotr Domek; Natalia Jakubowska-Krepska; Kinga Kwasizur; Beata Messyasz; Aleksandra PeÅechata; Mariusz PeÅechaty; Mikolaj Kokocinski; Beata Madrecka; Iwona Kostrzewska-Szlakowska; Magdalena FrÄ k; Agnieszka BaÅkowska-Sobczak; MichaÅ Wasilewicz; Agnieszka Ochocka; Agnieszka Pasztaleniec; Iwona Jasser; Ana M. AntĆ£o-Geraldes; Manel Leira; Armand HernĆ”ndez; Vitor Vasconcelos; JoĆ£o Morais; Micaela Vale; Pedro M. Raposeiro; VĆtor GonƧalves; Boris Aleksovski; Svetislav KrstiÄ; Hana Nemova; Iveta Drastichova; Lucia Chomova; Spela Remec-Rekar; Tina Elersek; Jordi Delgado-MartĆn; David GarcĆa; Jose LuĆs Cereijo; Joan GomĆ ; Mari Carmen Trapote; Teresa Vegas-VilarrĆŗbia; Biel Obrador; Ana GarcĆa-Murcia; Monserrat Real; Elvira Romans; Jordi Noguero-Ribes; David ParreƱo Duque; ElĆsabeth FernĆ”ndez-MorĆ”n; BĆ”rbara Ćbeda; JosĆ© Ćngel GĆ”lvez; Rafael MarcĆ©; NĆŗria CatalĆ”n; Carmen PĆ©rez-MartĆnez; EloĆsa Ramos-RodrĆguez; Carmen Cillero-Castro; Enrique Moreno-Ostos; JosĆ© MarĆa Blanco; Valeriano RodrĆguez; Jorge Juan Montes-PĆ©rez; Roberto L. Palomino; Estela RodrĆguez-PĆ©rez; Rafael Carballeira; Antonio Camacho; Antonio Picazo; Carlos Rochera; Anna C. Santamans; Carmen Ferriol; Susana Romo; Juan Soria; Lars-Anders Hansson; Pablo Urrutia-Cordero; Arda Ćzen; Andrea G. Bravo; Moritz Buck; William Colom-Montero; Kristiina Mustonen; Don Pierson; Yang Yang; Jolanda M. H. Verspagen; Lisette De Senerpont Domis; Laura Seelen; Sven Teurlincx; Yvon Verstijnen; Miquel Lürling; Valentini Maliaka; Elisabeth J. Faassen; Delphine Latour; Cayelan C. Carey; Hans W. Paerl; Andrea Torokne; Tünay Karan; Nilsun Demir; Meryem BeklioÄlu; Nur Filiz; Eti E. Levi; UÄur Iskin; Gizem Bezirci; Ćlkü Nihan TavÅanoÄlu; Kemal Ćelik; Koray Ozhan; Nusret Karakaya; Mehmet Ali Turan KoƧer; Mete Yilmaz; Faruk MaraÅlıoÄlu; Ćzden Fakioglu; Elif Neyran Soylu; Meral Apaydın YaÄcı; Åakir Ćınar; Kadir Ćapkın; Abdulkadir YaÄcı; Mehmet Cesur; Fuat Bilgin; Cafer Bulut; Rahmi Uysal; Latife Kƶker; Reyhan AkƧaalan; MeriƧ Albay; Mehmet Tahir Alp; Korhan Ćzkan; TuÄba Ongun Sevindik; Hatice Tunca; BurƧin Ćnem; Jessica Richardson; Christine Edwards; Victoria Bergkemper; Sarah O'Leary; Eilish Beirne; Hannah Cromie; Bastiaan W. Ibelings. A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins. Scientific Data 2018, 5, 1 -13.
AMA StyleEvanthia Mantzouki, James Campbell, Emiel van Loon, Petra Visser, Iosif Konstantinou, Maria Antoniou, Gregory Giuliani, Danielle Machado-Vieira, Alinne GurjĆ£o de Oliveira, Dubravka Å poljariÄ MaroniÄ, Filip SteviÄ, Tanja Žuna Pfeiffer, Itana Bokan VuceliÄ, Petar ŽutiniÄ, Marija Gligora UdoviÄ, AnÄelka PlenkoviÄ-Moraj, Nikoletta Tsiarta, LudÄk BlĆ”ha, Rodan GeriÅ”, MarkĆ©ta FrĆ”nkovĆ”, Kirsten Seestern Christoffersen, Trine Perlt Warming, TƵnu Feldmann, Alo Laas, Kristel Panksep, Lea Tuvikene, Kersti Kangro, Kerstin HƤggqvist, Pauliina Salmi, Lauri Arvola, Jutta Fastner, Dietmar Straile, Karl-Otto Rothhaupt, Jeremy Fonvielle, Hans-Peter Grossart, Christos Avagianos, Triantafyllos Kaloudis, Theodoros Triantis, Sevasti-Kiriaki Zervou, Anastasia Hiskia, Spyros Gkelis, Manthos Panou, Valerie McCarthy, Victor C. Perello, Ulrike Obertegger, Adriano Boscaini, Giovanna Flaim, Nico Salmaso, Leonardo Cerasino, Judita KoreivienÄ, JÅ«ratÄ KarosienÄ, JÅ«ratÄ KasperoviÄienÄ, Ksenija Savadova, Irma VitonytÄ, Sigrid Haande, Birger Skjelbred, Magdalena Grabowska, Maciej Karpowicz, Damian Chmura, Lidia Nawrocka, Justyna Kobos, Hanna Mazur-Marzec, Pablo Alcaraz-PĆ”rraga, Elzbieta Wilk-Wozniak, Wojciech KrztoÅ, Edward Walusiak, Ilona Gagala, Joanna Mankiewicz-Boczek, Magdalena Toporowska, Barbara Pawlik-Skowronska, MichaÅ NiedÅŗwiecki, Wojciech PÄczuÅa, Agnieszka Napiórkowska-Krzebietke, Julita Dunalska, Justyna SieÅska, Daniel SzymaÅski, Marek Kruk, Agnieszka BudzyÅska, Ryszard Goldyn, Anna Kozak, Joanna RosiÅska, Elżbieta SzelÄ g-Wasielewska, Piotr Domek, Natalia Jakubowska-Krepska, Kinga Kwasizur, Beata Messyasz, Aleksandra PeÅechata, Mariusz PeÅechaty, Mikolaj Kokocinski, Beata Madrecka, Iwona Kostrzewska-Szlakowska, Magdalena FrÄ k, Agnieszka BaÅkowska-Sobczak, MichaÅ Wasilewicz, Agnieszka Ochocka, Agnieszka Pasztaleniec, Iwona Jasser, Ana M. AntĆ£o-Geraldes, Manel Leira, Armand HernĆ”ndez, Vitor