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Devina Lobine
Department of Health Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius

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Review
Published: 12 June 2021 in Neurochemical Research
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Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifically proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that flavonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant effect, pharmacological models, seizure-inducing factors and response, effective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Miquel Martorell; Farukh Sharopov; Tugba Boyunegmez Tumer; Begum Kurt; Chintha Lankatillake; Anca Oana Docea; Ana Catarina Moreira; Daniel A. Dias; Mohamad Fawzi Mahomoodally; Devina Lobine; Natália Cruz-Martins; Manoj Kumar; Daniela Calina. A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research 2021, 1 -21.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Jesús Herrera-Bravo, Miquel Martorell, Farukh Sharopov, Tugba Boyunegmez Tumer, Begum Kurt, Chintha Lankatillake, Anca Oana Docea, Ana Catarina Moreira, Daniel A. Dias, Mohamad Fawzi Mahomoodally, Devina Lobine, Natália Cruz-Martins, Manoj Kumar, Daniela Calina. A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research. 2021; ():1-21.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Miquel Martorell; Farukh Sharopov; Tugba Boyunegmez Tumer; Begum Kurt; Chintha Lankatillake; Anca Oana Docea; Ana Catarina Moreira; Daniel A. Dias; Mohamad Fawzi Mahomoodally; Devina Lobine; Natália Cruz-Martins; Manoj Kumar; Daniela Calina. 2021. "A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy." Neurochemical Research , no. : 1-21.

Journal article
Published: 28 March 2021 in Molecules
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Croton hirtus L’Hér methanol extract was studied by NMR and two different LC-DAD-MSn using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources to obtain a quali-quantitative fingerprint. Forty different phytochemicals were identified, and twenty of them were quantified, whereas the main constituents were dihydro α ionol-O-[arabinosil(1-6) glucoside] (133 mg/g), dihydro β ionol-O-[arabinosil(1-6) glucoside] (80 mg/g), β-sitosterol (49 mg/g), and isorhamnetin-3-O-rutinoside (26 mg/g). C. hirtus was extracted with different solvents—namely, water, methanol, dichloromethane, and ethyl acetate—and the extracts were assayed using different in vitro tests. The methanolic extracts presented the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) values. All the tested extracts exhibited inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with a higher activity observed for dichloromethane (AChE: 5.03 and BChE: 16.41 mgGALAE/g), while the methanolic extract showed highest impact against tyrosinase (49.83 mgKAE/g). Taken together, these findings suggest C. hirtus as a novel source of bioactive phytochemicals with potential for commercial development.

ACS Style

Stefano Dall’Acqua; Kouadio Sinan; Stefania Sut; Irene Ferrarese; Ouattara Etienne; Mohamad Mahomoodally; Devina Lobine; Gokhan Zengin. Evaluation of Antioxidant and Enzyme Inhibition Properties of Croton hirtus L’Hér. Extracts Obtained with Different Solvents. Molecules 2021, 26, 1902 .

AMA Style

Stefano Dall’Acqua, Kouadio Sinan, Stefania Sut, Irene Ferrarese, Ouattara Etienne, Mohamad Mahomoodally, Devina Lobine, Gokhan Zengin. Evaluation of Antioxidant and Enzyme Inhibition Properties of Croton hirtus L’Hér. Extracts Obtained with Different Solvents. Molecules. 2021; 26 (7):1902.

Chicago/Turabian Style

Stefano Dall’Acqua; Kouadio Sinan; Stefania Sut; Irene Ferrarese; Ouattara Etienne; Mohamad Mahomoodally; Devina Lobine; Gokhan Zengin. 2021. "Evaluation of Antioxidant and Enzyme Inhibition Properties of Croton hirtus L’Hér. Extracts Obtained with Different Solvents." Molecules 26, no. 7: 1902.

Journal article
Published: 02 November 2020 in Current Medicinal Chemistry
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Background: Diabetes Mellitus (DM) is a severe endocrine metabolic disease coupled with various long-term complications. A plethora of targets have been identified, however with possible adverse effects. Therefore, researchers are in the perpetual quest for safe and more effective therapeutics. Natural products, particularly derived from plants have proven to exert anti-diabetic effects via diverse mechanisms. Methods: An overview of DM pathogenesis and its associated micro- and macro-vascular complications is presented. Possible underlying mechanisms of herbal remedies in DM management are provided highlighting some key therapeutic targets. The review also appraises the recent progress of herbal products in treating DM through regulating inflammation and gut microbiota. Finally, currently available pharmacological treatments are discussed. Results: The results show that numerous plants have proved to be promising sources of insulin secreting agents, αglucosidase and α-amylase inhibitors. Among the non- conventional targets, inhibition of key enzymes such as lipase, cholinesterases and angiotensin converting enzyme have been directly and/or indirectly linked to DM and DM complications. For instance, hypericin, pseudohypericin and I3,II8-biapigenin isolated from Hypericum perforatum L., and palmatine and columbamine isolated from Dichocarpum auriculatum (Franch.) W. T. Wang & P. K have been found to be powerful lipase and cholinesterase inhibitors, respectively. Moreover, a number of plant-derived compounds such as feruloylated oligosaccharides from maize bran, baicalein and berberine are reported to mediate anti-diabetic property via modulation of gut microbiota. Conclusion: The information amassed in this review is anticipated to provide useful scientific baseline information to support advanced research in natural antidiabetic drug development.

ACS Style

Mohamad Fawzi Mahomoodally; Devina Lobine; Marie Carene Nancy Picot-Allain; Nabeelah Sadeer; Sharmeen Jugreet; Gokhan Zengin. Conventional and non-conventional targets of natural products in the management of diabetes mellitus and associated complications. Current Medicinal Chemistry 2020, 27, 1 -28.

