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Dr. Kishneth Palaniveloo
University of Malaya

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0 Chemical Ecology
0 Spectroscopy
0 Natural products chemistry
0 chemical ecology, defensive secretions, natural products chemistry, university teaching, structural elucidation, pheromones, secondary metabolites
0 Marine Sciences

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Journal article
Published: 20 August 2021 in Foods
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Seaweeds are an important ingredient of functional foods recommended for daily food, due to their unique compositions and nutritional value. Padina tetrastromatica is a brown edible seaweed that is commonly found along the coastal regions of Peninsular Malaysia and consumed as food by some coastal communities. This study investigates the nutritional and antihyperglycaemic potential of P. tetrastromatica extracts, which is generally accepted as an important functional food. In our methodology, we induced diabetes intraperitoneally in experimental animals with a dose of 65 mg kg−1 body weight of streptozotocin. Oral treatment with 200 and 400 mg kg−1 of P. tetrastromatica ethanolic and ethyl acetate extracts were initiated, respectively, to experimental rats once daily for 18 days. Metformin was used as the positive control. Biochemical estimations and histopathological analysis were included in this study. Treatment with P. tetrastromatica extracts significantly lowered the plasma glucose levels in Streptozotocin-induced diabetic rats. In addition, P. tetrastromatica extract treatment also showed a significant reduction in serum alanine transaminase levels. However, no significant changes were observed in serum aspartate transaminase levels. The ethyl acetate extract of P. tetrastromatica at 400 mg kg−1 dose shows some nephroprotective effect, which is observed from the significant increase in the plasma albumin levels. Histopathological evaluation revealed no marked morphological changes in tissues of the isolated organs of the ethyl acetate extract-treated group, revealing the safe nature of P. tetrastromatica.

ACS Style

Kishneth Palaniveloo; Liaw Yee-Yinn; Leong Jia-Qi; Alvin Chelliah; Song Sze-Looi; Thilahgavani Nagappan; Shariza Abdul Razak; Kamal Dua; Jestin Chellian; Dinesh Kumar Chellappan; Anil Philip Kunnath. Nutritional Profile, Antioxidative and Antihyperglycemic Properties of Padina tetrastromatica from Tioman Island, Malaysia. Foods 2021, 10, 1932 .

AMA Style

Kishneth Palaniveloo, Liaw Yee-Yinn, Leong Jia-Qi, Alvin Chelliah, Song Sze-Looi, Thilahgavani Nagappan, Shariza Abdul Razak, Kamal Dua, Jestin Chellian, Dinesh Kumar Chellappan, Anil Philip Kunnath. Nutritional Profile, Antioxidative and Antihyperglycemic Properties of Padina tetrastromatica from Tioman Island, Malaysia. Foods. 2021; 10 (8):1932.

Chicago/Turabian Style

Kishneth Palaniveloo; Liaw Yee-Yinn; Leong Jia-Qi; Alvin Chelliah; Song Sze-Looi; Thilahgavani Nagappan; Shariza Abdul Razak; Kamal Dua; Jestin Chellian; Dinesh Kumar Chellappan; Anil Philip Kunnath. 2021. "Nutritional Profile, Antioxidative and Antihyperglycemic Properties of Padina tetrastromatica from Tioman Island, Malaysia." Foods 10, no. 8: 1932.

Review
Published: 27 May 2021 in Molecules
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Soft corals are widely distributed across the globe, especially in the Indo-Pacific region, with Sarcophyton being one of the most abundant genera. To date, there have been 50 species of identified Sarcophyton. These soft corals host a diverse range of marine fungi, which produce chemically diverse, bioactive secondary metabolites as part of their symbiotic nature with the soft coral hosts. The most prolific groups of compounds are terpenoids and indole alkaloids. Annually, there are more bio-active compounds being isolated and characterised. Thus, the importance of the metabolite compilation is very much important for future reference. This paper compiles the diversity of Sarcophyton species and metabolites produced by their associated marine fungi, as well as the bioactivity of these identified compounds. A total of 88 metabolites of structural diversity are highlighted, indicating the huge potential these symbiotic relationships hold for future research.