Vasconcelos, JoĆ£o Morais, Micaela Vale, Pedro M. Raposeiro, VĆtor GonƧalves, Boris Aleksovski, Svetislav KrstiÄ, Hana Nemova, Iveta Drastichova, Lucia Chomova, Spela Remec-Rekar, Tina Elersek, Jordi Delgado-MartĆn, David GarcĆa, Jose LuĆs Cereijo, Joan GomĆ , Mari Carmen Trapote, Teresa Vegas-VilarrĆŗbia, Biel Obrador, Ana GarcĆa-Murcia, Monserrat Real, Elvira Romans, Jordi Noguero-Ribes, David ParreƱo Duque, ElĆsabeth FernĆ”ndez-MorĆ”n, BĆ”rbara Ćbeda, JosĆ© Ćngel GĆ”lvez, Rafael MarcĆ©, NĆŗria CatalĆ”n, Carmen PĆ©rez-MartĆnez, EloĆsa Ramos-RodrĆguez, Carmen Cillero-Castro, Enrique Moreno-Ostos, JosĆ© MarĆa Blanco, Valeriano RodrĆguez, Jorge Juan Montes-PĆ©rez, Roberto L. Palomino, Estela RodrĆguez-PĆ©rez, Rafael Carballeira, Antonio Camacho, Antonio Picazo, Carlos Rochera, Anna C. Santamans, Carmen Ferriol, Susana Romo, Juan Soria, Lars-Anders Hansson, Pablo Urrutia-Cordero, Arda Ćzen, Andrea G. Bravo, Moritz Buck, William Colom-Montero, Kristiina Mustonen, Don Pierson, Yang Yang, Jolanda M. H. Verspagen, Lisette De Senerpont Domis, Laura Seelen, Sven Teurlincx, Yvon Verstijnen, Miquel Lürling, Valentini Maliaka, Elisabeth J. Faassen, Delphine Latour, Cayelan C. Carey, Hans W. Paerl, Andrea Torokne, Tünay Karan, Nilsun Demir, Meryem BeklioÄlu, Nur Filiz, Eti E. Levi, UÄur Iskin, Gizem Bezirci, Ćlkü Nihan TavÅanoÄlu, Kemal Ćelik, Koray Ozhan, Nusret Karakaya, Mehmet Ali Turan KoƧer, Mete Yilmaz, Faruk MaraÅlıoÄlu, Ćzden Fakioglu, Elif Neyran Soylu, Meral Apaydın YaÄcı, Åakir Ćınar, Kadir Ćapkın, Abdulkadir YaÄcı, Mehmet Cesur, Fuat Bilgin, Cafer Bulut, Rahmi Uysal, Latife Kƶker, Reyhan AkƧaalan, MeriƧ Albay, Mehmet Tahir Alp, Korhan Ćzkan, TuÄba Ongun Sevindik, Hatice Tunca, BurƧin Ćnem, Jessica Richardson, Christine Edwards, Victoria Bergkemper, Sarah O'Leary, Eilish Beirne, Hannah Cromie, Bastiaan W. Ibelings. A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins. Scientific Data. 2018; 5 (1):1-13.
Chicago/Turabian StyleEvanthia Mantzouki; James Campbell; Emiel van Loon; Petra Visser; Iosif Konstantinou; Maria Antoniou; Gregory Giuliani; Danielle Machado-Vieira; Alinne GurjĆ£o de Oliveira; Dubravka Å poljariÄ MaroniÄ; Filip SteviÄ; Tanja Žuna Pfeiffer; Itana Bokan VuceliÄ; Petar ŽutiniÄ; Marija Gligora UdoviÄ; AnÄelka PlenkoviÄ-Moraj; Nikoletta Tsiarta; LudÄk BlĆ”ha; Rodan GeriÅ”; MarkĆ©ta FrĆ”nkovĆ”; Kirsten Seestern Christoffersen; Trine Perlt Warming; TƵnu Feldmann; Alo Laas; Kristel Panksep; Lea Tuvikene; Kersti Kangro; Kerstin HƤggqvist; Pauliina Salmi; Lauri Arvola; Jutta Fastner; Dietmar Straile; Karl-Otto Rothhaupt; Jeremy Fonvielle; Hans-Peter Grossart; Christos Avagianos; Triantafyllos Kaloudis; Theodoros Triantis; Sevasti-Kiriaki Zervou; Anastasia Hiskia; Spyros Gkelis; Manthos Panou; Valerie McCarthy; Victor C. Perello; Ulrike Obertegger; Adriano Boscaini; Giovanna Flaim; Nico Salmaso; Leonardo Cerasino; Judita KoreivienÄ; JÅ«ratÄ KarosienÄ; JÅ«ratÄ KasperoviÄienÄ; Ksenija Savadova; Irma VitonytÄ; Sigrid Haande; Birger Skjelbred; Magdalena Grabowska; Maciej Karpowicz; Damian Chmura; Lidia Nawrocka; Justyna Kobos; Hanna Mazur-Marzec; Pablo Alcaraz-PĆ”rraga; Elzbieta Wilk-Wozniak; Wojciech KrztoÅ; Edward Walusiak; Ilona Gagala; Joanna Mankiewicz-Boczek; Magdalena Toporowska; Barbara Pawlik-Skowronska; MichaÅ NiedÅŗwiecki; Wojciech PÄczuÅa; Agnieszka Napiórkowska-Krzebietke; Julita Dunalska; Justyna SieÅska; Daniel SzymaÅski; Marek Kruk; Agnieszka BudzyÅska; Ryszard Goldyn; Anna Kozak; Joanna RosiÅska; Elżbieta SzelÄ g-Wasielewska; Piotr Domek; Natalia Jakubowska-Krepska; Kinga Kwasizur; Beata Messyasz; Aleksandra PeÅechata; Mariusz PeÅechaty; Mikolaj Kokocinski; Beata Madrecka; Iwona Kostrzewska-Szlakowska; Magdalena FrÄ k; Agnieszka BaÅkowska-Sobczak; MichaÅ Wasilewicz; Agnieszka Ochocka; Agnieszka Pasztaleniec; Iwona Jasser; Ana M. AntĆ£o-Geraldes; Manel Leira; Armand HernĆ”ndez; Vitor Vasconcelos; JoĆ£o Morais; Micaela Vale; Pedro M. Raposeiro; VĆtor GonƧalves; Boris Aleksovski; Svetislav KrstiÄ; Hana Nemova; Iveta Drastichova; Lucia Chomova; Spela Remec-Rekar; Tina Elersek; Jordi Delgado-MartĆn; David GarcĆa; Jose LuĆs Cereijo; Joan GomĆ ; Mari Carmen Trapote; Teresa Vegas-VilarrĆŗbia; Biel Obrador; Ana GarcĆa-Murcia; Monserrat