AMA Style

Mohamad Fawzi Mahomoodally, Devina Lobine, Marie Carene Nancy Picot-Allain, Nabeelah Sadeer, Sharmeen Jugreet, Gokhan Zengin. Conventional and non-conventional targets of natural products in the management of diabetes mellitus and associated complications. Current Medicinal Chemistry. 2020; 27 ():1-28.

Chicago/Turabian Style

Mohamad Fawzi Mahomoodally; Devina Lobine; Marie Carene Nancy Picot-Allain; Nabeelah Sadeer; Sharmeen Jugreet; Gokhan Zengin. 2020. "Conventional and non-conventional targets of natural products in the management of diabetes mellitus and associated complications." Current Medicinal Chemistry 27, no. : 1-28.

Journal article
Published: 10 October 2020 in Industrial Crops and Products
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Lophira lanceolata Tiegh. ex Keay, a native tropical plant to west and central Africa, is a multifunctional plant used as timber and also exploited in traditional medicine in Africa. The present study present the pharmacological properties of Lophira lanceolata leaf and stem bark extracts prepared from different extraction procedures (infusion, homogenizer‐assisted extraction, maceration, soxhlet). The detailed phytochemical composition, in vitro antioxidant and antiproliferative assays, as well as the key enzyme (cholinesterases, tyrosinase, α‐amylase and α‐glucosidase) inhibitory potentials of the extracts were evaluated. Chemical profiling confirmed the presence of lanceolatins and lophirones in all analyzed plant parts. Higher levels of total phenolics (156.42 mg gallic acid equivalent (GAE)/g for maceration-water), phenolic acids (165.84 mg caffeic acid equivalent (CE)/g for maceration-water) and flavanols (101.51 mg catechin equivalent (CAE)/g for soxhlet-methanol (MeOH)) were observed in the stem bark extracts. Antioxidant assays showed remarkable free radical scavenging and reducing power activities for all extracts, among which stem bark showed the highest potential. Stem bark extracts (IC50 values: 57.55–93.10 μg/ml for colorectal adenocarcinoma (HT29) and 78.18–89.58 μg/ml for metastatic breast cancer cell line (MCF7)) also showed better antiproliferative effect than leaf (424.14–790.27 μg/ml for HT29 and 374.46–943.09 μg/ml for MCF7) on carcinoma cells while they induced proliferation in normal human cell lines (normal skin fibroblasts (HFF)). In the enzyme inhibitory assays, the methanol extracts of both plant parts were confirmed as effective against AChE, BChE (only stem barks extracts) and α-glucosidase enzymes. Regarding anti-tyrosinase effects, the methanol leaf extracts (122.21–131.17 mg kojic acid equivalent (KAE)/g) and all stem bark extracts (94.58–153.21 mg KAE/g) exhibited inhibitory effects. Findings amassed herein tend to validate the traditional uses of L. lanceolata and advocate for the development of phyto-medicaments based on its extracts.

ACS Style

Kouadio Ibrahime Sinan; Lara Saftić Martinović; Željka Peršurić; Sandra Kraljević Pavelić; Petra Grbčić; Dario Matulja; Ouattara Katinan Etienne; Mohamad Fawzi Mahomoodally; Devina Lobine; Tapan Behl; Gokhan Zengin. Metabolite characterization, antioxidant, anti-proliferative and enzyme inhibitory activities of Lophira lanceolata Tiegh. ex Keay extracts. Industrial Crops and Products 2020, 158, 112982 .

AMA Style

Kouadio Ibrahime Sinan, Lara Saftić Martinović, Željka Peršurić, Sandra Kraljević Pavelić, Petra Grbčić, Dario Matulja, Ouattara Katinan Etienne, Mohamad Fawzi Mahomoodally, Devina Lobine, Tapan Behl, Gokhan Zengin. Metabolite characterization, antioxidant, anti-proliferative and enzyme inhibitory activities of Lophira lanceolata Tiegh. ex Keay extracts. Industrial Crops and Products. 2020; 158 ():112982.

Chicago/Turabian Style

Kouadio Ibrahime Sinan; Lara Saftić Martinović; Željka Peršurić; Sandra Kraljević Pavelić; Petra Grbčić; Dario Matulja; Ouattara Katinan Etienne; Mohamad Fawzi Mahomoodally; Devina Lobine; Tapan Behl; Gokhan Zengin. 2020. "Metabolite characterization, antioxidant, anti-proliferative and enzyme inhibitory activities of Lophira lanceolata Tiegh. ex Keay extracts." Industrial Crops and Products 158, no. : 112982.

Journal article
Published: 29 September 2020 in Industrial Crops and Products
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The genus Consolida is one of the most important within the Ranunculaceae family and several members of this genus contain important biologically active compounds, such as phenolics and alkaloids. The present study attempts for the first time to assess the biological properties and phytochemical constituents of six Consolida species (C. glandulosa (Boiss. & A. Huet) Bornm, C. hellospontica (Boiss.) Chater, C. raveyi (Boiss.) Schrödinger, C. regalis (Boiss.) Schrödinger, C. staminosa P.H. Davis & Sorger and C. stenocarpa (P.H. Davis & M. Hossain) P.H. Davis) growing in Turkey. A comprehensive phytochemical profiling of the different species was achieved by using an ultra-high-performance liquid chromatography-quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry, targeting polyphenols and diterpene alkaloids. Also, the in vitro antioxidant assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), metal chelating and phosphomolybdenum) and enzyme inhibition (cholinesterases, tyrosinase, α-amylase, and α-glucosidase) potentials of the different Consolida methanolic extracts were evaluated. The UHPLC-QTOF profiling revealed 492 compounds, being 236 flavonoids, 93 phenolic acids, 78 tyrosol derivatives, 49 diterpene alkaloids, 29 lignans, and 7 stilbenes. The cumulative phenolic content ranged from 17.65 mg Eq./g for C. staminosa up to 43.04 mg Eq./g for C. glandulosa, whilst the total diterpene alkaloids content was exclusively found in C. glandulosa extracts (3.53 mg Eq./g). Consolida regalis (58. 61 mg trolox equivalent (TE)/g for DPPH and 65.38 mg TE/g for ABTS) and C. stenocarpa (46.81 mg TE/g for DPPH and 78.12 mg TE/g for ABTS) exhibited the highest anti-radical abilities, while the best reducing power values were recorded for C. glandulosa (129.46 mg TE/g for CUPRAC and 77.01 mg TE/g for FRAP) and C. raveyi (124.56 mg TE/g for CUPRAC and 78.36 mg TE/g for FRAP). Also, following the cholinesterases inhibition assays, C. hellospontica and C. glandulosa exhibited the highest inhibitory effects. Regarding tyrosinase inhibitory effects, C. raveyi showed the highest value, being 126.60 mg kojic acid equivalent (KAE)/g, followed by C. glandulosa (125.82 mg KAE/g) and C. stenocarpa (123.09 mg KAE/g). Besides, Consolida staminosa showed potential inhibition against α-amylase, but low glucosidase inhibitory properties. Therefore, the present findings could provide a starting point for further investigations to promote the industrial exploitation of these species with the aim of designing novel phyto-pharmaceuticals.