ACS Style

Yuanwei Liu; Kishneth Palaniveloo; Siti Alias; Jaya Sathiya Seelan. Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi. Molecules 2021, 26, 3227 .

AMA Style

Yuanwei Liu, Kishneth Palaniveloo, Siti Alias, Jaya Sathiya Seelan. Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi. Molecules. 2021; 26 (11):3227.

Chicago/Turabian Style

Yuanwei Liu; Kishneth Palaniveloo; Siti Alias; Jaya Sathiya Seelan. 2021. "Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi." Molecules 26, no. 11: 3227.

Review
Published: 01 November 2020 in South African Journal of Botany
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Seagrasses, one of the most threatened yet overlooked ecosystems on Earth, are the only flowering plants to recolonising the seabed. Apart from their critical ecological prominence on the life of many marine organisms, seagrasses are also used as an alternative or complementary medicine to manage an array of pathological disorders such as muscle aches, wounds, abdominal pain, indigestion, hangover, and mental disorders. However, a compilation of existing work on their ethnopharmacological uses, nutritional values, pharmacological propensities and bioactive compounds is lacking. Thus, this review aims at elaborating on the biochemical composition, phytochemical analysis, and biological properties including antioxidant, antimicrobial activities of various species of seagrasses. Seagrasses harbour several metabolites with multiple bioactivities. The phytochemical compounds isolated from Zostera marina L., Thalassia testudinum K. D. Koenig. and Thalassodendron ciliatum (Forssk.) exhibit a plethora of biological activities, including cytotoxicity against cancer cell lines, anti-human immunodeficiency virus (HIV), antimicrobial, and skin regenerating properties. This review also identifies vital lacuna in seagrass research. For instance, the mechanism and site of action of compounds displaying potent biological activities has not been adequately addressed together with optimisation of extraction methods to isolate minor metabolites and applying technological advancements in biological assays. In conclusion, this review provides a synthesis of current knowledge and highlights future work that needs to be undertaken for the biomedical application of such natural resources.

ACS Style

Doo Hwan Kim; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Park Gyun Seok; Gokhan Zengin; Kishneth Palaniveloo; Anees Ahmed Khalil; Abdur Rauf; Kannan Rr Rengasamy. Nutritional and bioactive potential of seagrasses: A review. South African Journal of Botany 2020, 137, 216 -227.

AMA Style

Doo Hwan Kim, Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Park Gyun Seok, Gokhan Zengin, Kishneth Palaniveloo, Anees Ahmed Khalil, Abdur Rauf, Kannan Rr Rengasamy. Nutritional and bioactive potential of seagrasses: A review. South African Journal of Botany. 2020; 137 ():216-227.

Chicago/Turabian Style

Doo Hwan Kim; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Park Gyun Seok; Gokhan Zengin; Kishneth Palaniveloo; Anees Ahmed Khalil; Abdur Rauf; Kannan Rr Rengasamy. 2020. "Nutritional and bioactive potential of seagrasses: A review." South African Journal of Botany 137, no. : 216-227.

Journal article
Published: 18 September 2020 in Foods
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Caulerpa racemosa (Forsskal) J. Agardh is a green seaweed used as food and folk medicine since ancient times in the Indo-Pacific region, particularly in southeast Asia. In this study, the proximate nutrient composition, phytochemical, anti-oxidant and anti-diabetic properties of sea grape C. racemosa collected from culture fishponds in Johor, Malaysia were analysed. The contents (dry weight basis) of carbohydrate, crude protein, crude lipids, ash and caloric value obtained were 33.42 ± 1.34%, 20.27 ± 0.14%, 4.20 ± 0.32%, 28.25 ± 0.27% and 2544.67 ± 7.04 cal g−1, respectively. The amino acid score (AAs) and biological protein value (213.43 mg g−1) indicated that C. racemosa presented a better protein quality. The most abundant fatty acids were C16:0 (palmitic acid: 63.27%), followed by C18:1 (oleic acid: 5.80%), and C18:2 ῳ6 (linoleic acid: 5.33%). The analysis of the ash content indicated that essential minerals and trace elements, such as Ca, Fe, and Mn, were present in the seaweed. The total phenolic content (TPC) and total flavonoid content (TFC) observed in the ethyl acetate extract were 17.88 ± 0.78 mg GAE g−1 and 59.43 ± 2.45 mg QE g−1, respectively. The ethyl acetate extract of C. racemosa demonstrated notable anti-diabetic activity in diabetic induced rats. The low (100 mg kg−1) and high (200 mg kg−1) doses of cultivated C. racemosa extract exhibited a significant decrease (p < 0.05) in blood glucose levels while preventing weight loss, reducing plasma AST, ALT levels as a sign of hepatoprotective effect and recording albumin levels similar to positive control in diabetic induced rats. The results support the usefulness of cultivated C. racemosa as a potential functional food.