Real; Elvira Romans; Jordi Noguero-Ribes; David ParreƱo Duque; ElĆsabeth FernĆ”ndez-MorĆ”n; BĆ”rbara Ćbeda; JosĆ© Ćngel GĆ”lvez; Rafael MarcĆ©; NĆŗria CatalĆ”n; Carmen PĆ©rez-MartĆnez; EloĆsa Ramos-RodrĆguez; Carmen Cillero-Castro; Enrique Moreno-Ostos; JosĆ© MarĆa Blanco; Valeriano RodrĆguez; Jorge Juan Montes-PĆ©rez; Roberto L. Palomino; Estela RodrĆguez-PĆ©rez; Rafael Carballeira; Antonio Camacho; Antonio Picazo; Carlos Rochera; Anna C. Santamans; Carmen Ferriol; Susana Romo; Juan Soria; Lars-Anders Hansson; Pablo Urrutia-Cordero; Arda Ćzen; Andrea G. Bravo; Moritz Buck; William Colom-Montero; Kristiina Mustonen; Don Pierson; Yang Yang; Jolanda M. H. Verspagen; Lisette De Senerpont Domis; Laura Seelen; Sven Teurlincx; Yvon Verstijnen; Miquel Lürling; Valentini Maliaka; Elisabeth J. Faassen; Delphine Latour; Cayelan C. Carey; Hans W. Paerl; Andrea Torokne; Tünay Karan; Nilsun Demir; Meryem BeklioÄlu; Nur Filiz; Eti E. Levi; UÄur Iskin; Gizem Bezirci; Ćlkü Nihan TavÅanoÄlu; Kemal Ćelik; Koray Ozhan; Nusret Karakaya; Mehmet Ali Turan KoƧer; Mete Yilmaz; Faruk MaraÅlıoÄlu; Ćzden Fakioglu; Elif Neyran Soylu; Meral Apaydın YaÄcı; Åakir Ćınar; Kadir Ćapkın; Abdulkadir YaÄcı; Mehmet Cesur; Fuat Bilgin; Cafer Bulut; Rahmi Uysal; Latife Kƶker; Reyhan AkƧaalan; MeriƧ Albay; Mehmet Tahir Alp; Korhan Ćzkan; TuÄba Ongun Sevindik; Hatice Tunca; BurƧin Ćnem; Jessica Richardson; Christine Edwards; Victoria Bergkemper; Sarah O'Leary; Eilish Beirne; Hannah Cromie; Bastiaan W. Ibelings. 2018. "A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins." Scientific Data 5, no. 1: 1-13.
Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains.
Evanthia Mantzouki; Miquel Lürling; Jutta Fastner; Lisette De Senerpont Domis; Elżbieta Wilk-WoÅŗniak; Judita KoreivienÄ; Laura Seelen; Sven Teurlincx; Yvon Verstijnen; Wojciech KrztoÅ; Edward Walusiak; JÅ«ratÄ KarosienÄ; JÅ«ratÄ KasperoviÄienÄ; Ksenija Savadova; Irma VitonytÄ; Carmen Cillero-Castro; Agnieszka BudzyÅska; Ryszard Goldyn; Anna Kozak; Joanna RosiÅska; Elżbieta SzelÄ g-Wasielewska; Piotr Domek; Natalia Jakubowska-Krepska; Kinga Kwasizur; Beata Messyasz; Aleksandra PeÅechata; Mariusz PeÅechaty; Mikolaj Kokocinski; Ana GarcĆa-Murcia; Monserrat Real; Elvira Romans; Jordi Noguero-Ribes; David ParreƱo Duque; ElĆsabeth FernĆ”ndez-MorĆ”n; Nusret Karakaya; Kerstin HƤggqvist; Nilsun Demir; Meryem BeklioÄlu; Nur Filiz; Eti E. Levi; UÄur Iskin; Gizem Bezirci; Ćlkü Nihan TavÅanoÄlu; Koray Ćzhan; Spyros Gkelis; Manthos Panou; Ćzden Fakioglu; Christos Avagianos; Triantafyllos Kaloudis; Kemal Ćelik; Mete Yilmaz; Rafael MarcĆ©; Nuria CatalĆ”n; Andrea G. Bravo; Moritz Buck; William Colom-Montero; Kristiina Mustonen; Don Pierson; Yang Yang; Pedro M. Raposeiro; VĆtor GonƧalves; Maria G. Antoniou; Nikoletta Tsiarta; Valerie McCarthy; Victor C. Perello; TƵnu Feldmann; Alo Laas; Kristel Panksep; Lea Tuvikene; Ilona Gagala; Joana Mankiewicz-Boczek; Meral Apaydın YaÄcı; Åakir Ćınar; Kadir Ćapkın; Abdulkadir YaÄcı; Mehmet Cesur; Fuat Bilgin; Cafer Bulut; Rahmi Uysal; Ulrike Obertegger; Adriano Boscaini; Giovanna Flaim; Nico Salmaso; Leonardo Cerasino; Jessica Richardson; Petra M. Visser; Jolanda M. H. Verspagen; Tünay Karan; Elif Neyran Soylu; Faruk MaraÅlıoÄlu; Agnieszka Napiórkowska-Krzebietke; Agnieszka Ochocka; Agnieszka Pasztaleniec; Ana M. AntĆ£o-Geraldes; Vitor Vasconcelos; JoĆ£o Morais; Micaela Vale; Latife Kƶker; Reyhan AkƧaalan; MeriƧ Albay; Dubravka Å poljariÄ MaroniÄ; Filip SteviÄ; Tanja Žuna Pfeiffer; Jeremy Fonvielle; Dietmar Straile; Karl-Otto Rothhaupt; Lars-Anders Hansson; Pablo Urrutia-Cordero; LudÄk BlĆ”ha; Rodan GeriÅ”; MarkĆ©ta FrĆ”nkovĆ”; Mehmet Ali Turan KoƧer; Mehmet Tahir Alp; Spela Remec-Rekar; Tina Elersek; Theodoros Triantis; Sevasti-Kiriaki Zervou; Anastasia Hiskia; Sigrid Haande; Birger Skjelbred; Beata Madrecka; Hana Nemova; Iveta Drastichova; Lucia Chomova; Christine Edwards; TuÄba Ongun Sevindik; Hatice Tunca; BurƧin Ćnem; Boris Aleksovski; Svetislav KrstiÄ; Itana Bokan VuceliÄ; Lidia Nawrocka; Pauliina Salmi; Danielle Machado-Vieira; Alinne GurjĆ£o De Oliveira; Jordi Delgado-MartĆn; David GarcĆa; Jose LuĆs Cereijo; Joan GomĆ ; Mari Carmen Trapote; Teresa Vegas-VilarrĆŗbia; Biel Obrador; Magdalena