ACS Style

Gabriele Rocchetti; Gokhan Zengin; Yavuz Selim Cakmak; Mohamad Fawzi Mahomoodally; Muhammed Fettah Kaya; Sarah Mohammed Alsheikh; Jasmina Glamocilja; Marina Sokovic; Devina Lobine; Luigi Lucini. A UHPLC-QTOF-MS screening provides new insights into the phytochemical composition and biological properties of six Consolida species from Turkey. Industrial Crops and Products 2020, 158, 112966 .

AMA Style

Gabriele Rocchetti, Gokhan Zengin, Yavuz Selim Cakmak, Mohamad Fawzi Mahomoodally, Muhammed Fettah Kaya, Sarah Mohammed Alsheikh, Jasmina Glamocilja, Marina Sokovic, Devina Lobine, Luigi Lucini. A UHPLC-QTOF-MS screening provides new insights into the phytochemical composition and biological properties of six Consolida species from Turkey. Industrial Crops and Products. 2020; 158 ():112966.

Chicago/Turabian Style

Gabriele Rocchetti; Gokhan Zengin; Yavuz Selim Cakmak; Mohamad Fawzi Mahomoodally; Muhammed Fettah Kaya; Sarah Mohammed Alsheikh; Jasmina Glamocilja; Marina Sokovic; Devina Lobine; Luigi Lucini. 2020. "A UHPLC-QTOF-MS screening provides new insights into the phytochemical composition and biological properties of six Consolida species from Turkey." Industrial Crops and Products 158, no. : 112966.

Review
Published: 13 August 2020 in Biology
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Schistosomiasis, a parasitic disease caused by trematodes of the genus Schistosoma, is the second most prevalent parasitic disease in the world. It affects around 200 million people. Clinical treatment, prophylaxis, and prevention are performed in countries susceptible to schistosomiasis. In the pharmacological treatment for an acute form of schistosomiasis, the use of antiparasitics, mainly praziquantel, is more common. As an alternative way, prevention methods such as reducing the population of intermediate hosts (mollusks) with molluscicides are important in the control of this disease by interrupting the biological cycle of this etiological parasite. Despite the importance of pharmacological agents and molluscicides, they have side effects and environmental toxicity. In addition, they can lead to the development of resistance enhancing of parasites, and lead to the search for new and effective drugs, including resources of vegetal origin, which in turn, are abundant in the affected countries. Thus, the purpose of this review is to summarize recent studies on botanical products with potential for the control of schistosomiasis, including anti-Schistosoma and molluscicide activities. In addition, species and plant derivatives according to their origin or geographical importance indicating a possible utility of local resources for countries most affected by the disease are presented.

ACS Style

Ricardo Diego Duarte Galhardo De Albuquerque; Mohamad Fawzi Mahomoodally; Devina Lobine; Shanno Suroowan; Kannan Rr Rengasamy. Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions. Biology 2020, 9, 223 .

AMA Style

Ricardo Diego Duarte Galhardo De Albuquerque, Mohamad Fawzi Mahomoodally, Devina Lobine, Shanno Suroowan, Kannan Rr Rengasamy. Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions. Biology. 2020; 9 (8):223.

Chicago/Turabian Style

Ricardo Diego Duarte Galhardo De Albuquerque; Mohamad Fawzi Mahomoodally; Devina Lobine; Shanno Suroowan; Kannan Rr Rengasamy. 2020. "Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions." Biology 9, no. 8: 223.

Journal article
Published: 08 July 2020 in Industrial Crops and Products
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Scorzonera tomentosa L. (family Asteraceae), endemic to Turkey is reputed for its medicinal attributes in the folkloric medicine. However, only few studies on the chemical composition and pharmacological properties of this plant have been published so far. In this direction, this study aimed to shed light on the phenolic composition, antioxidant and key enzyme inhibitory properties of S. tomentosa aerial parts and roots extracts prepared using different solvents (dichloromethane, ethyl acetate, hexane, water and methanol). Overall, the methanolic extracts and the infusion of both plant parts were better sources of total polyphenolics with 40.33 and 39.30 mg gallic acid equivalent (GAE)/g, respectively, while for the aerial parts, 22.42 and 21.84 mg GAE/g were measured for methanolic extract and root infusion, respectively. Extracts of the aerial parts showed considerable amount of total flavonoid content (2.96–34.93 mg rutin equivalent (RE)/g) as compared with the root extract (0.40–2.65 mg RE/g), with highest content observed in methanolic extract. For this reason, the methanolic extract of roots and aerial parts were subjected to liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MSn) analysis. The methanolic and aqueous extracts of both plant parts proved to be most significant radical quenchers (1.05–45.89 mg trolox equivalent (TE)/g in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay; and 1.82–82.94 mg TE/g in 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay) and reducing agents (39.40–164.06 mg TE/g in cupric reducing antioxidant capacity (CUPRAC) and 15.54–79.78 mg TE/g in ferric reducing antioxidant power (FRAP)). The dichloromethane extracts were significant metal chelators (13.92 and 6.24 mg ethylenediaminetetraacetate equivalent (EDTAE)/g for aerial parts and roots). Extracts of both plant parts showed selective inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Notable anti-tyrosinase activity was observed for all the extracts (aerial part: 16.40 ± 1.30 - 64.83 ± 0.28 and roots: 6.29 ± 0.50–65.46 ± 0.31 mg kojic acid equivalent (KAE)/g), while modest inhibitory activity against α-amylase (0.08−0.61 mmol acarbose equivalent (ACAE)/g) and α-glucosidase (0.09−0.83 mmol ACAE/g) for all the tested extracts. In addition, to provide the first scientific insight on the biological and chemical profile of S. tomentosa, observations from this present study tend to identify this plant as a valuable source of biologically active molecules for possible phytopharmaceutical and cosmeceuticals exploitation.