ACS Style

Abdul Qudus B Aroyehun; Shariza Abdul Razak; Kishneth Palaniveloo; Thilahgavani Nagappan; Nur Suraiza Nabila Rahmah; Gan Wee Jin; Dinesh Kumar Chellappan; Jestin Chellian; Anil Philip Kunnath. Bioprospecting Cultivated Tropical Green Algae, Caulerpa Racemosa: A Perspective on Nutritional Properties, Antioxidative Capacity and Anti-Diabetic Potential. Foods 2020, 9, 1313 .

AMA Style

Abdul Qudus B Aroyehun, Shariza Abdul Razak, Kishneth Palaniveloo, Thilahgavani Nagappan, Nur Suraiza Nabila Rahmah, Gan Wee Jin, Dinesh Kumar Chellappan, Jestin Chellian, Anil Philip Kunnath. Bioprospecting Cultivated Tropical Green Algae, Caulerpa Racemosa: A Perspective on Nutritional Properties, Antioxidative Capacity and Anti-Diabetic Potential. Foods. 2020; 9 (9):1313.

Chicago/Turabian Style

Abdul Qudus B Aroyehun; Shariza Abdul Razak; Kishneth Palaniveloo; Thilahgavani Nagappan; Nur Suraiza Nabila Rahmah; Gan Wee Jin; Dinesh Kumar Chellappan; Jestin Chellian; Anil Philip Kunnath. 2020. "Bioprospecting Cultivated Tropical Green Algae, Caulerpa Racemosa: A Perspective on Nutritional Properties, Antioxidative Capacity and Anti-Diabetic Potential." Foods 9, no. 9: 1313.

Review
Published: 22 June 2020 in Processes
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Over the last decade, food waste has been one of the major issues globally as it brings a negative impact on the environment and health. Rotting discharges methane, causing greenhouse effect and adverse health effects due to pathogenic microorganisms or toxic leachates that reach agricultural land and water system. As a solution, composting is implemented to manage and reduce food waste in line with global sustainable development goals (SDGs). This review compiles input on the types of organic composting, its characteristics, physico-chemical properties involved, role of microbes and tools available in determining the microbial community structure. Composting types: vermi-composting, windrow composting, aerated static pile composting and in-vessel composting are discussed. The diversity of microorganisms in each of the three stages in composting is highlighted and the techniques used to determine the microbial community structure during composting such as biochemical identification, polymerase chain reaction denaturing gradient gel electrophoresis (PCR-DGGE), terminal restriction fragment length polymorphism (T-RFLP) and single strand-conformation polymorphism (SSCP), microarray analysis and next-generation sequencing (NGS) are discussed. Overall, a good compost, not only reduces waste issues, but also contributes substantially to the economic and social sectors of a nation.

ACS Style

Kishneth Palaniveloo; Muhammad Azri Amran; Nur Azeyanti Norhashim; Nuradilla Mohamad-Fauzi; Fang Peng-Hui; Low Hui-Wen; Yap Kai-Lin; Looi Jiale; Melissa Goh Chian-Yee; Lai Jing-Yi; Baskaran Gunasekaran; Shariza Abdul Razak. Food Waste Composting and Microbial Community Structure Profiling. Processes 2020, 8, 723 .