Grabowska; Maciej Karpowicz; Damian Chmura; BĆ”rbara Ćbeda; JosĆ© Ćngel GĆ”lvez; Arda Ćzen; Kirsten Seestern Christoffersen; Trine Perlt Warming; Justyna Kobos; Hanna Mazur-Marzec; Carmen PĆ©rez-MartĆnez; EloĆsa Ramos-RodrĆguez; Lauri Arvola; Pablo Alcaraz-PĆ”rraga; Magdalena Toporowska; Barbara Pawlik-Skowronska; MichaÅ NiedÅŗwiecki; Wojciech PÄczuÅa; Manel Leira; Armand HernĆ”ndez; Enrique Moreno-Ostos; JosĆ© MarĆa Blanco; Valeriano RodrĆguez; Jorge Juan Montes-PĆ©rez; Roberto L. Palomino; Estela RodrĆguez-PĆ©rez; Rafael Carballeira; Antonio Camacho; Antonio Picazo; Carlos Rochera; Anna C. Santamans; Carmen Ferriol; Susana Romo; Juan Miguel Soria; Julita Dunalska; Justyna SieÅska; Daniel SzymaÅski; Marek Kruk; Iwona Kostrzewska-Szlakowska; Iwona Jasser; Petar ŽutiniÄ; Marija Gligora UdoviÄ; AnÄelka PlenkoviÄ-Moraj; Magdalena FrÄ k; Agnieszka BaÅkowska-Sobczak; MichaÅ Wasilewicz; Korhan Ćzkan; Valentini Maliaka; Kersti Kangro; Hans-Peter Grossart; Hans Paerl; Cayelan C. Carey; Bas W. Ibelings. Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins. Toxins 2018, 10, 156 .
AMA StyleEvanthia Mantzouki, Miquel Lürling, Jutta Fastner, Lisette De Senerpont Domis, Elżbieta Wilk-WoÅŗniak, Judita KoreivienÄ, Laura Seelen, Sven Teurlincx, Yvon Verstijnen, Wojciech KrztoÅ, Edward Walusiak, JÅ«ratÄ KarosienÄ, JÅ«ratÄ KasperoviÄienÄ, Ksenija Savadova, Irma VitonytÄ, Carmen Cillero-Castro, Agnieszka BudzyÅska, Ryszard Goldyn, Anna Kozak, Joanna RosiÅska, Elżbieta SzelÄ g-Wasielewska, Piotr Domek, Natalia Jakubowska-Krepska, Kinga Kwasizur, Beata Messyasz, Aleksandra PeÅechata, Mariusz PeÅechaty, Mikolaj Kokocinski, Ana GarcĆa-Murcia, Monserrat Real, Elvira Romans, Jordi Noguero-Ribes, David ParreƱo Duque, ElĆsabeth FernĆ”ndez-MorĆ”n, Nusret Karakaya, Kerstin HƤggqvist, Nilsun Demir, Meryem BeklioÄlu, Nur Filiz, Eti E. Levi, UÄur Iskin, Gizem Bezirci, Ćlkü Nihan TavÅanoÄlu, Koray Ćzhan, Spyros Gkelis, Manthos Panou, Ćzden Fakioglu, Christos Avagianos, Triantafyllos Kaloudis, Kemal Ćelik, Mete Yilmaz, Rafael MarcĆ©, Nuria CatalĆ”n, Andrea G. Bravo, Moritz Buck, William Colom-Montero, Kristiina Mustonen, Don Pierson, Yang Yang, Pedro M. Raposeiro, VĆtor GonƧalves, Maria G. Antoniou, Nikoletta Tsiarta, Valerie McCarthy, Victor C. Perello, TƵnu Feldmann, Alo Laas, Kristel Panksep, Lea Tuvikene, Ilona Gagala, Joana Mankiewicz-Boczek, Meral Apaydın YaÄcı, Åakir Ćınar, Kadir Ćapkın, Abdulkadir YaÄcı, Mehmet Cesur, Fuat Bilgin, Cafer Bulut, Rahmi Uysal, Ulrike Obertegger, Adriano Boscaini, Giovanna Flaim, Nico Salmaso, Leonardo Cerasino, Jessica Richardson, Petra M. Visser, Jolanda M. H. Verspagen, Tünay Karan, Elif Neyran Soylu, Faruk MaraÅlıoÄlu, Agnieszka Napiórkowska-Krzebietke, Agnieszka Ochocka, Agnieszka Pasztaleniec, Ana M. AntĆ£o-Geraldes, Vitor Vasconcelos, JoĆ£o Morais, Micaela Vale, Latife Kƶker, Reyhan AkƧaalan, MeriƧ Albay, Dubravka Å poljariÄ MaroniÄ, Filip SteviÄ, Tanja Žuna Pfeiffer, Jeremy Fonvielle, Dietmar Straile, Karl-Otto Rothhaupt, Lars-Anders Hansson, Pablo Urrutia-Cordero, LudÄk BlĆ”ha, Rodan GeriÅ”, MarkĆ©ta FrĆ”nkovĆ”, Mehmet Ali Turan KoƧer, Mehmet Tahir Alp, Spela Remec-Rekar, Tina Elersek, Theodoros Triantis, Sevasti-Kiriaki Zervou, Anastasia Hiskia, Sigrid Haande, Birger Skjelbred, Beata Madrecka, Hana Nemova, Iveta Drastichova, Lucia Chomova, Christine Edwards, TuÄba Ongun Sevindik, Hatice Tunca, BurƧin Ćnem, Boris Aleksovski, Svetislav KrstiÄ, Itana Bokan VuceliÄ, Lidia Nawrocka, Pauliina Salmi, Danielle Machado-Vieira, Alinne GurjĆ£o De Oliveira, Jordi Delgado-MartĆn, David GarcĆa, Jose LuĆs Cereijo, Joan GomĆ , Mari Carmen Trapote, Teresa Vegas-VilarrĆŗbia, Biel Obrador, Magdalena Grabowska, Maciej Karpowicz, Damian Chmura, BĆ”rbara Ćbeda, JosĆ© Ćngel GĆ”lvez, Arda Ćzen, Kirsten Seestern Christoffersen, Trine Perlt Warming, Justyna Kobos, Hanna Mazur-Marzec, Carmen PĆ©rez-MartĆnez, EloĆsa Ramos-RodrĆguez, Lauri Arvola, Pablo Alcaraz-PĆ”rraga, Magdalena Toporowska, Barbara Pawlik-Skowronska, MichaÅ NiedÅŗwiecki, Wojciech PÄczuÅa, Manel Leira, Armand HernĆ”ndez, Enrique Moreno-Ostos, JosĆ© MarĆa Blanco, Valeriano RodrĆguez, Jorge Juan Montes-PĆ©rez, Roberto L. Palomino, Estela RodrĆguez-PĆ©rez, Rafael Carballeira, Antonio Camacho, Antonio Picazo, Carlos Rochera, Anna C. Santamans, Carmen Ferriol, Susana Romo, Juan Miguel Soria, Julita Dunalska, Justyna SieÅska, Daniel SzymaÅski, Marek Kruk, Iwona Kostrzewska-Szlakowska, Iwona Jasser, Petar ŽutiniÄ, Marija Gligora UdoviÄ, AnÄelka PlenkoviÄ-Moraj, Magdalena FrÄ k, Agnieszka BaÅkowska-Sobczak, MichaÅ Wasilewicz, Korhan Ćzkan, Valentini Maliaka, Kersti Kangro, Hans-Peter Grossart, Hans Paerl, Cayelan C. Carey, Bas W. Ibelings. Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins. Toxins. 2018; 10 (4):156.
