Zhazira Mukazhanova

Dr. Zhazira Mukazhanova

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
18 December 2024 in Molecules
Verified
Journal Article
Open access
PDF file
ADAkmaral Darmenbayeva
Akmaral Darmenbayeva
RRReshmy Rajesekharan
Reshmy Rajesekharan
BMBakytgul Massalimova
Bakytgul Massalimova
NBNesiphan Bektenov
Nesiphan Bektenov
RTRaushan Taubayeva
Raushan Taubayeva
AUAisulu Ungarbayeva
Aisulu Ungarbayeva
Cellulose-based sorbents are promising materials for wastewater treatment due to their environmental friendliness, biodegradability, and high sorption capacity. This paper presents an overview of cellulose modification methods, including carboxylation, amination, oxidation, graphene, and plasma treatments, as well as combined approaches. Their effect on key physicochemical properties, such as porosity, morphology, and chemical stability, is considered. Examples from the literature confirm the effectiveness of modified cellulose sorbents in removing heavy metal ions and organic pollutants from wastewater. The analysis shows that combined methods allow for creating materials with improved characteristics that are resistant to extreme operating conditions. The main advantages and disadvantages of cellulose sorbents, as well as challenges associated with their scalability and cost-effectiveness, are discussed. The paper emphasizes the importance of further research to advance these materials as a key element of sustainable water treatment technologies.

18 March 2025 in Molecules
Verified
Journal Article
Open access
PDF file
AAArailym Amanzholkyzy
Arailym Amanzholkyzy
SZShynar Zhumagaliyeva
Shynar Zhumagaliyeva
NSNurgul A Sultanova
Nurgul A Sultanova
ZAZharylkasyn Abilov
Zharylkasyn Abilov
DODamira Ongalbek
Damira Ongalbek
ZMZhazira Mukazhanova
Zhazira Mukazhanova
Hydrogel delivery systems are popular dosage forms that have a number of advantages, such as ease of use, painlessness, increased efficiency due to prolongation of rheological, swelling and sorption characteristics, regulation of drug release, and stimulus sensitivity. Particular interest is shown in hydrogels of cellulose ether derivatives due to the possibility of obtaining their modified forms to vary the solubility, the degree of prolonged action, and the release of the active substance, as well as their widespread availability, affordability, and the possibility of sourcing raw materials from different sources. Hydroxypropyl methylcellulose (HPMC, “hypromellose”) is one of the most popular cellulose ethers in the production of medicines as a filler, coating and carrier. Research on hydrogel carriers based on polymer complexes and modified forms of HPMC using acrylic, citric, and lactic acids, PVP, chitosan, Na-CMC, and gelatin is of particular interest, as they provide the necessary rheological and swelling characteristics. There is growing interest in medical transdermal hydrogels, films, capsules, membranes, nanocrystals, and nanofibers based on HPMC with the incorporation of biologically active substances (BASs), especially those of plant origin, as antibacterial, wound-healing, antimicrobial, mucoadhesive, anti-inflammatory, and antioxidant agents. The aim of this article is to review modern research and achievements in the field of hydrogel systems based on cellulose ethers, particularly HPMC, analyzing their properties, methods of production, and prospects for application in medicine and pharmacy.

27 July 2024 in Pharmaceuticals
Verified
Journal Article
Open access
PDF file
AAkmaral Kozhantayeva
Akmaral Kozhantayeva
NTNurgul Tursynova
Nurgul Tursynova
AKAinagul Kolpek
Ainagul Kolpek
YAYelaman K. Aibuldinov
Yelaman K. Aibuldinov
ATArailym Tursynova
Arailym Tursynova
YTYerbolat Tashenov
Yerbolat Tashenov
The study investigates the phytochemical profile, antioxidant capacity, and antimicrobial activities of ethanol (ChL-EtOH) and ethyl acetate (ChL-EtOAc) extracts from Chamaenerion latifolium L. (ChL) harvested in Kazakhstan. The ChL-EtOH extract exhibited higher total phenolic (267.48 ± 3.44 mg GAE/g DE) and flavonoid content (24.18 ± 1.06 mg QE/g DE) compared to ChL-EtOAc. HPLC-UV-ESI/MS identified key phenolic acids and flavonoids, including gallic acid, chlorogenic acid, and quercetin 3-glucoside. FT-IR analysis confirmed the presence of characteristic functional groups. Antioxidant assays revealed strong DPPH scavenging and FRAP activities, with ChL-EtOH showing superior results (IC50 = 21.31 ± 0.65 μg/mL and 18.13 ± 0.15 μg/mL, respectively). Additionally, ChL-EtOH displayed notable antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as well as the fungal strain Candida albicans. These findings suggest that ethanol extraction is more efficient for isolating bioactive compounds from ChL, underscoring its potential for pharmaceutical and nutraceutical applications.