AMA Style

Kishneth Palaniveloo, Muhammad Azri Amran, Nur Azeyanti Norhashim, Nuradilla Mohamad-Fauzi, Fang Peng-Hui, Low Hui-Wen, Yap Kai-Lin, Looi Jiale, Melissa Goh Chian-Yee, Lai Jing-Yi, Baskaran Gunasekaran, Shariza Abdul Razak. Food Waste Composting and Microbial Community Structure Profiling. Processes. 2020; 8 (6):723.

Chicago/Turabian Style

Kishneth Palaniveloo; Muhammad Azri Amran; Nur Azeyanti Norhashim; Nuradilla Mohamad-Fauzi; Fang Peng-Hui; Low Hui-Wen; Yap Kai-Lin; Looi Jiale; Melissa Goh Chian-Yee; Lai Jing-Yi; Baskaran Gunasekaran; Shariza Abdul Razak. 2020. "Food Waste Composting and Microbial Community Structure Profiling." Processes 8, no. 6: 723.

Journal article
Published: 08 April 2020 in Marine Drugs
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Seaweeds have been exploited as both food products and therapeutics to manage human ailments for centuries. This study investigated the metabolite profile of five seaweeds (Halimeda spp., Spyridia hypnoides (Bory de Saint-Vincent) Papenfuss, Valoniopsis pachynema (G. Martens) Børgesen, Gracilaria fergusonii J. Agardh and Amphiroa anceps (Lamarck) Decaisne using ultra-high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UHPLC-ESI-MS/MS). Furthermore, these seaweeds were assessed for antioxidant and inhibitory effects against α-amylase, α-glucosidase, acetyl-cholinesterase (AChE), butyryl-cholinesterase (BChE) and tyrosinase. Valoniopsis pachynema and A. anceps yielded the highest flavonoid (4.30 ± 0.29 mg RE/g) and phenolic content (7.83 ± 0.08 mg RE/g), respectively. Additionally, A. anceps exhibited significant antioxidant properties with all assays and significantly depressed BChE (IC50 = 6.68 ± 0.83 mg/mL) and α-amylase activities (IC50 = 5.34 ± 0.14 mg/mL). Interestingly, the five seaweeds revealed potent inhibitory effects against tyrosinase activity. In conclusion, A. anceps might be considered as a key source of phytoantioxidants and a potential candidate to develop nutritional supplements. Besides, the five tested seaweeds warrant further study and may be exploited as promising natural sources for managing hyperpigmentation.

ACS Style

Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Gokhan Zengin; Zoltán Cziáky; József Jekő; Alina Diuzheva; Kouadio Ibrahime Sinan; Kishneth Palaniveloo; Doo Hwan Kim; Kannan R. R. Rengasamy. In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds. Marine Drugs 2020, 18, 198 .

AMA Style

Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Gokhan Zengin, Zoltán Cziáky, József Jekő, Alina Diuzheva, Kouadio Ibrahime Sinan, Kishneth Palaniveloo, Doo Hwan Kim, Kannan R. R. Rengasamy. In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds. Marine Drugs. 2020; 18 (4):198.

Chicago/Turabian Style

Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Gokhan Zengin; Zoltán Cziáky; József Jekő; Alina Diuzheva; Kouadio Ibrahime Sinan; Kishneth Palaniveloo; Doo Hwan Kim; Kannan R. R. Rengasamy. 2020. "In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds." Marine Drugs 18, no. 4: 198.

Review
Published: 13 February 2020 in Molecules
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Invertebrates are an important source of structurally-diverse and biologically-active halogenated metabolites. The sea hare Aplysia dactylomela Rang has long been known to possess halogenated metabolites of dietary origin that are used as a self-defense mechanism. The compounds from Aplysia dactylomela Rang are comprised mainly of terpenoids and small percentages of C-15 acetogenins, indoles, macrolides, sterols and alkaloids with potent cytotoxic, anti-microbial and anti-inflammatory properties. For decades the metabolites discovered have been investigated for their medical and pharmaceutical applications, so much so that the ecological role of the metabolites has been overlooked. The interaction between Aplysia dactylomela Rang and its diet that is comprised of seaweed can provide information into the distribution and diversity of the seaweed, the application of bioaccumulated secondary metabolites as part of its defense mechanism and the potential roles of these metabolites for adaptation in the marine environment. This paper compiles the diversity of halogenated secondary metabolites documented from Aplysia dactylomela Rang.