ACS Style

Stefano Dall’Acqua; Gunes Ak; Stefania Sut; Irene Ferrarese; Gokhan Zengin; Evren Yıldıztugay; Mohamad Fawzi Mahomoodally; Kouadio Ibrahime Sinan; Devina Lobine. Phenolics from Scorzonera tomentosa L.: Exploring the potential use in industrial applications via an integrated approach. Industrial Crops and Products 2020, 154, 112751 .

AMA Style

Stefano Dall’Acqua, Gunes Ak, Stefania Sut, Irene Ferrarese, Gokhan Zengin, Evren Yıldıztugay, Mohamad Fawzi Mahomoodally, Kouadio Ibrahime Sinan, Devina Lobine. Phenolics from Scorzonera tomentosa L.: Exploring the potential use in industrial applications via an integrated approach. Industrial Crops and Products. 2020; 154 ():112751.

Chicago/Turabian Style

Stefano Dall’Acqua; Gunes Ak; Stefania Sut; Irene Ferrarese; Gokhan Zengin; Evren Yıldıztugay; Mohamad Fawzi Mahomoodally; Kouadio Ibrahime Sinan; Devina Lobine. 2020. "Phenolics from Scorzonera tomentosa L.: Exploring the potential use in industrial applications via an integrated approach." Industrial Crops and Products 154, no. : 112751.

Journal article
Published: 03 June 2020 in Food Research International
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Members of Scorzonera genus are known for their potential application in both food and pharmaceutical industries. The present study reports the chemical component and bioactivity of the dichloromethane, ethyl acetate, hexane, methanol and infused extracts of Scorzonera hieraciifolia Hayek aerial parts and roots. The methanolic extracts of both aerial parts and roots were good sources of total phenolic and flavonoid content. For the aerial parts, the infused and methanolic extracts showed highest (p<0.05) free radical scavenging (2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS)), reducing (cupric reducing antioxidant capacity (CUPRAC))and ferric reducing antioxidant power (FRAP)) and metal chelating capacities. Whilst, for the root extracts, overall most remarkable free scavenging and reducing activity was observed for the methanolic extracts (p<0.05) while the hexane extracts showed highest metal chelating activity. The inhibitory activity of the extracts was evaluated against key enzymes. Overall, the hexane extracts of both aerial parts (acetylcholinesterase (AChE): 2.27±0.04 and butyrlcholinesterase (BChE): 5.75±0.48 mg galantamine equivalent (GALAE)/g) and roots (AChE: 2.44±0.35 and BChE: 53.17±0.22 mg GALAE/g) were most potent against AChE and BChE, suggesting a role for the more lipophilic compounds in this regard. The highest inhibitory activity against tyrosinase was displayed by methanolic extracts of aerial parts (64.70±0.26 mg kojic acid equivalent (KAE)/g) and roots (63.63±0.20 mg KAE/g). Modest activity was observed against α-amylase and α-glucosidase, two major enzymes implicated in the pathology of diabetes. Liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) analysis showed the presence of 40 compounds such as caffeic, ursolic, betulinic and oleanolic acid and their derivatives in the studied extracts. Multivariate analysis showed that the biological activities were dependent on the plant parts used as well as on the type of solvent used. Overall, the results showed that S. hieraciifolia is a valuable source of phytochemicals for both the nutraceutical and pharmaceutical sectors.

ACS Style

Stefano Dall'Acqua; Gunes Ak; Stefania Sut; Gokhan Zengin; Evren Yıldıztugay; Mohamad Fawzi Mahomoodally; Kouadio Ibrahime Sinan; Devina Lobine. Comprehensive bioactivity and chemical characterization of the endemic plant Scorzonera hieraciifolia Hayek extracts: A promising source of bioactive compounds. Food Research International 2020, 137, 109371 .

AMA Style

Stefano Dall'Acqua, Gunes Ak, Stefania Sut, Gokhan Zengin, Evren Yıldıztugay, Mohamad Fawzi Mahomoodally, Kouadio Ibrahime Sinan, Devina Lobine. Comprehensive bioactivity and chemical characterization of the endemic plant Scorzonera hieraciifolia Hayek extracts: A promising source of bioactive compounds. Food Research International. 2020; 137 ():109371.

Chicago/Turabian Style

Stefano Dall'Acqua; Gunes Ak; Stefania Sut; Gokhan Zengin; Evren Yıldıztugay; Mohamad Fawzi Mahomoodally; Kouadio Ibrahime Sinan; Devina Lobine. 2020. "Comprehensive bioactivity and chemical characterization of the endemic plant Scorzonera hieraciifolia Hayek extracts: A promising source of bioactive compounds." Food Research International 137, no. : 109371.