Chicago/Turabian StyleEvanthia Mantzouki; Miquel Lürling; Jutta Fastner; Lisette De Senerpont Domis; Elżbieta Wilk-WoÅŗniak; Judita KoreivienÄ; Laura Seelen; Sven Teurlincx; Yvon Verstijnen; Wojciech KrztoÅ; Edward Walusiak; JÅ«ratÄ KarosienÄ; JÅ«ratÄ KasperoviÄienÄ; Ksenija Savadova; Irma VitonytÄ; Carmen Cillero-Castro; Agnieszka BudzyÅska; Ryszard Goldyn; Anna Kozak; Joanna RosiÅska; Elżbieta SzelÄ g-Wasielewska; Piotr Domek; Natalia Jakubowska-Krepska; Kinga Kwasizur; Beata Messyasz; Aleksandra PeÅechata; Mariusz PeÅechaty; Mikolaj Kokocinski; Ana GarcĆa-Murcia; Monserrat Real; Elvira Romans; Jordi Noguero-Ribes; David ParreƱo Duque; ElĆsabeth FernĆ”ndez-MorĆ”n; Nusret Karakaya; Kerstin HƤggqvist; Nilsun Demir; Meryem BeklioÄlu; Nur Filiz; Eti E. Levi; UÄur Iskin; Gizem Bezirci; Ćlkü Nihan TavÅanoÄlu; Koray Ćzhan; Spyros Gkelis; Manthos Panou; Ćzden Fakioglu; Christos Avagianos; Triantafyllos Kaloudis; Kemal Ćelik; Mete Yilmaz; Rafael MarcĆ©; Nuria CatalĆ”n; Andrea G. Bravo; Moritz Buck; William Colom-Montero; Kristiina Mustonen; Don Pierson; Yang Yang; Pedro M. Raposeiro; VĆtor GonƧalves; Maria G. Antoniou; Nikoletta Tsiarta; Valerie McCarthy; Victor C. Perello; TƵnu Feldmann; Alo Laas; Kristel Panksep; Lea Tuvikene; Ilona Gagala; Joana Mankiewicz-Boczek; Meral Apaydın YaÄcı; Åakir Ćınar; Kadir Ćapkın; Abdulkadir YaÄcı; Mehmet Cesur; Fuat Bilgin; Cafer Bulut; Rahmi Uysal; Ulrike Obertegger; Adriano Boscaini; Giovanna Flaim; Nico Salmaso; Leonardo Cerasino; Jessica Richardson; Petra M. Visser; Jolanda M. H. Verspagen; Tünay Karan; Elif Neyran Soylu; Faruk MaraÅlıoÄlu; Agnieszka Napiórkowska-Krzebietke; Agnieszka Ochocka; Agnieszka Pasztaleniec; Ana M. AntĆ£o-Geraldes; Vitor Vasconcelos; JoĆ£o Morais; Micaela Vale; Latife Kƶker; Reyhan AkƧaalan; MeriƧ Albay; Dubravka Å poljariÄ MaroniÄ; Filip SteviÄ; Tanja Žuna Pfeiffer; Jeremy Fonvielle; Dietmar Straile; Karl-Otto Rothhaupt; Lars-Anders Hansson; Pablo Urrutia-Cordero; LudÄk BlĆ”ha; Rodan GeriÅ”; MarkĆ©ta FrĆ”nkovĆ”; Mehmet Ali Turan KoƧer; Mehmet Tahir Alp; Spela Remec-Rekar; Tina Elersek; Theodoros Triantis; Sevasti-Kiriaki Zervou; Anastasia Hiskia; Sigrid Haande; Birger Skjelbred; Beata Madrecka; Hana Nemova; Iveta Drastichova; Lucia Chomova; Christine Edwards; TuÄba Ongun Sevindik; Hatice Tunca; BurƧin Ćnem; Boris Aleksovski; Svetislav KrstiÄ; Itana Bokan VuceliÄ; Lidia Nawrocka; Pauliina Salmi; Danielle Machado-Vieira; Alinne GurjĆ£o De Oliveira; Jordi Delgado-MartĆn; David GarcĆa; Jose LuĆs Cereijo; Joan GomĆ ; Mari Carmen Trapote; Teresa Vegas-VilarrĆŗbia; Biel Obrador; Magdalena Grabowska; Maciej Karpowicz; Damian Chmura; BĆ”rbara Ćbeda; JosĆ© Ćngel GĆ”lvez; Arda Ćzen; Kirsten Seestern Christoffersen; Trine Perlt Warming; Justyna Kobos; Hanna Mazur-Marzec; Carmen PĆ©rez-MartĆnez; EloĆsa Ramos-RodrĆguez; Lauri Arvola; Pablo Alcaraz-PĆ”rraga; Magdalena Toporowska; Barbara Pawlik-Skowronska; MichaÅ NiedÅŗwiecki; Wojciech PÄczuÅa; Manel Leira; Armand HernĆ”ndez; Enrique Moreno-Ostos; JosĆ© MarĆa Blanco; Valeriano RodrĆguez; Jorge Juan Montes-PĆ©rez; Roberto L. Palomino; Estela RodrĆguez-PĆ©rez; Rafael Carballeira; Antonio Camacho; Antonio Picazo; Carlos Rochera; Anna C. Santamans; Carmen Ferriol; Susana Romo; Juan Miguel Soria; Julita Dunalska; Justyna SieÅska; Daniel SzymaÅski; Marek Kruk; Iwona Kostrzewska-Szlakowska; Iwona Jasser; Petar ŽutiniÄ; Marija Gligora UdoviÄ; AnÄelka PlenkoviÄ-Moraj; Magdalena FrÄ k; Agnieszka BaÅkowska-Sobczak; MichaÅ Wasilewicz; Korhan Ćzkan; Valentini Maliaka; Kersti Kangro; Hans-Peter Grossart; Hans Paerl; Cayelan C. Carey; Bas W. Ibelings. 2018. "Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins." Toxins 10, no. 4: 156.