ACS Style

Kishneth Palaniveloo; Mohammed Rizman-Idid; Thilahgavani Nagappan; Shariza Abdul Razak. Halogenated Metabolites from the Diet of Aplysia dactylomela Rang. Molecules 2020, 25, 815 .

AMA Style

Kishneth Palaniveloo, Mohammed Rizman-Idid, Thilahgavani Nagappan, Shariza Abdul Razak. Halogenated Metabolites from the Diet of Aplysia dactylomela Rang. Molecules. 2020; 25 (4):815.

Chicago/Turabian Style

Kishneth Palaniveloo; Mohammed Rizman-Idid; Thilahgavani Nagappan; Shariza Abdul Razak. 2020. "Halogenated Metabolites from the Diet of Aplysia dactylomela Rang." Molecules 25, no. 4: 815.

Journal article
Published: 10 September 2019 in Molecules
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This study evaluated the effect of seasonal variation on the physicochemical, biochemical, and nutritional composition of Gracilaria manilaensis. Sampling was designed during the main monsoon seasons in Malaysia—the Southwest monsoon (SWM) and Northeast monsoon (NEM)—to understand the intraspecific variation (p < 0.05). Carbohydrates, protein, and dietary fiber were found to be higher in NEM–G. manilaensis, whereas a higher ash content was quantified in SWM–G. manilaensis. No significant differences were found in crude lipid and moisture content (p > 0.05). Vitamin B2 was calculated as (0.29 ± 0.06 mg 100 g−1) and (0.38 ± 0.06 mg 100 g−1) for the NEM and SWM samples, respectively (p < 0.05). The fatty acid profile showed the dominance of saturated fatty acids (SFAs)—palmitic acids, stearic acid, and myristic acid—while the mineral contents were found to be good sources of calcium (1750.97–4047.74 mg 100 g−1) and iron (1512.55–1346.05 mg 100 g−1). Tryptophan and lysine were recorded as the limiting essential amino acids (EAAs) in NEM G. manilaensis, while leucine and phenylalanine were found to be the limiting EAAs in the SWM samples. None of the extracts exhibited antibacterial properties against the screened strains. The study concluded that seasonal changes have a great effect on the biochemical composition of G. manilaensis.

ACS Style

Abdul Qudus Aroyehun; Kishneth Palaniveloo; Farid Ghazali; Mohammed Rizman-Idid; Shariza Abdul Razak. Effects of Seasonal Variability on the Physicochemical, Biochemical, and Nutritional Composition of Western Peninsular Malaysia Gracilaria manilaensis. Molecules 2019, 24, 3298 .

AMA Style

Abdul Qudus Aroyehun, Kishneth Palaniveloo, Farid Ghazali, Mohammed Rizman-Idid, Shariza Abdul Razak. Effects of Seasonal Variability on the Physicochemical, Biochemical, and Nutritional Composition of Western Peninsular Malaysia Gracilaria manilaensis. Molecules. 2019; 24 (18):3298.

Chicago/Turabian Style

Abdul Qudus Aroyehun; Kishneth Palaniveloo; Farid Ghazali; Mohammed Rizman-Idid; Shariza Abdul Razak. 2019. "Effects of Seasonal Variability on the Physicochemical, Biochemical, and Nutritional Composition of Western Peninsular Malaysia Gracilaria manilaensis." Molecules 24, no. 18: 3298.