Journal article
Published: 23 April 2020 in Molecules
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Achyranthes aspera Linn. (Amaranthaceae), commonly known as the Prickly Chaff flower, is used as herbal medicine in the Ivorian’s culture, Africa. Nonetheless, there is currently a paucity of scientific information on A. aspera from the Ivory Coast. Herein, the antioxidant activity of A. aspera extracts (methanol, dichloromethane, ethyl acetate and infusion) as well as the enzymatic inhibitory potentials towards key enzymes in human diseases, namely Alzheimer’s disease, (cholinesterases: AchE and BChE), type 2 diabetes (α-glucosidase and α-amylase) and hyperpigmentation (tyrosinase) were assessed. The total phenolic (TPC) and flavonoid (TFC) content was determined using colorimetric methods and the individual compounds were characterized using ultra-high performance liquid chromatography coupled with hybrid quadrupole-Orbitrap high resolution mass spectrometry (UHPLC-HRMS). Furthermore, a network pharmacology analysis was conducted to predict putative targets of identified phenolic compounds. The highest TPC was observed in the infused extract (28.86 ± 0.12 mg GAE/g), while the dichloromethane extract (38.48 ± 1.48 mg RE/g) showed the highest level of TFC. UHPLC-HRMS analysis has revealed an abundance of fatty acids, flavonoids, phenols and acylquinic acids. Among tested extracts, the infused extract displayed the highest free radical quenching, reducing and metal-chelating ability. The extracts (except infusion) were effective as enzyme inhibitors against AChE, while only methanolic and infused extracts showed noteworthy anti-BChE effects. The methanolic extract showed a remarkable antityrosinase effect (56.24 ± 5.05 mg KAE/g), as well. Modest to moderate inhibitory activity was observed against α-amylase (all extracts) and α-glucosidase (only dichloromethane extract). Finally, the network pharmacology analysis suggested the carbonic anhydrase II enzyme as a putative target for explaining, at least in part, the traditional use of A. aspera preparations as diuretic and blood clotting agent. Data amassed herein tend to validate the use of A. aspera in traditional medicine, as well as act as a stepping stone for further studies in the quest for novel phytopharmaceuticals. In this context, it is desirable that this study will contribute to the validation of the traditional uses of this plant in the African herbal medicine, and to the valorization of the whole chain production of A. aspera, as a local and sustainable botanical resource.

ACS Style

Kouadio Ibrahime Sinan; Gokhan Zengin; Dimitrina Zheleva-Dimitrova; Ouattara Katinan Etienne; Mohamad Fawzi Mahomoodally; Abdelhakim Bouyahya; Devina Lobine; Annalisa Chiavaroli; Claudio Ferrante; Luigi Menghini; Lucia Recinella; Luigi Brunetti; Sheila Leone; Giustino Orlando. Qualitative Phytochemical Fingerprint and Network Pharmacology Investigation of Achyranthes aspera Linn. Extracts. Molecules 2020, 25, 1973 .

AMA Style

Kouadio Ibrahime Sinan, Gokhan Zengin, Dimitrina Zheleva-Dimitrova, Ouattara Katinan Etienne, Mohamad Fawzi Mahomoodally, Abdelhakim Bouyahya, Devina Lobine, Annalisa Chiavaroli, Claudio Ferrante, Luigi Menghini, Lucia Recinella, Luigi Brunetti, Sheila Leone, Giustino Orlando. Qualitative Phytochemical Fingerprint and Network Pharmacology Investigation of Achyranthes aspera Linn. Extracts. Molecules. 2020; 25 (8):1973.

Chicago/Turabian Style

Kouadio Ibrahime Sinan; Gokhan Zengin; Dimitrina Zheleva-Dimitrova; Ouattara Katinan Etienne; Mohamad Fawzi Mahomoodally; Abdelhakim Bouyahya; Devina Lobine; Annalisa Chiavaroli; Claudio Ferrante; Luigi Menghini; Lucia Recinella; Luigi Brunetti; Sheila Leone; Giustino Orlando. 2020. "Qualitative Phytochemical Fingerprint and Network Pharmacology Investigation of Achyranthes aspera Linn. Extracts." Molecules 25, no. 8: 1973.

Research article
Published: 20 April 2020 in Drug Development Research
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Globally, approximately 12% of the population is inflicted by various types of urolithiasis. Standard treatments are available both to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds which holds immense potential as therapeutic for treating kidney stone. This review aims to provide an integrative description on how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various mechanisms such as antioxidant, anti‐inflammatory, diuretic, and angiotensin‐converting enzyme inhibition. Some of the pentacylic triterpenes which shows promising activities include lupeol, oleanolic acid, betulin, and taraxasterol. Moreover, future perspectives in the development of pentacyclic triterpenes in formulations/drugs for urinary stone prevention are highlighted. It is anticipated that compiled information would serve as a scientific baseline to advocate further investigations on the potential of pentacyclic triterpenes in urolithiasis remediation.

ACS Style

Devina Lobine; Salman Ahmed; Michael Aschner; Haroon Khan; Hamed Mirzaei; Mohamad F. Mahomoodally. Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects. Drug Development Research 2020, 81, 671 -684.

AMA Style

Devina Lobine, Salman Ahmed, Michael Aschner, Haroon Khan, Hamed Mirzaei, Mohamad F. Mahomoodally. Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects. Drug Development Research. 2020; 81 (6):671-684.

Chicago/Turabian Style

Devina Lobine; Salman Ahmed; Michael Aschner; Haroon Khan; Hamed Mirzaei; Mohamad F. Mahomoodally. 2020. "Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects." Drug Development Research 81, no. 6: 671-684.

Review
Published: 08 April 2020 in Journal of Clinical Medicine
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Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.

ACS Style

Mehdi Sharifi-Rad; Chintha Lankatillake; Daniel A. Dias; Anca Oana Docea; Mohamad Fawzi Mahomoodally; Devina Lobine; Paul L. Chazot; Begum Kurt; Tugba Boyunegmez Tumer; Ana Catarina Moreira; Farukh Sharopov; Miquel Martorell; Natália Martins; William C. Cho; Daniela Calina; Javad Sharifi-Rad. Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. Journal of Clinical Medicine 2020, 9, 1061 .