Suresh C. Pillai; Niall B. McGuinness; Ciara Byrne; ChangSeok Han; Jacob Lalley; Mallikarjuna Nadagouda; Polycarpos Falaras; Athanassios G. Kontos; Miguel A. Gracia-Pinilla; Kevin O'shea; Ramalinga V. Mangalaraja; Christophoros Christophoridis; Theodoros Triantis; Anastasia Hiskia; Dionysios D. Dionysiou. Photocatalysis as an effective advanced oxidation process. Water Intelligence Online 2017, 16, 333 -381.
AMA StyleSuresh C. Pillai, Niall B. McGuinness, Ciara Byrne, ChangSeok Han, Jacob Lalley, Mallikarjuna Nadagouda, Polycarpos Falaras, Athanassios G. Kontos, Miguel A. Gracia-Pinilla, Kevin O'shea, Ramalinga V. Mangalaraja, Christophoros Christophoridis, Theodoros Triantis, Anastasia Hiskia, Dionysios D. Dionysiou. Photocatalysis as an effective advanced oxidation process. Water Intelligence Online. 2017; 16 ():333-381.
Chicago/Turabian StyleSuresh C. Pillai; Niall B. McGuinness; Ciara Byrne; ChangSeok Han; Jacob Lalley; Mallikarjuna Nadagouda; Polycarpos Falaras; Athanassios G. Kontos; Miguel A. Gracia-Pinilla; Kevin O'shea; Ramalinga V. Mangalaraja; Christophoros Christophoridis; Theodoros Triantis; Anastasia Hiskia; Dionysios D. Dionysiou. 2017. "Photocatalysis as an effective advanced oxidation process." Water Intelligence Online 16, no. : 333-381.
This review aims to summarise the outcomes of some recent European research concerning toxic cyanobacteria and cyanotoxins, with an emphasis on developments within the framework of the CYANOCOST Action (COST Action ES1105, Cyanobacterial Blooms and Toxins in Water Resources: Occurrence, Impacts and Management). State of the art research and management capabilities in Europe on cyanobacteria have benefitted from input from the pure and applied life sciences, the human and animal health sectors, water engineers, economists and planners. Many of these professional groups have been brought together and they interacted favourably within the framework of CYANOCOST.Highlights of the Action include phycological and ecological studies, development of advanced techniques for cyanotoxin analysis, elucidation of cyanotoxin modes of action, management techniques to reduce cyanobacterial mass development, and research on methods and practices for cyanotoxin removal during drinking water treatment. The CYANOCOST Action has had an active outreach policy throughout its lifetime, resulting in e.g. three handbooks, two special issues in scientific journals and activities in the social media. The many contact channels to end-users, including environmental and drinking water supply authorities, health professionals and the general public are described in this review.Furthermore, the authors have identified a number of gaps in knowledge. Proposed directions for future research in the field of toxic cyanobacteria and cyanotoxins are also discussed.
Jussi Meriluoto; Ludek Blaha; Gorenka Bojadzija; Myriam Bormans; Luc Brient; Geoffrey A. Codd; Damjana Drobac; Elisabeth J. Faassen; Jutta Fastner; Anastasia Hiskia; Bastiaan W. Ibelings; Triantafyllos Kaloudis; Mikolaj Kokocinski; Rainer Kurmayer; Dijana PanteliÄ; Antonio Quesada; Nico Salmaso; Nada Tokodi; Theodoros Triantis; Petra M. Visser; Zorica SvirÄev. Toxic cyanobacteria and cyanotoxins in European waters ā recent progress achieved through the CYANOCOST Action and challenges for further research. Advances in Oceanography and Limnology 2017, 8, 1 .
AMA StyleJussi Meriluoto, Ludek Blaha, Gorenka Bojadzija, Myriam Bormans, Luc Brient, Geoffrey A. Codd, Damjana Drobac, Elisabeth J. Faassen, Jutta Fastner, Anastasia Hiskia, Bastiaan W. Ibelings, Triantafyllos Kaloudis, Mikolaj Kokocinski, Rainer Kurmayer, Dijana PanteliÄ, Antonio Quesada, Nico Salmaso, Nada Tokodi, Theodoros Triantis, Petra M. Visser, Zorica SvirÄev. Toxic cyanobacteria and cyanotoxins in European waters ā recent progress achieved through the CYANOCOST Action and challenges for further research. Advances in Oceanography and Limnology. 2017; 8 (1):1.