Soil microbiology
Published: 04 August 2017 in Microbial Ecology
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Decline in forest productivity due to forest conversion is defining the Bornean landscape. Responses of bacterial communities due to land-use changes are vital and could define our understanding of ecosystem functions. This study reports the changes in bacterial community structure in organic soil (0–5 cm; O-Horizon) and organic-mineral soil (5–15 cm; A-Horizon) across Maliau Basin Conservation Area old growth forest (MBOG), Fragment E logged forest (FELF) located in Kalabakan Forest Reserve to Benta Wawasan oil palm plantation (BWOP) using two-step PCR amplicon analysis of bacteria DNA on Illumina Miseq next generation sequencing. A total of 30 soil samples yielded 893,752-OTU reads at ≥97% similarity from 5,446,512 good quality sequences. Soil from BWOP plantation showed highest unshared OTUs for organic (49.2%) and organic-mineral (50.9%) soil. MBOG soil showed a drop in unshared OTUs between organic (48.6%) and organic-mineral (33.9%). At phylum level, Proteobacteria dominated MBOG but shifted to Actinobacteria in logged and plantation soil. Present findings also indicated that only FELF exhibited change in bacterial communities along the soil depth, moving from the organic to the organic-mineral layer. Both layers of BWOP plantation soils deviated from other forests’ soil in β-diversity analysis. To our knowledge, this is the first report on transitions of bacterial community structures with different soil horizons in the tropical rainforest including Borneo, Sabah. Borneo tropical soils form a large reservoir for soil bacteria and future exploration is needed for fully understanding the diversity structure and their bacterial functional properties.

ACS Style

Hoe Seng Tin; Kishneth Palaniveloo; Junia Anilik; Mathavan Vickneswaran; Yukihiro Tashiro; Charles S. Vairappan; Kenji Sakai. Impact of Land-use Change on Vertical Soil Bacterial Communities in Sabah. Microbial Ecology 2017, 75, 459 -467.

AMA Style

Hoe Seng Tin, Kishneth Palaniveloo, Junia Anilik, Mathavan Vickneswaran, Yukihiro Tashiro, Charles S. Vairappan, Kenji Sakai. Impact of Land-use Change on Vertical Soil Bacterial Communities in Sabah. Microbial Ecology. 2017; 75 (2):459-467.

Chicago/Turabian Style

Hoe Seng Tin; Kishneth Palaniveloo; Junia Anilik; Mathavan Vickneswaran; Yukihiro Tashiro; Charles S. Vairappan; Kenji Sakai. 2017. "Impact of Land-use Change on Vertical Soil Bacterial Communities in Sabah." Microbial Ecology 75, no. 2: 459-467.

Research article
Published: 01 June 2015 in Natural Product Communications
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A new manoalide-related sesterterpene, (4 E,6 E)-dehydro-25- O-methylmanoalide (1), was isolated from the organic extracts of the Bornean marine sponge Luffariella variabilis, together with the known compound (4 E,6 E)-dehydromanoalide (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data.

ACS Style

Toshiyuki Hamada; Daisuke Harada; Mitsunobu Hirata; Keisuke Yamashita; Kishneth Palaniveloo; Hiroaki Okamura; Tetsuo Iwagawa; Naomichi Arima; Toshiyuki Iriguchi; Nicole J. De Voogd; Charles S Vairappan. Manoalide-related Sesterterpene from the Marine Sponge Luffariella variabilis. Natural Product Communications 2015, 10, 863 -4.

AMA Style

Toshiyuki Hamada, Daisuke Harada, Mitsunobu Hirata, Keisuke Yamashita, Kishneth Palaniveloo, Hiroaki Okamura, Tetsuo Iwagawa, Naomichi Arima, Toshiyuki Iriguchi, Nicole J. De Voogd, Charles S Vairappan. Manoalide-related Sesterterpene from the Marine Sponge Luffariella variabilis. Natural Product Communications. 2015; 10 (6):863-4.

Chicago/Turabian Style

Toshiyuki Hamada; Daisuke Harada; Mitsunobu Hirata; Keisuke Yamashita; Kishneth Palaniveloo; Hiroaki Okamura; Tetsuo Iwagawa; Naomichi Arima; Toshiyuki Iriguchi; Nicole J. De Voogd; Charles S Vairappan. 2015. "Manoalide-related Sesterterpene from the Marine Sponge Luffariella variabilis." Natural Product Communications 10, no. 6: 863-4.

Journal article
Published: 19 May 2015 in Marine Drugs
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Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1b and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.