AMA Style

Mehdi Sharifi-Rad, Chintha Lankatillake, Daniel A. Dias, Anca Oana Docea, Mohamad Fawzi Mahomoodally, Devina Lobine, Paul L. Chazot, Begum Kurt, Tugba Boyunegmez Tumer, Ana Catarina Moreira, Farukh Sharopov, Miquel Martorell, Natália Martins, William C. Cho, Daniela Calina, Javad Sharifi-Rad. Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. Journal of Clinical Medicine. 2020; 9 (4):1061.

Chicago/Turabian Style

Mehdi Sharifi-Rad; Chintha Lankatillake; Daniel A. Dias; Anca Oana Docea; Mohamad Fawzi Mahomoodally; Devina Lobine; Paul L. Chazot; Begum Kurt; Tugba Boyunegmez Tumer; Ana Catarina Moreira; Farukh Sharopov; Miquel Martorell; Natália Martins; William C. Cho; Daniela Calina; Javad Sharifi-Rad. 2020. "Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics." Journal of Clinical Medicine 9, no. 4: 1061.

Journal article
Published: 11 December 2019 in Antioxidants
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Like other members of the Colchicum genus, C. szovitsii subsp. szovitsii is also of medicinal importance in Turkish traditional medicine. However, its biological properties have not been fully investigated. Herein, we focused on the evaluation of the in vitro antioxidant and enzyme inhibitory effects of flower, root and leaf extracts, obtained using different extraction methods. In addition, a comprehensive (poly)-phenolic and alkaloid profiling of the different extracts was undertaken. In this regard, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) allowed us to putatively annotate 195 polyphenols and 87 alkaloids. The most abundant polyphenols were flavonoids (83 compounds), whilst colchicine and 2-demethylcolchicine were some of the most widespread alkaloids in each extract analyzed. However, our findings showed that C. szovitsii leaf extracts were a superior source of both total polyphenols and total alkaloids (being, on average 24.00 and 2.50 mg/g, respectively). Overall, methanolic leaf extracts showed the highest (p < 0.05) ferric reducing antioxidant power (FRAP) reducing power (on average 109.52 mgTE/g) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (on average 90.98 mgTE/g). Interestingly, each C. szovitsii methanolic extract was more active than the water extracts when considering enzymatic inhibition such as against tyrosinase, glucosidase, and acetylcholinesterase (AChE). Strong correlations (p < 0.01) were also observed between polyphenols/alkaloids and the biological activities determined. Multivariate statistics based on supervised orthogonal projections to latent structures discriminant analysis (OPLS-DA) allowed for the detection of those compounds most affected by the different extraction methods. Therefore, this is the first detailed evidence showing that C. szovitsii subsp. szovitsii might provide beneficial effects against oxidative stress and the associated chronic diseases. Nevertheless, the detailed mechanisms of action need to be further investigated.

ACS Style

Gabriele Rocchetti; Biancamaria Senizza; Gokhan Zengin; Murat Ali Okur; Domenico Montesano; Evren Yildiztugay; Devina Lobine; Mohamad Fawzi Mahomoodally; Luigi Lucini. Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii. Antioxidants 2019, 8, 632 .

AMA Style

Gabriele Rocchetti, Biancamaria Senizza, Gokhan Zengin, Murat Ali Okur, Domenico Montesano, Evren Yildiztugay, Devina Lobine, Mohamad Fawzi Mahomoodally, Luigi Lucini. Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii. Antioxidants. 2019; 8 (12):632.

Chicago/Turabian Style

Gabriele Rocchetti; Biancamaria Senizza; Gokhan Zengin; Murat Ali Okur; Domenico Montesano; Evren Yildiztugay; Devina Lobine; Mohamad Fawzi Mahomoodally; Luigi Lucini. 2019. "Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii." Antioxidants 8, no. 12: 632.

Review
Published: 29 November 2019 in Processes
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Herpes simplex viruses (HSVs) are common human pathogens belonging to the subfamily alpha-herpesvirinae that trigger severe infections in neonates and immunocompromised patients. After primary infection, the HSVs establish a lifelong latent infection in the vegetative neural ganglia of their hosts. HSV infections contribute to substantial disease burden in humans as well as in newborns. Despite a fair number of drugs being available for the treatment of HSV infections, new, effective, and safe antiviral agents, exerting different mechanisms of action, are urgently required, mainly due to the increasing number of resistant strains. Accumulating pieces of evidence have suggested that structurally diverse compounds from marine algae possess promising anti-HSV potentials. Several studies have documented a variety of algal polysaccharides possessing anti-HSV activity, including carrageenan and fucan. This review aimed to compile previous anti-HSV studies on marine algae–derived compounds, especially sulfated polysaccharides, along with their mode of action, toward their development as novel natural anti-HSV agents for future investigations.

ACS Style

Mohamad Fawzi Mahomoodally; Devina Lobine; Kannan R. R. Rengasamy; Shanmugaraj Gowrishankar; Devesh Tewari; Gokhan Zengin; Doo Hwan Kim; Iyyakkannu Sivanesan. Marine Algae: A Potential Resource of Anti-HSV Molecules. Processes 2019, 7, 887 .

AMA Style

Mohamad Fawzi Mahomoodally, Devina Lobine, Kannan R. R. Rengasamy, Shanmugaraj Gowrishankar, Devesh Tewari, Gokhan Zengin, Doo Hwan Kim, Iyyakkannu Sivanesan. Marine Algae: A Potential Resource of Anti-HSV Molecules. Processes. 2019; 7 (12):887.

Chicago/Turabian Style

Mohamad Fawzi Mahomoodally; Devina Lobine; Kannan R. R. Rengasamy; Shanmugaraj Gowrishankar; Devesh Tewari; Gokhan Zengin; Doo Hwan Kim; Iyyakkannu Sivanesan. 2019. "Marine Algae: A Potential Resource of Anti-HSV Molecules." Processes 7, no. 12: 887.