26 December 2024 in Polymers
Verified
Journal Article
Open access
PDF file
ADAkmaral Darmenbayeva
Akmaral Darmenbayeva
GZGaziza Zhussipnazarova
Gaziza Zhussipnazarova
RRReshmy Rajesekharan
Reshmy Rajesekharan
BMBakytgul Massalimova
Bakytgul Massalimova
RZRoza Zharlykapova
Roza Zharlykapova
ASAssem Shinibekova
Assem Shinibekova
This review presents a comprehensive review of cellulose–chitosan-based biocomposites that have high potential as sustainable alternatives to synthetic polymers. These biocomposites, due to biocompatibility, biodegradability, and antimicrobial properties, attract attention for wide application in various industries. This review includes modern methods for producing cellulose–chitosan composites aimed at improving their mechanical and chemical properties, such as strength, flexibility, and water resistance. Particular attention is paid to the use of composites in packaging materials, where they provide protection and durability of products, and help reduce the environmental footprint. In medicine, such composites are used for drug delivery and tissue engineering, providing controlled release of active substances and tissue regeneration. In addition, their advantages in wastewater treatment are discussed, where the composites effectively remove heavy metal ions and organic pollutants due to their high sorption capacity. This study focuses on the wide potential of cellulose–chitosan biocomposites and their role in solving environmental problems.

25 May 2026 in Polymers
Verified
Journal Article
Open access
PDF file
ADAkmaral Darmenbayeva
Akmaral Darmenbayeva
RRReshmy Rajesekharan
Reshmy Rajesekharan
BMBakytgul Massalimova
Bakytgul Massalimova
MAMurshida Aimova
Murshida Aimova
NUNurbala Ubaidulayeva
Nurbala Ubaidulayeva
ZMZhazira Mukazhanova
Zhazira Mukazhanova
The growing demand for sustainable and high-performance materials has positioned cellulose as a key biopolymer for next-generation functional systems. Beyond its traditional use, cellulose undergoes a qualitative transformation at the nanoscale, where increased surface area, interfacial dominance, and tunable chemistry enable functions unattainable in bulk form. This review provides a critical and integrative analysis of functionalization strategies governing the transition from structural modification to application-specific performance in cellulose and nanocellulose-based materials. A unified structure–property–function–process (SPFP) framework is introduced to systematically connect modification approaches with resulting structural features, physicochemical properties, and functional outcomes. Chemical, physical, and surface/interface modification strategies are comparatively evaluated with respect to their efficiency, scalability, and environmental trade-offs. Rather than cataloguing methods, the review emphasizes cross-domain synthesis and identifies key limitations, including high energy demand, reagent consumption, structural instability, and challenges in large-scale implementation. Particular attention is given to applications in biomedicine, environmental remediation, and energy technologies, where performance is governed by surface reactivity, accessibility, and hierarchical organization. The analysis highlights that no single modification strategy is universally optimal, and that effective material design requires balancing performance, sustainability, and process feasibility. By integrating conceptual frameworks, comparative analysis, and emerging design principles, this review provides a forward-looking perspective on the development of cellulose-based functional materials, supporting their transition from laboratory-scale demonstrations to application-ready technologies.

1 December 2023 in Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Verified
Journal Article
Closed access
PDF file
OTOrynbassar Tleuberlina
Orynbassar Tleuberlina
AMAsem Mamurova
Asem Mamurova
ZIZhanar Iskakova
Zhanar Iskakova
YAYelaman K. Aibuldinov
Yelaman K. Aibuldinov
AKAinagul Kolpek
Ainagul Kolpek
MKMeruyert Kurmanbayeva
Meruyert Kurmanbayeva
Background:: The Capparidaceae family includes the medicinal herb Capparis her-bacea Willd. The aerial and underground parts of plant C.herbacea were studied for their chemical composition, antioxidant, and cytotoxic properties Methods: Using gas chromatography with mass spectrometric detection (7890A/5975C), 94 chemicals were identified in ethanol extract from leaves, roots, seeds, and stems of C. her-bacea. Main components were (leaves) phytol 18.16%, hexanedioic acid, bis(2-ethylhexyl) ester 16.75%, vitamin E 11.95%, (roots) sucrose 13.94%, hexadecanoic acid, ethylester 22.80%, octadecanoic acid, ethylester 37.77%; (seeds) hexadecanoic acid, ethylester 13.96%, ethyl9.cis.,11.trans.-octadecadienoate 48.54%, bis(2-ethylhexyl) phthalate 9.77%; (stems) 1-propene-1,2,3-tricarboxylic acid, tributyl ester 42.69%, and tributylacetylcitrate 19.63%. Nine components were identified in the makeup of the C. herbacea sample's essential oil using the method of chromatography-mass spectrometry. Results:: The main components were (in%): T-cadinol (29.56), meta-cymene (16.12), pulegone (14.11), and σ-amorphene (12.26). Chloroform and methanol extracts of Capparis herbacia roots at concentrations of 1 mg/ml showed higher average antioxidant activity, while ethyl acetate root extract at concentrations of 0.75 and 1 mg/ml showed higher average antioxidant activity compared to gallic acid AOA. Conclusion:: In addition, plant extracts have cytotoxic activity. Essential oils of leaves and stems, fruit and roots of Capparis herbacia plants exhibited cytotoxicity, all larvae died, and larval mortality was 96%.