This article presents a facile synthesis method used to obtain new composite films based on polylactic acid and micro-structured hydroxyapatite particles. The composite films were synthesized starting from a polymeric solution in chloroform (12 wt.%) in which various concentrations of hydroxyapatite (1, 2, and 4 wt.% related to polymer) were homogenously dispersed using ultrasonication followed by solvent evaporation. The synthesized composite films were morphologically (through SEM and atomic force microscopy (AFM)) and structurally (through FT-IR and Raman spectroscopy) characterized. The thermal behavior of the composite films was also determined. The SEM and AFM analyses showed the presence of micro-structured hydroxyapatite particles in the film’s structure, as well as changes in the surface morphology. There was a significant decrease in the crystallinity of the composite films compared to the pure polymer, this being explained by a decrease in the arrangement of the polymer chains and a concurrent increase in the degree of their clutter. The presence of hydroxyapatite crystals did not have a significant influence on the degradation temperature of the composite film.

Risk assessment for environmental projects consists of studying the probability that projects will achieve a satisfactory performance for threshold - values of internal rate of return (IRR) or net present value (NPV).Risk analysis identifies and estimates risks and their level as well as measures considered to mitigate their negative impact. Quantitative risk analysis is performed for estimating the risk of the project by numeric resources.Monte Carlo simulation method can be widely applied in this area due to the advantages recognized both by practitioners and the academic community.By using this method, the distribution of all possible outcomes of an event is generated by analyzing a model several times, each time using random input values selected from the probability distributions considered normal of the components that comprise the model

Addiction to psychostimulants (ie, amphetamines and cocaine) imposes a major socioeconomic burden. Prevention and treatment represent unmet medical needs, which may be addressed, if the mechanisms underlying psychostimulant action are understood. Cocaine acts as a blocker at the transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET), but amphetamines are substrates that do not only block the uptake of monoamines but also induce substrate efflux by promoting reverse transport. Reverse transport has been a focus of research for decades but its mechanistic basis still remains enigmatic. Recently, transporter-interacting proteins were found to regulate amphetamine-triggered reverse transport: calmodulin kinase IIα (αCaMKII) is a prominent example, because it binds the carboxyl terminus of DAT, phosphorylates its amino terminus, and supports amphetamine-induced substrate efflux in vitro. Here, we investigated whether, in vivo, the action of amphetamine was contingent on the presence of αCaMKII by recording the behavioral and neurochemical effects of amphetamine. Measurement of dopamine efflux in the dorsal striatum by microdialysis revealed that amphetamine induced less dopamine efflux in mice lacking αCaMKII. Consistent with this observation, the acute locomotor responses to amphetamine were also significantly blunted in αCaMKII-deficient mice. In addition, while the rewarding properties of amphetamine were preserved in αCaMKII-deficient mice, their behavioral sensitization to amphetamine was markedly reduced. Our findings demonstrate that amphetamine requires the presence of αCaMKII to elicit a full-fledged effect on DAT in vivo: αCaMKII does not only support acute amphetamine-induced dopamine efflux but is also important in shaping the chronic response to amphetamine.

Waste electrical and electronic equipment is the fastest growing waste stream internationally. Due to its physical characteristics, e-waste is a suitable subject for the development of recovery, repair, and recycling policies, prolonging products’ life cycle for as long as possible, and is an objective pursued by the specific mechanisms of the circular economy. From the point of view of economic development models, e-waste management is one of the areas with significant potential for the implementation of the circular economy. The circular economy is analyzed through a set of 10 indicators that can be found in the Eurostat database. In this paper, we focus on the relationship between two main indicators with significance for this topic (e-waste recycling and eco-investment) and their evolution in European countries. An econometric model regarding the influence of eco-investment on e-waste recycling in EU member states will highlight the impact of circular economy indicators and the importance of promoting the reduce-reuse-recycle paradigm, especially for e-waste. A panel analysis was performed on data from European Union (EU) countries for the period (2008–2018). The analysis uses e-waste recycled per inhabitant as the determined variable and eco-investment per inhabitant as independent variable. The results of the econometric analysis performed show that, although all EU member states benefit from eco-investment, there is a group of countries that have already achieved a high capacity of e-waste recycling, while others should increase eco-investment further.

The main objective of this paper is to identify the intensity and the sense of the impact that eco-innovation and recycling exert on raw material consumption in the European Union member-states. The basic hypothesis is that eco-innovation and recycling have a significant influence on raw material consumption. The authors consider that, in the long run, by promoting eco-innovation and recycling, countries will minimize their demand and use of raw materials. In the paper, the material footprint per capita has been considered as an adequate indicator to measure the material consumption induced by economic and social activities. The model used has estimated the influence of eco-innovation and recycling on the material footprint per capita using panel data regression by considering the 27 EU countries, for the 2010–2019 time period. The authors found that the most adequate econometric model is the panel model with fixed effects. The respective econometric model validates the hypothesis that eco-innovation and recycling have significant influence on reducing the material footprint per capita and reveals heterogeneity existing among EU countries. At the same time, the model shows the intensity of influence exerted by each regressor. The eco-innovation and recycling have an important role in decreasing the material footprint per capita and should be in the centre of policies aimed at decoupling the economic growth from the raw material consumption.

Bone tissue engineering is constantly in need of new material development with improved biocompatibility or mechanical features closer to those of natural bone. Other important factors are the sustainability, cost, and origin of the natural precursors involved in the technological process. This study focused on two widely used polymers in tissue engineering, namely polylactic acid (PLA) and thermoplastic polyurethane (TPU), as well as bovine-bone-derived hydroxyapatite (HA) for the manufacturing of core-shell structures. In order to embed the ceramic particles on the polymeric filaments surface, the materials were introduced in an electrical oven at various temperatures and exposure times and under various pressing forces. The obtained core-shell structures were characterized in terms of morphology and composition, and a pull-out test was used to demonstrate the particles adhesion on the polymeric filaments structure. Thermal properties (modulated temperature and exposure time) and the pressing force’s influence upon HA particles’ insertion degree were evaluated. More to the point, the form variation factor and the mass variation led to the optimal technological parameters for the synthesis of core-shell materials for prospect additive manufacturing and regenerative medicine applications.