ACS Style

Chin-Soon Phan; Shean-Yeaw Ng; Eun-A Kim; You-Jin Jeon; Kishneth Palaniveloo; Charles Santhanaraju Vairappan. Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp. Marine Drugs 2015, 13, 3103 -3115.

AMA Style

Chin-Soon Phan, Shean-Yeaw Ng, Eun-A Kim, You-Jin Jeon, Kishneth Palaniveloo, Charles Santhanaraju Vairappan. Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp. Marine Drugs. 2015; 13 (5):3103-3115.

Chicago/Turabian Style

Chin-Soon Phan; Shean-Yeaw Ng; Eun-A Kim; You-Jin Jeon; Kishneth Palaniveloo; Charles Santhanaraju Vairappan. 2015. "Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp." Marine Drugs 13, no. 5: 3103-3115.

Research article
Published: 01 August 2014 in Natural Product Communications
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A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2-Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2-Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.

ACS Style

Anu Bahl; Sanjay M. Jachak; Kishneth Palaniveloo; Tulasiramanan Ramachandram; Charles S Vairappan; Harish K. Chopra. 2-Acetoxyverecynarmin C, a New Briarane COX Inhibitory Diterpenoid from Pennatula aculeata. Natural Product Communications 2014, 9, 1139 -41.

AMA Style

Anu Bahl, Sanjay M. Jachak, Kishneth Palaniveloo, Tulasiramanan Ramachandram, Charles S Vairappan, Harish K. Chopra. 2-Acetoxyverecynarmin C, a New Briarane COX Inhibitory Diterpenoid from Pennatula aculeata. Natural Product Communications. 2014; 9 (8):1139-41.

Chicago/Turabian Style

Anu Bahl; Sanjay M. Jachak; Kishneth Palaniveloo; Tulasiramanan Ramachandram; Charles S Vairappan; Harish K. Chopra. 2014. "2-Acetoxyverecynarmin C, a New Briarane COX Inhibitory Diterpenoid from Pennatula aculeata." Natural Product Communications 9, no. 8: 1139-41.

Journal article
Published: 24 September 2013 in Environmental Biology of Fishes
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Red algae genus Laurencia is an interesting alga with the ability to produce halogenated secondary metabolites that exhibits ecological and pharmaceutical potential. In nature, Laurencia is selectively grazed by sea hares (Aplysia dactylomela). In this study, Laurencia populations in three islands (Mantanani, Sulug, and Dinawan Islands) in the coastal waters of North Borneo were investigated and their chemical relationship with sea hare determined. Four species of Laurencia were found to grow abundantly in these waters, Laurencia snackeyi, Laurencia majuscula, Laurencia nangii, and Laurencia similis. Sea hares, Aplysia dactylomela, found grazing on Laurencia were collected and their chemical composition determined. A total of 20 halogenated metabolites were isolated and identified via spectroscopic data. Isolated compounds could be grouped into syndrean (5), chamigrane (6), non-chamigrane sesquiterpene (3), cuparane (1), bromoindole (2), and C15 acetogenin (acetylene type) (3). Sea hares from Mantanani, Sulug, and Dinawan Islands contained a total of 9, 10, and 10 compounds, respectively. In addition, 12-acetoxypalisadin B (1), which was isolated from sea hares of Sulug Island is a first record of its existence in nature.

ACS Style

Kishneth Palaniveloo; Charles Santhanaraju Vairappan. Chemical relationship between red algae genus Laurencia and sea hare (Aplysia dactylomela Rang) in the North Borneo Island. Environmental Biology of Fishes 2013, 26, 1199 -1205.

AMA Style

Kishneth Palaniveloo, Charles Santhanaraju Vairappan. Chemical relationship between red algae genus Laurencia and sea hare (Aplysia dactylomela Rang) in the North Borneo Island. Environmental Biology of Fishes. 2013; 26 (2):1199-1205.

Chicago/Turabian Style

Kishneth Palaniveloo; Charles Santhanaraju Vairappan. 2013. "Chemical relationship between red algae genus Laurencia and sea hare (Aplysia dactylomela Rang) in the North Borneo Island." Environmental Biology of Fishes 26, no. 2: 1199-1205.