Review
Published: 09 August 2019 in Biomolecules
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α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants, animals, and humans. It has various properties, among them great antioxidant potential and is widely used as a racemic drug for diabetic polyneuropathy-associated pain and paresthesia. Naturally, ALA is located in mitochondria, where it is used as a cofactor for pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase complexes. Despite its various potentials, ALA therapeutic efficacy is relatively low due to its pharmacokinetic profile. Data suggests that ALA has a short half-life and bioavailability (about 30%) triggered by its hepatic degradation, reduced solubility as well as instability in the stomach. However, the use of various innovative formulations has greatly improved ALA bioavailability. The R enantiomer of ALA shows better pharmacokinetic parameters, including increased bioavailability as compared to its S enantiomer. Indeed, the use of amphiphilic matrices has capability to improve ALA bioavailability and intestinal absorption. Also, ALA’s liquid formulations are associated with greater plasma concentration and bioavailability as compared to its solidified dosage form. Thus, improved formulations can increase both ALA absorption and bioavailability, leading to a raise in therapeutic efficacy. Interestingly, ALA bioavailability will be dependent on age, while no difference has been found for gender. The present review aims to provide an updated on studies from preclinical to clinical trials assessing ALA’s usages in diabetic patients with neuropathy, obesity, central nervous system-related diseases and abnormalities in pregnancy.

ACS Style

Bahare Salehi; Yakup Berkay Yılmaz; Gizem Antika; Tugba Boyunegmez Tumer; Mohamad Fawzi Mahomoodally; Devina Lobine; Muhammad Akram; Muhammad Riaz; Esra Capanoglu; Farukh Sharopov; Natália Martins; William C. Cho; Javad Sharifi-Rad. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules 2019, 9, 356 .

AMA Style

Bahare Salehi, Yakup Berkay Yılmaz, Gizem Antika, Tugba Boyunegmez Tumer, Mohamad Fawzi Mahomoodally, Devina Lobine, Muhammad Akram, Muhammad Riaz, Esra Capanoglu, Farukh Sharopov, Natália Martins, William C. Cho, Javad Sharifi-Rad. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019; 9 (8):356.

Chicago/Turabian Style

Bahare Salehi; Yakup Berkay Yılmaz; Gizem Antika; Tugba Boyunegmez Tumer; Mohamad Fawzi Mahomoodally; Devina Lobine; Muhammad Akram; Muhammad Riaz; Esra Capanoglu; Farukh Sharopov; Natália Martins; William C. Cho; Javad Sharifi-Rad. 2019. "Insights on the Use of α-Lipoic Acid for Therapeutic Purposes." Biomolecules 9, no. 8: 356.

Journal article
Published: 07 August 2019 in Processes
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Artemisia species are used as folk medicines in several countries. This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase α-amylase, and α-glucosidase) as well of their antioxidant and pharmacological effects. The chemical profile of the essential oil was determined using gas chromatography coupled to mass spectrometry (GC-MS) analysis, while the extracts were chemically characterized by high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Forty-nine constituents were identified and camphor (36.6%), 1,8-cineole (10.2%), α-thujone (10.1%), borneol (4.5%), and β-thujone (3.6%) were the major components. Overall, 45, 74, and 67 components were identified from the ethyl acetate, methanol, and water extracts, respectively. The EO and extracts showed significant antioxidant properties, in a cell-free model; particularly, methanol and water extracts revealed promising sources of antioxidant compounds. Additionally, we evaluated protective effects of EO and extracts in isolated rat colon tissue challenged with lipopolysaccharide (LPS), as an ex vivo model of colon inflammation, and human colon cancer HCT116 cell line. Particularly, we observed that, among all tested samples, A. santonicum ethyl acetate displayed the best pharmacological profile, being able to blunt LPS-induced levels of all tested biomarkers of inflammation and oxidative stress, including colon nitrites, lactate dehydrogenase, prostaglandin E2, and serotonin. Additionally, this extract was also able to reduce HCT116 cell viability, thus suggesting potential antiproliferative effects against colon cancer cells. Based on our results, A. santonicum has great potential for developing novel functional agents including pharmaceuticals, cosmeceuticals, and nutraceuticals.

ACS Style

Claudio Ferrante; Gokhan Zengin; Luigi Menghini; Alina Diuzheva; József Jekő; Zoltán Cziáky; Lucia Recinella; Annalisa Chiavaroli; Sheila Leone; Luigi Brunetti; Devina Lobine; Ismail Senkardes; Mohamad Fawzi Mahomoodally; Giustino Orlando. Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L. Processes 2019, 7, 522 .

AMA Style

Claudio Ferrante, Gokhan Zengin, Luigi Menghini, Alina Diuzheva, József Jekő, Zoltán Cziáky, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Luigi Brunetti, Devina Lobine, Ismail Senkardes, Mohamad Fawzi Mahomoodally, Giustino Orlando. Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L. Processes. 2019; 7 (8):522.

Chicago/Turabian Style

Claudio Ferrante; Gokhan Zengin; Luigi Menghini; Alina Diuzheva; József Jekő; Zoltán Cziáky; Lucia Recinella; Annalisa Chiavaroli; Sheila Leone; Luigi Brunetti; Devina Lobine; Ismail Senkardes; Mohamad Fawzi Mahomoodally; Giustino Orlando. 2019. "Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L." Processes 7, no. 8: 522.