Chicago/Turabian StyleJussi Meriluoto; Ludek Blaha; Gorenka Bojadzija; Myriam Bormans; Luc Brient; Geoffrey A. Codd; Damjana Drobac; Elisabeth J. Faassen; Jutta Fastner; Anastasia Hiskia; Bastiaan W. Ibelings; Triantafyllos Kaloudis; Mikolaj Kokocinski; Rainer Kurmayer; Dijana PanteliÄ; Antonio Quesada; Nico Salmaso; Nada Tokodi; Theodoros Triantis; Petra M. Visser; Zorica SvirÄev. 2017. "Toxic cyanobacteria and cyanotoxins in European waters ā recent progress achieved through the CYANOCOST Action and challenges for further research." Advances in Oceanography and Limnology 8, no. 1: 1.
Lake Karla (Central Greece) is a unique example - at European scale - of a shallow lake ecosystem that was dried in the 1960s and in 2009 started to be restored. The lake is listed in the network of the Greek protected areas as it is considered a vital aquatic ecosystem, in terms of biodiversity. It has, however, already been adversely affected by both agricultural and industrial land uses in the surrounding area, leading to eutrophication and shifting algal community towards bloom-forming toxic cyanobacterial species. After repeated heavy-blooms, cyanotoxin occurrence and mass fish kills, the local ecosystem management authority has implemented a water quality monitoring program (July 2013 - July 2015) to assess environmental pressures and the response of aquatic biota in the lake. Microscopic, immunological, and molecular techniques combined with physico-chemical parameters, complemented by liquid chromatography tandem mass spectrometry (LC-MS/MS), were used to monitor cyanobacteria blooms and the associated cyanotoxin production from three different sites in Lake Karla and from the adjacent Kalamaki Reservoir. Water quality was also assessed by the structure of benthic invertebrate community on the sediment. Cyanobacteria were the main phytoplankton component, representing more than 70% of the total phytoplankton abundance; dominant taxa belonged to Cylindrospermopsis raciborskii, Limnothrix redekei, Anabaenopsis elenkinii, and Microcystis spp. Euglenophytes (Euglena), diatoms (Nitzschia), and chlorophytes (Scenedesmus) were also important phytoplankton constituents. LC-MS/MS confirmed the co-occurrence of microcystins, cylindrospermopsin, saxitoxin, neo-saxitoxin and anatoxin-a. The occurrence of cyanotoxins in relation to the persistent and dominant cyanobacteria and the impact of cyanobacterial harmful algal blooms on the newly constructed lake along with the land uses and the emergent mitigation measures are discussed.
Spyros Gkelis; Manthos Panou; Ioannis Chronis; Sevasti-Kiriaki Zervou; Christophoros Christophoridis; Korina Manolidi; Chrysoula Ntislidou; Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia; Ifigenia Kagalou; Maria Lazaridou. Monitoring a newly re-born patient: water quality and cyanotoxin occurrence in a reconstructed shallow Mediterranean lake. Advances in Oceanography and Limnology 2017, 8, 1 .
AMA StyleSpyros Gkelis, Manthos Panou, Ioannis Chronis, Sevasti-Kiriaki Zervou, Christophoros Christophoridis, Korina Manolidi, Chrysoula Ntislidou, Theodoros M. Triantis, Triantafyllos Kaloudis, Anastasia Hiskia, Ifigenia Kagalou, Maria Lazaridou. Monitoring a newly re-born patient: water quality and cyanotoxin occurrence in a reconstructed shallow Mediterranean lake. Advances in Oceanography and Limnology. 2017; 8 (1):1.
Chicago/Turabian StyleSpyros Gkelis; Manthos Panou; Ioannis Chronis; Sevasti-Kiriaki Zervou; Christophoros Christophoridis; Korina Manolidi; Chrysoula Ntislidou; Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia; Ifigenia Kagalou; Maria Lazaridou. 2017. "Monitoring a newly re-born patient: water quality and cyanotoxin occurrence in a reconstructed shallow Mediterranean lake." Advances in Oceanography and Limnology 8, no. 1: 1.
The protein phosphatase inhibition assay (PPIA) can be used for a quantitative screening of microcystins and nodularin. Commercially kits for PPIA are available in microplate format, using p-nitrophenyl phosphate as substrate and photometric measurement of its conversion to p-nitrophenol. This SOP gives additional guidance for the application of commercially available PPIA kits in water samples with focus on in-house validation and quality control of measurements.
Triantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. Quantitative Screening of Microcystins and Nodularin in Water Samples with Commercially Available PPIA Kits. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 393 -395.
AMA StyleTriantafyllos Kaloudis, Theodoros M. Triantis, Anastasia Hiskia. Quantitative Screening of Microcystins and Nodularin in Water Samples with Commercially Available PPIA Kits. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():393-395.
Chicago/Turabian StyleTriantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. 2017. "Quantitative Screening of Microcystins and Nodularin in Water Samples with Commercially Available PPIA Kits." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 393-395.
This SOP specifies a method for the determination of anatoxin-a in filtered water (e.g. filtered surface water) and drinking water samples by LC-MS/MS. The method avoids interferences from the presence of phenylalanine that has the same mass fragmentation pattern with anatoxin-a. This is achieved through chromatographic separation of anatoxin-a and phenylalanine. The method can be applied after solid-phase extraction of anatoxin-a using reversed phase HPLC and tandem triple-quadrupole mass spectrometry (MS/MS). Phenylalanine-d5 is used as a surrogate standard. Validation data have shown that the method is suitable for determinations at the low ng Lā1 levels of anatoxin-a.
Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. Determination of Anatoxin-a in Filtered and Drinking Water by LC-MS/MS. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 408 -412.
AMA StyleTheodoros M. Triantis, Triantafyllos Kaloudis, Anastasia Hiskia. Determination of Anatoxin-a in Filtered and Drinking Water by LC-MS/MS. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():408-412.
Chicago/Turabian StyleTheodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. 2017. "Determination of Anatoxin-a in Filtered and Drinking Water by LC-MS/MS." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 408-412.
Cyanobacteria produce a wide range of taste and odour compounds (T&O) that are generally not toxic but degrade the aesthetic quality of water sources and supplies. Cyanobacteria T&O consist of several chemical groups with the terpenoids geosmin and 2-methylisoborneol being the most widespread in water resources. Detection and identification of water T&O compounds can be carried out by sensory evaluation, instrumental chemical analysis techniques, or combinations of both. Among sensory evaluation methods, flavour profile analysis is the most suitable for the determination of the characteristics and intensities of odour/flavour of water. For chemical analysis of T&O, gas chromatography coupled to mass spectrometry is most commonly used. High selectivity and detection at very low levels (nanograms per litre) can be achieved by using sample preconcentration techniques such as solid-phase microextraction, solid-phase extraction, purge and trap, closed-loop stripping analysis, and stir-bar sorptive extraction.