Review article
Published: 22 April 2019 in Medicinal Research Reviews
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Antiplatelet drugs reduce the risks associated with atherothrombotic events and show various applications in diverse cardiovascular diseases including myocardial infarctions. Efficacy of the current antiplatelet medicines including aspirin, clopidogrel, prasugrel and ticagrelor, and the glycoprotein IIb/IIIa antagonists, are limited due to their increased risks of bleeding, and antiplatelet drug resistance. Hence, it is important to develop new effective antiplatelet drugs, with fewer side‐effects. The vast repertoire of natural peptides can be explored towards this goal. Proteins and peptides derived from snake venoms and plants represent exciting candidates for the development of novel and potent antiplatelet agents. Consequently, this review discusses multiple peptides that have displayed antiplatelet aggregation activity in preclinical drug development stages. This review also describes the antiplatelet mechanisms of the peptides, emphasizing the signaling pathways intervened by them. Also, the hurdles encountered during the development of peptides into antiplatelet drugs have been listed. Finally, hitherto unexplored peptides with the potential to prevent platelet aggregation are explored.

ACS Style

Kannan R.R. Rengasamy; Haroon Khan; Imad Ahmad; Devina Lobine; Fawzi Mahomoodally; Shanoo Suroowan; Sherif T.S. Hassan; Suowen Xu; Seema Patel; Maria Daglia; Seyed Mohammad Nabavi; Shunmugiah Karutha Pandian. Bioactive peptides and proteins as alternative antiplatelet drugs. Medicinal Research Reviews 2019, 39, 2153 -2171.

AMA Style

Kannan R.R. Rengasamy, Haroon Khan, Imad Ahmad, Devina Lobine, Fawzi Mahomoodally, Shanoo Suroowan, Sherif T.S. Hassan, Suowen Xu, Seema Patel, Maria Daglia, Seyed Mohammad Nabavi, Shunmugiah Karutha Pandian. Bioactive peptides and proteins as alternative antiplatelet drugs. Medicinal Research Reviews. 2019; 39 (6):2153-2171.

Chicago/Turabian Style

Kannan R.R. Rengasamy; Haroon Khan; Imad Ahmad; Devina Lobine; Fawzi Mahomoodally; Shanoo Suroowan; Sherif T.S. Hassan; Suowen Xu; Seema Patel; Maria Daglia; Seyed Mohammad Nabavi; Shunmugiah Karutha Pandian. 2019. "Bioactive peptides and proteins as alternative antiplatelet drugs." Medicinal Research Reviews 39, no. 6: 2153-2171.

Journal article
Published: 19 September 2018 in Industrial Crops and Products
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Amelanchier parviflora var. dentata is an endemic medicinal plant traditionally consumed to treat stomach pain, cardiovascular diseases, and urinary tract infections in Turkey’s folk medicine. Although Amelanchier genus is an excellent source of phytochemicals with a panoply of biological activities, no report has been made available on Amelanchier parviflora var. dentata. Thus, the metabolic profiles of methanol, ethyl acetate, and water extracts were obtained using HPLC–MS/MS. Besides, the pharmacological properties such as antioxidant activity and enzyme inhibition effects against acetyl/butyrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase were evaluated. In total, 62, 38, and 16 metabolites were identified from the methanolic, water, and ethyl acetate extracts, respectively. The identified metabolites belong to anthocyanins, phenolic acids, and flavonoids. The tested extracts exhibited different enzyme inhibitory activity against cholinesterases (acetylcholinesterase: 0.52–2.47 mg GEs/g extract and butyrylcholinesterase: 0.47–3.59 mg GEs/g extract), tyrosinase (19.0–145.54 mg KAEs/g extract), α-amylase (0.23–1.10 mmol ACEs/g extract), and α-glucosidase (8.89–9.92 mmol ACEs/ g extract). Evidence from the present study supports the necessity for more research in an endeavor to discover biologically active secondary metabolites from A. parviflora to manage specific ailments.

ACS Style

Gokhan Zengin; Alina Diuzheva; József Jekő; Zoltán Cziáky; Gizem Bulut; Ahmet Dogan; Mehmet Zeki Haznedaroglu; Kannan R.R. Rengasamy; Devina Lobine; Mir Babak Bahadori; Mohamad Fawzi Mahomoodally. HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata. Industrial Crops and Products 2018, 124, 699 -706.

AMA Style

Gokhan Zengin, Alina Diuzheva, József Jekő, Zoltán Cziáky, Gizem Bulut, Ahmet Dogan, Mehmet Zeki Haznedaroglu, Kannan R.R. Rengasamy, Devina Lobine, Mir Babak Bahadori, Mohamad Fawzi Mahomoodally. HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata. Industrial Crops and Products. 2018; 124 ():699-706.

Chicago/Turabian Style

Gokhan Zengin; Alina Diuzheva; József Jekő; Zoltán Cziáky; Gizem Bulut; Ahmet Dogan; Mehmet Zeki Haznedaroglu; Kannan R.R. Rengasamy; Devina Lobine; Mir Babak Bahadori; Mohamad Fawzi Mahomoodally. 2018. "HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata." Industrial Crops and Products 124, no. : 699-706.

Journals
Published: 06 February 2018 in New Journal of Chemistry
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Members of theHypericumgenus are spread throughout the world and have a long history of use in traditional systems of medicines.

ACS Style

Eulogio J. Llorent-Martínez; Gokhan Zengin; Devina Lobine; Lucia Molina-García; Adriano Mollica; Mohamad Fawzi Mahomoodally. Phytochemical characterization,in vitroandin silicoapproaches for threeHypericumspecies. New Journal of Chemistry 2018, 42, 5204 -5214.

AMA Style

Eulogio J. Llorent-Martínez, Gokhan Zengin, Devina Lobine, Lucia Molina-García, Adriano Mollica, Mohamad Fawzi Mahomoodally. Phytochemical characterization,in vitroandin silicoapproaches for threeHypericumspecies. New Journal of Chemistry. 2018; 42 (7):5204-5214.

Chicago/Turabian Style

Eulogio J. Llorent-Martínez; Gokhan Zengin; Devina Lobine; Lucia Molina-García; Adriano Mollica; Mohamad Fawzi Mahomoodally. 2018. "Phytochemical characterization,in vitroandin silicoapproaches for threeHypericumspecies." New Journal of Chemistry 42, no. 7: 5204-5214.