Triantafyllos Kaloudis; Theodoros Triantis; Anastasia Hiskia. Taste and Odour Compounds Produced by Cyanobacteria. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 196 -201.
AMA StyleTriantafyllos Kaloudis, Theodoros Triantis, Anastasia Hiskia. Taste and Odour Compounds Produced by Cyanobacteria. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():196-201.
Chicago/Turabian StyleTriantafyllos Kaloudis; Theodoros Triantis; Anastasia Hiskia. 2017. "Taste and Odour Compounds Produced by Cyanobacteria." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 196-201.
Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. Solid-Phase Extraction of Cylindrospermopsin from Filtered and Drinking Water. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 396 -398.
AMA StyleTheodoros M. Triantis, Triantafyllos Kaloudis, Anastasia Hiskia. Solid-Phase Extraction of Cylindrospermopsin from Filtered and Drinking Water. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():396-398.
Chicago/Turabian StyleTheodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. 2017. "Solid-Phase Extraction of Cylindrospermopsin from Filtered and Drinking Water." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 396-398.
Method validation is an important requirement in the practice of chemical analysis and laboratory accreditation according to ISO 17025. Validation of analytical methods includes the confirmation by examination and provision of objective evidence that the particular requirements for a specific intended use are fulfilled. In subsequent parts of the chapter, the performance criteria and validation protocols for the analysis of cyanotoxins in environmental samples are presented. The most common performance parameters which are usually assessed during validation studies of methods for cyanotoxin analysis are measurement range (measuring interval), selectivity, trueness, precision, limit of detection/quantification (LOD/LOQ), robustness (ruggedness) and estimation of measurement uncertainty. The chapter also includes an extended description of important validation issues for cyanotoxins analysis such as the lack of standardized methods for cyanotoxin analysis and the limited commercial availability of cyanotoxins and proficiency testing schemes.
Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. Method Validation Guidelines for the Analysis of Cyanotoxins. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 285 -291.
AMA StyleTheodoros M. Triantis, Triantafyllos Kaloudis, Anastasia Hiskia. Method Validation Guidelines for the Analysis of Cyanotoxins. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():285-291.
Chicago/Turabian StyleTheodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. 2017. "Method Validation Guidelines for the Analysis of Cyanotoxins." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 285-291.
Geosmin (GSM) and 2-methylisoborneol (2-MIB) are the two most common cyanobacterial metabolites that give unfavourable taste and odour to water. Their odour thresholds in water are extremely low, in the range of a few ng/l. This SOP describes a method for the detection and quantitative determination of GSM and 2-MIB at low ng/L concentrations in water. The method employs headspace solid-phase microextraction (HS-SPME) with subsequent gas chromatographic-mass spectrometric (GC-MS) detection. Performance data show that the method is suitable for determinations in drinking water and surface water, at levels below the odor threshold values of the compounds.
Triantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. Determination of Geosmin and 2-Methylisoborneol in Water by HS-SPME-GC/MS. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 469 -474.
AMA StyleTriantafyllos Kaloudis, Theodoros M. Triantis, Anastasia Hiskia. Determination of Geosmin and 2-Methylisoborneol in Water by HS-SPME-GC/MS. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():469-474.
Chicago/Turabian StyleTriantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. 2017. "Determination of Geosmin and 2-Methylisoborneol in Water by HS-SPME-GC/MS." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 469-474.
This SOP outlines a basic protocol for in-house validation of methods for cyanotoxins analysis in environmental samples. This protocol can be used for laboratory accreditation according to ISO 17025. The protocol assesses repeatability, reproducibility, trueness, limit of quantitation, limit of detection, and range of measurement and can be used with any analytical technique (chromatographic, spectrophotometric, etc.).
Triantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. Basic Validation Protocol for the Analysis of Cyanotoxins in Environmental Samples. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 481 -485.
AMA StyleTriantafyllos Kaloudis, Theodoros M. Triantis, Anastasia Hiskia. Basic Validation Protocol for the Analysis of Cyanotoxins in Environmental Samples. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():481-485.
Chicago/Turabian StyleTriantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. 2017. "Basic Validation Protocol for the Analysis of Cyanotoxins in Environmental Samples." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 481-485.
This SOP specifies a method for the solid-phase extraction of anatoxin-a from drinking water or filtered water samples. The extracts produced by this method are suitable for subsequent analysis by LC-MS/MS. This extraction method is suitable for the determination of anatoxin-a that is dissolved in water (not inside cells or bound to other material). It has been shown that this extraction process, when coupled to LC-MS/MS measurements, meets the criteria of 70ā120% mean recovery and <20% RSD.
Theodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. Solid-Phase Extraction of Anatoxin-a from Filtered and Drinking Water. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 405 -407.
AMA StyleTheodoros M. Triantis, Triantafyllos Kaloudis, Anastasia Hiskia. Solid-Phase Extraction of Anatoxin-a from Filtered and Drinking Water. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():405-407.
Chicago/Turabian StyleTheodoros M. Triantis; Triantafyllos Kaloudis; Anastasia Hiskia. 2017. "Solid-Phase Extraction of Anatoxin-a from Filtered and Drinking Water." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 405-407.
Various enzyme-linked immunosorbent assay (ELISA) kits are commercially available for screening of microcystins (MCs) and nodularins (NODs). The kits are based on competitive-photometric assays using various protocols and antibodies in microplate format. As performance of ELISA kits varies widely with sample matrix and protocol used, it is recommended that laboratories carry out in-house validation and follow rigorous quality control procedures. This SOP provides guidance regarding the use of ELISA kits for screening of MCs and NODs with focus on validation and quality control.
Triantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. Quantitative Screening of Microcystins and Nodularin in Water Samples with Commercially Available ELISA Kits. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis 2017, 390 -392.
AMA StyleTriantafyllos Kaloudis, Theodoros M. Triantis, Anastasia Hiskia. Quantitative Screening of Microcystins and Nodularin in Water Samples with Commercially Available ELISA Kits. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. 2017; ():390-392.
Chicago/Turabian StyleTriantafyllos Kaloudis; Theodoros M. Triantis; Anastasia Hiskia. 2017. "Quantitative Screening of Microcystins and Nodularin in Water Samples with Commercially Available ELISA Kits." Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis , no. : 390-392.